Research Topics
Genomes and GenesSpecies | Malcolm J LowSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Role of proopiomelanocortin neurons and peptides in the regulation of energy homeostasisM J Low
Vollum Institute, Department of Behavioral Neuroscience, and Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, OR 97239 3098, USA
J Endocrinol Invest 27:95-100. 2004..Both melanocortin peptides and the opioid beta-endorphin processed from POMC mediate the homeostatic and behavioral responses linked to POMC neuronal circuits...- Clinical endocrinology and metabolism. The somatostatin neuroendocrine system: physiology and clinical relevance in gastrointestinal and pancreatic disordersMalcolm J Low
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
Best Pract Res Clin Endocrinol Metab 18:607-22. 2004..Somatostatin analogs coupled to high-energy radionuclides show promise as novel cytotoxic agents for certain metastatic tumors... 
Pituitary adenomas in man and mouse: oncogenic potential of a truncated fibroblast growth factor receptor 4Malcolm J Low
The Vollum Institute, L-474, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA
J Clin Invest 109:15-6. 2002- Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growthM J Low
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
J Clin Invest 107:1571-80. 2001..In the absence of SST, male and female mice exhibit similarly altered plasma GH profiles that eliminate sexually dimorphic liver function but do not affect dimorphic growth... - Proopiomelanocortin neurons in nucleus tractus solitarius are activated by visceral afferents: regulation by cholecystokinin and opioidsSuzanne M Appleyard
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Neurosci 25:3578-85. 2005..These findings identify a potential satiety pathway in which visceral afferents directly activate NTS POMC-EGFP neurons with excitatory inputs that are appropriately modulated by appetite regulators... - State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphinMalcolm J Low
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Ann N Y Acad Sci 994:192-201. 2003.... - Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient miceJames L Smart
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Clin Invest 116:495-505. 2006..Restoration of pituitary POMC expression to create a de facto neuronal POMC deficiency exacerbated the development of obesity, largely via glucocorticoid modulation of appetite, metabolism, and energy partitioning... - Visceral afferents directly activate catecholamine neurons in the solitary tract nucleusSuzanne M Appleyard
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 27:13292-302. 2007..Thus, NTS CA neurons are directly driven by visceral afferents with output being modulated by presynaptic peptide receptors and postsynaptic potassium channels... - Central dysregulation of the hypothalamic-pituitary-adrenal axis in neuron-specific proopiomelanocortin-deficient miceJames L Smart
Center for the Study of Weight Regulation and Associated Disorders, L 481, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Endocrinology 148:647-59. 2007.... - Naloxone's suppression of spontaneous and food-conditioned locomotor activity is diminished in mice lacking either the dopamine D(2) receptor or enkephalinMichael D Hayward
Vollum Institute L 474, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Portland, OR 97239, USA
Brain Res Mol Brain Res 140:91-8. 2005..We suggest that the D2 dopamine receptor is necessary for modulation of spontaneous locomotor activity stimulated by the endogenous opioid enkephalin... - GABA release from proopiomelanocortin neuronsShane T Hentges
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 24:1578-83. 2004.... - Operant self-administration of ethanol in C57BL/6 mice lacking beta-endorphin and enkephalinMichael D Hayward
Vollum Institute, L 474, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
Pharmacol Biochem Behav 79:171-81. 2004..These results suggest that the rewarding effects of ethanol do not require beta-endorphin or enkephalin signaling... - A transgenic marker for newly born granule cells in dentate gyrusLinda S Overstreet
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
J Neurosci 24:3251-9. 2004..Our results indicate that POMC-EGFP marks immature granule cells and that adult-generated granule cells integrate quite slowly into the hippocampal circuitry... - A role for the endogenous opioid beta-endorphin in energy homeostasisSuzanne M Appleyard
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Endocrinology 144:1753-60. 2003.... - Ovarian dependence for pituitary tumorigenesis in D2 dopamine receptor-deficient miceShane T Hentges
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
Endocrinology 143:4536-43. 2002..These findings illustrate the importance of genetic background when analyzing endocrine regulation in mutant mouse models... - Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic backgroundJames L Smart
