Owen Jt McCarty

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear
    Michelle A Berny
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 5:e10415. 2010
  2. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
  3. pmc Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
    Joseph E Aslan
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Mail Code CH13B, Portland, OR 97239 USA
    J Mol Signal 6:11. 2011
  4. ncbi request reprint von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively
    O J T McCarty
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 4:1367-78. 2006
  5. pmc Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    Owen J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
    J Biol Chem 280:39474-84. 2005
  6. doi request reprint Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading
    S D J Calaminus
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 6:1944-52. 2008
  7. ncbi request reprint Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion
    O J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Thromb Haemost 2:1823-33. 2004
  8. pmc A major role for Scar/WAVE-1 downstream of GPVI in platelets
    S D J Calaminus
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 5:535-41. 2007
  9. ncbi request reprint GPVI and integrin alphaIIb beta3 signaling in platelets
    S P Watson
    Division of Medical Sciences, Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 3:1752-62. 2005
  10. doi request reprint Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
    T C White
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Thromb Haemost 6:995-1002. 2008

Collaborators

Detail Information

Publications25

  1. pmc Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear
    Michelle A Berny
    Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 5:e10415. 2010
    ..We sought to determine where activated factor X (FXa), (pro)thrombin, and fibrin(ogen) are localized in thrombi formed under venous shear...
  2. pmc Characterization of human platelet binding of recombinant T cell receptor ligand
    Asako Itakura
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, USA
    J Neuroinflammation 7:75. 2010
    ..The mechanisms by which RTLs impede local recruitment and retention of inflammatory cells in the CNS, however, are not completely understood...
  3. pmc Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets
    Joseph E Aslan
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Mail Code CH13B, Portland, OR 97239 USA
    J Mol Signal 6:11. 2011
    ..abstract:..
  4. ncbi request reprint von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively
    O J T McCarty
    Centre for Cardiovascular Sciences, University of Birmingham, Birmingham, UK
    J Thromb Haemost 4:1367-78. 2006
    ..To accomplish this, VWF binds to two distinct platelet receptors: glycoprotein (GP)Ib-IX-V and integrin alpha(IIb)beta3...
  5. pmc Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow
    Owen J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, School of Biosciences, University of Birmingham, United Kingdom
    J Biol Chem 280:39474-84. 2005
    ....
  6. doi request reprint Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading
    S D J Calaminus
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 6:1944-52. 2008
    ..In the present study, we report the identification of a novel actin-rich structure, termed an actin nodule, which appears prior to lamellipodia and stress fibre formation...
  7. ncbi request reprint Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion
    O J T McCarty
    Centre for Cardiovascular Sciences, The Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Thromb Haemost 2:1823-33. 2004
    ..These results highlight a possible role for fibronectin in supporting thrombus formation...
  8. pmc A major role for Scar/WAVE-1 downstream of GPVI in platelets
    S D J Calaminus
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 5:535-41. 2007
    ..Rac mediates actin assembly via Scar/WAVE, a family of scaffolding proteins that direct actin reorganization by relaying signals from Rac to the Arp2/3 complex...
  9. ncbi request reprint GPVI and integrin alphaIIb beta3 signaling in platelets
    S P Watson
    Division of Medical Sciences, Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 3:1752-62. 2005
    ..The significance of these signaling cascades in platelet adhesion and platelet aggregation at arterial rates of shear is discussed...
  10. doi request reprint Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
    T C White
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Thromb Haemost 6:995-1002. 2008
    ..Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if protein C interacts with cells in an alternative manner...
  11. ncbi request reprint MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability
    S D J Calaminus
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, The Medical School, University of Birmingham, Birmingham, UK
    J Thromb Haemost 5:2136-45. 2007
