Research Topics
Species | Stephanie MurphySummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative eraStephanie Murphy
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Endocrine 21:17-26. 2003..This review critiques estrogen and SERMs' neuroprotective potential in experimental and clinical studies of stroke and cerebrovascular disease...
Can gender differences be evaluated in a rhesus macaque (Macaca mulatta) model of focal cerebral ischemia?Stephanie J Murphy
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
Comp Med 58:588-96. 2008..The female rhesus macaque ischemic stroke model could be used after rodent studies to provide preclinical data for clinical trials in women...- Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brainLan Wang
Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 28:1824-34. 2008..In OVX+ERbeta agonist, IsoPC increased cortical infarct volume. Estradiol depresses the brain's protective response to IsoPC and may exacerbate cortical ischemic injury mainly through an ERbeta-dependent mechanism... - Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivoMichael P Hutchens
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHN 2, Portland, Oregon 97239, USA
Anesthesiology 112:395-405. 2010..In this study, cardiac arrest and cardiopulmonary resuscitation were used to assess whether estradiol is renoprotective via an estrogen receptor (ER)-dependent mechanism... - A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte cultureMingyue Liu
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR, 97239 3098, USA
J Neurosci Methods 171:214-7. 2008..This innovative technique may also be applied to other in vitro studies of sex-related functional differences... - GPR30 contributes to estrogen-induced thymic atrophyChunhe Wang
Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
Mol Endocrinol 22:636-48. 2008..Our study distinguishes, for the first time, the respective contributions of nuclear and membrane E2 receptors in negative regulation of thymic development... - Progesterone administration during reperfusion, but not preischemia alone, reduces injury in ovariectomized ratsStephanie J Murphy
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 22:1181-8. 2002..End-ischemic regional CBF and CBF recovery during initial reperfusion was unaffected by progesterone treatment. These data suggest that progesterone administration both before MCAO and during reperfusion decreases ischemic brain injury... - Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouseToshiaki Mito
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Blalock 1404, Baltimore, MD 21287, USA
Stroke 40:278-84. 2009..Effects of transfusion of high-oxygen-affinity hemoglobin polymers of different weight ranges were determined... - Dietary soy may not confound acute experimental stroke infarct volume outcomes in ovariectomized female ratsKamm D Prongay
Department of Comparative Medicine, Oregon Health and Science University, Portland, OR 97239, USA
Lab Anim 44:238-46. 2010..More studies addressing the potential confounding effects of dietary soy in 'oestrogen-sensitive' stroke models are needed if investigators are to make informed choices regarding diets used in experimental stroke research... - A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasisJian Qiu
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA
J Neurosci 26:5649-55. 2006..Therefore, this membrane-delimited signaling pathway plays a critical role in the control of energy homeostasis and may provide a novel therapeutic target for treatment of postmenopausal symptoms and eating disorders in females... - Refining timed pregnancies in two strains of genetically engineered miceSarah L Mader
Oregon Health and Science University, Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA
Lab Anim (NY) 38:305-10. 2009..Further evaluations and protocol refinements are planned based on litter size and litter number in these colonies... - Stroke in the female: role of biological sex and estrogenStephanie J Murphy
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, OR, USA
ILAR J 45:147-59. 2004.... - Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABAHung Dong Joh
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 26:518-26. 2006..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors... - High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in ratsDavid F Antezana
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosurg 98:860-6. 2003.... - Effects of combined estrogen and progesterone on brain infarction in reproductively senescent female ratsThomas J Toung
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 24:1160-6. 2004..These data have potential clinical implications relative to stroke for postmenopausal women taking combined hormone replacement therapy... - Animal models of ischemic stroke: balancing experimental aims and animal careSharon M Graham
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
Comp Med 54:486-96. 2004.... - Effects of estrogen on platelet reactivity after transient forebrain ischemia in ratsMarguerite T Littleton-Kearney
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biol Res Nurs 7:135-45. 2005..In this rodent global cerebral ischemic model, physiologic doses of estrogen are not deleterious to platelet reactivity and may initially reduce postischemic platelet reactivity... - Inhalational anesthetics as preconditioning agents in ischemic brainLan Wang
Oregon Health and Science University, Department of Anesthesiology and Peri Operative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
Curr Opin Pharmacol 8:104-10. 2008..Anesthetics, however, may play an important and unique role as preconditioning agents, particularly during the perioperative period... - Gender-specific response to isoflurane preconditioning in focal cerebral ischemiaHideto Kitano
Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 27:1377-86. 2007..Male IsoPC neuroprotection was lost in Akt1-deficient male mice. We conclude that IsoPC is beneficial only in ischemic male brain and that sex differences in IsoPC are mediated through Akt activation and basal NIPK expression... - Lack of correlation of vaginal impedance measurements with hormone levels in the ratSylvia J Singletary
Department of Comparative Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
Contemp Top Lab Anim Sci 44:37-42. 2005..Vaginal impedance may be useful in distinguishing estrus from nonestrus rats but may be limited for chronic estrous cycle monitoring because of the possible risk of inducing pseudopregnancy... - Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brainHideto Kitano
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 27:1108-28. 2007..Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed...
Research Grants
- Perioperative Stroke and Cerebral Conditioning in the FemaleStephanie Murphy; Fiscal Year: 2007..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..
- Perioperative Stroke and Cerebral Conditioning in the FemaleStephanie J Murphy; Fiscal Year: 2010..Our findings will elucidate the mechanisms by which female stroke outcomes are worsened by preischemic isoflurane exposure. ..