Jau Shin Lou

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Levodopa improves physical fatigue in Parkinson's disease: a double-blind, placebo-controlled, crossover study
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Mov Disord 18:1108-14. 2003
  2. pmc Effect of expectancy and personality on cortical excitability in Parkinson's disease
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Mov Disord 28:1257-62. 2013
  3. doi request reprint Techniques in assessing fatigue in neuromuscular diseases
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Phys Med Rehabil Clin N Am 23:11-22, ix. 2012
  4. doi request reprint Using modafinil to treat fatigue in Parkinson disease: a double-blind, placebo-controlled pilot study
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Clin Neuropharmacol 32:305-10. 2009
  5. doi request reprint Correlates of quality of life in ALS: Lessons from the minocycline study
    Jau Shin Lou
    Oregon Health and Science University, Portland, 97239, USA
    Amyotroph Lateral Scler 11:116-21. 2010
  6. doi request reprint Physical and mental fatigue in Parkinson's disease: epidemiology, pathophysiology and treatment
    Jau Shin Lou
    Oregon Health and Science University, Portland, Oregon, USA
    Drugs Aging 26:195-208. 2009
  7. doi request reprint Fatigue in amyotrophic lateral sclerosis
    Jau Shin Lou
    ALS Center of Oregon, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR120, Portland, OR 97239, USA
    Phys Med Rehabil Clin N Am 19:533-43, ix. 2008
  8. ncbi request reprint Exacerbated physical fatigue and mental fatigue in Parkinson's disease
    J S Lou
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mov Disord 16:190-6. 2001
  9. ncbi request reprint Approaching fatigue in neuromuscular diseases
    Jau Shin Lou
    MDA Clinic, ALS Center of Oregon, EMG Laboratory, and Department of Neurology, CR120, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97234, USA
    Phys Med Rehabil Clin N Am 16:1063-79, xi. 2005
  10. ncbi request reprint Fatigue and depression are associated with poor quality of life in ALS
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland 97201, USA
    Neurology 60:122-3. 2003

