Tamara J Phillips

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol
    Abraham A Palmer
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    Psychopharmacology (Berl) 176:386-97. 2004
  2. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
  3. ncbi request reprint Behavioral sensitization to ethanol: genetics and the effects of stress
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Pharmacol Biochem Behav 57:487-93. 1997
  4. ncbi request reprint Complex-trait genetics: emergence of multivariate strategies
    Tamara J Phillips
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201, USA
    Nat Rev Neurosci 3:478-85. 2002
  5. ncbi request reprint Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice
    Tamara J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 26:593-602. 2002
  6. ncbi request reprint Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Nat Neurosci 1:610-5. 1998
  7. pmc A method for mapping intralocus interactions influencing excessive alcohol drinking
    Tamara J Phillips
    Veterans Affairs Medical Center, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, 97239, USA
    Mamm Genome 21:39-51. 2010
  8. pmc Behavioral genetic contributions to the study of addiction-related amphetamine effects
    Tamara J Phillips
    Veterans Affairs Medical Center, Portland, OR 97239, USA
    Neurosci Biobehav Rev 32:707-59. 2008
  9. ncbi request reprint Harnessing the mouse to unravel the genetics of human disease
    T J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 1:14-26. 2002
  10. ncbi request reprint Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 119:892-910. 2005

Research Grants

  1. Mapping and Microarray Gene Expression Analysis in a Model of Excessive Drinking
    Tamara Phillips; Fiscal Year: 2007
  2. BIOLOGICAL BASES OF ALCOHOLISM
    Tamara Phillips; Fiscal Year: 2007
  3. Studies of CRH and Alcohol Effects
    Tamara Phillips; Fiscal Year: 2005

Detail Information

Publications83

  1. ncbi request reprint Corticotropin-releasing factor overexpression decreases ethanol drinking and increases sensitivity to the sedative effects of ethanol
    Abraham A Palmer
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    Psychopharmacology (Berl) 176:386-97. 2004
    ..Corticotropin-releasing factor (CRF) may play a significant role in drug and alcohol abuse...
  2. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  3. ncbi request reprint Behavioral sensitization to ethanol: genetics and the effects of stress
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Pharmacol Biochem Behav 57:487-93. 1997
    ..A biological link between drug reward and drug sensitization involving HPA axis hormones may exist and, thus, study of the sensitization process may elucidate mechanisms relevant to drug abuse...
  4. ncbi request reprint Complex-trait genetics: emergence of multivariate strategies
    Tamara J Phillips
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201, USA
    Nat Rev Neurosci 3:478-85. 2002
    ....
  5. ncbi request reprint Forward, relaxed, and reverse selection for reduced and enhanced sensitivity to ethanol's locomotor stimulant effects in mice
    Tamara J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 26:593-602. 2002
    ....
  6. ncbi request reprint Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Nat Neurosci 1:610-5. 1998
    ..These data demonstrate that dopamine signaling via D2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity...
  7. pmc A method for mapping intralocus interactions influencing excessive alcohol drinking
    Tamara J Phillips
    Veterans Affairs Medical Center, Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, 97239, USA
    Mamm Genome 21:39-51. 2010
    ..No evidence was found for epistasis between any pair of significant or suggestive QTLs. This indicates that the hybrid overdominance is due to intralocus interactions at the level of individual QTL...
  8. pmc Behavioral genetic contributions to the study of addiction-related amphetamine effects
    Tamara J Phillips
    Veterans Affairs Medical Center, Portland, OR 97239, USA
    Neurosci Biobehav Rev 32:707-59. 2008
    ..This information might help to identify at-risk individuals and in the future to develop treatments that take advantage of individualized genetic information...
  9. ncbi request reprint Harnessing the mouse to unravel the genetics of human disease
    T J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 1:14-26. 2002
    ..We assert that unique combinations of classical approaches with current behavioral and molecular genomic approaches will more rapidly advance the field...
  10. ncbi request reprint Genetic correlational analyses of ethanol reward and aversion phenotypes in short-term selected mouse lines bred for ethanol drinking or ethanol-induced conditioned taste aversion
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 119:892-910. 2005
    ..The interpretation of ethanol-induced CTA as more genetically distinct must be tempered by the inability to test the CTA lines beyond Selection Generation 2...
