Malcolm J Low

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Role of proopiomelanocortin neurons and peptides in the regulation of energy homeostasis
    M J Low
    Vollum Institute, Department of Behavioral Neuroscience, and Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Endocrinol Invest 27:95-100. 2004
  2. ncbi request reprint Clinical endocrinology and metabolism. The somatostatin neuroendocrine system: physiology and clinical relevance in gastrointestinal and pancreatic disorders
    Malcolm J Low
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Best Pract Res Clin Endocrinol Metab 18:607-22. 2004
  3. pmc Pituitary adenomas in man and mouse: oncogenic potential of a truncated fibroblast growth factor receptor 4
    Malcolm J Low
    The Vollum Institute, L 474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    J Clin Invest 109:15-6. 2002
  4. pmc Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
    M J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Invest 107:1571-80. 2001
  5. ncbi request reprint Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3578-85. 2005
  6. ncbi request reprint State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin
    Malcolm J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:192-201. 2003
  7. pmc Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 116:495-505. 2006
  8. ncbi request reprint Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:13292-302. 2007
  9. ncbi request reprint Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Center for the Study of Weight Regulation and Associated Disorders, L 481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Endocrinology 148:647-59. 2007
  10. ncbi request reprint Naloxone's suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin
    Michael D Hayward
    Vollum Institute L 474, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Portland, OR 97239, USA
    Brain Res Mol Brain Res 140:91-8. 2005

Research Grants

  1. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004

Detail Information

Publications76

  1. ncbi request reprint Role of proopiomelanocortin neurons and peptides in the regulation of energy homeostasis
    M J Low
    Vollum Institute, Department of Behavioral Neuroscience, and Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Endocrinol Invest 27:95-100. 2004
    ..Both melanocortin peptides and the opioid beta-endorphin processed from POMC mediate the homeostatic and behavioral responses linked to POMC neuronal circuits...
  2. ncbi request reprint Clinical endocrinology and metabolism. The somatostatin neuroendocrine system: physiology and clinical relevance in gastrointestinal and pancreatic disorders
    Malcolm J Low
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Best Pract Res Clin Endocrinol Metab 18:607-22. 2004
    ..Somatostatin analogs coupled to high-energy radionuclides show promise as novel cytotoxic agents for certain metastatic tumors...
  3. pmc Pituitary adenomas in man and mouse: oncogenic potential of a truncated fibroblast growth factor receptor 4
    Malcolm J Low
    The Vollum Institute, L 474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
    J Clin Invest 109:15-6. 2002
  4. pmc Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
    M J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Invest 107:1571-80. 2001
    ..In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth...
  5. ncbi request reprint Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioids
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 25:3578-85. 2005
    ..These findings identify a potential satiety pathway in which visceral afferents directly activate NTS POMC-EGFP neurons with excitatory inputs that are appropriately modulated by appetite regulators...
  6. ncbi request reprint State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin
    Malcolm J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:192-201. 2003
    ....
  7. pmc Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 116:495-505. 2006
    ..Restoration of pituitary POMC expression to create a de facto neuronal POMC deficiency exacerbated the development of obesity, largely via glucocorticoid modulation of appetite, metabolism, and energy partitioning...
  8. ncbi request reprint Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:13292-302. 2007
    ..Thus, NTS CA neurons are directly driven by visceral afferents with output being modulated by presynaptic peptide receptors and postsynaptic potassium channels...
  9. ncbi request reprint Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Center for the Study of Weight Regulation and Associated Disorders, L 481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Endocrinology 148:647-59. 2007
    ....
  10. ncbi request reprint Naloxone's suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalin
    Michael D Hayward
    Vollum Institute L 474, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Portland, OR 97239, USA
    Brain Res Mol Brain Res 140:91-8. 2005
    ..We suggest that the D2 dopamine receptor is necessary for modulation of spontaneous locomotor activity stimulated by the endogenous opioid enkephalin...
  11. ncbi request reprint GABA release from proopiomelanocortin neurons
    Shane T Hentges
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 24:1578-83. 2004
    ....
