Gayle A Orner

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Carcinog 5:6. 2006
  2. pmc Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac
    Gayle A Orner
    Linus Pauling Institute and Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 24:263-7. 2003
  3. ncbi request reprint Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Gayle A Orner
    Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mutat Res 506:121-7. 2002
  4. pmc Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
    Environ Health Perspect 116:1047-55. 2008
  5. ncbi request reprint Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling
    Carmen A Blum
    Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Mutat Res 523:217-23. 2003
  6. ncbi request reprint Tumor-suppressing effects of antioxidants from tea
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 134:3177S-3178S. 2004
  7. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
  8. pmc Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:1581-6. 2008
  9. pmc Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study
    George S Bailey
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 22:1264-76. 2009
  10. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007

Collaborators

Detail Information

Publications14

  1. pmc Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Carcinog 5:6. 2006
    ..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats...
  2. pmc Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac
    Gayle A Orner
    Linus Pauling Institute and Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 24:263-7. 2003
    ....
  3. ncbi request reprint Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Gayle A Orner
    Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mutat Res 506:121-7. 2002
    ..Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway...
  4. pmc Genomic profiling reveals an alternate mechanism for hepatic tumor promotion by perfluorooctanoic acid in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon, USA
    Environ Health Perspect 116:1047-55. 2008
    ..Previous studies with rainbow trout indicate they are also insensitive to peroxisome proliferation by the PP dehydroepiandrosterone (DHEA), but are still susceptible to enhanced hepatocarcinogenesis after chronic exposure...
  5. ncbi request reprint Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling
    Carmen A Blum
    Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Mutat Res 523:217-23. 2003
    ....
  6. ncbi request reprint Tumor-suppressing effects of antioxidants from tea
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 134:3177S-3178S. 2004
  7. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
    ..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon...
  8. pmc Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:1581-6. 2008
    ..This is the first demonstration that maternal ingestion of green tea, during pregnancy and nursing, provides protection against transplacental carcinogenesis...
  9. pmc Nonlinear cancer response at ultralow dose: a 40800-animal ED(001) tumor and biomarker study
    George S Bailey
    Department of Environmental and Molecular Toxicology, Marine and Freshwater Biomedical Sciences Center, Linus Pauling Institute, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon 97331, USA
    Chem Res Toxicol 22:1264-76. 2009
    ..They provide the first experimental estimation in any model of the degree of conservatism that may exist for the EPA default linear assumption for a genotoxic carcinogen...
  10. ncbi request reprint Gene expression analysis during tumor enhancement by the dietary phytochemical, 3,3'-diindolylmethane, in rainbow trout
    Susan C Tilton
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1589-98. 2007
    ..They confirm the importance of estrogenic signaling in the mechanism of promotion by dietary indoles in trout liver and indicate a possible dual effect that enhances tumor incidence and decreases potential for metastasis...
  11. pmc Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    FASEB J 20:506-8. 2006
    ....
  12. ncbi request reprint Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
    Wan Mohaiza Dashwood
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochem Biophys Res Commun 296:584-8. 2002
    ..These data are consistent with the findings from in vivo studies, showing the suppression of intestinal polyps by tea, via an apparent down-regulation of beta-catenin and Wnt target genes...
  13. ncbi request reprint The rainbow trout (Oncorhynchus mykiss) tumor model: recent applications in low-dose exposures to tumor initiators and promoters
    David E William
    Marine Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon, USA
    Toxicol Pathol 31:58-61. 2003
    ..If these results can be confirmed with other carcinogens (genotoxic and perhaps nongenotoxic) and other targets, this could have a significant impact on the utilization of animal tumor data in human risk assessment...
  14. ncbi request reprint Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts
    Orianna Carter
    Ohio University Southern, 1804 Liberty Avenue, Ironton, OH 45638, USA
    Nutr Cancer 58:60-5. 2007
    ..5 +/- 0.4 (P > 0.05, not significant). The data imply that white tea, caffeine, and EGCG may be most effective post-initiation, via the inhibition of cell proliferation in the colon and through the suppression of early lesions...