  11. ncbi request reprint Let's not discourage innovative approaches to complex questions
    Tamara J Phillips
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 28:1607-8. 2004
  12. pmc Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism
    Raul Pastor
    Departments of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 105:9070-5. 2008
    ..A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH...
  13. ncbi request reprint Ethanol-related traits in mice selectively bred for differential sensitivity to methamphetamine-induced activation
    Helen M Kamens
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, OR, USA
    Behav Neurosci 120:1356-66. 2006
    ..A small difference in ethanol clearance rate (0.1 mg/ml/h) likely had little impact on behavior. Some common genes may influence the locomotor response to MA and ethanol, as well as ethanol drinking...
  14. ncbi request reprint Mice deficient in corticotropin-releasing factor receptor type 2 exhibit normal ethanol-associated behaviors
    Amanda L Sharpe
    Department of Behavioral Neuroscience, the Portland Alcohol Research Center, Oregon Health and Science University, and the Research Service, Portland VA Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 29:1601-9. 2005
    ..The objective of these studies was to examine the effect of corticotropin-releasing factor receptor type 2 (CRF2) on ethanol consumption, conditioned taste aversion, sedation, and hypothermia...
  15. pmc Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice
    Raul Pastor
    Behavioral Neuroscience Department and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR, USA
    Psychopharmacology (Berl) 218:169-77. 2011
    ..CRF(1) play a role in EtOH-induced behavioral neuroadaptation, in binge-like EtOH consumption, and in heightened EtOH consumption in dependent animals...
  16. pmc Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization
    Raul Pastor
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Addict Biol 15:324-35. 2010
    ..These data are consistent with current literature suggesting an enhancing effect of drug-induced sensitization on motivational processes involved in reinforcement...
  17. pmc Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 179:265-72. 2007
    ..These findings support the premise that manipulations in brain ALLO levels may influence the regulatory processes governing ethanol consumption...
  18. pmc Selective breeding for magnitude of methamphetamine-induced sensitization alters methamphetamine consumption
    Angela C Scibelli
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, and Veterans Affairs Medical Center, Portland, OR 97239, USA
    Psychopharmacology (Berl) 214:791-804. 2011
    ..Genetically determined differences in susceptibility to drug-induced sensitization could be related to risk for drug consumption...
  19. ncbi request reprint The Edinger-Westphal-lateral septum urocortin pathway and its relationship to alcohol consumption
    Ryan K Bachtell
    Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, Oregon 97239, USA
    J Neurosci 23:2477-87. 2003
    ..Taken together, these studies provide substantial evidence for involvement of the EW-LS Ucn pathway in alcohol consumption...
  20. pmc Central urocortin 3 administration decreases limited-access ethanol intake in nondependent mice
    Amanda L Sharpe
    Department of Behavioral Neuroscience, the Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Behav Pharmacol 20:346-51. 2009
    ..Food intake at both 2 h and 24 h after injection was statistically unaffected by Ucn 3 administration. These results establish a role for CRF type 2 receptors in a nondependent mouse model of ethanol self-administration...
  21. ncbi request reprint Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis
    Abraham A Palmer
    Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
    Behav Genet 33:311-24. 2003
    ..The impact of the Drd2 null mutation on a subset of ethanol-related behavioral traits is subject to epistatic influences...
  22. ncbi request reprint Reverse selection for differential response to the locomotor stimulant effects of ethanol provides evidence for pleiotropic genetic influence on locomotor response to other drugs of abuse
    Hadley C Bergstrom
    Department of Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 27:1535-47. 2003
    ..These lines are well suited for asking whether the same alleles that influence sensitivity to ethanol are also responsible for these later arising differences in drug sensitivity...
  23. ncbi request reprint A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine- or methamphetamine-induced stimulation
    Helen M Kamens
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 196:377-87. 2008
    ..Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse...
  24. ncbi request reprint The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2
    Christoph Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, and US Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 29:708-20. 2005
    ..5, p = 3 x 10(-16)). The specific gene(s) in the QTL interval responsible for phenotypic variation in ethanol preference drinking has not been identified...
