E S Orwoll

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Protein co-expression network analysis (ProCoNA)
    David L Gibbs
    Division of Bioinformatics and Computational Biology, Oregon Health and Science University, 3181 S, W, Sam Jackson Park Rd, Portland, OR 97239, USA
    J Clin Bioinforma 3:11. 2013
  2. pmc Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
    Per Anton Westerberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Nephrol 14:85. 2013
  3. doi request reprint A randomized, placebo-controlled study of the effects of denosumab for the treatment of men with low bone mineral density
    Eric Orwoll
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 97:3161-9. 2012
  4. ncbi request reprint Genetic aspects of osteoporosis
    E Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Ann Endocrinol (Paris) 67:113. 2006
  5. ncbi request reprint Testosterone and estradiol among older men
    Eric Orwoll
    CR113, Oregon Health and Science University, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 91:1336-44. 2006
  6. ncbi request reprint Combination therapy of osteoporosis
    E Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Ann Endocrinol (Paris) 67:174-5. 2006
  7. ncbi request reprint Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men
    Eric Orwoll
    Oregon Health and Science University, CR 113, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Contemp Clin Trials 26:569-85. 2005
  8. ncbi request reprint Endogenous testosterone levels, physical performance, and fall risk in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Arch Intern Med 166:2124-31. 2006
  9. ncbi request reprint Treatment of osteoporosis in men
    E S Orwoll
    Bone and Mineral Unit, Oregon Health and Sciences University and the Veterans Administration Medical Center, Portland, OR 97201, USA
    Calcif Tissue Int 75:114-9. 2004
  10. ncbi request reprint Toward an expanded understanding of the role of the periosteum in skeletal health
    Eric S Orwoll
    Bone and Mineral Research Unit, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    J Bone Miner Res 18:949-54. 2003

Detail Information

Publications51

  1. pmc Protein co-expression network analysis (ProCoNA)
    David L Gibbs
    Division of Bioinformatics and Computational Biology, Oregon Health and Science University, 3181 S, W, Sam Jackson Park Rd, Portland, OR 97239, USA
    J Clin Bioinforma 3:11. 2013
    ..Proteomics provides a critical data source for such models, but currently lacks robust de novo methods for network construction, which could bring important insights in systems biology...
  2. pmc Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
    Per Anton Westerberg
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    BMC Nephrol 14:85. 2013
    ..The primary aim of this study is to examine the association between FGF23 and mortality, in relation to renal function in the community. A secondary aim is to examine the association between FGF23 and CVD related death...
  3. doi request reprint A randomized, placebo-controlled study of the effects of denosumab for the treatment of men with low bone mineral density
    Eric Orwoll
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 97:3161-9. 2012
    ..Men with low bone mineral density (BMD) were treated with denosumab...
  4. ncbi request reprint Genetic aspects of osteoporosis
    E Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Ann Endocrinol (Paris) 67:113. 2006
  5. ncbi request reprint Testosterone and estradiol among older men
    Eric Orwoll
    CR113, Oregon Health and Science University, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 91:1336-44. 2006
    ..Testosterone and estradiol levels decline with age in men. This change may affect multiple clinical outcomes, but there have been few reports of the distribution and correlates of testosterone and estradiol concentrations in elderly men...
  6. ncbi request reprint Combination therapy of osteoporosis
    E Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Ann Endocrinol (Paris) 67:174-5. 2006
  7. ncbi request reprint Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men
    Eric Orwoll
    Oregon Health and Science University, CR 113, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Contemp Clin Trials 26:569-85. 2005
    ..The MrOS cohort should provide valuable information concerning the determinants of fracture in men and should help set the stage for the development of effective methods to identify those at risk...
  8. ncbi request reprint Endogenous testosterone levels, physical performance, and fall risk in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, USA
    Arch Intern Med 166:2124-31. 2006
    ..Gonadal steroid levels decline with age in men. Whether low testosterone levels affect the development of common age-related disorders, including physical functioning and falling, is unclear...
  9. ncbi request reprint Treatment of osteoporosis in men
    E S Orwoll
    Bone and Mineral Unit, Oregon Health and Sciences University and the Veterans Administration Medical Center, Portland, OR 97201, USA
    Calcif Tissue Int 75:114-9. 2004
  10. ncbi request reprint Toward an expanded understanding of the role of the periosteum in skeletal health
    Eric S Orwoll
    Bone and Mineral Research Unit, Oregon Health and Sciences University, Portland, Oregon 97201, USA
    J Bone Miner Res 18:949-54. 2003
  11. ncbi request reprint Men, bone and estrogen: unresolved issues
    E S Orwoll
    Bone and Mineral Unit CR113, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Osteoporos Int 14:93-8. 2003
    ....
