LOUIS J contact PICKER

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
  2. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
  3. pmc Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines
    Yoshinori Fukazawa
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA
    Nat Med 18:1673-81. 2012
  4. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
  5. pmc Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis
    Afam Okoye
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 206:1575-88. 2009
  6. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
  7. pmc Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection
    Afam A Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 209:641-51. 2012
  8. pmc In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques
    Annelie Tjernlund
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Retrovirology 7:12. 2010
  9. pmc New paradigms for HIV/AIDS vaccine development
    Louis J Picker
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Annu Rev Med 63:95-111. 2012
  10. pmc IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    Louis J Picker
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Clin Invest 116:1514-24. 2006

Collaborators

Detail Information

Publications37

  1. pmc Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    Andrew W Sylwester
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
    J Exp Med 202:673-85. 2005
    ..These data provide the first glimpse of the total human T cell response to a complex infectious agent and will provide insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans...
  2. pmc Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection
    Afam Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 204:2171-85. 2007
    ....
  3. pmc Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines
    Yoshinori Fukazawa
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA
    Nat Med 18:1673-81. 2012
    ....
  4. pmc Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, and the Oregon National Primate Research Center, Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Nat Med 15:293-9. 2009
    ..These data suggest a new paradigm for AIDS vaccine development--vaccines capable of generating and maintaining HIV-specific TEM cells might decrease the incidence of HIV acquisition after sexual exposure...
  5. pmc Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis
    Afam Okoye
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 206:1575-88. 2009
    ..These data suggest that CD8(+) lymphocyte function has a larger impact on the outcome of acute SIV infection than the number and/or activation status of target cells available for infection and viral production...
  6. pmc Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    Scott G Hansen
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Nature 473:523-7. 2011
    ..Thus, persistent vectors such as CMV and their associated T(EM) responses might significantly contribute to an efficacious HIV/AIDS vaccine...
  7. pmc Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection
    Afam A Okoye
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Exp Med 209:641-51. 2012
    ....
  8. pmc In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques
    Annelie Tjernlund
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Retrovirology 7:12. 2010
    ..SIV and HIV predominantly replicate in lymphoid tissue, but the study of virus specific CD8+ T cells in intact lymphoid tissue is difficult, as traditional in situ tetramer staining requires fresh tissue...
  9. pmc New paradigms for HIV/AIDS vaccine development
    Louis J Picker
    Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Annu Rev Med 63:95-111. 2012
    ....
  10. pmc IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates
    Louis J Picker
    Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Clin Invest 116:1514-24. 2006
    ....
  11. ncbi request reprint The CD4(+) T cell response to HIV-1
    L J Picker
    Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Mail Code L220, Portland, OR 97201 3098, USA
    Curr Opin Immunol 12:381-6. 2000
    ..Recent advances in quantifying and functionally characterizing HIV-1-specific T cells may shed light on the participation of these cells in anti-HIV-1 host defense...
  12. pmc Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection
    Louis J Picker
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, West Campus, 505 NW 185th Ave, Beaverton, OR 97006, USA
    J Exp Med 200:1299-314. 2004
    ....
  13. ncbi request reprint Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus
    A D Bitmansour
    Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 167:1151-63. 2001
    ....
  14. ncbi request reprint Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection
    Jacob D Estes
    Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
    J Infect Dis 193:703-12. 2006
    ..We conclude that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared...
  15. ncbi request reprint Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  16. pmc Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primates
    Luka Cicin-Sain
    Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 104:19960-5. 2007
    ..Thus, homeostatic T cell proliferation exhibits temporal antagonistic pleiotropy, being beneficial to T cell maintenance in adulthood but detrimental to the long-term T cell maintenance in aging individuals...
  17. ncbi request reprint Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaques
    David A Price
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 180:269-80. 2008
    ....
  18. pmc Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression follow
    Helen Horton
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:7187-202. 2002
    ..01). However, despite the induction of virus-specific cellular immune responses and reduced peak viral loads, most animals still suffered from gradual CD4 depletion and progressed to disease...
  19. ncbi request reprint An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons
    Jesus Saavedra-Lozano
    Cancer Immunobiology Center and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8576, USA
    J Infect Dis 185:306-14. 2002
    ..In contrast, CD4(+) CD45RA(+) naive T cells and a proportion of CD4(+) CD45RO(lo) memory T cells are spared...
  20. pmc Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection
    Bianca R Mothe
    Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
    J Virol 76:875-84. 2002
    ..In most of the Mamu-A*01-positive macaques tested, CTL responses against epitopes bound by Mamu-A*01 dominated the CD8(+) cellular immune response...
  21. ncbi request reprint Development and homeostasis of T cell memory in rhesus macaque
    Christine J Pitcher
    Vaccine and Gene Therapy Institute, Oregon Regional Primate Research Center, Oregon Health and Science University, West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Immunol 168:29-43. 2002
    ..The effector memory subset demonstrated similar in vivo proliferative activity and survival as CD28+ "central memory" T cells, consistent with independent homeostatic regulation...
  22. ncbi request reprint Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic study
    Andrew D Weinberg
    Earle A Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, 5F40, Portland, OR 97213, USA
    J Immunother 29:575-85. 2006
    ..These studies demonstrate the immune-stimulatory properties and safety of anti-OX40 in primates and provide a strong scientific rationale to pursue clinical trials in humans...
  23. ncbi request reprint Immunopathogenesis of acute AIDS virus infection
    Louis J Picker
    Vaccine and Gene Therapy Institute, and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006, USA
    Curr Opin Immunol 18:399-405. 2006
    ..With time, uncontrolled viral replication leads to loss of these cells in tissue below a crucial threshold, resulting in increased susceptibility to opportunistic infection...
  24. pmc Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239
    Nancy A Wilson
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
    J Virol 80:5875-85. 2006
    ....
  25. ncbi request reprint Multicolor flow cytometric analysis in SIV-infected rhesus macaque
    Joshua M Walker
    Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, West Campus Beaverton, Oregon 97006, USA
    Methods Cell Biol 75:535-57. 2004
  26. ncbi request reprint HIV pathogenesis: the first cut is the deepest
    Louis J Picker
    Nat Immunol 6:430-2. 2005
  27. ncbi request reprint T cell dynamics in HIV-1 infection
    Daniel C Douek
    Human Immunology Section Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 21:265-304. 2003
    ....
  28. ncbi request reprint Differences between T cell epitopes recognized after immunization and after infection
    Thorsten U Vogel
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capital Court, Madison, WI 53715, USA
    J Immunol 169:4511-21. 2002
    ..The repertoire of the immune response detected in the peripheral blood after immunization substantially differed from the immune response detected in the peripheral blood after infection...
  29. ncbi request reprint Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
    Zvi Grossman
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:289-95. 2006
    ....
  30. ncbi request reprint Direct ex vivo analysis of human CD4(+) memory T cell activation requirements at the single clonotype level
    Arlene D Bitmansour
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97201, USA
    J Immunol 169:1207-18. 2002
    ....
  31. pmc Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infections
    Shannon M Murray
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    J Virol 82:5981-5. 2008
    ..This finding can also explain the highly efficient transmission of FVs among NHPs...
  32. ncbi request reprint Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individuals
    Florian Kern
    Institut für Medizinische Immunologie der Charité, Campus Mitte, 10098 Berlin, Germany
    J Infect Dis 185:1709-16. 2002
    ..Several new T cell epitopes were identified...
  33. ncbi request reprint Skewed maturation of virus-specific CTLs?
    Laila E Gamadia
    Nat Immunol 3:203. 2002
  34. ncbi request reprint Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG study
    Rob Roy MacGregor
    Infectious Diseases Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    AIDS Res Hum Retroviruses 21:689-95. 2005
    ..MAC-specific T cell responses apparently develop and persist during DMAC, but are dysfunctional or too infrequent to prevent persistence...
  35. pmc Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
    Ilhem Messaoudi
    Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 103:19448-53. 2006
    ..Our results provide evidence that CR can delay immune senescence in nonhuman primates, potentially contributing to an extended lifespan by reducing susceptibility to infectious disease...
  36. ncbi request reprint Mapping T cell epitopes by flow cytometry
    Bodo Hoffmeister
    Department of Medical Immunology, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 21, 10117 Berlin, Germany
    Methods 29:270-81. 2003
    ..This article includes information on peptide configuration, a section on the design and efficient application of peptide pools, and working laboratory protocols for both assays...
  37. pmc Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses
    DAVID H O'CONNOR
    Wisconsin Regional Primate Research Center and Department of Pathology and Laboratory Medicine, Madison, Wisconsin, USA
    J Virol 77:9029-40. 2003
    ....