  25. ncbi request reprint Mouse lines selected for alcohol consumption differ on certain measures of impulsivity
    Clare J Wilhelm
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 31:1839-45. 2007
    ..The aim of this study was to examine the role of genetics by comparing impulsivity in short-term selected lines of mice bred to voluntarily drink either high (STDRHI2) or low (STDRLO2) amounts of 10% ethanol...
  26. pmc Mice selectively bred for high- or low-alcohol-induced locomotion exhibit differences in dopamine neuron function
    Michael J Beckstead
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    J Pharmacol Exp Ther 329:342-9. 2009
    ....
  27. ncbi request reprint Behavioral sensitization to ethanol does not result in cross-sensitization to NMDA receptor antagonists
    Paul J Meyer
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 195:103-15. 2007
    ..We hypothesized that sensitization to ethanol would be associated with changes in sensitivity to NMDA receptor ligands...
  28. ncbi request reprint Neurosteroid consumption has anxiolytic effects in mice
    Deborah A Finn
    Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    Pharmacol Biochem Behav 76:451-62. 2003
    ....
  29. pmc Ethanol- and cocaine-induced locomotion are genetically related to increases in accumbal dopamine
    Paul J Meyer
    Portland Alcohol Research Center, Portland, OR, USA
    Genes Brain Behav 8:346-55. 2009
    ....
  30. ncbi request reprint Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice
    A J Roberts
    Department of Medical Psychology, Oregon Health Sciences University, Portland, USA
    Behav Neurosci 109:1199-208. 1995
    ..Overall these results indicate that gene action significantly influences stress responsiveness and suggest possible chromosomal locations of these genes...
  31. pmc GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice
    Sarah E Holstein
    Dept of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Behav Brain Res 237:49-58. 2013
    ..Further, although GABA(B) receptors do modulate the locomotor stimulant response to ethanol in FAST mice, this effect does not appear to be due to a reduction in tonic dopamine signaling in the nucleus accumbens...
  32. pmc Profound reduction in sensitivity to the aversive effects of methamphetamine in mice bred for high methamphetamine intake
    Shkelzen Shabani
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road L470, Portland, OR 97239 3098, USA
    Neuropharmacology 62:1134-41. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  33. ncbi request reprint Delay discounting predicts behavioral sensitization to ethanol in outbred WSC mice
    Suzanne H Mitchell
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 30:429-37. 2006
    ....
  34. pmc A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication
    John C Crabbe
    Portland Alcohol Research Center, Portland, Oregon, USA
    Biol Psychiatry 65:662-70. 2009
    ..We report progress toward the development of a new genetic animal model for high levels of alcohol drinking...
  35. pmc Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists
    Angela C Scibelli
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 33:435-47. 2009
    ....
  36. pmc Role of corticotropin-releasing factor and corticosterone in behavioral sensitization to ethanol
    Raul Pastor
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    J Pharmacol Exp Ther 341:455-63. 2012
    ..The present results are consistent with current theories proposing a key role for CRF and CRF₁ in drug-induced neuroplasticity, dependence, and addictive behavior...
  37. pmc Behavioral inhibition in mice bred for high vs. low levels of methamphetamine consumption or sensitization
    Travis M Moschak
    Department of Behavioral Neuroscience L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Psychopharmacology (Berl) 222:353-65. 2012
    ..Other studies have suggested that heightened levels of impulsivity, including low levels of behavioral inhibition, are associated with the use of drugs, including MA...
  38. pmc The complexity of alcohol drinking: studies in rodent genetic models
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Genet 40:737-50. 2010
    ..We report here results from a second replicate of that selection and compare them with the first replicate...
  39. ncbi request reprint Pharmacogenetic studies of alcohol self-administration and withdrawal
    John C Crabbe
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR 97239, USA
    Psychopharmacology (Berl) 174:539-60. 2004
  40. ncbi request reprint Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice
    Rachna S Sinnott
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and Department of Veterans Affairs Medical Center, Portland, OR 97201, USA
    Psychopharmacology (Berl) 162:438-47. 2002
    ..Recent findings indicate that ethanol (EtOH) and ALLOP share common mechanisms of action and that ALLOP may modulate some of EtOH's abuse-related effects...
  41. ncbi request reprint Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, OR 97201, USA
    Psychopharmacology (Berl) 162:313-22. 2002
    ..We also postulated that tolerance would develop to these two drugs by similar mechanisms, such that tolerance to one would impart cross-tolerance to the other...