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Ann N Y Acad Sci 994:202-10. 2003.... - Differential activation and trafficking of micro-opioid receptors in brain slicesSeksiri Arttamangkul
Vollum Institute, L474, Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 W Sam Jackson Park Dr, Portland, OR 97239, USA
Mol Pharmacol 74:972-9. 2008.... - Meal pattern analysis in neural-specific proopiomelanocortin-deficient miceChristian D Richard
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States
Eur J Pharmacol 660:131-8. 2011..The combination of larger, more rapidly consumed meals and prolonged intermeal intervals suggests that proopiomelanocortin peptides are necessary for normal meal termination, but not the maintenance of satiety... - Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channelsNurhadi Ibrahim
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA
Endocrinology 144:1331-40. 2003..Therefore, it appears that POMC neurons may function as an integrator of metabolic cues and synaptic input for controlling homeostasis in the mammal... - Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoidsShane T Hentges
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97329, USA
J Neurosci 25:9746-51. 2005.... - In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient miceVirginie Tolle
Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon, USA
Diabetes 57:86-94. 2008..We investigated whether AgRP functions similarly in vivo using mouse models that lack all neuronal MSH, thereby precluding competitive antagonism of MC-R by AgRP... - The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasisMichael A Cowley
The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Neuron 37:649-61. 2003..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis... - Differential involvement of endogenous opioids in sucrose consumption and food reinforcementMichael D Hayward
Center for the Study of Weight Regulation, Oregon Health and Science University, Portland OR 97239, USA
Pharmacol Biochem Behav 85:601-11. 2006..However, dynorphin was not necessary to support wildtype levels of operant responding suggesting that only enkephalin and beta-endorphin modulate conditioned food reinforcement... - Intravenous self-administration of ethanol in beta-endorphin-deficient miceN J Grahame
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, USA
Alcohol Clin Exp Res 22:1093-8. 1998..These findings may indicate that BE is not essential for the postingestive reinforcing effects of ethanol in these animals... - Proopiomelanocortin peptides are not essential for development of ethanol-induced behavioral sensitizationAmanda L Sharpe
Center for the Study of Weight Regulation and Associated Disorders, Department of Behavioral Neuroscience, Science University, Portland, OR, USA
Alcohol Clin Exp Res 33:1202-7. 2009..This study used a genetically engineered mouse strain that is deficient for neural POMC to directly determine if any POMC peptides are necessary for the development of ethanol-induced locomotor sensitization... - The contribution of endogenous opioids to food reward is dependent on sex and background strainM D Hayward
Center for the Study of Weight Regulation, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Neuroscience 144:17-25. 2007.... - Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout miceM A Kelly
Vollum Institute, Oregon Health and Science University, Portland, OR, USA
Genes Brain Behav 7:568-77. 2008.... - Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasisAbraham A Palmer
Veterans Affairs Medical Center, Research Service, Portland, Oregon 97239, USA
Behav Genet 33:311-24. 2003..The impact of the Drd2 null mutation on a subset of ethanol-related behavioral traits is subject to epistatic influences... - Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusM A Cowley
The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
Nature 411:480-4. 2001..On the basis of our results, we propose an integrated model of leptin action and neuronal architecture in the arcuate nucleus of the hypothalamus... - Gonadotroph-specific expression of the human follicle stimulating hormone beta gene in transgenic miceT Rajendra Kumar
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Mol Cell Endocrinol 247:103-15. 2006.... - Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptorsT J Phillips
Department of Veterans Affairs Medical Center, Portland, Oregon 97201, USA
Nat Neurosci 1:610-5. 1998..These data demonstrate that dopamine signaling via D2 receptors is an essential component of the molecular pathway determining ethanol self-administration and sensitivity... - The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasisR D Cone
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
Int J Obes Relat Metab Disord 25:S63-7. 2001.... - Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptationsM A Kelly
Oregon Health Sciences University, Portland, Oregon 97201, USA