Research Grants20

  1. FUNCTION & HOMEOSTASIS OF VIRAL PATHOGEN-SPECIFIC CD4+
    Louis Picker; Fiscal Year: 2000
    ..abstract_text> ..
  2. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2007
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  3. Role of memory T cell dynamics in SIV infection
    Louis Picker; Fiscal Year: 2006
    ..abstract_text> ..
  4. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2005
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  5. FUNCTION & HOMEOSTASIS OF VIRAL PATHOGEN-SPECIFIC CD4+
    Louis Picker; Fiscal Year: 2002
    ..abstract_text> ..
  6. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2009
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  7. Rejuvenation of the T-cell compartment in aging primates
    LOUIS J contact PICKER; Fiscal Year: 2010
    ..Successful completion of these experiments would allow us to proceed with therapy of human immune aging with the ultimate goal to reduce, and eventually eliminate, excessive death and illness of the elderly from infectious diseases. ..
  8. FUNCTION & HOMEOSTASIS OF VIRAL PATHOGEN-SPECIFIC CD4+
    Louis Picker; Fiscal Year: 2001
    ..abstract_text> ..
  9. Role of memory T cell dynamics in SIV infection
    Louis Picker; Fiscal Year: 2007
    ..abstract_text> ..
  10. Rejuvenation of the T-cell compartment in aging primates
    Louis Picker; Fiscal Year: 2009
    ..Successful completion of these experiments would allow us to proceed with therapy of human immune aging with the ultimate goal to reduce, and eventually eliminate, excessive death and illness of the elderly from infectious diseases. ..
  11. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2006
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  12. Development of RhCMV Vectors for SIV Infection
    Louis Picker; Fiscal Year: 2004
    ..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
  13. Role of memory T cell dynamics in SIV infection
    Louis Picker; Fiscal Year: 2003
    ....
  14. FUNCTION AND HOMEOSTASIS OF VIRAL PATHOGEN SPECIFIC CD4+
    Louis Picker; Fiscal Year: 1999
    ..abstract_text> ..
  15. Efficacy of Oral CMV/SIV Vectors
    Louis J Picker; Fiscal Year: 2011
    ..The work in this proposal will provide crucial information for the further clinical development of this novel vaccine approach by defining the protective mechanism(s) of CMV vectors and optimizing their efficacy. ..