P Metten

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Limited access ethanol drinking in the dark in adolescent and adult mice
    Pamela Metten
    Portland Alcohol Research Center, Research Service, VA Medical Center, OR 97239, USA
    Pharmacol Biochem Behav 98:279-85. 2011
  2. pmc Withdrawal severity after chronic intermittent ethanol in inbred mouse strains
    Pamela Metten
    Department of Veterans Affairs and Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 34:1552-64. 2010
  3. pmc Genetic correlates of morphine withdrawal in 14 inbred mouse strains
    Pamela Metten
    Portland Alcohol Research Center, Department of Veterans Affairs, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Drug Alcohol Depend 99:123-31. 2009
  4. ncbi request reprint Use of a novel mouse genotype to model acute benzodiazepine withdrawal
    Pamela Metten
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Genet 37:160-70. 2007
  5. ncbi request reprint Alcohol withdrawal severity in inbred mouse (Mus musculus) strains
    Pamela Metten
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Neurosci 119:911-25. 2005
  6. ncbi request reprint Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
    Pamela Metten
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Appl Physiol 97:360-8. 2004
  7. ncbi request reprint Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal
    P Metten
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and Department of Veteran s Affairs Medical Center, Portland 97201, USA
    Behav Brain Res 95:113-22. 1998
  8. ncbi request reprint Potential pleiotropic effects of Mpdz on vulnerability to seizures
    C Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 3:8-19. 2004
  9. ncbi request reprint Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
    K J Buck
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 17:3946-55. 1997
  10. ncbi request reprint Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11
    H M Hood
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97006 8921, USA
    Genes Brain Behav 5:1-10. 2006

