H Offner

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis
    Kary A Latham
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 171:5820-7. 2003
  2. ncbi request reprint Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 174:2387-95. 2005
  3. ncbi request reprint Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta
    Sandhya Subramanian
    Neuroimmunology Research R and D 31, Portland Veterans Affairs Medical Center, 3710 SE U S Veterans Hospital Road, Portland, OR 97239, USA
    Clin Immunol 115:162-72. 2005
  4. pmc RTL therapy for multiple sclerosis: a Phase I clinical study
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States
    J Neuroimmunol 231:7-14. 2011
  5. pmc RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon, United States of America
    PLoS ONE 6:e21868. 2011
  6. pmc PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1
    Sheetal Bodhankar
    Neuroimmunology Research, R and D 31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    J Neuroinflammation 10:111. 2013
  7. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
  8. pmc GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol
    Melissa A Yates
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR, USA
    BMC Immunol 11:20. 2010
  9. pmc Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression
    H Offner
    Neuroimmunology Research R and D 31, Portland Veterans Affairs Medical Center, 3710 Southwest US Veterans Hospital Road, and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 158:1098-111. 2009
  10. pmc Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    Rev Neurosci 19:327-39. 2008

Research Grants

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis
    Kary A Latham
    Veterans Affairs Medical Center, Memphis, TN 38104, USA
    J Immunol 171:5820-7. 2003
    ....
  2. ncbi request reprint Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 174:2387-95. 2005
    ..These data are the first to define age-dependent differences in EAE expression and response to hormone therapy...
  3. ncbi request reprint Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta
    Sandhya Subramanian
    Neuroimmunology Research R and D 31, Portland Veterans Affairs Medical Center, 3710 SE U S Veterans Hospital Road, Portland, OR 97239, USA
    Clin Immunol 115:162-72. 2005
    ..This is the first report demonstrating effective treatment of joint inflammation and clinical signs of CIA with orally administered ethinyl estradiol, thus supporting its possible clinical use for treating rheumatoid arthritis in humans...
  4. pmc RTL therapy for multiple sclerosis: a Phase I clinical study
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States
    J Neuroimmunol 231:7-14. 2011
    ..RTL1000 represents a novel approach for the treatment of MS that promises potent immunoregulation and CNS repair without global immunosuppression...
  5. pmc RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon, United States of America
    PLoS ONE 6:e21868. 2011
    ..These novel results demonstrate that a major effect of RTL therapy is to attenuate Th1 specific changes in CD4+ T-cells during EAE and prevent expansion of effector T-cells that mediate clinical signs and CNS inflammation in EAE...
  6. pmc PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1
    Sheetal Bodhankar
    Neuroimmunology Research, R and D 31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    J Neuroinflammation 10:111. 2013
    ..The purpose of this study was to determine if this protective effect of PD-1 involves either of its ligands, PD-L1 or PD-L2...
  7. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
    ..The mechanisms by which RTLs impede local recruitment and retention of inflammatory cells in the CNS, however, are not completely understood...
  8. pmc GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol
    Melissa A Yates
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR, USA
    BMC Immunol 11:20. 2010
    ..In the current study, the influence of estrogen receptor-alpha (ERalpha) and the G-protein coupled estrogen receptor (GPR30 or GPER) on EE's ability to treat EAE was explored...
  9. pmc Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression
    H Offner
    Neuroimmunology Research R and D 31, Portland Veterans Affairs Medical Center, 3710 Southwest US Veterans Hospital Road, and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 158:1098-111. 2009
    ..Equally important for the recovering stroke patient are approaches that can derail the second phase of immune dysfunction and restore the ability to mount a defense against systemic infectious insults...
  10. pmc Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    Rev Neurosci 19:327-39. 2008
    ..These properties of RTL suggest that this novel antigen-specific approach may hold unusual promise as a therapy for multiple sclerosis...
  11. ncbi request reprint A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE
    Halina Offner
    Department of Neurology, Oregon Health and Science University, 97201, Portland, OR, USA
    J Neuroimmunol 130:128-39. 2002
    ..These observations suggest that HE2500 and/or HE2200 limit the production of autoimmune Th1 associated cytokines, and ultimately may be beneficial for patients with MS or other autoimmune diseases...