  12. pmc Finite element analysis of the proximal femur and hip fracture risk in older men
    Eric S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland Oregon 97239, USA
    J Bone Miner Res 24:475-83. 2009
    ..1, 95% CI: 1.6-6.1). These results provide insight into hip fracture etiology and demonstrate the ability of FE-based biomechanical analysis of QCT scans to prospectively predict hip fractures in men...
  13. pmc Vitamin D deficiency in older men
    Eric Orwoll
    Bone and Mineral Unit, Oregon Health and Sciences University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:1214-22. 2009
    ..Vitamin D deficiency is not adequately evaluated in older men...
  14. pmc Sex steroids, periodontal health, and tooth loss in older men
    E S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, CR113, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    J Dent Res 88:704-8. 2009
    ..Although periodontitis, progression of periodontitis, and tooth loss are common in older men, they were not associated with sex steroids...
  15. pmc Evidence for geographical and racial variation in serum sex steroid levels in older men
    Eric S Orwoll
    Bone and Mineral Unit, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 95:E151-60. 2010
    ..We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men...
  16. ncbi request reprint Longitudinal study of bone density and periodontal disease in men
    K R Phipps
    Oregon Health and Science University, CR 113, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Dent Res 86:1110-4. 2007
    ..We found little evidence of an association between periodontitis and skeletal BMD among older men...
  17. pmc Rate and circumstances of clinical vertebral fractures in older men
    S S Freitas
    Department of Medicine, Oregon Health and Science University, Portland, OR, USA
    Osteoporos Int 19:615-23. 2008
    ..Fractures were more common in the most elderly men, and were usually associated with falls and other low-energy trauma...
  18. ncbi request reprint Mapping quantitative trait loci that influence femoral cross-sectional area in mice
    Robert F Klein
    Department of Medicine, Oregon Health and Science University, Portland 97201 3098, USA
    J Bone Miner Res 17:1752-60. 2002
    ..The identification of the genes responsible for geometric differences in bone development should reveal fundamentally important processes in the control of skeletal integrity...
  19. ncbi request reprint Transcriptional up-regulation of the human androgen receptor by androgen in bone cells
    K M Wiren
    Bone and Mineral Research Unit, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Endocrinology 138:2291-300. 1997
    ..These results suggest that physiological concentrations of androgens have significant effects on AR expression in skeletal tissue...
  20. pmc Community water fluoridation, bone mineral density, and fractures: prospective study of effects in older women
    K R Phipps
    School of Dentistry, Oregon Health Sciences University, 611 SW Campus Drive, Portland, OR 97201, USA
    BMJ 321:860-4. 2000
    ..To determine whether fluoridation influences bone mineral density and fractures in older women...
  21. ncbi request reprint Androgens: basic biology and clinical implication
    E S Orwoll
    Bone and Mineral Unit, Oregon Health Sciences University, Portland 97201, USA
    Calcif Tissue Int 69:185-8. 2001
    ..Androgens may well provide advantages in the prevention and therapy of metabolic bone disorders in both men and women...
  22. pmc Association between sex steroids and cognition in elderly men
    Erin S LeBlanc
    Division of Endocrinology, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Endocrinol (Oxf) 72:393-403. 2010
    ..To examine the association of cognitive function with sex steroid and sex hormone binding globulin (SHBG) levels among elderly men...
  23. ncbi request reprint Regulation of bone mass in mice by the lipoxygenase gene Alox15
    Robert F Klein
    Bone and Mineral Research Unit, Department of Medicine, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Science 303:229-32. 2004
    ..Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis...
  24. ncbi request reprint Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Bone Miner Res 21:1197-206. 2006
    ..Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct...
  25. pmc Mortality risk in older men associated with changes in weight, lean mass, and fat mass
    Christine G Lee
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Geriatr Soc 59:233-40. 2011
    ..To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men...
  26. pmc BMI and fracture risk in older men: the osteoporotic fractures in men study (MrOS)
    Carrie M Nielson
    School of Medicine, Oregon Health and Science University, Portland, OR, USA
    J Bone Miner Res 26:496-502. 2011
    ..90-2.28, for obese II). Obesity is common among older men, and when BMD is held constant, it is associated with an increased risk of fracture. This association is at least partially explained by worse physical function in obese men...