Detail Information

Publications29

  1. pmc Limited access ethanol drinking in the dark in adolescent and adult mice
    Pamela Metten
    Portland Alcohol Research Center, Research Service, VA Medical Center, OR 97239, USA
    Pharmacol Biochem Behav 98:279-85. 2011
    ..Early DID led to increased drinking as adults only in HS/Npt mice. HDID-1 mice provide a useful animal model for exploring whether DID and continuous access preference drinking have parallel consequences when initiated in adolescence...
  2. pmc Withdrawal severity after chronic intermittent ethanol in inbred mouse strains
    Pamela Metten
    Department of Veterans Affairs and Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Alcohol Clin Exp Res 34:1552-64. 2010
    ..We also sought to compare the withdrawal responses of inbred strains across acute, chronic continuous, and chronic intermittent exposure regimens...
  3. pmc Genetic correlates of morphine withdrawal in 14 inbred mouse strains
    Pamela Metten
    Portland Alcohol Research Center, Department of Veterans Affairs, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Drug Alcohol Depend 99:123-31. 2009
    ....
  4. ncbi request reprint Use of a novel mouse genotype to model acute benzodiazepine withdrawal
    Pamela Metten
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Genet 37:160-70. 2007
    ..Withdrawal convulsions were seen after all of the drugs by at least one method, suggesting that BZR agonists as a class elicit acute physical dependence in this susceptible genotype...
  5. ncbi request reprint Alcohol withdrawal severity in inbred mouse (Mus musculus) strains
    Pamela Metten
    Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Neurosci 119:911-25. 2005
    ..Also supported were the positive genetic correlations among EtOH, barbiturate, and benzodiazepine withdrawal. Sensitivity of naive mice to several chemical convulsant-induced seizures was also correlated with EtOH withdrawal...
  6. ncbi request reprint Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
    Pamela Metten
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Appl Physiol 97:360-8. 2004
    ..Modest strain mean correlations among behaviors indicate that these behaviors are probably under control of largely different genes and that ataxia rating scales should rate separate behaviors on discrete scales...
  7. ncbi request reprint Drug withdrawal convulsions and susceptibility to convulsants after short-term selective breeding for acute ethanol withdrawal
    P Metten
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and Department of Veteran s Affairs Medical Center, Portland 97201, USA
    Behav Brain Res 95:113-22. 1998
    ..No line differences were detected. These results indicate that genes influencing severity of withdrawal from several depressant drugs are largely different from those affecting susceptibility to GABAergic or glutamatergic convulsants...
  8. ncbi request reprint Potential pleiotropic effects of Mpdz on vulnerability to seizures
    C Fehr
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 3:8-19. 2004
    ....
  9. ncbi request reprint Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice
    K J Buck
    Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 17:3946-55. 1997
    ..Syntenic conservation between human and mouse chromosomes suggests that human homologs of genes that increase risk for physiological dependence may localize to 1q21-q32, 2q24-q37/11p13, 9p21-p23/1p32-p22.1, and 5q32-q35...
  10. ncbi request reprint Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11
    H M Hood
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97006 8921, USA
    Genes Brain Behav 5:1-10. 2006
    ....
  11. ncbi request reprint Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11
    K Buck
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, USA
    Mamm Genome 10:431-7. 1999
    ..These data represent the first detection and mapping of loci influencing risk for physiological dependence on barbiturates, and suggest the involvement of common genes in physiological dependence on pentobarbital and alcohol...
  12. ncbi request reprint Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests
    J C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Genes Brain Behav 2:201-13. 2003
    ..These results suggest that different specific versions of a test reflect the influence of different genes, and that genetic influences on different tests were also distinct...
  13. ncbi request reprint Use of recombinant inbred strains for studying genetic determinants of responses to alcohol
    J C Crabbe
    Oregon Health Sciences University, Portland, USA
    Alcohol Alcohol Suppl 2:67-71. 1994
    ..A cluster of genes (Scn1, Scn2, Scn3) code for voltage-sensitive sodium channel proteins. These genes are plausible candidates for affecting withdrawal HIC...
  14. ncbi request reprint Mapping of quantitative trait loci underlying ethanol metabolism in BXD recombinant inbred mouse strains
    Judith E Grisel
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 26:610-6. 2002
    ..However, these variant genes are either alcohol or aldehyde dehydrogenases, and the identification of new gene products that contribute to variation in alcohol metabolism would be useful...
  15. ncbi request reprint Scheduled access to ethanol results in motor impairment and tolerance in female C57BL/6J mice
    K Cronise
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States
    Pharmacol Biochem Behav 81:943-53. 2005
    ....
  16. ncbi request reprint Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugs
    Christopher L Kliethermes
    Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, Veterans Affairs Medical Center, c o Portland VA Medical Center, Portland, OR 97239, USA
    Brain Res 1009:17-25. 2004
    ..These results indicate that some of the same genes that affect the severity of withdrawal from pentobarbital also influence ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these genes...
  17. pmc A line of mice selected for high blood ethanol concentrations shows drinking in the dark to intoxication
    John C Crabbe
    Portland Alcohol Research Center, Portland, Oregon, USA
    Biol Psychiatry 65:662-70. 2009
    ..We report progress toward the development of a new genetic animal model for high levels of alcohol drinking...
  18. doi request reprint Motor impairment: a new ethanol withdrawal phenotype in mice
    Scott D Philibin
    Portland Alcohol Research Center, VAMC Research, Oregon, USA
    Behav Pharmacol 19:604-14. 2008
    ..The accelerating rotarod seems to be a simple behavioral measure of ethanol withdrawal that is suitable for comparing genotypes...
  19. ncbi request reprint Genetic determinants of sensitivity to pentobarbital in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, VA Medical Center, Oregon Health and Science University, Portland, OR 97201, USA
    Psychopharmacology (Berl) 161:408-16. 2002
    ..We postulated that genetic determinants of different responses to pentobarbital (PB) in mice would differ from response to response...
  20. ncbi request reprint Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
    Behav Genet 36:536-52. 2006
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences...
  21. ncbi request reprint Genotypic differences in ethanol sensitivity in two tests of motor incoordination
    John C Crabbe
    VA Medical Center, R and D 12 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    J Appl Physiol 95:1338-51. 2003
    ..These results make clear that a single set of task parameters is insufficient to characterize genetic influences on behavior. Several other issues affect the interpretation of data using these tests...
  22. ncbi request reprint Mapping murine loci for physical dependence on ethanol
    Kari J Buck
    Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, VA Medical Center, Research Service mailcode RD40, 3710 SW US Veteran s Hospital Road, Portland, OR 97201, USA
    Psychopharmacology (Berl) 160:398-407. 2002
    ..A quantitative trait locus (QTL) identifies the genomic location of a gene (or genes) affecting a trait of interest...
  23. ncbi request reprint An analysis of the genetics of alcohol intoxication in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Neurosci Biobehav Rev 28:785-802. 2005
    ..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety)...
  24. pmc Multivariate analyses reveal common and drug-specific genetic influences on responses to four drugs of abuse
    John K Belknap
    Research Service, Veterans Affairs Medical Center, Department of Behavioral Neuroscience and the Portland Alcohol Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Trends Pharmacol Sci 29:537-43. 2008
    ..Thus, similar analyses should be applicable to other laboratories, traits and genotypes...
  25. pmc Hybrid C57BL/6J x FVB/NJ mice drink more alcohol than do C57BL/6J mice
    Yuri A Blednov
    Waggoner Center for Alcohol and Addictions Research, University of Texas, Austin, TX 78712 0159, USA
    Alcohol Clin Exp Res 29:1949-58. 2005
    ..No strain has been found to consume more ethanol than B6. In one of our laboratories (Texas), we noted a markedly greater intake of ethanol in an F1 hybrid of B6 and FVB/NJ (FVB) mice...
  26. ncbi request reprint Chromosomal loci influencing chronic alcohol withdrawal severity
    Susan E Bergeson
    Waggoner Center for Alcohol and Addiction Research, Section of Neurobiology, University of Texas, Austin, Texas 78712, USA
    Mamm Genome 14:454-63. 2003
    ....
  27. ncbi request reprint Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  28. ncbi request reprint Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Brain Res 971:47-54. 2003
    ..Brain size varied greatly among strains but for any one strain was almost identical in mice housed for 5 weeks in the two laboratories. Sex differences in brain weight and forebrain commissure sizes were not statistically significant...
  29. ncbi request reprint In search of a better mouse test
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Trends Neurosci 26:132-6. 2003
    ..The optimal apparatus configuration for certain genetic or pharmacological analyses might depend on the particular laboratory environment. Despite our best efforts, the mice will continue to win some innings...