Kazuhiro Nakamura

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc A thermosensory pathway that controls body temperature
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Nat Neurosci 11:62-71. 2008
  2. pmc Central neural pathways for thermoregulation
    Shaun F Morrison
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci (Landmark Ed) 16:74-104. 2011
  3. doi Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region
    Battuvshin Lkhagvasuren
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurosci 34:1442-52. 2011
  4. pmc Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 292:R127-36. 2007
  5. ncbi In vivo function of Rnd2 in the development of neocortical pyramidal neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Neurosci Res 54:149-53. 2006
  6. pmc Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus
    Yoshiko Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:3137-46. 2005
  7. pmc Preoptic mechanism for cold-defensive responses to skin cooling
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Physiol 586:2611-20. 2008
  8. ncbi Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 24:5370-80. 2004
  9. pmc Central efferent pathways for cold-defensive and febrile shivering
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Physiol 589:3641-58. 2011
  10. pmc Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
    Maria Manczak
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Hum Mol Genet 18:3876-93. 2009

Collaborators

Detail Information

Publications41

  1. pmc A thermosensory pathway that controls body temperature
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, OR 97006, USA
    Nat Neurosci 11:62-71. 2008
    ..These findings make an important contribution to our understanding of both the somatosensory system and thermal homeostasis -- two mechanisms that are fundamental to the nervous system and to our survival...
  2. pmc Central neural pathways for thermoregulation
    Shaun F Morrison
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Front Biosci (Landmark Ed) 16:74-104. 2011
    ..A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction...
  3. doi Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region
    Battuvshin Lkhagvasuren
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurosci 34:1442-52. 2011
    ..These results suggest that psychological stress signals activate VGLUT3-expressing medullary raphe sympathetic premotor neurons, which then drive hyperthermic effector responses including BAT thermogenesis through β(3) -adrenoreceptors...
  4. pmc Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Am J Physiol Regul Integr Comp Physiol 292:R127-36. 2007
    ....
  5. ncbi In vivo function of Rnd2 in the development of neocortical pyramidal neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Neurosci Res 54:149-53. 2006
    ..These results indicate that Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons...
  6. pmc Direct pyrogenic input from prostaglandin EP3 receptor-expressing preoptic neurons to the dorsomedial hypothalamus
    Yoshiko Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 22:3137-46. 2005
    ..These results suggest that a direct projection of EP3 receptor-expressing POA neurons to the DMH/DH region mediates febrile responses via a GABAergic mechanism...
  7. pmc Preoptic mechanism for cold-defensive responses to skin cooling
    Kazuhiro Nakamura
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Physiol 586:2611-20. 2008
    ....
  8. ncbi Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Neurosci 24:5370-80. 2004
    ....
  9. pmc Central efferent pathways for cold-defensive and febrile shivering
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Physiol 589:3641-58. 2011
    ..These results provide the interesting notion that, under the demand for increasing levels of heat production, parallel central efferent pathways control the somatic and sympathetic motor systems to drive thermogenesis...
  10. pmc Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
    Maria Manczak
    Oregon National Primate Research Center, Beaverton, 97006, USA
    Hum Mol Genet 18:3876-93. 2009
    ..These findings indicating the ability of the anti-GM-CSF antibody to reduce Abeta1-42 and microglial activity in Tg2576 mice may have therapeutic implications for Alzheimer's disease...
  11. ncbi Sympathetic premotor neurons mediating thermoregulatory functions
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neurosci Res 51:1-8. 2005
    ..The VGLUT3-expressing premotor neurons would mediate thermoregulation including fever induction, and could be also involved in the control of energy metabolism...
  12. pmc Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
    Sheng Xi Wu
    Department of Morphological Brain Science and Laboratory of Immunological Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:17172-7. 2005
    ..Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain...
  13. ncbi Chemically specific circuit composed of vesicular glutamate transporter 3- and preprotachykinin B-producing interneurons in the rat neocortex
    Hiroyuki Hioki
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cereb Cortex 14:1266-75. 2004