  42. pmc Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist
    Sarah E Holstein
    Portland Alcohol Research Center and the Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 33:108-20. 2009
    ..As ethanol has its own GABA mimetic properties, it is critical to determine the mechanism by which GABAergic drugs may reduce the response to ethanol (i.e., via an inhibition or an accentuation of the neurobiological effects of ethanol)...
  43. pmc A genetic animal model of differential sensitivity to methamphetamine reinforcement
    Shkelzen Shabani
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Neuropharmacology 62:2169-77. 2012
    ..Thus, genetic risk factors play a critical role in the reinforcing efficacy of MA and the oral self-administration procedure is suitable for delineating genetic contributions to MA reinforcement...
  44. pmc GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol
    Sarah E Holstein
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L 470, Portland, OR 97239, USA
    Pharmacol Biochem Behav 85:697-704. 2006
    ....
  45. doi request reprint Internet resources for genomic, bioinformatics, and medical genetics information
    Tamara J Phillips
    Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon, USA
    Curr Protoc Neurosci . 2003
    ....
  46. pmc Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains
    Noah R Gubner
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 34:1353-62. 2010
    ..High levels of impulsivity have been associated with a number of substance abuse disorders including alcohol abuse. Research has not yet revealed whether these high levels predate the development of alcohol abuse...
  47. ncbi request reprint Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects
    Paul J Meyer
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, USA
    Alcohol Clin Exp Res 27:1701-9. 2003
    ..Two initial studies characterized ketamine-induced locomotion in DBA/2J (D2) mice, an inbred strain chosen for its high sensitivity to ethanol-induced locomotion...
  48. ncbi request reprint Alcohol-related genes: contributions from studies with genetically engineered mice
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, USA
    Addict Biol 11:195-269. 2006
    ..Novel modulatory effects of protein kinase C and G protein-activated inwardly rectifying K+ (GIRK) channels are also suggested. Some newer research with cannabinoid systems is promising, and has led to ongoing clinical trials...
  49. ncbi request reprint Sensitivity to the locomotor stimulant effects of ethanol and allopregnanolone is influenced by common genes
    Abraham A Palmer
    Portland Alcohol Research Center, Oregon Health and Science University, USA
    Behav Neurosci 116:126-37. 2002
    ..FAST mice were more sensitive to the stimulant effects of allopregnanolone compared with SLOW mice. These data suggest that sensitivity to the locomotor stimulant effects of these drugs is influenced by common genes...
  50. pmc Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
    M A Kelly
    Vollum Institute, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 7:568-77. 2008
    ....
  51. ncbi request reprint Genes on mouse chromosomes 2 and 9 determine variation in ethanol consumption
    T J Phillips
    Veterans Administration Medical Center, R and D 32, 3710 SW US Veterans Hospital Rd, Portland, Oregon 97201, USA
    Mamm Genome 9:936-41. 1998
    ..These data suggest that the determinants of these two measures are genetically diverse, but may share some common genetic elements...
  52. ncbi request reprint Effect of forward and reverse selection for ethanol-induced locomotor response on other measures of ethanol sensitivity
    Abraham A Palmer
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 26:1322-9. 2002
    ..The reverse-selected lines, named r-FAST and r-SLOW, were virtually equally sensitive to the stimulant effects of the selection dose of ethanol after 16 generations of reverse selection...
  53. pmc Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, the Portland Alcohol Research Center, and Veterans Affairs Medical Center Research, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 29:1630-40. 2005
    ..The purpose of this study was to evaluate the impact of exogenous neurosteroid challenges with the agonist ALLO and the partial agonist/antagonist epipregnanolone (EPI) on the microarchitecture of ethanol drinking patterns...
  54. ncbi request reprint Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, Oregon, USA
    Behav Neurosci 116:958-67. 2002
    ..Results support an effect of selection for ethanol sensitivity on allosteric modulation of the GABA-A receptor...
  55. pmc Genetically correlated effects of selective breeding for high and low methamphetamine consumption
    J M Wheeler
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 8:758-71. 2009
    ....
  56. ncbi request reprint Sensitivity to psychostimulants in mice bred for high and low stimulation to methamphetamine
    H M Kamens
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University and VA Medical Center, Portland, OR 97239, USA
    Genes Brain Behav 4:110-25. 2005
    ..Further, extreme sensitivity to MA may protect against MA and cocaine self-administration...
