Alfred Lewy

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint The dim light melatonin onset, melatonin assays and biological rhythm research in humans
    A J Lewy
    Oregon Health Sciences University, Portland, Oreg 97201, USA
    Biol Signals Recept 8:79-83. 1999
  2. pmc The phase shift hypothesis for the circadian component of winter depression
    Alfred J Lewy
    Oregon Health and Science University, Department of Psychiatry, Sleep and Mood Disorders Laboratory, Portland, Oregon, USA
    Dialogues Clin Neurosci 9:291-300. 2007
  3. ncbi request reprint Current understanding and future implications of the circadian uses of melatonin, a neurohormone discovered by Aaron B. Lerner
    Alfred J Lewy
    Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
    J Invest Dermatol 127:2082-5. 2007
  4. ncbi request reprint Circadian uses of melatonin in humans
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, Oregon 97239, USA
    Chronobiol Int 23:403-12. 2006
  5. pmc The circadian basis of winter depression
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:7414-9. 2006
  6. ncbi request reprint Melatonin entrains free-running blind people according to a physiological dose-response curve
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Chronobiol Int 22:1093-106. 2005
  7. ncbi request reprint Eventual entrainment of the human circadian pacemaker by melatonin is independent of the circadian phase of treatment initiation: clinical implications
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
    J Biol Rhythms 19:68-75. 2004
  8. ncbi request reprint Circadian misalignment in mood disturbances
    Alfred J Lewy
    Oregon Health and Science University, 3181 Southwest Sam Jackson Road, Portland, OR 97239, USA
    Curr Psychiatry Rep 11:459-65. 2009
  9. ncbi request reprint Melatonin treatment of winter depression: a pilot study
    A J Lewy
    Department of Psychiatry, Oregon Health Sciences University, Portland 97201 3098, USA
    Psychiatry Res 77:57-61. 1998
  10. ncbi request reprint Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Neurosci Lett 313:158-60. 2001