  12. ncbi request reprint A potential role for estrogen in experimental autoimmune encephalomyelitis and multiple sclerosis
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 SW U S Veterans Hospital Rd, Portland, OR 97239, USA
    Ann N Y Acad Sci 1089:343-72. 2006
    ..Alternatively, one might envision using E2 derivatives alone or in combination therapies in both male and female MS patients...
  13. ncbi request reprint Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 176:6523-31. 2006
    ....
  14. ncbi request reprint Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 175:4103-11. 2005
    ....
  15. ncbi request reprint Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    ..These data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system...
  16. ncbi request reprint Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medicial Center, Department of Neurology, Oregon Health and Science University, Portland, 97239, USA
    Int Rev Immunol 24:447-77. 2005
    ..The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS...
  17. ncbi request reprint Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis
    Halina Offner
    Department of Neurology, Oregon Health and Science University, Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Neurosci Res 78:603-24. 2004
    ..Alternatively, one might envision using EE or fluasterone metabolites alone or in combination therapies in both male and female MS patients...
  18. ncbi request reprint A synthetic androstene analogue inhibits collagen-induced arthritis in the mouse
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    Clin Immunol 110:181-90. 2004
    ..This is the first study to report that an IRH can ameliorate ongoing disease in a CIA mouse model with relevance to RA and to correlate that finding with decreases in pro-inflammatory cytokines...
  19. ncbi request reprint Regulation of encephalitogenic T cells with recombinant TCR ligands
    G G Burrows
    Department of Neurology, Biochemistry and Molecular Biology, and Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland 97201, USA
    J Immunol 164:6366-71. 2000
    ..These novel RTLs provide a platform for developing potent and selective human diagnostic and therapeutic agents for treatment of autoimmune disease...
  20. ncbi request reprint Vaccination with BV8S2 protein amplifies TCR-specific regulation and protection against experimental autoimmune encephalomyelitis in TCR BV8S2 transgenic mice
    H Offner
    Portland Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University 97201, USA
    J Immunol 161:2178-86. 1998
    ..These results suggest that immune regulation occurs through a nondeletional cytokine-driven suppressive mechanism...
  21. ncbi request reprint Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice
    A Ito
    Department of Neurology and Neurological Sciences Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 167:542-52. 2001
    ..Therefore, we propose that one mechanism by which estrogen protects females from the development of cell-mediated autoimmunity is through a hormone-dependent regulation of TNF-alpha production...
  22. ncbi request reprint Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis
    G G Burrows
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Immunol 161:5987-96. 1998
    ..This new class of small soluble polypeptide may provide a template for designing human homologues useful in detecting and regulating potentially autopathogenic T cells...
  23. ncbi request reprint Gonadal hormones influence the immune response to PLP 139-151 and the clinical course of relapsing experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Neuroimmunol 84:122-30. 1998
    ..Our data suggests an important regulatory role for androgens on the immune response to PLP 139-151 and the clinical course of R-EAE...
  24. pmc Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis
    M A Yates
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR, United States
    J Neuroimmunol 220:136-9. 2010
    ..Decreased chemokine and chemokine receptor expression in the spinal cord also contributed to decreased lesions in the spinal cord...
  25. ncbi request reprint Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, USA
    J Immunol 162:35-40. 1999
    ....
  26. ncbi request reprint Reduced chemokine and chemokine receptor expression in spinal cords of TCR BV8S2 transgenic mice protected against experimental autoimmune encephalomyelitis with BV8S2 protein
    A Matejuk
    Department of Neurology and Molecular Microbiology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 164:3924-31. 2000
    ..These results demonstrate that TCR vaccination results in selective reduction of inflammatory chemokines and chemokine receptors in SC, the target organ most affected during EAE...
  27. ncbi request reprint Variation in H-2K(k) peptide motif revealed by sequencing naturally processed peptides from T-cell hybridoma class I molecules
    G G Burrows
    Veterans Affairs Medical Center, Portland, Oregon, USA
    J Neurosci Res 45:803-11. 1996
    ..The variation in naturally processed peptides loaded onto the same class I allele most likely reflects the nature of the pool of peptides within the cell available for loading class I molecules...