  12. ncbi request reprint Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalin
    Michael D Hayward
    Vollum Institute, L 474, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Pharmacol Biochem Behav 79:171-81. 2004
    ..These results suggest that the rewarding effects of ethanol do not require beta-endorphin or enkephalin signaling...
  13. ncbi request reprint A transgenic marker for newly born granule cells in dentate gyrus
    Linda S Overstreet
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 24:3251-9. 2004
    ..Our results indicate that POMC-EGFP marks immature granule cells and that adult-generated granule cells integrate quite slowly into the hippocampal circuitry...
  14. ncbi request reprint A role for the endogenous opioid beta-endorphin in energy homeostasis
    Suzanne M Appleyard
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 144:1753-60. 2003
    ....
  15. ncbi request reprint Ovarian dependence for pituitary tumorigenesis in D2 dopamine receptor-deficient mice
    Shane T Hentges
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Endocrinology 143:4536-43. 2002
    ..These findings illustrate the importance of genetic background when analyzing endocrine regulation in mutant mouse models...
  16. ncbi request reprint Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background
    James L Smart
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:202-10. 2003
    ....
  17. pmc Differential activation and trafficking of micro-opioid receptors in brain slices
    Seksiri Arttamangkul
    Vollum Institute, L474, Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 W Sam Jackson Park Dr, Portland, OR 97239, USA
    Mol Pharmacol 74:972-9. 2008
    ....
  18. pmc Meal pattern analysis in neural-specific proopiomelanocortin-deficient mice
    Christian D Richard
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
    Eur J Pharmacol 660:131-8. 2011
    ..The combination of larger, more rapidly consumed meals and prolonged intermeal intervals suggests that proopiomelanocortin peptides are necessary for normal meal termination, but not the maintenance of satiety...
  19. ncbi request reprint Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels
    Nurhadi Ibrahim
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Endocrinology 144:1331-40. 2003
    ..Therefore, it appears that POMC neurons may function as an integrator of metabolic cues and synaptic input for controlling homeostasis in the mammal...
  20. ncbi request reprint Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids
    Shane T Hentges
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97329, USA
    J Neurosci 25:9746-51. 2005
    ....
  21. ncbi request reprint In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice
    Virginie Tolle
    Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes 57:86-94. 2008
    ..We investigated whether AgRP functions similarly in vivo using mouse models that lack all neuronal MSH, thereby precluding competitive antagonism of MC-R by AgRP...
  22. pmc Differential involvement of endogenous opioids in sucrose consumption and food reinforcement
    Michael D Hayward
    Center for the Study of Weight Regulation, Oregon Health and Science University, Portland OR 97239, USA
    Pharmacol Biochem Behav 85:601-11. 2006
    ..However, dynorphin was not necessary to support wildtype levels of operant responding suggesting that only enkephalin and beta-endorphin modulate conditioned food reinforcement...
  23. ncbi request reprint Intravenous self-administration of ethanol in beta-endorphin-deficient mice
    N J Grahame
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, USA
    Alcohol Clin Exp Res 22:1093-8. 1998
    ..These findings may indicate that BE is not essential for the postingestive reinforcing effects of ethanol in these animals...
  24. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  25. pmc Proopiomelanocortin peptides are not essential for development of ethanol-induced behavioral sensitization
    Amanda L Sharpe
    Center for the Study of Weight Regulation and Associated Disorders, Department of Behavioral Neuroscience, Science University, Portland, OR, USA
    Alcohol Clin Exp Res 33:1202-7. 2009
    ..This study used a genetically engineered mouse strain that is deficient for neural POMC to directly determine if any POMC peptides are necessary for the development of ethanol-induced locomotor sensitization...
  26. ncbi request reprint The contribution of endogenous opioids to food reward is dependent on sex and background strain
    M D Hayward
    Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Neuroscience 144:17-25. 2007
    ....
  27. pmc Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice
    M A Kelly
    Vollum Institute, Oregon Health and Science University, Portland, OR, USA
    Genes Brain Behav 7:568-77. 2008
    ....
  28. ncbi request reprint Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis
    Abraham A Palmer
    Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
    Behav Genet 33:311-24. 2003
    ..The impact of the Drd2 null mutation on a subset of ethanol-related behavioral traits is subject to epistatic influences...
