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Affiliation: Oregon Health and Science University
VanSlyke J, Boswell B, Musil L. Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells. J Cell Sci. 2018;131: pubmed publisher
..This axis represents a novel target for prevention of late-onset posterior capsule opacification, a common but currently intractable complication of cataract surgery. ..
Boswell B, Musil L. Synergistic interaction between the fibroblast growth factor and bone morphogenetic protein signaling pathways in lens cells. Mol Biol Cell. 2015;26:2561-72 pubmed publisher
..This interaction provides a mechanistic explanation for why disruption of either FGF or BMP signaling in the lens leads to defects in lens development and function. ..
Boswell B, Korol A, West Mays J, Musil L. Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract. Mol Biol Cell. 2017;28:907-921 pubmed publisher
..In addition to providing novel potential therapeutic strategies for PCO, our findings extend the so-called TGF? paradox, in which TGF? can induce two disparate cell fates, to a new epithelial disease state. ..
Musil L. Primary cultures of embryonic chick lens cells as a model system to study lens gap junctions and fiber cell differentiation. J Membr Biol. 2012;245:357-68 pubmed publisher