  28. ncbi request reprint Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation
    Chunhe Wang
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 171:1934-40. 2003
    ....
  29. pmc Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research R and D 31, Portland VA Medical Center, Portland, OR 97239, USA
    J Neuroimmunol 225:52-61. 2010
    ..These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs...
  30. doi request reprint An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis
    Halina Offner
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Pharmacol Exp Ther 329:1100-9. 2009
    ....
  31. ncbi request reprint 17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis
    A Matejuk
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon, USA
    J Neurosci Res 65:529-42. 2001
    ....
  32. ncbi request reprint Effects of vaccination with T cell receptor peptides: epitope switching to a possible disease-protective determinant of myelin basic protein that is cross-reactive with a TCR BV peptide
    A A Vandenbark
    Research Service, Veterans Affairs Medical Center, Portland, OR 97201, USA
    Immunol Cell Biol 76:83-90. 1998
    ..This cross-reactivity, which may also occur between the human MBP-55-74 peptide and the BV12S2-38-58 sequence, has potentially important implications for human diseases such as multiple sclerosis...
  33. ncbi request reprint Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    B F Bebo
    Department of Veterans Affairs, Neuroimmunology Research, Oregon Health Sciences University, Portland, OR 97201, USA
    J Immunol 166:2080-9. 2001
    ....
  34. ncbi request reprint A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci 27:12531-9. 2007
    ..These findings indicate that targeted immunotherapy of antigen-specific T-cells can result in a reversal of CNS lesion formation and lend strong support to the application of the RTL approach for therapy in MS...
  35. ncbi request reprint Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch
    Jianya Huan
    Department of Neurology, Oregon Health and Science University, Portland, OR 97207, USA
    J Immunol 172:4556-66. 2004
    ..These results strongly support the clinical application of this novel class of peptide/MHC class II constructs in patients with multiple sclerosis who have focused T cell responses to known encephalitogenic myelin peptides...
  36. ncbi request reprint Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis
    Atsushi Ito
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Clin Immunol 102:275-82. 2002
    ..We propose that the mechanism of E2 protection may involve both systemic inhibition of TNF-alpha expression and local (CNS) recruitment of inflammatory cells, with modest effects on TNF-alpha expression by resident CNS microglial cells...
  37. ncbi request reprint Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice
    Arthur A Vandenbark
    Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center and Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 171:127-33. 2003
    ....
  38. ncbi request reprint Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, R and D 31, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Int Immunol 19:337-43. 2007
    ..These data clearly demonstrate that E2 can affect multiple regulatory elements that influence Treg suppression, including both PD-1-dependent and PD-1-independent pathways...
  39. ncbi request reprint IL-7 enhances Ag-specific human T cell response by increasing expression of IL-2R alpha and gamma chains
    Y K Chou
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Neuroimmunol 96:101-11. 1999
    ..These studies demonstrate that IL-7 promotes the growth and survival of circulating Ag-specific human Th1 cells through a mechanism that probably involves the gammac common receptor for IL-2 family members that includes IL-7...
  40. ncbi request reprint Diminished frequency of interleukin-10-secreting, T-cell receptor peptide-reactive T cells in multiple sclerosis patients might allow expansion of activated memory T cells bearing the cognate BV gene
    A A Vandenbark
    Tykeson MS Research Laboratory, Neuroimmunology Research, VA Medical Center, Portland, OR 97207, USA
    J Neurosci Res 66:171-6. 2001
    ..These results suggest that MS patients have diminished frequencies of innate TCR-reactive T cells that may allow oligoclonal expansion of activated autoreactive Th1 effector cells expressing cognate V genes...
  41. ncbi request reprint Gender differences in experimental autoimmune encephalomyelitis develop during the induction of the immune response to encephalitogenic peptides
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon
    J Neurosci Res 52:420-6. 1998
    ..Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase...
  42. ncbi request reprint Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis
    G Adamus
    R S Dow Neurological Sciences Institute, Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon, USA
    J Neurosci Res 50:531-8. 1997
    ..MCP-1 seems to contribute to the initial recruitment of inflammatory cells into both the tissues of the eye and CNS over the course of disease...