J Neurosci 18:3470-9. 1998..We conclude that D2R-deficient mice are not a model of Parkinson's disease. Our studies highlight the interaction of multiple genetic factors in the analysis of complex behaviors in gene knock-out mice... - Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient miceC L Cunningham
Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201 3098, USA
Pharmacol Biochem Behav 67:693-9. 2000..Overall, this study strongly supports the conclusion that dopamine D2 receptors normally influence ethanol reward in mice... - Lack of operant ethanol self-administration in dopamine D2 receptor knockout miceF O Risinger
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
Psychopharmacology (Berl) 152:343-50. 2000..Dopamine D2 receptors are postulated to play an important role in modulating the reinforcing effects of abused drugs including ethanol... - Effect of the mu-opioid agonist DAMGO on medial basal hypothalamic neurons in beta-endorphin knockout miceR M Slugg
Department of Physiology and Pharmacology, Oregon Health Sciences University, Portland, OR 97201, USA
Neuroendocrinology 72:208-17. 2000..Therefore, we conclude that the complete absence of beta-END throughout development did not alter either the expression of mu-opioid receptors or their coupling to K(+) channels in MBH neurons... - Strategies for cellular identification in nucleus tractus solitarius slicesMark W Doyle
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239-3098, USA
J Neurosci Methods 137:37-48. 2004..Coupling tracing techniques with electrophysiology adds important new dimensions to NTS studies and such strategies provide bridging information between cellular mechanisms, neuroanatomy and systems integration... - Lack of prolactin receptor signaling in mice results in lactotroph proliferation and prolactinomas by dopamine-dependent and -independent mechanismsKathryn G Schuff
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
J Clin Invest 110:973-81. 2002..We conclude that PRL inhibits lactotrophs by two distinct mechanisms: (a) indirectly by activation of hypothalamic dopamine neurons and (b) directly within the pituitary in a dopamine-independent fashion... - Selective reward deficit in mice lacking beta-endorphin and enkephalinMichael D Hayward
The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
J Neurosci 22:8251-8. 2002..Because the attenuation of operant responding was observed only during a nondeprived motivational state, the hedonics of feeding are likely altered rather than energy homeostasis... - Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal glandR G Allen
Center for Research on Occupational and Environmental Toxicology, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Mol Endocrinol 9:1005-16. 1995.... - DNA elements with AT-rich core sequences direct pituitary cell-specific expression of the pro-opiomelanocortin gene in transgenic miceB Liu
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Biochem J 312:827-32. 1995..However, PP1 is distinct from Brn 3.0, a POU protein that also binds to site 3. We conclude that PP1 is a transcriptional activator for pituitary-specific POMC gene expression... - Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient miceM A Kelly
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Neuron 19:103-13. 1997.... - Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptidesW Chen
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Cell 91:789-98. 1997..These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides... - Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C geneM A Whitney
Department of Molecular and Medical Genetics, Vollum Institute, Oregon Regional Primate Center, Portland, USA
Blood 88:49-58. 1996..Progenitor cells from fac knock-out mice were hypersensitive to interferon gamma. This previously unrecognized phenotype may form the basis for BM failure in human FA... - The effect of naloxone on operant behavior for food reinforcers in DBA/2 miceM D Hayward
The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Brain Res Bull 56:537-43. 2001..These data suggest that opioids specifically influence consumatory behavior in mice, but our findings on instrumental behavior were confounded by an independent inhibitory effect of an i.p. saline injection... - Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2S C Coste
Departments of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
Nat Genet 24:403-9. 2000..Moreover, Crhr2-/- mice have elevated basal blood pressure, demonstrating that Crhr2 participates in cardiovascular homeostasis. Our results identify specific responses in the brain and periphery that involve Crhr2... - GH in the dwarf dopaminergic D2 receptor knockout mouse: somatotrope population, GH release, and responsiveness to GH-releasing factors and somatostatinIsabel Garcia-Tornadú
Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET and University of Buenos Aires, V Obligado 2490, 1428 Buenos Aires, Argentina
J Endocrinol 190:611-9. 2006..Our data also reveal that somatotrope cell number is much more sensitive to changes in neonatal GHRH input than their capacity to develop properly regulated GH-secretory function... - Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in miceVictoria B Risbrough