  29. ncbi request reprint Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
    M A Cowley
    The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    Nature 411:480-4. 2001
    ..On the basis of our results, we propose an integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus...
  30. ncbi request reprint Gonadotroph-specific expression of the human follicle stimulating hormone beta gene in transgenic mice
    T Rajendra Kumar
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Mol Cell Endocrinol 247:103-15. 2006
    ....
  31. ncbi request reprint Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors
    T J Phillips
    Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Nat Neurosci 1:610-5. 1998
    ..These data demonstrate that dopamine signaling via D2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity...
  32. ncbi request reprint The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
    R D Cone
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Int J Obes Relat Metab Disord 25:S63-7. 2001
    ....
  33. ncbi request reprint Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations
    M A Kelly
    Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 18:3470-9. 1998
    ..We conclude that D2R-deficient mice are not a model of Parkinson's disease. Our studies highlight the interaction of multiple genetic factors in the analysis of complex behaviors in gene knock-out mice...
  34. ncbi request reprint Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice
    C L Cunningham
    Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Pharmacol Biochem Behav 67:693-9. 2000
    ..Overall, this study strongly supports the conclusion that dopamine D2 receptors normally influence ethanol reward in mice...
  35. ncbi request reprint Lack of operant ethanol self-administration in dopamine D2 receptor knockout mice
    F O Risinger
    Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
    Psychopharmacology (Berl) 152:343-50. 2000
    ..Dopamine D2 receptors are postulated to play an important role in modulating the reinforcing effects of abused drugs including ethanol...
  36. ncbi request reprint Effect of the mu-opioid agonist DAMGO on medial basal hypothalamic neurons in beta-endorphin knockout mice
    R M Slugg
    Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, USA
    Neuroendocrinology 72:208-17. 2000
    ..Therefore, we conclude that the complete absence of beta-END throughout development did not alter either the expression of mu-opioid receptors or their coupling to K(+) channels in MBH neurons...
  37. ncbi request reprint Strategies for cellular identification in nucleus tractus solitarius slices
    Mark W Doyle
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Neurosci Methods 137:37-48. 2004
    ..Coupling tracing techniques with electrophysiology adds important new dimensions to NTS studies and such strategies provide bridging information between cellular mechanisms, neuroanatomy and systems integration...
  38. pmc Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanisms
    Kathryn G Schuff
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Clin Invest 110:973-81. 2002
    ..We conclude that PRL inhibits lactotrophs by two distinct mechanisms: (a) indirectly by activation of hypothalamic dopamine neurons and (b) directly within the pituitary in a dopamine-independent fashion...
  39. ncbi request reprint Selective reward deficit in mice lacking beta-endorphin and enkephalin
    Michael D Hayward
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurosci 22:8251-8. 2002
    ..Because the attenuation of operant responding was observed only during a nondeprived motivational state, the hedonics of feeding are likely altered rather than energy homeostasis...
  40. ncbi request reprint Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland
    R G Allen
    Center for Research on Occupational and Environmental Toxicology, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Mol Endocrinol 9:1005-16. 1995
    ....
  41. pmc DNA elements with AT-rich core sequences direct pituitary cell-specific expression of the pro-opiomelanocortin gene in transgenic mice
    B Liu
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Biochem J 312:827-32. 1995
    ..However, PP1 is distinct from Brn 3.0, a POU protein that also binds to site 3. We conclude that PP1 is a transcriptional activator for pituitary-specific POMC gene expression...
  42. ncbi request reprint Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice
    M A Kelly
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Neuron 19:103-13. 1997
    ....
  43. ncbi request reprint Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides
    W Chen
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Cell 91:789-98. 1997
    ..These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides...
  44. ncbi request reprint Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
    M A Whitney
    Department of Molecular and Medical Genetics, Vollum Institute, Oregon Regional Primate Center, Portland, USA
    Blood 88:49-58. 1996
    ..Progenitor cells from fac knock-out mice were hypersensitive to interferon gamma. This previously unrecognized phenotype may form the basis for BM failure in human FA...
