Alejandro Lomniczi

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Epigenetic control of female puberty
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA
    Nat Neurosci 16:281-9. 2013
  2. pmc A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Neuroscience, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 153:339-49. 2012
  3. pmc A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Horm Behav 64:175-86. 2013
  4. ncbi request reprint Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon, Health and Science University, Beaverton, 97006, USA
    Int J Androl 29:256-63; discussion 286-90. 2006
  5. ncbi request reprint Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty
    Christian L Roth
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Endocrinology 148:5147-61. 2007
  6. pmc Hypothalamic EAP1 (enhanced at puberty 1) is required for menstrual cyclicity in nonhuman primates
    Gregory A Dissen
    Division of Neuroscience, Oregon National Primate Research Center, 505 North West 185th Avenue, Beaverton, Oregon 97006 3448, USA
    Endocrinology 153:350-61. 2012
  7. ncbi request reprint Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 147:1166-74. 2006
  8. ncbi request reprint Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 26:51-62. 2006
  9. ncbi request reprint erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function
    Vincent Prevot
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Sciences Unversity, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 146:1465-72. 2005
  10. ncbi request reprint The neurobiology of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Ore 97006, USA
    Horm Res 60:15-20. 2003

Collaborators

Detail Information

Publications21

  1. pmc Epigenetic control of female puberty
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon, USA
    Nat Neurosci 16:281-9. 2013
    ..Our results identify epigenetic silencing as a mechanism underlying the neuroendocrine control of female puberty...
  2. pmc A single-nucleotide polymorphism in the EAP1 gene is associated with amenorrhea/oligomenorrhea in nonhuman primates
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Neuroscience, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 153:339-49. 2012
    ..They also raise the possibility that polymorphisms in EAP1 may increase the risk of functional hypothalamic amenorrhea in humans...
  3. pmc A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Horm Behav 64:175-86. 2013
    ..The integrative response of these gene networks to external inputs is postulated to be coordinated by epigenetic mechanisms. ..
  4. ncbi request reprint Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon, Health and Science University, Beaverton, 97006, USA
    Int J Androl 29:256-63; discussion 286-90. 2006
    ....
  5. ncbi request reprint Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty
    Christian L Roth
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Endocrinology 148:5147-61. 2007
    ..TRGs may be expressed in the mammalian hypothalamus as components of a regulatory gene network that facilitates and integrates cellular and cell-cell communication programs required for the acquisition of female reproductive competence...
  6. pmc Hypothalamic EAP1 (enhanced at puberty 1) is required for menstrual cyclicity in nonhuman primates
    Gregory A Dissen
    Division of Neuroscience, Oregon National Primate Research Center, 505 North West 185th Avenue, Beaverton, Oregon 97006 3448, USA
    Endocrinology 153:350-61. 2012
    ....
  7. ncbi request reprint Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 147:1166-74. 2006
    ....
  8. ncbi request reprint Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain
    Alejandro Lomniczi
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 26:51-62. 2006
    ..These results suggest that TACE is a component of the neuron-to-glia signaling process used by glutamatergic neurons to control female sexual development...
  9. ncbi request reprint erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function
    Vincent Prevot
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Sciences Unversity, 505 Northwest 185th Avenue, Beaverton, Oregon 97006, USA
    Endocrinology 146:1465-72. 2005
    ..Thus, a coordinated involvement of erbB-1 and erbB-4 signaling systems is required for the normalcy of sexual development and the maintenance of mature female reproductive function...
  10. ncbi request reprint The neurobiology of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Ore 97006, USA
    Horm Res 60:15-20. 2003
    ..A neuron-to-glia signaling pathway mediated by excitatory amino acids serves to coordinate the simultaneous activation of transsynaptic and glia-to-neuron communication required for the advent of sexual maturity...
  11. pmc Gene networks and the neuroendocrine regulation of puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon, Health and Science University, 505 N W 185th Avenue, Beaverton, OR, USA
    Mol Cell Endocrinol 324:3-11. 2010
    ....
  12. pmc The transcriptional control of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Brain Res 1364:164-74. 2010
    ..More recently, we have begun to explore the concept that a more dynamic and encompassing level of integrative coordination is provided by epigenetic mechanisms...
  13. ncbi request reprint Neuron-to-glia signaling mediated by excitatory amino acid receptors regulates ErbB receptor function in astroglial cells of the neuroendocrine brain
    Barbara Dziedzic
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 23:915-26. 2003
    ....
  14. ncbi request reprint Glia-to-neuron signaling and the neuroendocrine control of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Ann Med 35:244-55. 2003
    ..A different--and perhaps higher--level of control may involve the transcriptional regulation of subordinate genes that, by contributing to neuroendocrine maturation, are required for the initiation of the pubertal process...
  15. pmc Contribution of glial-neuronal interactions to the neuroendocrine control of female puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health Sciences University, 505 N W, 185th Avenue, Beaverton, OR 97006, USA
    Eur J Neurosci 32:2003-10. 2010
    ..These findings indicate that the interaction of glial cells with GnRH neurons involves not only secreted bioactive molecules, but also cell-surface adhesive proteins able to set in motion intracellular signaling cascades...
  16. doi request reprint New concepts on the control of the onset of puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oreg, USA
    Endocr Dev 17:44-51. 2010
    ..These observations suggest that the genetic underpinnings of puberty are polygenic rather than specified by a single gene, and that epigenetic mechanisms may provide coordination and transcriptional plasticity to this genetic network...
  17. ncbi request reprint Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty
    Christian L Roth
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Mol Cell Endocrinol 254:51-9. 2006
    ..Thus, an increase excitatory drive to the LHRH neuronal network provided by glutamatergic inputs of glial origin, is an event contributing to the pubertal activation of LHRH secretion...
  18. pmc In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles
    Gregory A Dissen
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, OR 97006 3448, USA
    Methods 49:70-7. 2009
    ..Finally, we describe in detail the lentiviral vector production protocol we use and provide examples of how the vector can be employed to target peripheral tissues and the brain...
  19. pmc An alternative transcription start site yields estrogen-unresponsive kiss1 mRNA transcripts in the hypothalamus of prepubertal female rats
    Juan Manuel Castellano
    Division of Neuroscience, Oregon National Primate Research Center Oregon Health and Science University, Beaverton, Oreg, USA
    Neuroendocrinology 99:94-107. 2014
    ..2014 S. Karger AG, Basel. ..
  20. ncbi request reprint Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes
    Vincent Prevot
    Division of Neuroscience, Oregon Regional Primate Research Center Oregon Health Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 23:230-9. 2003
    ..Thus, neuron-astroglia communication via NRG-erbB4/2 receptor signaling appears to be essential for the timely unfolding of the developmental program by which the brain controls mammalian sexual maturation...
  21. doi request reprint Puberty in 2013: Unravelling the mystery of puberty
    Sergio R Ojeda
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Nat Rev Endocrinol 10:67-9. 2014
    ..It was also discovered that nutritional deprivation delays puberty by repressing reproductive neuroendocrine function...