R W O'Rourke

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Adipose tissue NK cells manifest an activated phenotype in human obesity
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, OR, USA Electronic address
    Metabolism 62:1557-61. 2013
  2. pmc Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e71165. 2013
  3. pmc Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Metabolism 61:1152-61. 2012
  4. doi Management strategies for internal hernia after gastric bypass
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223A, Portland, OR 97239 3098, USA
    J Gastrointest Surg 15:1049-54. 2011
  5. pmc Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223A, Portland, OR, USA
    Diabetologia 54:1480-90. 2011
  6. pmc Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Int J Obes (Lond) 33:978-90. 2009
  7. doi Molecular mechanisms of obesity and diabetes: at the intersection of weight regulation, inflammation, and glucose homeostasis
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, 3181 S W Sam Jackson Park Road L 223A, Portland, OR, 97239 3098, USA
    World J Surg 33:2007-13. 2009
  8. ncbi Perioperative morbidity associated with bariatric surgery: an academic center experience
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, USA
    Arch Surg 141:262-8. 2006
  9. ncbi Simultaneous surgical management of achalasia and morbid obesity
    ROBERT W O'ROURKE
    Department of Surgery L223A, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Obes Surg 17:547-9. 2007
  10. ncbi Esophageal motility disorders after gastric banding
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Dis Esophagus 20:269-73. 2007

Detail Information

Publications17

  1. pmc Adipose tissue NK cells manifest an activated phenotype in human obesity
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, OR, USA Electronic address
    Metabolism 62:1557-61. 2013
    ..Natural killer (NK) cells are an understudied cell type in the context of obesity. The goal of this study was to determine the phenotype of human adipose tissue NK cells...
  2. pmc Hexosamine biosynthesis is a possible mechanism underlying hypoxia's effects on lipid metabolism in human adipocytes
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e71165. 2013
    ..Hypoxia regulates adipocyte metabolism. Hexosamine biosynthesis is implicated in murine 3T3L1 adipocyte differentiation and is a possible underlying mechanism for hypoxia's effects on adipocyte metabolism...
  3. pmc Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Metabolism 61:1152-61. 2012
    ..These data suggest a role for IFN-γ in the regulation of inflammation and glucose homeostasis in obesity though multiple potential mechanisms, including effects on adipogenesis, cytokine expression, and macrophage phenotype...
  4. doi Management strategies for internal hernia after gastric bypass
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223A, Portland, OR 97239 3098, USA
    J Gastrointest Surg 15:1049-54. 2011
    ..Internal hernia after gastric bypass is common, occurring with an incidence approaching 10% in some series. Operative management of internal hernia after gastric bypass presents significant conceptual and technical challenges...
  5. pmc Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L223A, Portland, OR, USA
    Diabetologia 54:1480-90. 2011
    ..The goal of this study was to define in vitro inflammatory responses of human adipose tissue to hypoxia and identify molecular mechanisms of hypoxia-induced inflammation...
  6. pmc Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Int J Obes (Lond) 33:978-90. 2009
    ..Defining depot-specific differences in inflammatory function may reveal underlying mechanisms of adipose-tissue-based inflammation...
  7. doi Molecular mechanisms of obesity and diabetes: at the intersection of weight regulation, inflammation, and glucose homeostasis
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, 3181 S W Sam Jackson Park Road L 223A, Portland, OR, 97239 3098, USA
    World J Surg 33:2007-13. 2009
    ..Study of these mediators and the specific mechanisms underlying inflammation and insulin resistance in obesity holds the promise for novel pharmacotherapy for obesity-related metabolic disease...
  8. ncbi Perioperative morbidity associated with bariatric surgery: an academic center experience
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, USA
    Arch Surg 141:262-8. 2006
    ..We hypothesize that specific clinical variables predict postoperative morbidity after bariatric surgery.Design, Setting, and..
  9. ncbi Simultaneous surgical management of achalasia and morbid obesity
    ROBERT W O'ROURKE
    Department of Surgery L223A, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Obes Surg 17:547-9. 2007
    ..The sparse literature addressing these rare patients is reviewed and management considerations discussed. Simultaneous laparoscopic esophageal myotomy and gastric bypass is safe, feasible and provides good results...
  10. ncbi Esophageal motility disorders after gastric banding
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Dis Esophagus 20:269-73. 2007
    ..The current literature addressing the effects of gastric banding on esophageal function in light of this case report is discussed...
  11. pmc Alterations in peripheral blood lymphocyte cytokine expression in obesity
    R W O'Rourke
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Exp Immunol 146:39-46. 2006
    ....
  12. ncbi Alterations in T-cell subset frequency in peripheral blood in obesity
    ROBERT W O'ROURKE
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Obes Surg 15:1463-8. 2005
    ..Obesity affects the regulation of immune and inflammatory responses. This study characterizes differences in peripheral blood lymphocyte phenotype in obese humans...
  13. ncbi Transthoracic hepatic radiofrequency ablation
    N N Lee
    Oregon Health and Science University Medical School, Portland, OR, USA
    Surg Endosc 18:1672-4. 2004
    ..Tumors beneath the diaphragmatic dome may be difficult to access by laparoscopy. In these cases, a transthoracic transdiaphragmatic approach for delivering RFA can be used...
  14. doi Recombinant vascular endothelial growth factor165 gene therapy improves anastomotic healing in an animal model of ischemic esophagogastrostomy
    C K Enestvedt
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Dis Esophagus 25:456-64. 2012
    ..These findings suggest that VEGF gene therapy has the potential to reduce anastomotic morbidity and improve surgical outcomes in a wide array of patients...
  15. doi Trends in the management of esophageal carcinoma based on provider volume: treatment practices of 618 esophageal surgeons
    C K Enestvedt
    Department of Surgery, Oregon Health and Science University, Portland, Oregon, USA
    Dis Esophagus 23:136-44. 2010
    ..These results highlight the need for controlled trials to determine best practices in the treatment of this complex patient population...
  16. ncbi Laparoscopic radiofrequency ablation and hepatic artery infusion pump placement in the evolving treatment of colorectal hepatic metastases
    J Cheng
    Department of Minimally Invasive Surgery, Legacy Health System, 501 North Graham Street, Suite 120, Portland, OR 97227, USA
    Surg Endosc 17:61-7. 2003
    ..This study investigates the selection criteria, safety, efficacy, and preliminary outcomes of patients treated with LRFA and LHAIP placement...
  17. pmc Psychiatric illness delays diagnosis of esophageal cancer
    R W O'Rourke
    Departments of Surgery and Radiation Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Dis Esophagus 21:416-21. 2008
    ..Dementia is associated with worse survival in these patients. These findings emphasize the importance of prompt evaluation of foregut symptoms in patients with psychiatric illness...