  57. ncbi request reprint Behavioral sensitization to ethanol is modulated by environmental conditions, but is not associated with cross-sensitization to allopregnanolone or pentobarbital in DBA/2J mice
    P J Meyer
    Portland Alcohol Research Center, Portland, OR, USA
    Neuroscience 131:263-73. 2005
    ..Two procedures that produced differences in the magnitude of expression of ethanol-induced locomotor sensitization were used...
  58. ncbi request reprint Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations
    M A Kelly
    Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 18:3470-9. 1998
    ..We conclude that D2R-deficient mice are not a model of Parkinson's disease. Our studies highlight the interaction of multiple genetic factors in the analysis of complex behaviors in gene knock-out mice...
  59. pmc Effects of sodium butyrate on methamphetamine-sensitized locomotor activity
    John H Harkness
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR 97239 3098, USA
    Behav Brain Res 239:139-47. 2013
    ....
  60. ncbi request reprint Bivalent effects of MK-801 on ethanol-induced sensitization do not parallel its effects on ethanol-induced tolerance
    Paul J Meyer
    Portland Alcohol Research Center, Oregon Health and Science University, Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
    Behav Neurosci 117:641-9. 2003
    ..MK-801's effects on ethanol sensitization appeared to be related to its own behavioral effects, rather than NMDA receptor blockade per se. Further, these studies demonstrate dissociation between ethanol sensitization and tolerance...
  61. ncbi request reprint Cross-sensitization between the locomotor stimulant effects of ethanol and those of morphine and cocaine in mice
    Christina N Lessov
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, USA
    Alcohol Clin Exp Res 27:616-27. 2003
    ..Drugs of abuse may share some common mechanisms of action. We examined this idea by determining whether cross-sensitization would occur between the locomotor stimulant effects of ethanol (EtOH) and those of morphine and cocaine...
  62. ncbi request reprint The effect of fostering on the genetic expression of locomotor sensitivity to alcohol
    Debra L Hickman
    Research and Development Service, Portland VA Medical Center, Oregon, USA
    Comp Med 55:498-502. 2005
    ....
  63. ncbi request reprint Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice
    Sarah E Holstein
    Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 182:277-89. 2005
    ..For example, mice bred for sensitivity (FAST) or insensitivity (SLOW) to the locomotor stimulant effects of ethanol differ in their locomotor response to morphine...
  64. pmc Muscarinic type 2 receptors in the lateral dorsal tegmental area modulate cocaine and food seeking behavior in rats
    S Shabani
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road L470, Portland, OR 97239 3098, USA
    Neuroscience 170:559-69. 2010
    ..These effects cannot be attributed to significant alterations of locomotor behavior and are likely accomplished through LDTg muscarinic autoreceptors...
  65. ncbi request reprint Mapping genes that regulate density of dopamine transporters and correlated behaviors in recombinant inbred mice
    A Janowsky
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Pharmacol Exp Ther 298:634-43. 2001
    ..The results suggest that there is a gene(s) on proximal chromosome 19 that strongly influences DAT expression in neostriatum and may influence psychostimulant-induced activity and thermal responses...
  66. ncbi request reprint QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits
    J K Belknap
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Behav Genet 31:5-15. 2001
    ..We argue that these two complementary genetic methods have much to offer in efforts to highlight genes and pathways most likely to influence the susceptibility and progression of common diseases in human populations...
  67. ncbi request reprint Quantitative trait loci associated with brain weight in the BXD/Ty recombinant inbred mouse strains
    J K Belknap
    Research Service 151W, VA Medical Center, Portland, OR
    Brain Res Bull 29:337-44. 1992
    ..The genetic correlation between brain and body weight was low (r = 0.28), indicating that these two traits are largely genetically independent in the BXD RI series...
  68. ncbi request reprint Characterization of the parallel rod floor apparatus to test motor incoordination in mice
    H M Kamens
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, OR 97239, USA
    Genes Brain Behav 4:253-66. 2005
    ....
  69. ncbi request reprint Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice
    D A Finn
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 123:813-9. 2004
    ..These results have important implications for studies investigating the potential role of endogenous allopregnanolone levels in modulating susceptibility to ethanol abuse...