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0804, USA
Neuropsychopharmacology 31:2349-58. 2006..More specifically, D1 receptor activation appears to modify the type of activity (linear vs circumscribed), whereas D2 receptor activation appears to contribute to the repetitive circling behavior produced by MDMA... - Dopaminergic D2 receptor knockout mouse: an animal model of prolactinomaCarolina Cristina
, Vuelta de Obligado 1490, 1428 Buenos Aires, Argentina
Front Horm Res 35:50-63. 2006..The D2R knockout mouse represents a unique animal model to study dopamine-resistant prolactinomas, and VEGF-A may be an alternative therapeutic target in this pathology... - Reduced basal and ethanol stimulation of striatal extracellular dopamine concentrations in dopamine D2 receptor knockout miceMartin O Job
The University of Texas at Austin, PHAR Pharmacology, Austin, Texas 78712, USA
Synapse 60:158-64. 2006..In addition, the blunted ethanol-evoked DA response in the D2 knockouts may contribute, in part, to some of the behavioral deficits previously observed in response to ethanol... - Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fearTomas L Falzone
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular CONICET and Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Eur J Neurosci 15:158-64. 2002.... - Heightened seizure severity in somatostatin knockout micePaul S Buckmaster
Department of Comparative Medicine, Stanford University, 300 Pasteur Drive, R102 Edwards Building, MC 5330, Stanford, CA 94305 5330, USA
Epilepsy Res 48:43-56. 2002.... - Central serotonin and melanocortin pathways regulating energy homeostasisLora K Heisler
Departments of Medicine and Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 994:169-74. 2003..The data reviewed in this paper incorporate the central 5-HT system to the growing list of metabolic signals that converge on melanocortin neurons in the hypothalamus... - Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergenceViviana F Bumaschny
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
Mol Endocrinol 21:2738-49. 2007.... 
Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin geneAndrea M Santangelo
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
PLoS Genet 3:1813-26. 2007..Together, our results provide clear evidence of the functional novelties that transposed elements contributed to their host genomes throughout evolution...- Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasisLijie Gong
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 550 East Canfield, Detroit, MI 48201, USA
Endocrinology 149:3346-54. 2008..We conclude that Stat3 in Agrp/Npy neurons is required for normal energy homeostasis, but Stat3 signaling in other brain areas also contributes to the regulation of energy homeostasis... - Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptorsIzhak Nir
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
J Neurosci 22:2063-73. 2002..These findings indicate that dopamine D4 receptors normally play a major role in regulating photoreceptor cAMP metabolism and adaptive retinal responses to changing environmental illumination... - Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out miceGreg I Elmer
Neuroscience Program, Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
J Neurosci 22:RC224. 2002..Under this range of doses and response requirements, the rewarding effects of morphine appear to depend critically on an intact D2 receptor system... - Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-IYe Lauren Liu
Fraser Laboratories, Department of Medicine, Royal Victoria Hospital, McGill University, M3 15, 687 Pine Avenue West, Quebec, H3A 1A1, Montreal, Canada
Mol Cell Endocrinol 189:97-103. 2002..Our results support a role of ghrelin in growth/metabolism in juvenile and young adult mice of both sexes and in sexually dimorphic regulation of GH secretion in aged mice... - Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant miceJonathan L Katz
Medications Discovery Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA
Psychopharmacology (Berl) 170:108-14. 2003..However, given the lack of selectivity of most of the available pharmacological tools among D(2), D(3) and D(4) dopamine receptors, the roles of these specific receptors remain unclear... - Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neuronsDiego M Gelman
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas and Departmento de Fisiología, Biologia Molecular y Celular, Universidad de Buenos Aires, Argentina
Genesis 36:196-202. 2003..Therefore, we have generated a valuable transgenic mouse strain to induce specific mutations of "floxed" genes in catecholaminergic neurons... - Treatment of Helicobacter gastritis with IL-4 requires somatostatinYana Zavros