    ..Thus, VGLUT3-expressing GABAergic interneurons form a chemically specific circuit within the PPTB-producing interneuron group and it is likely that glutamate is used within the chemically specific circuit...
  14. doi Central circuitries for body temperature regulation and fever
    Kazuhiro Nakamura
    Career Path Promotion Unit for Young Life Scientists, Kyoto Univ, School of Medicine Bldg E, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Am J Physiol Regul Integr Comp Physiol 301:R1207-28. 2011
    ..This central thermoregulatory mechanism also functions for metabolic regulation and stress-induced hyperthermia...
  15. pmc A thermosensory pathway mediating heat-defense responses
    Kazuhiro Nakamura
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Proc Natl Acad Sci U S A 107:8848-53. 2010
    ..These findings provide a fundamental framework for understanding the neural circuitry maintaining thermal homeostasis, which is critical to survive severe environmental temperatures...
  16. pmc Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's disease and multiple sclerosis
    P Hemachandra Reddy
    Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurochem 111:1514-28. 2009
    ..The findings from this study may have implications for anti-inflammatory effects of Alzheimer's disease and experimental autoimmune encephalomyelitis mice (a multiple sclerosis mouse model)...
  17. pmc Central control of thermogenesis in mammals
    Shaun F Morrison
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Exp Physiol 93:773-97. 2008
    ....
  18. doi Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors
    Hiroyoshi Tsuchiya
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 283:11064-71. 2008
    ..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever...
  19. ncbi Developmental changes in expression of small GTPase RhoG mRNA in the rat brain
    Yukio Ishikawa
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Japan
    Brain Res Mol Brain Res 106:145-50. 2002
    ..These results suggest distinct pre- and postnatal roles of RhoG in the development of the central nervous system...
  20. ncbi Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation
    Toshimitsu Fuse
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, and SORST, Japan Science and Technology Agency, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 318:665-72. 2004
    ..These results suggest that the conditional activation of RhoA signaling suppressed the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation...
  21. ncbi Independent inputs by VGLUT2- and VGLUT3-positive glutamatergic terminals onto rat sympathetic preganglionic neurons
    Kazuhiro Nakamura
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuroreport 15:431-6. 2004
    ..These results indicate at least two independent glutamatergic terminal populations, which include a distinct monoaminergic subpopulation, making excitatory inputs onto SPNs...
  22. ncbi Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves
    Ulla C Kopp
    Department of Internal Medicine, Department of Veterans Affairs Medical Center and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Renal Physiol 287:F1269-82. 2004
    ..L-161,982 also blocked the ARNA response to increasing renal pelvic pressure 10 mmHg, 85 +/- 5%. In conclusion, PGE(2) increases renal pelvic release of SP and ARNA by activating EP4 receptors on renal sensory nerve fibers...
  23. ncbi Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3
    Kyoko Yoshida
    Veterinary Physiology, and Institute of Virology, Justus Liebig University Giessen, Frankfurter Strasse 100 and 107, D 35392 Giessen, Germany
    Eur J Neurosci 18:1848-60. 2003
    ....
  24. ncbi The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area
    Kazuhiro Nakamura
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Department of Intelligence Science and Technology, Japan Science and Technology, Sakyo ku, Kyoto 606 8502, Japan
    J Neurosci 22:4600-10. 2002
    ..Our results demonstrate that the rRPa, which has never been associated with the fever mechanism, mediates the pyrogenic neurotransmission from the POA to the peripheral sympathetic effectors contributing to fever development...
  25. ncbi Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating
    Kazuhiro Nakamura
    Department of Pathology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Mol Biol 363:345-54. 2006
    ..Thus, maintaining proper serotonin levels during childhood may be important for mature sensorimotor gating in adulthood...
  26. ncbi Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses
    Yan Xiu
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:4340-6. 2002
    ....
  27. ncbi MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Cancer Cell 2:289-300. 2002
    ..Thus, a block of MMP9 induction via VEGFR-1 inhibition could be useful for the prevention of tumor metastasis in lung...
  28. ncbi Molecular characterization of a novel nuclear transglutaminase that is expressed during starfish embryogenesis
    Hiroyuki Sugino
    Department of Applied Biochemistry, Hiroshima University, Japan
    Eur J Biochem 269:1957-67. 2002