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The dim light melatonin onset, melatonin assays and biological rhythm research in humans
    A J Lewy
    Oregon Health Sciences University, Portland, Oreg 97201, USA
    Biol Signals Recept 8:79-83. 1999
    ....
  2. pmc The phase shift hypothesis for the circadian component of winter depression
    Alfred J Lewy
    Oregon Health and Science University, Department of Psychiatry, Sleep and Mood Disorders Laboratory, Portland, Oregon, USA
    Dialogues Clin Neurosci 9:291-300. 2007
    ....
  3. ncbi request reprint Current understanding and future implications of the circadian uses of melatonin, a neurohormone discovered by Aaron B. Lerner
    Alfred J Lewy
    Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
    J Invest Dermatol 127:2082-5. 2007
  4. ncbi request reprint Circadian uses of melatonin in humans
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, Oregon 97239, USA
    Chronobiol Int 23:403-12. 2006
    ....
  5. pmc The circadian basis of winter depression
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:7414-9. 2006
    ..The findings support the phase-shift hypothesis for SAD, as well as suggest a way to assess the circadian component of other psychiatric, sleep, and chronobiologic disorders...
  6. ncbi request reprint Melatonin entrains free-running blind people according to a physiological dose-response curve
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Chronobiol Int 22:1093-106. 2005
    ..Left untreated, their free-running endocrine, metabolic, behavioral, and sleep/wake cycles can be almost as burdensome as not having vision...
  7. ncbi request reprint Eventual entrainment of the human circadian pacemaker by melatonin is independent of the circadian phase of treatment initiation: clinical implications
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
    J Biol Rhythms 19:68-75. 2004
    ..Therefore, it is not essential that circadian phase be ascertained before starting low-dose melatonin treatment of blind people...
  8. ncbi request reprint Circadian misalignment in mood disturbances
    Alfred J Lewy
    Oregon Health and Science University, 3181 Southwest Sam Jackson Road, Portland, OR 97239, USA
    Curr Psychiatry Rep 11:459-65. 2009
    ..Phase-advanced disorders can be treated with bright light in the evening and/or low-dose melatonin in the morning...
  9. ncbi request reprint Melatonin treatment of winter depression: a pilot study
    A J Lewy
    Department of Psychiatry, Oregon Health Sciences University, Portland 97201 3098, USA
    Psychiatry Res 77:57-61. 1998
    ..If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported...
  10. ncbi request reprint Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Neurosci Lett 313:158-60. 2001
    ..Comp. Physiol., 106 (1976) 291-331]...
  11. ncbi request reprint Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin
    A J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, School of Medicine, Oregon Health Sciences University, 3181 S W Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Brain Res 918:96-100. 2001
    ..5 mg initially capture free-running rhythms? Following withdrawal of the stepped-down 0.5 mg dose and consequent release into a free-run, the same three individuals were given 0.5 mg of melatonin de novo. All entrained within a few weeks...
  12. ncbi request reprint Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin
    Alfred J Lewy
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
    Chronobiol Int 20:837-52. 2003
    ....
  13. pmc Phase angle of entrainment in morning- and evening-types under naturalistic conditions
    Jonathan S Emens
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Chronobiol Int 26:474-93. 2009
    ..Specifically, evening types, compared to morning types, had a higher ratio of phase advancing to phase delaying by light. We interpret this as indicating a longer circadian period (tau) in evening types...
  14. ncbi request reprint Relative coordination to unknown "weak zeitgebers" in free-running blind individuals
    Jonathan S Emens
    Sleep and Mood Disorders Laboratory, Department of Psychiatry, Oregon Health and Science University, Portland 97239, USA
    J Biol Rhythms 20:159-67. 2005
    ..Sighted individuals may also be affected by such weak zeitgebers, which may be obscured by the stronger light/dark cycle...
  15. doi request reprint Circadian misalignment in major depressive disorder
    Jonathan Emens
    Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA
    Psychiatry Res 168:259-61. 2009
    ..We sought to determine if misalignment between the timing of sleep and the pacemaker correlated with symptom severity in MDD. Depression severity correlated with circadian misalignment: the more delayed, the more severe the symptoms...
  16. ncbi request reprint Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period
    Alfred J Lewy
    Department of Psychiatry, Oregon Health and Science University, Portland, USA
    Chronobiol Int 19:649-58. 2002
    ..We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve...
  17. pmc Review of disrupted sleep patterns in Smith-Magenis syndrome and normal melatonin secretion in a patient with an atypical interstitial 17p11.2 deletion
    Eilis A Boudreau
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97207, USA
    Am J Med Genet A 149:1382-91. 2009
    ..These two patients are significant because they suggest that the sleep disturbances in SMS cannot be solely attributed to the abnormal diurnal melatonin secretion versus the normal nocturnal pattern...
  18. ncbi request reprint Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals
    John A Schoenhard
    Thromb Haemost 98:479-81. 2007
  19. pmc Measuring melatonin in humans
    Susan Benloucif
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    J Clin Sleep Med 4:66-9. 2008
    ....

Research Grants26

  1. Melatonin Studies of Totally Blind Children
    Alfred Lewy; Fiscal Year: 2006
    ..of melatonin rhythms in blind children provides an opportunity to understand the physiology of the circadian system in children unperturbed by the light/dark cycle - without having to use a temporal isolation facility ..
  2. Melatonin Entrainment of Elderly Blind Free-runners
    Alfred Lewy; Fiscal Year: 2006
    ..The study of blind people provides an opportunity to understand the physiology of the circadian system in humans unperturbed by the light/dark cycle. ..
  3. MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
    Alfred Lewy; Fiscal Year: 2007
    ....
  4. MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
    Alfred Lewy; Fiscal Year: 2009
    ....
  5. Melatonin Studies of Totaly Blind Children
    Alfred Lewy; Fiscal Year: 2009
    ..In a future grant application, we will assess feasibility of a large-scale, multi-center study of melatonin safety and efficacy, which may also be of benefit sighted people with circadian rhythm sleep and mood disorders ..
  6. MELATONIN FOR CIRCADIAN SLEEP DISORDERS IN THE BLIND
    Alfred J Lewy; Fiscal Year: 2010
    ....
  7. PHASE SHIFTING EFFECTS OF MELATONIN IN WINTER DEPRESSION
    Alfred Lewy; Fiscal Year: 2001
    ..The proposed study should further our understanding of light melatonin and biological rhythms in winter depression. ..
  8. Melatonin Studies of Totaly Blind Children
    Alfred J Lewy; Fiscal Year: 2010
    ..In a future grant application, we will assess feasibility of a large-scale, multi-center study of melatonin safety and efficacy, which may also be of benefit sighted people with circadian rhythm sleep and mood disorders ..