  70. ncbi request reprint Short-term selective breeding as a tool for QTL mapping: ethanol preference drinking in mice
    J K Belknap
    VA Medical Center, Portland, Oregon 97201, USA
    Behav Genet 27:55-66. 1997
    ..Combining the BXD and two-way selection line results, the most probable QTL was found on chromosome 3 (near the adhl locus; LOD approximately 2.9), other probable QTLs were found with LOD 2.4-2.6...
  71. ncbi request reprint Rewarding effect of the neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one in mice
    D A Finn
    Dept of Veteran Affairs Medical Center Portland, OR 97201, USA
    Pharmacol Biochem Behav 56:261-4. 1997
    ..These results provide the first demonstration that 3 alpha,5 alpha-P, an endogenous modulator of GABAA receptor function, possesses rewarding properties using the conditioned place preference paradigm...
  72. ncbi request reprint Sensitivity to ethanol-induced motor incoordination in 5-HT(1B) receptor null mutant mice is task-dependent: implications for behavioral assessment of genetically altered mice
    S L Boehm
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Oregon 97201, USA
    Behav Neurosci 114:401-9. 2000
    ..These experiments suggest that within a behavioral domain, alternative tests of function are not equivalent, so multiple assessment tools should be used to avoid misinterpretation of gene function...
  73. ncbi request reprint Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis
    Stephen L Boehm
    Oregon Health and Science University, Portland, Oregon, USA
    Psychopharmacology (Berl) 161:54-63. 2002
    ..Another possibility is that this behavioral phenotype may represent an altered state of anxiety, and/or stress axis activation...
  74. ncbi request reprint Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors
    J C Crabbe
    Department of Veterans, Affairs Medical Center, Portland, Oregon, USA
    Nat Genet 14:98-101. 1996
    ....
  75. ncbi request reprint Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice
    S L Boehm
    Portland Alcohol Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 115:185-200. 2002
    ..However, differences in GABA(B) receptor densities in the VTA or substantia nigra pars compacta cannot explain the selected line difference...
  76. ncbi request reprint Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress
    S C Coste
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University and Research Service, Portland, 97239, USA
    Genes Brain Behav 5:131-8. 2006
    ..Collectively, these results point toward a role for CRF(2) pathways in neural circuits that subserve stress-coping behaviors...
  77. doi request reprint Involvement of the beta-endorphin neurons of the hypothalamic arcuate nucleus in ethanol-induced place preference conditioning in mice
    Raul Pastor
    Area de Psicobiologia, Universitat Jaume I, Castellon, Spain
    Alcohol Clin Exp Res 35:2019-29. 2011
    ....
  78. ncbi request reprint Attenuation of ethanol-induced conditioned taste aversion in mice sensitized to the locomotor stimulant effects of ethanol
    C N Lessov
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, USA
    Behav Neurosci 115:146-53. 2001
    ....
  79. ncbi request reprint Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
    S C Coste
    Departments of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
    Nat Genet 24:403-9. 2000
    ..Moreover, Crhr2-/- mice have elevated basal blood pressure, demonstrating that Crhr2 participates in cardiovascular homeostasis. Our results identify specific responses in the brain and periphery that involve Crhr2...
  80. ncbi request reprint The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice
    Michele A Kelly
    HHMI and Dept Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Mamm Genome 14:692-702. 2003
    ....
  81. ncbi request reprint Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
  82. ncbi request reprint Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  83. ncbi request reprint Mother nature meets mother nurture
    John C Crabbe
    Nat Neurosci 6:440-2. 2003

Research Grants11

  1. Mapping and Microarray Gene Expression Analysis in a Model of Excessive Drinking
    Tamara Phillips; Fiscal Year: 2007
    ..Future work will also be focused on the most significant candidate genes implicated by our combined bQTL:eQTL analyses. ..
  2. BIOLOGICAL BASES OF ALCOHOLISM
    Tamara Phillips; Fiscal Year: 2007
    ....
  3. Studies of CRH and Alcohol Effects
    Tamara Phillips; Fiscal Year: 2005
    ..This research represents an important step toward the validation of CRH receptors as targets for future medications development in the treatment and prevention of alcoholism. ..