    ..These results suggest that the nuclear accumulation of the transglutaminase may play an important role in nuclear remodeling during early starfish embryogenesis...
  29. ncbi Elicited ponto-geniculo-occipital waves by auditory stimuli are synchronized with hippocampal theta-waves
    Akihiro Karashima
    Laboratory of Neurophysiology and Bioinformatics, Graduate School of Information Sciences, Tohoku University, Amaraki, Sendai, Japan
    Psychiatry Clin Neurosci 56:343-4. 2002
    ..Because the occurrence of PGO(E) and spontaneous PGO waves shared the same phase-dependency on theta-waves, the results strongly suggest that the PGO wave generator was driven by theta-waves, as originally hypothesized...
  30. ncbi Association of galectin-9 with eosinophil apoptosis
    Naoki Saita
    First Department of Internal Medicine, Kumamoto University, School of Medicine, Kumamoto, Japan
    Int Arch Allergy Immunol 128:42-50. 2002
    ..There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders...
  31. pmc Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    Jormay Lim
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1877-89. 2008
    ..Thus, Pin1 has opposite effects on the tauopathy phenotype depending on whether the tau is WT or a P301L mutant, indicating the need for disease-specific therapies for tauopathies...
  32. ncbi Phase-locking of spontaneous and elicited ponto-geniculo-occipital waves is associated with acceleration of hippocampal theta waves during rapid eye movement sleep in cats
    Akihiro Karashima
    Laboratory of Neurophysiology and Bioinformatics, Graduate School of Information Sciences, Tohoku University, Aoba yama 05, Aramaki Sendai 980 8579, Japan
    Brain Res 958:347-58. 2002
    ..The interaction between PGO and hippocampal theta waves is expected to be involved in the possible functions of REM sleep...
  33. pmc A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model
    Shuji Matsuoka
    Department of Pathology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Exp Med 198:497-503. 2003
    ....
  34. pmc Role of a serotonin precursor in development of gut microvilli
    Kazuhiro Nakamura
    Department of Biosciences, Teikyo University of Science and Technology, Uenohara 409 0193, Japan
    Am J Pathol 172:333-44. 2008
    ..Thus, 5-HTP and serotonin contribute to distinct cell-type-specific functions via common mediators. Our study might create an opportunity to explore the effects of exogenously applied 5-HTP in humans...
  35. pmc CD3 and immunoglobulin G Fc receptor regulate cerebellar functions
    Kazuhiro Nakamura
    Department of Pathology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Mol Cell Biol 27:5128-34. 2007
    ..In the two knockout mice, enhanced paired-pulse facilitation of parallel fiber-Purkinje cell synapses was shared. These results indicate that diverse immune molecules play critical roles in the functional establishment in the cerebellum...
  36. ncbi Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus
    Qingshun Lin
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 177:1646-54. 2006
    ....
  37. pmc PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation
    Kazuhiro Nakamura
    Department of Pharmacology, CB 7365, 1108 Mary Ellen Jones Building, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7365, USA
    Mol Cell Biol 26:2065-79. 2006
    ..The MEK5 PB1 domain confers stringent MAP3K regulation of ERK5 relative to more promiscuous MAP3K control of ERK1/2, JNK, and p38...
  38. ncbi Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels
    Kazuhiro Nakamura
    Department of Pathology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    J Neurosci 26:530-4. 2006
    ..Considering an involvement of developmental brain disturbance in psychiatric disorders, TPH1 may act specifically on development of 5-HT neurons, and thereby influence behavior later in life...
  39. ncbi Is state-dependent alternation of slow dynamics in central single neurons during sleep present in the rat ventroposterior thalamic nucleus?
    Kazumi Takahashi
    Department of Physiology, School of Medicine, Fukushima Medical University, Fukushima 960 1295, Japan
    Neurosci Res 48:203-10. 2004
    ..Fluctuations observed in living organisms may be involved in essential processes in generation and function of sleep states...
  40. pmc Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo
    Amy N Abell
    Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
    Mol Cell Biol 25:8948-59. 2005
    ..Together, these data demonstrate MEKK4 regulation of p38 and that substrates downstream of p38 control cellular homeostasis. The findings are the first demonstration that MEKK4-regulated p38 activity is critical for neurulation...
  41. ncbi A method for measuring the decay time of hyperpolarized 129Xe magnetization in rat brain without estimation of RF flip angles
    Atsushi Wakai
    Akita Research Institute of Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Magn Reson Med Sci 4:19-25. 2005
    ..We present a two-pulse protocol for estimating the decay time without the need for flip-angle estimation and demonstrate it in the rat brain...