  43. pmc Estrogen potentiates treatment with T-cell receptor protein of female mice with experimental encephalomyelitis
    H Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Clin Invest 105:1465-72. 2000
    ..These findings imply that supplemental estrogen can enhance the efficacy of TCR-based immunotherapy for autoimmune diseases that predominate in females...
  44. pmc MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis
    Jianya Huan
    Neuroimmunology Research, Veterans Affairs Medical Center, Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland 97201, USA
    J Immunol 180:1249-57. 2008
    ..This is the first report demonstrating effective prevention of joint inflammation and clinical signs of CIA with an I-Aq-derived RTL, thus supporting the possible clinical use of this approach for treating rheumatoid arthritis in humans...
  45. ncbi request reprint Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 173:2227-30. 2004
    ..In summary, our data suggest E2 promotes tolerance by expanding the regulatory T cell compartment...
  46. pmc T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
    Patricia D Hurn
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
    J Cereb Blood Flow Metab 27:1798-805. 2007
    ....
  47. ncbi request reprint Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity
    Laura Tsaknaridis
    Neuroimmunology Research and Tykeson MS Research Laboratory, Veterans Affairs Medical Center and Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 74:296-308. 2003
    ..Our results are highly consistent with those reported for murine Treg cells and are the first to demonstrate that suppressive activity of human CD4+CD25+ T cells declines with age...
  48. ncbi request reprint Endogenous CD4+BV8S2- T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 71:89-103. 2003
    ..These three Sp-EAE protective T cell subpopulations possessed distinctive properties and induced a variety of effects in T/R- recipients, thus implicating differing mechanisms of protection...
  49. ncbi request reprint A TCR V alpha CDR3-specific motif associated with Lewis rat autoimmune encephalomyelitis and basic protein-specific T cell clones
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Immunol 158:5472-83. 1997
    ..Thus, we demonstrate that the Asn3+ V alpha CDR3 motif is strongly associated with experimental autoimmune encephalomyelitis in the Lewis rat and propose that it plays a role in TCR recognition of a specific BP peptide/MHC complex...
  50. ncbi request reprint Multiple class I motifs revealed by sequencing naturally processed peptides eluted from rat T cell MHC molecules
    G G Burrows
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    J Neurosci Res 49:107-16. 1997
    ..Identification of these class I peptide binding motifs will be useful for predicting potential CTL epitopes in studies on autoimmunity, immunoregulation and transplantation in the Lewis rat...
  51. ncbi request reprint Estrogen inhibition of EAE involves effects on dendritic cell function
    Hong Yan Liu
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 70:238-48. 2002
    ..Thus, E2 treatment appears to have multiple effects on the DC population, which may contribute to a down-regulation or block in the activation of Th1 cells involved in the induction of EAE...
  52. pmc The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97201, USA
    Am J Pathol 163:1599-605. 2003
    ..These results indicate that the immunomodulatory effects of E2 in EAE are dependent on Esr1 and not Esr2 signaling...
  53. pmc Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke
    Bing Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Immunol 184:4087-94. 2010
    ..These results demonstrate for the first time that E2 replacement in ovariectomized female mice improves stroke-induced peripheral immunosuppression...
  54. pmc Single-chain recombinant HLA-DQ2.5/peptide molecules block α2-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease
    J Huan
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Mucosal Immunol 4:112-20. 2011
    ..5-derived molecules could significantly inhibit and perhaps reverse the intestinal pathology caused by T-cell-mediated inflammation and the associated production of proinflammatory cytokines...
  55. pmc Recombinant T cell receptor ligand treats experimental stroke
    Sandhya Subramanian
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR 97239, USA
    Stroke 40:2539-45. 2009
    ..We tested the hypothesis that RTL would improve ischemic outcome in the brain without exacerbating defects in the peripheral immune system function...