  27. pmc Race and ethnic variation in proximal femur structure and BMD among older men
    Lynn M Marshall
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland Oregon, USA
    J Bone Miner Res 23:121-30. 2008
    ..All had similar stature-adjusted mean femoral neck volume, but black and Asian men had thicker cortices and higher trabecular vBMD, which may increase bone strength...
  28. ncbi request reprint Incident fall risk and physical activity and physical performance among older men: the Osteoporotic Fractures in Men Study
    Benjamin K S Chan
    Department of Endocrinology, School of Medicine, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Am J Epidemiol 165:696-703. 2007
    ..69, 0.85). Partitioning components of activity showed no association between fall risk and leisure activities but a positive association with household activities (for highest quartile vs.lowest: relative risk = 1.17, 95% CI: 1.07, 1.28)...
  29. pmc Trochanteric soft tissue thickness and hip fracture in older men
    Carrie M Nielson
    Bone and Mineral Unit, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Clin Endocrinol Metab 94:491-6. 2009
    ..The effect of trochanteric soft tissue thickness on the risk of incident hip fracture has not been evaluated in men...
  30. ncbi request reprint The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis
    E S Orwoll
    Bone and Mineral Research Unit, Oregon Health and Sciences University and Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Bone Miner Res 18:9-17. 2003
    ..This study shows that teriparatide treatment results in an increase in bone mineral density and is a potentially useful therapy for osteoporosis in men...
  31. pmc A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
    ..These data suggest that this polymorphism affects TRPV4 function in vivo and likely influences systemic water balance on a population-wide basis...
  32. pmc The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men
    Erin S LeBlanc
    Bone and Mineral Unit, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:3337-46. 2009
    ..The relationship between sex steroids and fracture is poorly understood...
  33. ncbi request reprint Hip fracture in women without osteoporosis
    Stacey A Wainwright
    Bone and Mineral Research Unit, Department of Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Mail Code CR113, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 90:2787-93. 2005
    ..These findings call attention to the many older women who suffer hip fracture but do not have particularly low antecedent BMD measures and help begin to identify risk factors associated with higher bone density levels...
  34. doi request reprint Efficacy and safety of monthly ibandronate in men with low bone density
    Eric S Orwoll
    Oregon Health and Science University, Bone and Mineral Unit, Portland, OR 97239, USA
    Bone 46:970-6. 2010
    ..The STudy Researching Osteoporosis iN Guys (STRONG) investigated the efficacy and safety of 150-mg monthly oral ibandronate in men with primary, idiopathic, or hypogonadism-related low bone density...
  35. ncbi request reprint Cognitive impairment and intracranial calcification in chronic hypoparathyroidism
    K V Kowdley
    Bone and Mineral Research Unit, Portland VA Medical Center, Oregon Health Sciences University, USA
    Am J Med Sci 317:273-7. 1999
    ..The purpose of this study was to determine whether chronic hypoparathyroidism is associated with cognitive impairment...
  36. ncbi request reprint Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice
    O F Klein
    Department of Medicine, Bone and Mineral Research Unit, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, 97201 3098, USA
    J Bone Miner Res 16:1953-61. 2001
    ..In light of this, we believe that findings in mice should aid in the identification of specific candidate genes for study in humans...
  37. ncbi request reprint North American male reference population for speed of sound in bone at multiple skeletal sites
    Stephen R Hayman
    Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    J Clin Densitom 5:63-71. 2002
    ..Longitudinal monitoring of healthy men should be performed to confirm these cross-sectional results...
  38. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  39. ncbi request reprint Association between Parkinson's disease and low bone density and falls in older men: the osteoporotic fractures in men study
    Howard A Fink
    Geriatric Research Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    J Am Geriatr Soc 53:1559-64. 2005
    ..To examine the association between Parkinson's disease (PD) and bone mineral density (BMD) and risk of falls...
  40. ncbi request reprint Association of testosterone and estradiol deficiency with osteoporosis and rapid bone loss in older men
    Howard A Fink
    Geriatric Research Eduction and Clinical Center, Veterans Affairs Medical Center, One Veterans Drive, Box 11G, Minneapolis, MN 55417, USA
    J Clin Endocrinol Metab 91:3908-15. 2006
    ..The clinical value of measuring testosterone and estradiol in older men with osteoporosis and of measuring bone mineral density (BMD) in older men with testosterone or estradiol deficiency is uncertain...
  41. ncbi request reprint BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women
    Steven R Cummings
    San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California 94107, USA
    J Bone Miner Res 21:1550-6. 2006
    ..The relationship between hip BMD and hip fracture risk seemed to be stronger than observed in a large prospective study of women. Hip BMD is an excellent test for predicting fracture risk in men...