Detail Information

Publications25

  1. ncbi request reprint Levodopa improves physical fatigue in Parkinson's disease: a double-blind, placebo-controlled, crossover study
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Mov Disord 18:1108-14. 2003
    ....
  2. pmc Effect of expectancy and personality on cortical excitability in Parkinson's disease
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Mov Disord 28:1257-62. 2013
    ..Expectancy is associated with changes in cortical excitability. Further studies are needed to examine the relationship between personality and placebo effect in Parkinson's patients. © 2013 Movement Disorder Society. ..
  3. doi request reprint Techniques in assessing fatigue in neuromuscular diseases
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Phys Med Rehabil Clin N Am 23:11-22, ix. 2012
    ..Using these techniques to further understand the mechanisms of subjective and physiologic fatigue will help physicians to develop more effective treatments for fatigue and improve patients' quality of life...
  4. doi request reprint Using modafinil to treat fatigue in Parkinson disease: a double-blind, placebo-controlled pilot study
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Clin Neuropharmacol 32:305-10. 2009
    ..Fatigue is a major nonmotor symptom in Parkinson disease(PD). It is associated with reduced activity and lower quality of life...
  5. doi request reprint Correlates of quality of life in ALS: Lessons from the minocycline study
    Jau Shin Lou
    Oregon Health and Science University, Portland, 97239, USA
    Amyotroph Lateral Scler 11:116-21. 2010
    ..01). Our study demonstrated that QoL does decline with advancing ALS in subjects who participated in a minocycline trial, that the slope of QoL predicts survival, and that both NIV and PEG have beneficial impacts on QoL...
  6. doi request reprint Physical and mental fatigue in Parkinson's disease: epidemiology, pathophysiology and treatment
    Jau Shin Lou
    Oregon Health and Science University, Portland, Oregon, USA
    Drugs Aging 26:195-208. 2009
    ..Future fatigue research should focus on developing gold standards for fatigue measurement and developing treatments for fatigue and fatigability in PD...
  7. doi request reprint Fatigue in amyotrophic lateral sclerosis
    Jau Shin Lou
    ALS Center of Oregon, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR120, Portland, OR 97239, USA
    Phys Med Rehabil Clin N Am 19:533-43, ix. 2008
    ..Palliative care measures, such as noninvasive ventilation and high-frequency chest wall oscillation, may also reduce fatigue...
  8. ncbi request reprint Exacerbated physical fatigue and mental fatigue in Parkinson's disease
    J S Lou
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mov Disord 16:190-6. 2001
    ..To characterize fatigue in Parkinson's disease (PD)...
  9. ncbi request reprint Approaching fatigue in neuromuscular diseases
    Jau Shin Lou
    MDA Clinic, ALS Center of Oregon, EMG Laboratory, and Department of Neurology, CR120, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97234, USA
    Phys Med Rehabil Clin N Am 16:1063-79, xi. 2005
  10. ncbi request reprint Fatigue and depression are associated with poor quality of life in ALS
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, Portland 97201, USA
    Neurology 60:122-3. 2003
    ..Fatigue, depression, and excessive somnolence are more pronounced in ALS subjects than in normal controls. Both fatigue and depression are associated with poorer quality of life in subjects with ALS, and should be treated aggressively...
  11. ncbi request reprint Levodopa normalizes exercise related cortico-motoneuron excitability abnormalities in Parkinson's disease
    Jau Shin Lou
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code CR120, Portland 97201, USA
    Clin Neurophysiol 114:930-7. 2003
    ..To measure exercise induced changes in cortico-motoneuron excitability in Parkinson's disease (PD) before and after levodopa...
  12. ncbi request reprint Quantitative electromyography of the anal sphincter after uncomplicated vaginal delivery
    W Thomas Gregory
    Division of Urogynecology and Reconstructive Pelvic Surgery and Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Obstet Gynecol 104:327-35. 2004
    ..We performed quantitative electromyography (EMG) to compare multiple motor unit action potential parameters between recently postpartum women and nulliparous women...
  13. ncbi request reprint Hand coordination as a quantitative measure of motor abnormality and therapeutic response in Parkinson's disease
    Ted S Benice
    Department of Neurology, CR 120, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, United States
    Clin Neurophysiol 118:1776-84. 2007
    ..We designed this study to investigate if the PGLT outcome variables correlate with the UPDRS motor scores and if all PGLT outcome variables are "responsive" to levodopa...
  14. doi request reprint Assessment and management of fatigue in neuromuscular disease
    Jau Shin Lou
    Oregon Health and Science University, Portland, USA
    Am J Hosp Palliat Care 27:145-57. 2010
    ..Nutraceutical agents, such as creatine monohydrate, coenzyme Q10 (CoQ10), and alpha-lipoic acid, may also improve neuromuscular function and reduce fatigue...
  15. ncbi request reprint Anal sphincter electromyography: editing of sampled motor unit action potentials
    W Thomas Gregory
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Mail code L466, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Muscle Nerve 31:256-9. 2005
    ..Editing of selected EAS MUAPs during multi-MUAP analysis is required, and development of common protocols is essential to enable meaningful comparisons between similar studies...
  16. pmc Quantitative anal sphincter electromyography in primiparous women with anal incontinence
    W Thomas Gregory
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
    Am J Obstet Gynecol 198:550.e1-6. 2008
    ..The purpose of this study was to determine whether evidence of denervation/reinnervation of the external anal sphincter is associated with anal incontinence symptoms immediately after delivery...
  17. doi request reprint A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS
    Paul H Gordon
    Department of Neurology, Columbia University, New York, USA
    Amyotroph Lateral Scler 9:212-22. 2008
    ..This phase II design was efficient, leading to treatment selection after just 60 patients, and can be used in other phase II trials to assess different agents...
  18. doi request reprint A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor
    Valerie C Anderson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97236, USA
    Neurosci Lett 462:166-70. 2009
    ..That timing regularity is improved ipsilateral to the stimulated thalamus provides evidence that DBS influences a widespread neural network involved in timing of simple repetitive movements...
  19. ncbi request reprint Purposes of AAC device use for persons with ALS as reported by caregivers
    Melanie Fried-Oken
    Oregon Health and Science University, Oregon Institute on Disability and Development, P O Box 574, Portland, OR 97207, USA
    Augment Altern Commun 22:209-21. 2006
    ..Clinical and research implications are discussed...
  20. doi request reprint Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect
    Erik P Pioro
    Section of ALS and Related Disorders, Department of Neurology, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Neurol 68:693-702. 2010
    ..To evaluate dextromethorphan combined with ultra low-dose quinidine (DMq) for treating pseudobulbar affect (PBA) in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS)...
  21. pmc Determining the shape of the turns-amplitude cloud during anal sphincter quantitative EMG
    W Thomas Gregory
    Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR 97239, USA
    Int Urogynecol J Pelvic Floor Dysfunct 19:971-6. 2008
    ..5, slope = 0.3, and resultant cloud of raw data has a convex upper boundary. These appear slightly different than previously published reports, potentially influencing the determination of normal and abnormal studies...
  22. pmc Creatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRS
    Jeffrey Rosenfeld
    The Carolinas Neuromuscular ALS Center, Charlotte North Carolina, Carolinas Medical Center, USA
    Amyotroph Lateral Scler 9:266-72. 2008
    ..The trend toward improved survival was also found in another recently completed blinded trial using creatine monohydrate. Further investigation on the possible survival benefit of creatine in this patient population is ongoing...
  23. ncbi request reprint Modafinil to treat fatigue in amyotrophic lateral sclerosis: an open label pilot study
    Gregory T Carter
    Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Hosp Palliat Care 22:55-9. 2005
    ..1 (SD 5.4), with p < 0.01. This pilot study suggests that modafinil is well-tolerated and may reduce symptoms of fatigue in ALS. Further blinded, controlled studies of modafinil in larger numbers of ALS patients are warranted...
  24. pmc Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery
    Katrina Gwinn
    National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1254. 2007
    ..This resource should facilitate genetic discoveries which we anticipate will ultimately provide a better understanding of the biological mechanisms of neurodegeneration in ALS...
  25. ncbi request reprint Fatigue in Parkinson's disease: a review
    Joseph H Friedman
    NeuroHealth, Warwick, Rhode Island 02886, USA
    Mov Disord 22:297-308. 2007
    ..This article reviews what is known about the symptom, putting it into the context of fatigue in other disorders, and outlines a program for developing better understanding and therapy...

Research Grants2

  1. Transcranial Magnetic Stimulation and Neuromodulation
    Jau Shin Lou; Fiscal Year: 2003
    ..The results will provide us with vital information that will allow us to further develop rTMS as a noninvasive therapeutic modality for PD. ..
  2. Centella asiatica triterpene extract for diabetic neuropathy - a pilot study
    Jau Shin Lou; Fiscal Year: 2007
    ..This project evaluates a product derived from the herb Centella asiatica, as a potential cure for this distressing, presently irreversible, condition. ..