  56. ncbi request reprint Inhibitory effects of incomplete Freund's adjuvant on experimental autoimmune encephalomyelitis
    Alex Zamora
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201, USA
    Autoimmunity 35:21-8. 2002
    ..These data demonstrate for the first time a direct inhibitory effect of IFA/saline on EAE, and re-emphasize the need to properly control experiments using IFA to induce antigen-specific tolerance...
  57. pmc Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice
    Magdalena Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Am J Pathol 164:1915-24. 2004
    ..These results indicate that the heterotic effect at Esr2 is a function of the nonhematopoietic compartment...
  58. pmc T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis
    Magdalena J Polanczyk
    Department of Neurology, Oregon Health and Science University, Portland, Orgeon, USA
    Am J Pathol 165:2069-77. 2004
    ....
  59. pmc Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis
    Chunhe Wang
    Veterans Affairs Medical Center, Portland, Oregon, USA
    J Neurosci Res 88:7-15. 2010
    ..Therefore, down-modulation of PD-1 in Treg cells may abrogate Treg-mediated immune suppression, permitting the activation of myelin-reactive T cells and induction of EAE...
  60. ncbi request reprint Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system
    Sandhya Subramanian
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201, USA
    J Immunol 170:1548-55. 2003
    ..These results suggest that oral ethinyl estradiol might be a successful candidate as therapy for multiple sclerosis...
  61. pmc Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG
    Sushmita Sinha
    Neuroimmunology Research, Portland VA Medical Center, 3710 SW U S Veterans Hospital Rd, Portland, OR 97239, USA
    J Neuroimmune Pharmacol 5:231-9. 2010
    ..The results of our study lend support for the use of RTL therapy for treatment of MS subjects whose disease includes inflammatory T cells as well as those with an additional antibody component...
  62. ncbi request reprint Epitope recognition and T cell receptors in recurrent autoimmune anterior uveitis in Lewis rats immunized with myelin basic protein
    G Adamus
    Neurological Sciences Institute, Oregon Health Sciences University, Mailing Code L 111, Portland, OR 97201, USA
    J Neuroimmunol 108:122-30. 2000
    ..This process may involve a shifting of T cell specificity from the major encephalitogenic peptide utilizing the Vbeta8.2 receptor to a more diverse cell repertoire...
  63. ncbi request reprint Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis
    B F Bebo
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Cytokine 12:324-31. 2000
    ..These results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders...
  64. ncbi request reprint 17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97201, USA
    Arch Immunol Ther Exp (Warsz) 51:185-93. 2003
    ..The identification of genes with altered expression patterns in the spinal cords of estrogen-treated mice provides unique insight into the process that ultimately results in protection against EAE...
  65. ncbi request reprint CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon
    J Neurosci Res 73:667-78. 2003
    ....
  66. pmc Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci 29:3816-23. 2009
    ..These results show that treatment with single RTLs can induce a cytokine switch in cognate T-cells that inhibits both the target and bystander T-cells, providing new evidence for the potential applicability of RTL therapy in MS...
  67. ncbi request reprint Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells
    G G Burrows
    Department of Neurology, Oregon Health and Science University, Portland, OR 97201, USA
    J Immunol 167:4386-95. 2001
    ..Activation with RTLs provides a novel strategy for generating autoantigen-specific bystander suppression useful for treatment of complex autoimmune diseases...
  68. ncbi request reprint Rat RT1.B-transfected fibroblast lines process and present myelin antigens and activate T cells to induce experimental autoimmune encephalomyelitis
    A C Buenafe
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Neuroimmunol 112:106-14. 2001
    ..Thus, the RT1.B molecule is functionally expressed on the surface of transfected Dap.3 fibroblasts and is capable of MHC Class II-restricted, antigen-specific presentation to rat T cells...
  69. ncbi request reprint Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 67:680-8. 2002
    ..Our results not only identify the cellular source of chemokines in CNS, but also implicate MIP-1alpha, MIP-2, and MCP-1 in controlling CNS inflammation and severity of EAE...
  70. ncbi request reprint HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes
    Thomas P Finn
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci Res 78:100-14. 2004
    ....
  71. ncbi request reprint Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Neuroimmunol 170:85-92. 2005
    ..APC that both contribute to overt suppression, but such effects are overcome and focused towards enhanced suppression in inflammatory environments produced during pregnancy and EAE...