  42. ncbi request reprint New QCT analysis approach shows the importance of fall orientation on femoral neck strength
    R Dana Carpenter
    Bone and Joint Center, VA Palo Alto Health Care System, Palo Alto, California, USA
    J Bone Miner Res 20:1533-42. 2005
    ..A new image analysis technique showed that the strength of the femoral neck in 37 males varied significantly along the neck axis and that bending strength varied by a factor of up to 2.8 for different loading directions...
  43. ncbi request reprint Factors associated with the lumbar spine and proximal femur bone mineral density in older men
    Jane A Cauley
    Department of Epidemiology, University of Pittsburgh, 130 DeSoto Street, Crabtree Hall A524, Pittsburgh, PA 15261, USA
    Osteoporos Int 16:1525-37. 2005
    ..Identification of these correlates could improve methods to identify men at risk for fracture and improve our understanding of fracture etiology...
  44. ncbi request reprint Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 54:1649-57. 2006
    ..To examine the association between alcohol intake and problem drinking history and bone mineral density (BMD), falls and fracture risk...
  45. ncbi request reprint Alcohol use, physical performance, and functional limitations in older men
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107, USA
    J Am Geriatr Soc 55:212-20. 2007
    ..To describe associations between recent alcohol intake, physical performance, and functional limitations in older men...
  46. ncbi request reprint Prevalence, severity, and health correlates of lower urinary tract symptoms among older men: the MrOS study
    Brent C Taylor
    Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Urology 68:804-9. 2006
    ..To describe the prevalence, severity, and health correlates of lower urinary tract symptoms (LUTS) in older community-dwelling U.S. men...
  47. ncbi request reprint Human ALOX12, but not ALOX15, is associated with BMD in white men and women
    Shoji Ichikawa
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5121, USA
    J Bone Miner Res 21:556-64. 2006
    ..Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD...
  48. ncbi request reprint Frailty in older men: prevalence, progression, and relationship with mortality
    Peggy M Cawthon
    Research Institute, California Pacific Medical Center, San Francisco, California 94107 1762, USA
    J Am Geriatr Soc 55:1216-23. 2007
    ..To describe the association between frailty and health status, the progression of frailty, and the relationship between frailty and mortality in older men...
  49. ncbi request reprint Cost-effectiveness of bone densitometry followed by treatment of osteoporosis in older men
    John T Schousboe
    Rheumatology, Park Nicollet Health Services, Minneapolis, MN 55416, USA
    JAMA 298:629-37. 2007
    ..Osteoporotic fractures are common among elderly men...
  50. ncbi request reprint The COMT val158met polymorphism is associated with prevalent fractures in Swedish men
    Anna L Eriksson
    Center for Bone Research at the Sahlgrenska Academy, Departments of Internal Medicine and Geriatrics, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Bone 42:107-12. 2008
    ..We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men. The aim of this study was to investigate associations between COMT val158met, BMD and fractures in elderly men...
  51. doi request reprint IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden
    Louise Strandberg
    Institute of Neuroscience and Physiology Endocrinology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Obesity (Silver Spring) 16:710-3. 2008
    ..In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men...

Research Grants21

  1. Osteporotic Fractures in Men (MrOS)- Admin Center
    Eric Orwoll; Fiscal Year: 2007
    ....
  2. Oregon Clinical and Translational Science Institute
    Eric Orwoll; Fiscal Year: 2007
    ..There are particular opportunities to accelerate progress in pediatric and child health, community based research, and human genetics. ..
  3. Oregon Clinical and Translational Science Institute
    Eric Orwoll; Fiscal Year: 2007
    ..There are particular opportunities to accelerate progress in pediatric and childhealth, community based research, and human genetics. ..
  4. Oregon Clinical and Translational Science Institute
    Eric Orwoll; Fiscal Year: 2007
    ..There are particular opportunities to accelerate progress in pediatric and child health, community based research, and human genetics. ..
  5. Osteoporotic Fractures in Men: MrOS Renewal-Portland
    Eric Orwoll; Fiscal Year: 2007
    ....
  6. ORAL AND SKELETAL BONE LOSS IN OLDER MEN
    Eric Orwoll; Fiscal Year: 2006
    ..Since the MrOS cohort is already established through other funds, this request will provide a very cost-effective means for addressing these important oral health issues. ..
  7. Outcomes of Sleep Disorders in Older Men-Portland
    Eric Orwoll; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..