H L Lutsep

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint MATCH results: implications for the internist
    Helmi L Lutsep
    Oregon Stroke Center and Department of Neurology, Oregon Health and Science University, Portland, Ore 97239 3098, USA
    Am J Med 119:526.e1-7. 2006
  2. doi request reprint Neurologic safety event rates in the SENTIS trial control population
    H L Lutsep
    Oregon Health and Science University, Portland, USA
    Acta Neurol Scand 127:e5-7. 2013
  3. doi request reprint Effects of sex on mechanical embolectomy outcome
    Helmi L Lutsep
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Stroke Cerebrovasc Dis 21:240-2. 2012
  4. ncbi request reprint The era of the device in ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA
    Curr Neurol Neurosci Rep 4:263-5. 2004
  5. ncbi request reprint Current status of hemorrhagic stroke and acute nonthrombolytic ischemic stroke treatment
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, CR 131, Portland, OR 97239, USA
    Stroke 35:2746-7. 2004
  6. doi request reprint Mechanical endovascular recanalization therapies
    Helmi L Lutsep
    Oregon Health and Science University and Oregon Stroke Center, Portland, OR 97239 3098, USA
    Curr Opin Neurol 21:70-5. 2008
  7. ncbi request reprint Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Drug Targets CNS Neurol Disord 4:119-20. 2005
  8. ncbi request reprint New developments in secondary stroke prevention: impact of the European/Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT) on clinical management
    Helmi L Lutsep
    Department of Neurology, Oregon Health and Science University, Oregon Stroke Center, Portland, OR 97239, USA
    J Stroke Cerebrovasc Dis 16:263-7. 2007
  9. ncbi request reprint Thrombolytic and newer mechanical device treatment for acute ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center and Associate Professor, Oregon Health and Science University, Department of Neurology, 3181 SW Sam Jackson Park Road, CR 131 Portland, OR 97239 3098, USA
    Expert Rev Neurother 6:1099-105. 2006
  10. ncbi request reprint Plasma total homocysteine levels in stroke patients screened for the vitamin intervention for stroke prevention clinical trial in the era of folate fortification
    Helmi L Lutsep
    Oregon Stroke Center, OHSU, Portland, OR 97239, USA
    Neuroepidemiology 26:45-51. 2006

Detail Information

Publications36

  1. ncbi request reprint MATCH results: implications for the internist
    Helmi L Lutsep
    Oregon Stroke Center and Department of Neurology, Oregon Health and Science University, Portland, Ore 97239 3098, USA
    Am J Med 119:526.e1-7. 2006
    ..Given these findings, clopidogrel + aspirin cannot be recommended at this time for the secondary prevention of stroke in patients who have had a previous ischemic stroke or TIA...
  2. doi request reprint Neurologic safety event rates in the SENTIS trial control population
    H L Lutsep
    Oregon Health and Science University, Portland, USA
    Acta Neurol Scand 127:e5-7. 2013
    ..Adverse event (AE) rates for interventional stroke trials are not well established...
  3. doi request reprint Effects of sex on mechanical embolectomy outcome
    Helmi L Lutsep
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    J Stroke Cerebrovasc Dis 21:240-2. 2012
    ..Our data suggest that the sex differences seen in thrombolytic trials might be due to factors other than immediate postprocedural large vessel opening...
  4. ncbi request reprint The era of the device in ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA
    Curr Neurol Neurosci Rep 4:263-5. 2004
  5. ncbi request reprint Current status of hemorrhagic stroke and acute nonthrombolytic ischemic stroke treatment
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, CR 131, Portland, OR 97239, USA
    Stroke 35:2746-7. 2004
  6. doi request reprint Mechanical endovascular recanalization therapies
    Helmi L Lutsep
    Oregon Health and Science University and Oregon Stroke Center, Portland, OR 97239 3098, USA
    Curr Opin Neurol 21:70-5. 2008
    ..The review compares recent trials using mechanical endovascular therapies with and without adjuvants to treat acute stroke...
  7. ncbi request reprint Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Drug Targets CNS Neurol Disord 4:119-20. 2005
    ..Early clinical trials showed that the drug was safe, and displayed primarily serotonergic side effects such as nausea and vomiting. A phase IIb trial in moderate to moderately severe strokes completed enrollment in June 2004...
  8. ncbi request reprint New developments in secondary stroke prevention: impact of the European/Australasian Stroke Prevention in Reversible Ischemia Trial (ESPRIT) on clinical management
    Helmi L Lutsep
    Department of Neurology, Oregon Health and Science University, Oregon Stroke Center, Portland, OR 97239, USA
    J Stroke Cerebrovasc Dis 16:263-7. 2007
    ....