  72. ncbi request reprint Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice
    Cathleen Rich
    Veterans Affairs Medical Center, Portland, OR 97207, USA
    Eur J Immunol 34:1251-61. 2004
    ..These findings demonstrate potent encephalitogenic activity of the mMOG-35-55 peptide in association with HLA-DR2, thus providing a strong rationale for further study of hMOG-35-55 peptide as a potential pathogenic determinant in humans...
  73. ncbi request reprint T cell receptor V genes in multiple sclerosis: increased use of TCRAV8 and TCRBV5 in MBP-specific clones
    H Offner
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Int Rev Immunol 18:9-36. 1999
    ....
  74. ncbi request reprint TCR peptide therapy in human autoimmune diseases
    A A Vandenbark
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97201, USA
    Neurochem Res 26:713-30. 2001
    ..TCR peptide vaccination represents a promising approach that is well-suited for treating complex autoimmune diseases...
  75. ncbi request reprint Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 76:129-40. 2004
    ..Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants...
  76. ncbi request reprint Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis
    Arthur A Vandenbark
    Department of Veterans Affairs Medical Center, Portland, OR, USA
    J Neuroimmunol 215:125-8. 2009
    ..This striking enhancement of two prominent immunoregulatory pathways lends support to the idea that beneficial effects of IFN-beta-1a in MS include control of pernicious autoimmunity...
  77. ncbi request reprint Estrogen treatment induces a novel population of regulatory cells, which suppresses experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 77:119-26. 2004
    ....
  78. pmc Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 182:3294-303. 2009
    ..This study is the first to evaluate the protective effect of GPR30 activation on EAE, and provides a strong foundation for the clinical application of GPR30 agonists such as G-1 in multiple sclerosis...
  79. pmc Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) Foxp3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells
    Abigail C Buenafe
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 130:114-24. 2010
    ....
  80. pmc Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, and Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Immunology 125:1-13. 2008
    ..However, Treg cells specific for the pathogenic T effector cells themselves have largely been overlooked and deserve consideration in future studies...
  81. ncbi request reprint T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice
    Yuan K Chou
    Neuroimmunology Research and Tykeson Multiple Sclerosis Research Laboratory, Veterans Affairs Medical Center, and Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci Res 77:670-80. 2004
    ....
  82. ncbi request reprint Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice
    Jason M Link
    Portland V A Medical Center, Neuroimmunology Research R and D 31, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    Clin Immunol 123:95-104. 2007
    ....
  83. ncbi request reprint Treatment of autoimmune anterior uveitis with recombinant TCR ligands
    Grazyna Adamus
    Neurological Sciences Institute, Department of Ophthalmology, Oregon Health and Science University, and Neuroimmunology Research, Veterans Affairs Medical Center, Portland, USA
    Invest Ophthalmol Vis Sci 47:2555-61. 2006
    ..RTLs comprise the rat RT1.B beta1alpha1 domains, linked either to the guinea pig MBP69-89 peptide (RTL201), to the corresponding rat MBP69-89 peptide (RTL200), or to the cardiac myosin peptide CM-2 (RTL203)...
  84. ncbi request reprint Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis
    Richard E Jones
    Veterans Affairs Medical Center, Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 170:1690-8. 2003
    ..The results provide direct experimental evidence relevant to discussions on the mechanisms of disease progression in MS and EAE...
  85. ncbi request reprint AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, 97239, and Department of Neurology, Oregon Health and Science University, USA
    J Neuroimmunol 176:51-62. 2006
    ..These results suggest that alphaB-specific T cells are immunocompetent but not encephalitogenic in 129SvEv mice, and that immune tolerance may not be the main factor that limits the encephalitogenic potential of alphaB...
  86. pmc Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis
    Arthur A Vandenbark
    Neuroimmunology Laboratory, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 123:66-78. 2008
    ....
  87. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
    ..Our study distinguishes, for the first time, the respective contributions of nuclear and membrane E2 receptors in negative regulation of thymic development...
