Stephanie Murphy

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative era
    Stephanie Murphy
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Endocrine 21:17-26. 2003
  2. pmc Can gender differences be evaluated in a rhesus macaque (Macaca mulatta) model of focal cerebral ischemia?
    Stephanie J Murphy
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Comp Med 58:588-96. 2008
  3. pmc Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain
    Lan Wang
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 28:1824-34. 2008
  4. pmc Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo
    Michael P Hutchens
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHN 2, Portland, Oregon 97239, USA
    Anesthesiology 112:395-405. 2010
  5. pmc A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte culture
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR, 97239 3098, USA
    J Neurosci Methods 171:214-7. 2008
  6. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
  7. ncbi request reprint Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats
    Stephanie J Murphy
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 22:1181-8. 2002
  8. pmc Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse
    Toshiaki Mito
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
    Stroke 40:278-84. 2009
  9. pmc Dietary soy may not confound acute experimental stroke infarct volume outcomes in ovariectomized female rats
    Kamm D Prongay
    Department of Comparative Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Lab Anim 44:238-46. 2010
  10. pmc A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis
    Jian Qiu
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:5649-55. 2006

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative era
    Stephanie Murphy
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Endocrine 21:17-26. 2003
    ..This review critiques estrogen and SERMs' neuroprotective potential in experimental and clinical studies of stroke and cerebrovascular disease...
  2. pmc Can gender differences be evaluated in a rhesus macaque (Macaca mulatta) model of focal cerebral ischemia?
    Stephanie J Murphy
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Comp Med 58:588-96. 2008
    ..The female rhesus macaque ischemic stroke model could be used after rodent studies to provide preclinical data for clinical trials in women...
  3. pmc Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain
    Lan Wang
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 28:1824-34. 2008
    ..In OVX+ERbeta agonist, IsoPC increased cortical infarct volume. Estradiol depresses the brain's protective response to IsoPC and may exacerbate cortical ischemic injury mainly through an ERbeta-dependent mechanism...
  4. pmc Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo
    Michael P Hutchens
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHN 2, Portland, Oregon 97239, USA
    Anesthesiology 112:395-405. 2010
    ..In this study, cardiac arrest and cardiopulmonary resuscitation were used to assess whether estradiol is renoprotective via an estrogen receptor (ER)-dependent mechanism...
  5. pmc A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte culture
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR, 97239 3098, USA
    J Neurosci Methods 171:214-7. 2008
    ..This innovative technique may also be applied to other in vitro studies of sex-related functional differences...
  6. pmc GPR30 contributes to estrogen-induced thymic atrophy
    Chunhe Wang
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    Mol Endocrinol 22:636-48. 2008
    ..Our study distinguishes, for the first time, the respective contributions of nuclear and membrane E2 receptors in negative regulation of thymic development...
  7. ncbi request reprint Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized rats
    Stephanie J Murphy
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 22:1181-8. 2002
    ..End-ischemic regional CBF and CBF recovery during initial reperfusion was unaffected by progesterone treatment. These data suggest that progesterone administration both before MCAO and during reperfusion decreases ischemic brain injury...
  8. pmc Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse
    Toshiaki Mito
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
    Stroke 40:278-84. 2009
    ..Effects of transfusion of high-oxygen-affinity hemoglobin polymers of different weight ranges were determined...
  9. pmc Dietary soy may not confound acute experimental stroke infarct volume outcomes in ovariectomized female rats
    Kamm D Prongay
    Department of Comparative Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Lab Anim 44:238-46. 2010
    ..More studies addressing the potential confounding effects of dietary soy in 'oestrogen-sensitive' stroke models are needed if investigators are to make informed choices regarding diets used in experimental stroke research...
  10. pmc A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis
    Jian Qiu
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 26:5649-55. 2006
    ..Therefore, this membrane-delimited signaling pathway plays a critical role in the control of energy homeostasis and may provide a novel therapeutic target for treatment of postmenopausal symptoms and eating disorders in females...
  11. pmc Refining timed pregnancies in two strains of genetically engineered mice
    Sarah L Mader
    Oregon Health and Science University, Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA
    Lab Anim (NY) 38:305-10. 2009
    ..Further evaluations and protocol refinements are planned based on litter size and litter number in these colonies...
  12. ncbi request reprint Stroke in the female: role of biological sex and estrogen
    Stephanie J Murphy
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, OR, USA
    ILAR J 45:147-59. 2004
    ....
  13. pmc Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA
    Hung Dong Joh
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 26:518-26. 2006
    ..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors...
  14. ncbi request reprint High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats
    David F Antezana
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg 98:860-6. 2003
    ..Ibuprofen treatment was compared with mild systemic hypothermia, which is known to be neuroprotective and is commonly used during neurosurgical procedures...
  15. ncbi request reprint Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female rats
    Thomas J Toung
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 24:1160-6. 2004
    ..These data have potential clinical implications relative to stroke for postmenopausal women taking combined hormone replacement therapy...
  16. ncbi request reprint Animal models of ischemic stroke: balancing experimental aims and animal care
    Sharon M Graham
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Comp Med 54:486-96. 2004
    ....
  17. pmc Effects of estrogen on platelet reactivity after transient forebrain ischemia in rats
    Marguerite T Littleton-Kearney
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biol Res Nurs 7:135-45. 2005
    ..In this rodent global cerebral ischemic model, physiologic doses of estrogen are not deleterious to platelet reactivity and may initially reduce postischemic platelet reactivity...
  18. pmc Inhalational anesthetics as preconditioning agents in ischemic brain
    Lan Wang
    Oregon Health and Science University, Department of Anesthesiology and Peri Operative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Curr Opin Pharmacol 8:104-10. 2008
    ..Anesthetics, however, may play an important and unique role as preconditioning agents, particularly during the perioperative period...
  19. pmc Gender-specific response to isoflurane preconditioning in focal cerebral ischemia
    Hideto Kitano
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 27:1377-86. 2007
    ..Male IsoPC neuroprotection was lost in Akt1-deficient male mice. We conclude that IsoPC is beneficial only in ischemic male brain and that sex differences in IsoPC are mediated through Akt activation and basal NIPK expression...
  20. pmc Lack of correlation of vaginal impedance measurements with hormone levels in the rat
    Sylvia J Singletary
    Department of Comparative Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Contemp Top Lab Anim Sci 44:37-42. 2005
    ..Vaginal impedance may be useful in distinguishing estrus from nonestrus rats but may be limited for chronic estrous cycle monitoring because of the possible risk of inducing pseudopregnancy...
  21. pmc Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain
    Hideto Kitano
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:1108-28. 2007
    ..Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed...

Research Grants5

  1. Perioperative Stroke and Cerebral Conditioning in the Female
    Stephanie Murphy; Fiscal Year: 2007
    ..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..
  2. Perioperative Stroke and Cerebral Conditioning in the Female
    Stephanie J Murphy; Fiscal Year: 2010
    ..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..