  9. ncbi request reprint Thrombolytic and newer mechanical device treatment for acute ischemic stroke
    Helmi L Lutsep
    Oregon Stroke Center and Associate Professor, Oregon Health and Science University, Department of Neurology, 3181 SW Sam Jackson Park Road, CR 131 Portland, OR 97239 3098, USA
    Expert Rev Neurother 6:1099-105. 2006
    ..This article reviews the study findings that are likely to contribute to current treatment decisions...
  10. ncbi request reprint Plasma total homocysteine levels in stroke patients screened for the vitamin intervention for stroke prevention clinical trial in the era of folate fortification
    Helmi L Lutsep
    Oregon Stroke Center, OHSU, Portland, OR 97239, USA
    Neuroepidemiology 26:45-51. 2006
    ..06 overall, 0.0003 in the oldest age group). US levels were 0.39 micromol/l (95% CI: -0.08, 0.85) lower than in Canada. Neither fasting nor time since stroke affected the results...
  11. doi request reprint Vertebrobasilar revascularization rates and outcomes in the MERCI and multi-MERCI trials
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Stroke Cerebrovasc Dis 17:55-7. 2008
    ..This study determined outcomes of patients with vertebrobasilar occlusion treated with mechanical embolus removal in cerebral ischemia (MERCI) retriever mechanical thrombectomy...
  12. doi request reprint Symptomatic intracranial stenosis: best medical treatment vs. intracranial stenting
    Helmi L Lutsep
    Oregon Health and Science University and Oregon Stroke Center, Portland, Oregon 97239 3098, USA
    Curr Opin Neurol 22:69-74. 2009
    ..The high risk of stroke and death in patients with symptomatic intracranial stenosis despite medical therapy has spurred interest in endovascular treatment approaches...
  13. doi request reprint Recent clinical trials of antiplatelet therapy in secondary stroke prevention: expectations and results for application in primary care settings
    Helmi L Lutsep
    Department of Neurology, Oregon Stroke Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Med 122:S21-31. 2009
    ..This review provides primary care physicians with timely evidence- and guideline-based recommendations on prevention of secondary stroke...
  14. ncbi request reprint Repinotan Bayer
    Helmi L Lutsep
    The University of Arizona, Department of Neurology, Tucson 85750, USA
    Curr Opin Investig Drugs 3:924-7. 2002
    ..Bayer predicts peak sales of Euro450 million [397137]...
  15. ncbi request reprint Current status of neuroprotective agents in the treatment of acute ischemic stroke
    H L Lutsep
    Oregon Stroke Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA
    Curr Neurol Neurosci Rep 1:13-8. 2001
    ..Ongoing clinical trials with novel agents are trying to enroll a more homogeneous population of stroke patients in an effort to demonstrate treatment benefit...
  16. ncbi request reprint An update of neuroprotectants in clinical development for acute stroke
    H Lutsep
    Oregon Stroke Center, OHSU, Portland 97201, USA
    Curr Opin Investig Drugs 2:1732-6. 2001
    ..In addition, ongoing trials and early trials using novel mechanisms of action, such as hypothermia and antioxidants, are discussed...
  17. doi request reprint Update on selecting and adjusting antiplatelet therapy for prevention of noncardiogenic, recurrent ischemic stroke
    Helmi Lutsep
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97239 3098, USA
    Expert Rev Cardiovasc Ther 9:1295-303. 2011
    ..The clinical implications of these issues will be discussed with respect to the secondary prevention of stroke...
  18. ncbi request reprint Does reversal of ischemia on diffusion-weighted imaging reflect higher apparent diffusion coefficient values?
    H L Lutsep
    Oregon Stroke Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA
    J Neuroimaging 11:313-6. 2001
    ..43 x 10(-3) mm2/s in the 6 regions that reversed and 7.31 x 10(-3) mm2/s in the 6 regions that persisted (P < .036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs...
  19. ncbi request reprint Association of intracranial stenosis with cortical symptoms or signs
    H L Lutsep
    Oregon Stroke Center, Oregon Health Sciences University, Portland 97201, USA
    Neurology 55:716-8. 2000
    ..Fifteen percent (5/33) of patients with cortical symptoms or signs had symptomatic intracranial stenosis of 50% or more by MR angiography or angiography, compared with 0% (0/15) of those without such findings (p < 0.005)...
  20. ncbi request reprint Medical treatment strategies: intravenous thrombolysis, neuronal protection, and anti-reperfusion injury agents
    W M Clark
    Department of Neurology, Oregon Stroke Center, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Neuroimaging Clin N Am 9:465-73. 1999
    ..The current status of other potential stroke therapies are also reviewed, including neuroprotective trials and agents designed to limit reperfusion injury...
