Research Topics
Species | LOUIS J contact PICKERSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaquesAnnelie Tjernlund
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Retrovirology 7:12. 2010..SIV and HIV predominantly replicate in lymphoid tissue, but the study of virus specific CD8+ T cells in intact lymphoid tissue is difficult, as traditional in situ tetramer staining requires fresh tissue...
The CD4(+) T cell response to HIV-1L J Picker
Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Mail Code L220, Portland, OR 97201 3098, USA
Curr Opin Immunol 12:381-6. 2000..Recent advances in quantifying and functionally characterizing HIV-1-specific T cells may shed light on the participation of these cells in anti-HIV-1 host defense...- IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primatesLouis J Picker
Vaccine and Gene Therapy Institute, Department of Pathology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
J Clin Invest 116:1514-24. 2006.... - New paradigms for HIV/AIDS vaccine developmentLouis J Picker
Vaccine and Gene Therapy Institute, Department of Molecular Microbiology, Oregon Health and Science University, Beaverton, Oregon 97006, USA
Annu Rev Med 63:95-111. 2012.... - Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infectionLouis J Picker
Vaccine and Gene Therapy Institute, Oregon Health and Science University, West Campus, 505 NW 185th Ave, Beaverton, OR 97006, USA
J Exp Med 200:1299-314. 2004.... - Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirusA D Bitmansour
Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Portland, OR 97201, USA
J Immunol 167:1151-63. 2001.... - Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infectionJacob D Estes
Department of Microbiology, Medical School, University of Minnesota, Minneapolis 55455, USA
J Infect Dis 193:703-12. 2006..We conclude that an early Treg cell response during acute SIV infection may contribute to viral persistence by prematurely limiting the antiviral immune response before infection is cleared... - Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjectsAndrew W Sylwester
Vaccine and Gene Therapy Institute, Department of Pathology, Oregon Health and Science University, Beaverton, 97006, USA
J Exp Med 202:673-85. 2005..These data provide the first glimpse of the total human T cell response to a complex infectious agent and will provide insight into the rules governing immunodominance and cross-reactivity in complex viral infections of humans... - Dramatic increase in naive T cell turnover is linked to loss of naive T cells from old primatesLuka Cicin Sain
Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
Proc Natl Acad Sci U S A 104:19960-5. 2007..Thus, homeostatic T cell proliferation exhibits temporal antagonistic pleiotropy, being beneficial to T cell maintenance in adulthood but detrimental to the long-term T cell maintenance in aging individuals... - Pathogenesis of HIV infection: what the virus spares is as important as what it destroysZvi Grossman
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:289-95. 2006.... - Development and homeostasis of T cell memory in rhesus macaqueChristine J Pitcher
Vaccine and Gene Therapy Institute, Oregon Regional Primate Research Center, Oregon Health and Science University, West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA
J Immunol 168:29-43. 2002..The effector memory subset demonstrated similar in vivo proliferative activity and survival as CD28+ "central memory" T cells, consistent with independent homeostatic regulation... - Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239Nancy A Wilson
Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, WI 53711, USA
J Virol 80:5875-85. 2006.... - Immunopathogenesis of acute AIDS virus infectionLouis J Picker
Vaccine and Gene Therapy Institute, and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006, USA
Curr Opin Immunol 18:399-405. 2006..With time, uncontrolled viral replication leads to loss of these cells in tissue below a crucial threshold, resulting in increased susceptibility to opportunistic infection... - Anti-OX40 (CD134) administration to nonhuman primates: immunostimulatory effects and toxicokinetic studyAndrew D Weinberg
Earle A Chiles Research Institute, Robert W Franz Cancer Center, Providence Portland Medical Center, 5F40, Portland, OR 97213, USA
J Immunother 29:575-85. 2006..These studies demonstrate the immune-stimulatory properties and safety of anti-OX40 in primates and provide a strong scientific rationale to pursue clinical trials in humans... - Microbial translocation is a cause of systemic immune activation in chronic HIV infectionJason M Brenchley
Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Med 12:1365-71. 2006..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection... - Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infectionBianca R Mothe
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 76:875-84. 2002..In most of the Mamu-A*01-positive macaques tested, CTL responses against epitopes bound by Mamu-A*01 dominated the CD8(+) cellular immune response... - HIV pathogenesis: the first cut is the deepestLouis J Picker
Nat Immunol 6:430-2. 2005 - Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression followHelen Horton
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA
J Virol 76:7187-202. 2002..01). However, despite the induction of virus-specific cellular immune responses and reduced peak viral loads, most animals still suffered from gradual CD4 depletion and progressed to disease... - Direct ex vivo analysis of human CD4(+) memory T cell activation requirements at the single clonotype levelArlene D Bitmansour
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR 97201, USA
J Immunol 169:1207-18. 2002.... - Differences between T cell epitopes recognized after immunization and after infectionThorsten U Vogel
Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capital Court, Madison, WI 53715, USA
J Immunol 169:4511-21. 2002..The repertoire of the immune response detected in the peripheral blood after immunization substantially differed from the immune response detected in the peripheral blood after infection... - T cell dynamics in HIV-1 infectionDaniel C Douek
Human Immunology Section Vaccine Research Center, NIAID, NIH, Bethesda, Maryland 20892, USA
Annu Rev Immunol 21:265-304. 2003.... - Induction and evolution of cytomegalovirus-specific CD4+ T cell clonotypes in rhesus macaquesDavid A Price
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
J Immunol 180:269-80. 2008.... - An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive personsJesus Saavedra-Lozano
Cancer Immunobiology Center and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 8576, USA
J Infect Dis 185:306-14. 2002..In contrast, CD4(+) CD45RA(+) naive T cells and a proportion of CD4(+) CD45RO(lo) memory T cells are spared... - Multicolor flow cytometric analysis in SIV-infected rhesus macaqueJoshua M Walker
Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, West Campus Beaverton, Oregon 97006, USA
Methods Cell Biol 75:535-57. 2004 
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infectionAfam Okoye
Vaccine and Gene Therapy Institute, Department of Pathology, and the Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
J Exp Med 204:2171-85. 2007....- Replication in a superficial epithelial cell niche explains the lack of pathogenicity of primate foamy virus infectionsShannon M Murray
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
J Virol 82:5981-5. 2008..This finding can also explain the highly efficient transmission of FVs among NHPs... - Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primatesIlhem Messaoudi
Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
Proc Natl Acad Sci U S A 103:19448-53. 2006..Our results provide evidence that CR can delay immune senescence in nonhuman primates, potentially contributing to an extended lifespan by reducing susceptibility to infectious disease... - Skewed maturation of virus-specific CTLs?Laila E Gamadia
Nat Immunol 3:203. 2002 - Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responsesBianca R Mothe
Wisconsin Regional Primate Research Center and Department of Pathology and Laboratory Medicine, Madison, Wisconsin, USA
J Virol 77:9029-40. 2003.... - Mapping T cell epitopes by flow cytometryBodo Hoffmeister
Department of Medical Immunology, Charit, , Schumannstrasse 21, 10117 Berlin, Germany
Methods 29:270-81. 2003..This article includes information on peptide configuration, a section on the design and efficient application of peptide pools, and working laboratory protocols for both assays... - Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individualsFlorian Kern
Institut für Medizinische Immunologie der Charité, Campus Mitte, 10098 Berlin, Germany
J Infect Dis 185:1709-16. 2002..Several new T cell epitopes were identified... - Clinical, microbiological, and immunological characteristics in HIV-infected subjects at risk for disseminated Mycobacterium avium complex disease: an AACTG studyRob Roy MacGregor
Infectious Diseases Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
AIDS Res Hum Retroviruses 21:689-95. 2005..MAC-specific T cell responses apparently develop and persist during DMAC, but are dysfunctional or too infrequent to prevent persistence...
Research Grants
- Role of memory T cell dynamics in SIV infectionLouis Picker; Fiscal Year: 2007..abstract_text> ..
- Rejuvenation of the T-cell compartment in aging primatesLOUIS J contact PICKER; Fiscal Year: 2010..Successful completion of these experiments would allow us to proceed with therapy of human immune aging with the ultimate goal to reduce, and eventually eliminate, excessive death and illness of the elderly from infectious diseases. ..
- Development of RhCMV Vectors for SIV InfectionLouis Picker; Fiscal Year: 2009..a conventional DNA/vaccinia prime-boost strategy to control pathogenic SIV challenge, explore mechanisms for vaccine failure, and determine the immunologic parameters predictive of protection. ..
- Role of memory T cell dynamics in SIV infectionLouis Picker; Fiscal Year: 2006..abstract_text> ..
- FUNCTION & HOMEOSTASIS OF VIRAL PATHOGEN-SPECIFIC CD4+Louis Picker; Fiscal Year: 2002..abstract_text> ..
- Role of memory T cell dynamics in SIV infectionLouis Picker; Fiscal Year: 2003....
- Efficacy of Oral CMV/SIV VectorsLouis J Picker; Fiscal Year: 2011..The work in this proposal will provide crucial information for the further clinical development of this novel vaccine approach by defining the protective mechanism(s) of CMV vectors and optimizing their efficacy. ..