  88. pmc IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis
    Sushmita Sinha
    Neuroimmunology Research, Veterans Affairs Medical Center, 3710 S W U S Veterans Hospital Road, Portland, OR 97239, USA
    J Immunol 180:2679-85. 2008
    ....
  89. pmc Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon, USA
    J Neurochem 98:1817-27. 2006
    ..These findings indicate that RTL therapy targeting encephalitogenic T cells may promote CNS neuroregenerative processes...
  90. pmc Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1
    Chunhe Wang
    Veterans Affairs Medical Center, Portland, OR 97239, USA
    Immunology 126:329-35. 2009
    ..Taken together, our results suggest that E(2)-induced protection against EAE is mediated by upregulation of PD-1 expression within the Treg-cell compartment...
  91. ncbi request reprint Evaluation of the effects of 17beta-estradiol (17beta-e2) on gene expression in experimental autoimmune encephalomyelitis using DNA microarray
    Agata Matejuk
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201, USA
    Endocrinology 143:313-9. 2002
    ..These results implicate a limited set of known and previously unsuspected E2-sensitive genes that may be crucial for inhibition of EAE and potentially the human disease, multiple sclerosis...
  92. ncbi request reprint Decreased FOXP3 levels in multiple sclerosis patients
    Jianya Huan
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Neurosci Res 81:45-52. 2005
    ..Future studies will evaluate the effects of therapies known to influence Treg cell function and FOXP3 expression, including TCR peptide vaccination and supplemental estrogen...
  93. ncbi request reprint A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis
    D N Bourdette
    Department of Neurology L226, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Mult Scler 11:552-61. 2005
    ..T cell receptor (TCR) peptide vaccination is a novel approach to treating multiple sclerosis (MS). The low immunogenicity of previous vaccines has hindered the development of TCR peptide vaccination for MS...
  94. pmc Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke
    Xuefang Ren
    DrMed, Neuroimmunology Research, R and D 31, Portland Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Stroke 42:2578-83. 2011
    ..Our goal was to evaluate the contribution of the well-described coinhibitory pathway, programmed death (PD)-1, to the development of middle cerebral artery occlusion...
  95. pmc Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells
    Cory Teuscher
    Department of Medicine, University of Vermont School of Medicine, Burlington, Vermont 05405, USA
    Am J Pathol 164:883-92. 2004
    ..Because MCP-1 is known to inhibit IL-12 production, the failure of H2RKO mice to generate encephalitogenic Th1 effector cell responses is consistent with inhibition of negative regulation of MCP-1 secretion by H2R signaling in APCs...
  96. ncbi request reprint Transfer of severe experimental autoimmune encephalomyelitis by IL-12- and IL-18-potentiated T cells is estrogen sensitive
    Atsushi Ito
    Department of Experimental Pathology, Institute for Medical Sciences, Kyoto University, Kyoto, Japan
    J Immunol 170:4802-9. 2003
    ....
  97. ncbi request reprint Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway
    Magdalena J Polanczyk
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Neurosci Res 84:370-8. 2006
    ..These novel findings indicate that E2-induced immunomodulation is mediated in part through potentiation in BM-DC of the PD-1 costimulatory pathway...
  98. pmc Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS
    Cory Teuscher
    Departments of Medicine and Pathology, University of Vermont, Burlington, VT 05405, USA
    Proc Natl Acad Sci U S A 104:10146-51. 2007
    ..Our data suggest that pharmacological targeting of the H3R may be useful in preventing the development and formation of new lesions in multiple sclerosis, thereby significantly limiting the progression of the disease...
  99. ncbi request reprint Identification of Bphs, an autoimmune disease locus, as histamine receptor H1
    Runlin Z Ma
    Laboratory Animal Center, Institute of Genetics, Chinese Academy of Sciences, Beijing, China 100101
    Science 297:620-3. 2002
    ..Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization...
  100. pmc von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis
    Rajkumar Noubade
    Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    Am J Pathol 173:892-900. 2008
    ..Taken together, these data indicate that VWF and/or Weibel-Palade bodies negatively regulate BBB permeability changes and autoimmune inflammatory lesion formation within the brain elicited by peripheral inflammatory stimuli...