    ..MyosinIIa phosphorylation underlies platelet rounding and stress fiber formation...
  12. pmc Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes
    Asako Itakura
    Department Cell and Developmental Biology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    J Leukoc Biol 90:923-7. 2011
    ..These studies highlight the interplay between inflammation and coagulation and suggest that FXIa may play a role in innate immunity...
  13. ncbi request reprint Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist
    Michelle A Berny
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 28:329-34. 2008
    ..The aim of this study was to delineate the molecular mechanism of direct WE-platelet interactions under static and shear conditions...
  14. pmc Minimal regulation of platelet activity by PECAM-1
    Tarvinder S Dhanjal
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Platelets 18:56-67. 2007
    ....
  15. pmc Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates
    Andras Gruber
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA
    Blood 109:3733-40. 2007
    ..Our data suggest that limited pharmacological protein C activation might exhibit considerable thrombosis specificity...
  16. ncbi request reprint Evaluation of platelet antagonists in in vitro flow models of thrombosis
    Owen J T McCarty
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA
    Methods Mol Med 93:21-34. 2004
  17. ncbi request reprint Preferential binding of platelets to monocytes over neutrophils under flow
    Kyung C Ahn
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA
    Biochem Biophys Res Commun 329:345-55. 2005
    ....
  18. ncbi request reprint Comparative efficacy between the glycoprotein IIb/IIIa antagonists roxifiban and orbofiban in inhibiting platelet responses in flow models of thrombosis
    Shaker A Mousa
    DuPont Pharmaceuticals Company, 141 and Henry Clay Road, Exp Station, E400 3470, Wilmington, DE 19880 0400, USA
    J Cardiovasc Pharmacol 39:552-60. 2002
    ....
  19. ncbi request reprint Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin
    Kelly Thornber
    Department of Biochemistry, University of Oxford, UK
    FEBS J 273:5032-43. 2006
    ..These results suggest that integrins may play an important role in lamellipodia formation triggered by nonintegrin ligands in platelets and possibly in other cell types...
  20. pmc Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3
    Andrew C Pearce
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem J 401:753-61. 2007
    ..These results demonstrate that Vav1 and Vav3 are required for optimal spreading and regulation of PLCgamma2 by integrin alphaIIbbeta3, but that their requirement is by-passed upon G-protein receptor activation...
  21. pmc GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk
    Sascha C Hughan
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, University of Birmingham, UK
    Arterioscler Thromb Vasc Biol 27:422-9. 2007
    ..The present study investigates the role of Src and Syk tyrosine kinases in signaling by G-protein coupled and platelet adhesion receptors...
  22. ncbi request reprint The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen
    Tara C White
    Department of Biomedical Engineering, Oregon Health and Science University, 13B CHH, 3303 SW Bond Avenue, Portland, OR 97239, USA
    FEBS J 274:1481-91. 2007
    ..This has significant implications for the use of saratin as a tool to inhibit platelet-collagen interactions...
  23. ncbi request reprint Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow
    Owen J T McCarty
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 2694, USA
    Am J Physiol Cell Physiol 284:C1223-34. 2003
    ..These studies provide insights for designing strategies based on blocking of eosinophil-platelet interactions to combat thrombotic disorders in hypereosinophilic patients...
  24. pmc Fluid shear regulates the kinetics and molecular mechanisms of activation-dependent platelet binding to colon carcinoma cells
    Owen J T McCarty
    Department of Chemical Engineering, Johns Hopkins University, Baltimore, Maryland 21218 USA
    Biophys J 83:836-48. 2002
    ..This study demonstrates that platelet activation and a fluid-mechanical environment representative of the vasculature affect platelet-tumor cell adhesive interactions pertinent to the process of blood-borne metastasis...
  25. pmc Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI
    Osamu Inoue
    Department of Clinical and Laboratory Medicine, Yamanashi Medical University, 1110 Shimokato Tamaho Nakakoma, Yamanashi 409 3898, Japan
    Blood 107:1405-12. 2006
    ..We speculate that laminin contributes to platelet spreading in vivo through a direct interaction with GPVI...

Research Grants1

  1. Characterization of coagulation factor-platelet interactions: role of FXI
    Owen J McCarty; Fiscal Year: 2010
    ..We propose that elucidation of the role that FXI plays in clot formation may provide the basis for the pharmaceutical development of such a novel class of FXI-targeted anti-thrombotics. ..