  45. ncbi request reprint The effect of naloxone on operant behavior for food reinforcers in DBA/2 mice
    M D Hayward
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Brain Res Bull 56:537-43. 2001
    ..These data suggest that opioids specifically influence consumatory behavior in mice, but our findings on instrumental behavior were confounded by an independent inhibitory effect of an i.p. saline injection...
  46. ncbi request reprint Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
    S C Coste
    Departments of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
    Nat Genet 24:403-9. 2000
    ..Moreover, Crhr2-/- mice have elevated basal blood pressure, demonstrating that Crhr2 participates in cardiovascular homeostasis. Our results identify specific responses in the brain and periphery that involve Crhr2...
  47. ncbi request reprint GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatin
    Isabel Garcia-Tornadú
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET and University of Buenos Aires, V Obligado 2490, 1428 Buenos Aires, Argentina
    J Endocrinol 190:611-9. 2006
    ..Our data also reveal that somatotrope cell number is much more sensitive to changes in neonatal GHRH input than their capacity to develop properly regulated GH-secretory function...
  48. ncbi request reprint Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice
    Victoria B Risbrough
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:2349-58. 2006
    ..More specifically, D1 receptor activation appears to modify the type of activity (linear vs circumscribed), whereas D2 receptor activation appears to contribute to the repetitive circling behavior produced by MDMA...
  49. ncbi request reprint Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma
    Carolina Cristina
    Instituto de Biologia y Medicina Experimental CONICET, Vuelta de Obligado 1490, 1428 Buenos Aires, Argentina
    Front Horm Res 35:50-63. 2006
    ..The D2R knockout mouse represents a unique animal model to study dopamine-resistant prolactinomas, and VEGF-A may be an alternative therapeutic target in this pathology...
  50. ncbi request reprint Reduced basal and ethanol stimulation of striatal extracellular dopamine concentrations in dopamine D2 receptor knockout mice
    Martin O Job
    The University of Texas at Austin, PHAR Pharmacology, Austin, Texas 78712, USA
    Synapse 60:158-64. 2006
    ..In addition, the blunted ethanol-evoked DA response in the D2 knockouts may contribute, in part, to some of the behavioral deficits previously observed in response to ethanol...
  51. ncbi request reprint Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear
    Tomas L Falzone
    Instituto de Investigaciones en Ingeniería Genética y Biología Molecular CONICET and Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Eur J Neurosci 15:158-64. 2002
    ....
  52. ncbi request reprint Heightened seizure severity in somatostatin knockout mice
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, R102 Edwards Building, MC 5330, Stanford, CA 94305 5330, USA
    Epilepsy Res 48:43-56. 2002
    ....
  53. ncbi request reprint Central serotonin and melanocortin pathways regulating energy homeostasis
    Lora K Heisler
    Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 994:169-74. 2003
    ..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus...
  54. ncbi request reprint Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence
    Viviana F Bumaschny
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Mol Endocrinol 21:2738-49. 2007
    ....
  55. pmc Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene
    Andrea M Santangelo
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    PLoS Genet 3:1813-26. 2007
    ..Together, our results provide clear evidence of the functional novelties that transposed elements contributed to their host genomes throughout evolution...
  56. pmc Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    Lijie Gong
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 550 East Canfield, Detroit, MI 48201, USA
    Endocrinology 149:3346-54. 2008
    ..We conclude that Stat3 in Agrp/Npy neurons is required for normal energy homeostasis, but Stat3 signaling in other brain areas also contributes to the regulation of energy homeostasis...
  57. ncbi request reprint Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors
    Izhak Nir
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Neurosci 22:2063-73. 2002
    ..These findings indicate that dopamine D4 receptors normally play a major role in regulating photoreceptor cAMP metabolism and adaptive retinal responses to changing environmental illumination...
  58. ncbi request reprint Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice
    Greg I Elmer
    Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    J Neurosci 22:RC224. 2002
    ..Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system...
  59. ncbi request reprint Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I
    Ye Lauren Liu
    Fraser Laboratories, Department of Medicine, Royal Victoria Hospital, McGill University, M3 15, 687 Pine Avenue West, Quebec, H3A 1A1, Montreal, Canada
    Mol Cell Endocrinol 189:97-103. 2002
    ..Our results support a role of ghrelin in growth/metabolism in juvenile and young adult mice of both sexes and in sexually dimorphic regulation of GH secretion in aged mice...