  101. ncbi request reprint Opposing roles for TGF-beta1 and TGF-beta3 isoforms in experimental autoimmune encephalomyelitis
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97201, USA
    Cytokine 25:45-51. 2004
    ..Of crucial importance, the TGF-beta3 isoform displayed anti-proliferative properties towards encephalitogenic cells in vitro. We propose that the TGF-beta1 and TGF-beta3 isoforms play opposing roles in the expression of EAE...

Research Grants35

  1. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2004
    ..Changes in these genes can be followed during estrogen treatment as surrogate markers to verify effective doses of estrogen. From this research, we will develop a solid basis for using estrogen replacement therapy for MS...
  2. GENDER INFLUENCES IMMUNOREGULATION IN R EAE
    Halina Offner; Fiscal Year: 2000
    ....
  3. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2010
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  4. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1999
    ..2+ T cells in vivo information that will emerge from this proposal is crucial to the understanding and clinical application of idiotypic immunoregulation directed at TCR and potentially other non- tolerogenic cellular determinants. ..
  5. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2005
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  6. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2002
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  7. GENDER INFLUENCES IMMUNOREGULATION IN R EAE
    Halina Offner; Fiscal Year: 2001
    ....
  8. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2001
    ..2+ T cells in vivo information that will emerge from this proposal is crucial to the understanding and clinical application of idiotypic immunoregulation directed at TCR and potentially other non- tolerogenic cellular determinants. ..
  9. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2006
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  10. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1999
    ..2+ T cells in vivo information that will emerge from this proposal is crucial to the understanding and clinical application of idiotypic immunoregulation directed at TCR and potentially other non- tolerogenic cellular determinants. ..
  11. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1992
    ..the CDR loops) could lead to a peptide vaccine which may have prophylactic and therapeutic values against EAE and other autoimmune diseases where preferential TcR V gene combinations can be identified...
  12. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1991
    ..the CDR loops) could lead to a peptide vaccine which may have prophylactic and therapeutic values against EAE and other autoimmune diseases where preferential TcR V gene combinations can be identified...
  13. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2005
    ..Changes in these genes can be followed during estrogen treatment as surrogate markers to verify effective doses of estrogen. From this research, we will develop a solid basis for using estrogen replacement therapy for MS...
  14. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2004
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  15. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2003
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  16. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2009
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  17. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2002
    ..Changes in these genes can be followed during estrogen treatment as surrogate markers to verify effective doses of estrogen. From this research, we will develop a solid basis for using estrogen replacement therapy for MS...
  18. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1990
    ..the CDR loops) could lead to a peptide vaccine which may have prophylactic and therapeutic values against EAE and other autoimmune diseases where preferential TcR V gene combinations can be identified...
  19. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2001
    ..These proposed studies will provide new and definitive insights into the biological importance and function of TCR-reactive T ceils in preventing and treating spontaneous and induced EAE, and will guide further human studies. ..
  20. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 1993
    ..the CDR loops) could lead to a peptide vaccine which may have prophylactic and therapeutic values against EAE and other autoimmune diseases where preferential TcR V gene combinations can be identified...
  21. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2007
    ..E2 in relapsing, chronic, and spontaneous models of EAE. These studies will clearly establish E2- and EE- dependent pathways of EAE protection and therapy that may have direct relevance for future clinical trials in MS patients. ..
  22. IMMUNOREGULATORY EFFECTS OF ESTROGEN IN EAE
    Halina Offner; Fiscal Year: 2003
    ..Changes in these genes can be followed during estrogen treatment as surrogate markers to verify effective doses of estrogen. From this research, we will develop a solid basis for using estrogen replacement therapy for MS...
  23. GENDER INFLUENCES IMMUNOREGULATION IN R EAE
    Halina Offner; Fiscal Year: 1999
    ....
  24. CLONOTYPIC REGULATION OF ENCEPHALITOGENIC T LYMPHOCYTES
    Halina Offner; Fiscal Year: 2000
    ..2+ T cells in vivo information that will emerge from this proposal is crucial to the understanding and clinical application of idiotypic immunoregulation directed at TCR and potentially other non- tolerogenic cellular determinants. ..