  21. pmc Endovascular mechanical thrombectomy for the treatment of acute ischemic stroke due to arterial dissection
    J D Fields
    Interventional Neuroradiology, Oregon Health and Science University, Portland, OR 07239 3098, USA
    Interv Neuroradiol 18:74-9. 2012
    ..These results suggest that mechanical thrombectomy in patients with acute stroke resulting from arterial dissection is feasible, safe, and may be associated with favorable functional outcomes...
  22. ncbi request reprint Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial
    Wade S Smith
    Department of Neurology, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 36:1432-8. 2005
    ..An alternative strategy for opening intracranial vessels during stroke is mechanical embolectomy, especially for patients ineligible for intravenous tPA...
  23. pmc Drug eluting stents for symptomatic intracranial and vertebral artery stenosis
    J D Fields
    Interventional Neuroradiology, Department of Neurology Oregon Health and Science University, Portland, USA
    Interv Neuroradiol 17:241-7. 2011
    ....
  24. doi request reprint Mechanical thrombectomy for the treatment of acute ischemic stroke
    Jeremy D Fields
    Neurosciences Critical Care, Department of Neurology, Interventional Neuroradiology, Dotter Interventional Institute, Oregon Health and Science University, OR, USA
    Expert Rev Cardiovasc Ther 8:581-92. 2010
    ..Ultimately, the results of ongoing trials are necessary to delineate the patient populations most likely to benefit from this therapy...
  25. doi request reprint Indications and applications of arterial stents for stroke prevention in atherosclerotic intracranial stenosis
    Jeremy D Fields
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR 127, Portland, OR 97239, USA
    Curr Cardiol Rep 12:20-8. 2010
    ....
  26. doi request reprint Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial
    Wade S Smith
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 39:1205-12. 2008
    ..Enhancements in embolectomy device design may improve recanalization rates...
  27. ncbi request reprint Thrombolysis in young adults
    Jeffrey C Wagner
    Oregon Stroke Center, Oregon Health and Science University, Portland, OR 97239, USA
    J Thromb Thrombolysis 20:133-6. 2005
    ..Current data support the use of thrombolytics for all ischemic stroke etiologies, including entities such as cervical artery dissection that are more common in young patients...
  28. doi request reprint Higher degrees of recanalization after mechanical thrombectomy for acute stroke are associated with improved outcome and decreased mortality: pooled analysis of the MERCI and Multi MERCI trials
    J D Fields
    Department of Interventional Neuroradiology, Oregon Health and Science University, Portland, OR 97239, USA
    AJNR Am J Neuroradiol 32:2170-4. 2011
    ..We hypothesized that greater degrees of recanalization would be associated with a higher likelihood of favorable functional outcomes...
  29. ncbi request reprint Potential of anticytokine therapies in central nervous system ischaemia
    W M Clark
    Oregon Stroke Center, Dept of Neurology UHS44, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    Expert Opin Biol Ther 1:227-37. 2001
    ..Although there are no current clinical 'anti-cytokine' treatment studies for stroke, experimental studies modulating IL-1 and TNF-alpha have shown neuroprotection...
  30. ncbi request reprint Intraarterial suction thrombectomy in acute stroke
    Helmi L Lutsep
    Oregon Stroke Center, Oregon Health Sciences University, Portland 97201, USA
    AJNR Am J Neuroradiol 23:783-6. 2002
    ..The median National Institutes of Health Stroke Scale score decreased from 22 (range, 12-23) to 4 (range, 2-22) at 3 months. IA suction thrombectomy may be safe and feasible in patients with acute stroke...
  31. ncbi request reprint GABA agonist: clomethiazole
    Anand Vaishnav
    Oregon Stroke Center, Oregon Health Sciences University, Portland 97201, USA
    Curr Med Res Opin 18:s5-8. 2002
    ..However, large randomized placebo controlled trials in Europe, Canada and North America did not show the superiority of clomethiazole over placebo that was seen in animal models...
  32. ncbi request reprint Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studies
    Steven C Cramer
    University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    Neurol Res 25:811-4. 2003
    ..Initial details are presented of a study using this approach to evaluate such a therapy...
  33. ncbi request reprint Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study
    Steven C Cramer
    University of Washington, Seattle, USA
    Stroke 35:46-50. 2004
    ..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT)...
  34. doi request reprint Mechanical endovascular acute stroke treatment: here to stay
    Helmi L Lutsep
    Expert Rev Med Devices 5:273-4. 2008
  35. ncbi request reprint Use of functional MRI to guide decisions in a clinical stroke trial
    Steven C Cramer
    University of California, Irvine, Calif, USA
    Stroke 36:e50-2. 2005
    ..The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial...
  36. ncbi request reprint Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety study
    Jeffrey A Brown
    Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA
    Neurosurgery 58:464-73. 2006
    ....