Research Topics
Species | James A McCormickSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
The WNKs: atypical protein kinases with pleiotropic actionsJames A McCormick
Division of Nephrology and Hypertension, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, Oregon 97239, USA
Physiol Rev 91:177-219. 2011..Next, consequences of these effects on integrated physiological function are outlined. Finally, we discuss the known and putative pathophysiological relevance of the WNKs...
Overexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertensionJames A McCormick
Division of Nephrology and Hypertension, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code L463, Portland, OR 97239 3098, USA
Hypertension 58:888-94. 2011....
A SPAK isoform switch modulates renal salt transport and blood pressureJames A McCormick
Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 3098, USA
Cell Metab 14:352-64. 2011..In mice, extracellular fluid volume depletion shifts SPAK isoform abundance to favor NaCl retention along both segments, indicating that a SPAK isoform switch modulates sodium avidity along the distal nephron...
The WNK kinase network regulating sodium, potassium, and blood pressureEwout J Hoorn
Division of Nephrology and Hypertension, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
J Am Soc Nephrol 22:605-14. 2011..Although many questions remain unanswered, the WNKs hold promise for unraveling the link between salt and hypertension, potentially leading to more effective interventions to prevent cardiorenal damage...
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertensionEwout J Hoorn
Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
Nat Med 17:1304-9. 2011....
High tail-cuff blood pressure in mice 1 week after shipping: the need for longer acclimationEwout J Hoorn
Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, USA
Am J Hypertens 24:534-6. 2011..For vendor-derived mice, an acclimation period of 1 week is usually recommended before blood pressure measurements are started. However, we observed hypertension in wild-type vendor-derived mice 1 week after shipping...
WNK kinases and renal sodium transport in health and disease: an integrated viewJames A McCormick
Division of Nephrology and Hypertension and Heart Research Center, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
Hypertension 51:588-96. 2008