  60. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
    Jonathan L Katz
    Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
    Psychopharmacology (Berl) 170:108-14. 2003
    ..However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear...
  61. ncbi request reprint Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons
    Diego M Gelman
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas and Departmento de Fisiología, Biologia Molecular y Celular, Universidad de Buenos Aires, Argentina
    Genesis 36:196-202. 2003
    ..Therefore, we have generated a valuable transgenic mouse strain to induce specific mutations of "floxed" genes in catecholaminergic neurons...
  62. pmc Treatment of Helicobacter gastritis with IL-4 requires somatostatin
    Yana Zavros
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:12944-9. 2003
    ..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells...
  63. ncbi request reprint Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
    Katsunori Tomiyama
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Synapse 51:71-81. 2004
    ..D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements...
  64. ncbi request reprint The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J mice
    Michele A Kelly
    HHMI and Dept Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
    Mamm Genome 14:692-702. 2003
    ....
  65. pmc Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk
    Marcelo Paez-Pereda
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Proc Natl Acad Sci U S A 100:1034-9. 2003
    ..This previously undescribed prolactinoma pathogenesis mechanism may participate in tumorigenicity in other cells where estrogens and the type beta transforming growth factor family have important roles...
  66. ncbi request reprint Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient mice
    Damian Refojo
    Laboratorio de Fisiologia y Biologia Molecular, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, C1428EHA, Buenos Aires, Argentina
    J Neuroimmunol 131:126-34. 2002
    ..These results are consistent with a postulated inhibitory role of endogenous beta-endorphin on the immune system at multiple levels...
  67. ncbi request reprint Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice
    Rebecca J Ralph-Williams
    Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 22:9604-11. 2002
    ..These findings emphasize that further cross-species comparisons of the pharmacology of PPI are essential to understand the relevance of rodent PPI studies to the deficits in PPI observed in patients with schizophrenia...
  68. ncbi request reprint Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice
    Allison L Chausmer
    Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 163:54-61. 2002
    ..Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear...
  69. ncbi request reprint Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  70. ncbi request reprint Brain somatostatin receptors are up-regulated in somatostatin-deficient mice
    Jose L Ramirez
    Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada, H3A 1A1
    Mol Endocrinol 16:1951-63. 2002
    ..SST-like immunoreactivity, however, was induced in the proximal midgut in SSTKO animals, suggesting intestinal expression of a novel SST-like gene...
  71. pmc Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background
    Andrzej Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Endocrinology 146:1245-53. 2005
    ..Whereas the latter implies feedback control of melanogenesis, it is also possible that the two mechanisms operate jointly in hair follicles...
  72. pmc Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting
    Flavio S J de Souza
    INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cell Biol 25:3076-86. 2005
    ..Our study advances the understanding of the molecular nature of hypothalamic POMC neurons and will be useful to determine whether polymorphisms in POMC regulatory regions play a role in the predisposition to obesity...
  73. ncbi request reprint Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  74. ncbi request reprint Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulation
    John W Ensinck
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle 98195, USA
    Endocrinology 143:2599-609. 2002
    ..Its localization in both GI endocrine cells and gut neurons suggests that thrittene may function as both a hormone and neurotransmitter...
  75. pmc Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating
    Christiaan H Vinkers
    Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Pharmacol Biochem Behav 86:550-8. 2007
    ..These results indicate that neither D(1)- nor D(2)-receptor activation is necessary for CRF to exert its effects on acoustic startle and PPI in mice...
  76. ncbi request reprint Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishes
    Flavio S J de Souza
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, CONICET, FCEyN, Universidad de Buenos Aires, Argentina
    Mol Biol Evol 22:2417-27. 2005
    ..The study of regulatory regions of fish POMC genes might shed light on the mechanisms of enhancer partitioning between duplicate genes, as well as the roles of POMC-derived peptides in fish physiology...

Research Grants2

  1. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004
    ..abstract_text> ..