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:12944-9. 2003..Thus, a mechanism by which IL-4 resolves inflammation in the stomach is by stimulating the release of SOM from gastric D cells... - Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"Katsunori Tomiyama
Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland
Synapse 51:71-81. 2004..D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements... - The mapping of quantitative trait loci underlying strain differences in locomotor activity between 129S6 and C57BL/6J miceMichele A Kelly
HHMI and Dept Molecular Genetics, The University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9050, USA
Mamm Genome 14:692-702. 2003.... - Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalkMarcelo Paez-Pereda
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
Proc Natl Acad Sci U S A 100:1034-9. 2003..This previously undescribed prolactinoma pathogenesis mechanism may participate in tumorigenicity in other cells where estrogens and the type beta transforming growth factor family have important roles... - Increased splenocyte proliferative response and cytokine production in beta-endorphin-deficient miceDamian Refojo
Laboratorio de Fisiologia y Biologia Molecular, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales FCEN, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, C1428EHA, Buenos Aires, Argentina
J Neuroimmunol 131:126-34. 2002..These results are consistent with a postulated inhibitory role of endogenous beta-endorphin on the immune system at multiple levels... - Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out miceRebecca J Ralph-Williams
Alcohol and Drug Abuse Research Center, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 22:9604-11. 2002..These findings emphasize that further cross-species comparisons of the pharmacology of PPI are essential to understand the relevance of rodent PPI studies to the deficits in PPI observed in patients with schizophrenia... - Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant miceAllison L Chausmer
Psychobiology Section, National Institute on Drug Abuse, Intramural Research Program, National Institute of Health, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 163:54-61. 2002..Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear... - Gut hormone PYY(3-36) physiologically inhibits food intakeRachel L Batterham
Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
Nature 418:650-4. 2002..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway... - Brain somatostatin receptors are up-regulated in somatostatin-deficient miceJose L Ramirez
Fraser Laboratories, Department of Medicine, McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada, H3A 1A1
Mol Endocrinol 16:1951-63. 2002..SST-like immunoreactivity, however, was induced in the proximal midgut in SSTKO animals, suggesting intestinal expression of a novel SST-like gene... - Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic backgroundAndrzej Slominski
Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
Endocrinology 146:1245-53. 2005..Whereas the latter implies feedback control of melanogenesis, it is also possible that the two mechanisms operate jointly in hair follicles... - Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprintingFlavio S J de Souza
INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Mol Cell Biol 25:3076-86. 2005..Our study advances the understanding of the molecular nature of hypothalamic POMC neurons and will be useful to determine whether polymorphisms in POMC regulatory regions play a role in the predisposition to obesity... - Activation of central melanocortin pathways by fenfluramineLora K Heisler
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Science 297:609-11. 2002..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments... - Thrittene, homologous with somatostatin-28((1-13)), is a novel peptide in mammalian gut and circulationJohn W Ensinck
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle 98195, USA
Endocrinology 143:2599-609. 2002..Its localization in both GI endocrine cells and gut neurons suggests that thrittene may function as both a hormone and neurotransmitter... - Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gatingChristiaan H Vinkers
Department of Psychopharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Pharmacol Biochem Behav 86:550-8. 2007..These results indicate that neither D(1)- nor D(2)-receptor activation is necessary for CRF to exert its effects on acoustic startle and PPI in mice... - Subfunctionalization of expression and peptide domains following the ancient duplication of the proopiomelanocortin gene in teleost fishesFlavio S J de Souza
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, CONICET, FCEyN, Universidad de Buenos Aires, Argentina
Mol Biol Evol 22:2417-27. 2005..The study of regulatory regions of fish POMC genes might shed light on the mechanisms of enhancer partitioning between duplicate genes, as well as the roles of POMC-derived peptides in fish physiology...
Research Grants
- Operant Responding in Opioid-Deficient MiceMalcolm Low; Fiscal Year: 2004..abstract_text> ..