DEBORAH LEWINSOHN

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Interferon-gamma release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in children
    Deborah A Lewinsohn
    Division of Infectious Disease, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Curr Opin Pediatr 22:71-6. 2010
  2. ncbi HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, 707 SW Gaines Road, CDRCP, Portland, OR 97201, USA
    Virology 294:13-21. 2002
  3. ncbi Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Respir Crit Care Med 168:1346-52. 2003
  4. ncbi Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities
    D A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland 97239, USA
    Int J Tuberc Lung Dis 8:658-74. 2004
  5. ncbi Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    PLoS ONE 3:e3407. 2008
  6. ncbi Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates
    Luka Cicin-Sain
    Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 184:6739-45. 2010
  7. ncbi HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells
    Amy S Heinzel
    Division of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health Sciences University, Portland, OR 97201, USA
    J Exp Med 196:1473-81. 2002
  8. ncbi The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle
    Jeff E Grotzke
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA
    PLoS Pathog 5:e1000374. 2009
  9. ncbi Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway
    Jeff E Grotzke
    Division of Infectious Diseases, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 185:4336-43. 2010
  10. ncbi Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    PLoS Pathog 3:1240-9. 2007

Research Grants

  1. EVALUATION OF ADOPTIVE T CELL THERAPY FOR HIV
    DEBORAH LEWINSOHN; Fiscal Year: 2002
  2. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2005
  3. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2006

Collaborators

Detail Information

Publications20

  1. ncbi Interferon-gamma release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in children
    Deborah A Lewinsohn
    Division of Infectious Disease, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Curr Opin Pediatr 22:71-6. 2010
    ..Until recently, diagnosis has relied upon the tuberculin skin test (TST). New interferon-gamma release assays (IGRAs) offer improvements over TST, but these tests have not been studied in children until recently...
  2. ncbi HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, 707 SW Gaines Road, CDRCP, Portland, OR 97201, USA
    Virology 294:13-21. 2002
    ..Furthermore, we confirm that HIV-1 Nef is able to provide partial protection from CTL recognition of infected cells. Thus, the inability of CTL to control HIV-1 infection is likely not due to direct inhibition of CTL-mediated apoptosis...
  3. ncbi Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Respir Crit Care Med 168:1346-52. 2003
    ....
  4. ncbi Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities
    D A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland 97239, USA
    Int J Tuberc Lung Dis 8:658-74. 2004
    ..tuberculosis-specific T-cell immunity in children, and potential application to immunodiagnostics and vaccine development will be reviewed...
  5. ncbi Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    PLoS ONE 3:e3407. 2008
    ..The objective of this study was to compare whole blood IFN-gamma production in response to mycobacterial antigens between children and adults in Uganda...
  6. ncbi Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates
    Luka Cicin-Sain
    Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    J Immunol 184:6739-45. 2010
    ..Therefore, our results argue that T cell repertoire constriction and naive cell loss have prognostic value for global immune function in aging primates...
  7. ncbi HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells
    Amy S Heinzel
    Division of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health Sciences University, Portland, OR 97201, USA
    J Exp Med 196:1473-81. 2002
    ..This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis...
  8. ncbi The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle
    Jeff E Grotzke
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA
    PLoS Pathog 5:e1000374. 2009
    ..This is, to our knowledge, the first description of this presentation pathway for an intracellular pathogen. Moreover, these data suggest that HLA-E may play a unique role in the presentation of phagosomal antigens...
  9. ncbi Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway
    Jeff E Grotzke
    Division of Infectious Diseases, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 185:4336-43. 2010
    ..Taken together, these data demonstrate that immunodominant M. tuberculosis CD8(+) Ags are processed and presented using a cytosolic pathway...
  10. ncbi Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
    Deborah A Lewinsohn
    Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
    PLoS Pathog 3:1240-9. 2007
    ..These findings provide an improved understanding of immunodominance in humans and may contribute to a development of an effective TB vaccine and improved immunodiagnostics...
  11. ncbi Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation
    Marielle C Gold
    Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
    PLoS ONE 2:e957. 2007
    ....
  12. ncbi Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes
    Marielle C Gold
    Department of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Pathog 4:e39. 2008
    ..Furthermore, this is the first demonstration of a human innate pathogen-specific alphabetaTCR(+) T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens...
  13. ncbi Interferon-gamma release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients
    Kevin L Winthrop
    Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin J Am Soc Nephrol 3:1357-63. 2008
    ..Outcome measures included the prevalence of positive test results, identification of factors associated with positive results, and test result discordance...
  14. ncbi High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque
    David M Lewinsohn
    Pulmonary and CCM, R and D 11, Portland VA Medical Center, 3710 SW US Veterans Road, Portland, OR 97239, USA
    Microbes Infect 8:2587-98. 2006
    ..In summary, computed tomography scanning in conjunction with immunologic monitoring provides a non-invasive, accurate, and rapid assessment of tuberculosis in the non-human primate...
  15. ncbi Human mucosal associated invariant T cells detect bacterially infected cells
    Marielle C Gold
    Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Biol 8:e1000407. 2010
    ..Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection...
  16. ncbi Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis--specific CD8+ T cells
    Deborah A Lewinsohn
    Division of Pediatric Infectious Diseases, Department of Molecular Microbiology and Immunology, Oregon Health and Science University Portland VA Medical Center, Portland, OR, USA
    Am J Respir Crit Care Med 166:843-8. 2002
    ..The technique will be useful in defining CD8+ T cell antigens and in measuring immunogenicity of tuberculosis vaccines...
  17. ncbi TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease
    David M Lewinsohn
    Division of Pulmonary and Critical Care Medicine, Department of Molecular Microbiology and Immunology, Oregon Health and Science University Portland VA Medical Center, Portland, OR 97201, USA
    Semin Respir Infect 18:320-38. 2003
    ....
  18. ncbi New diagnostic methods for tuberculosis
    Melissa R Nyendak
    Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239, USA
    Curr Opin Infect Dis 22:174-82. 2009
    ..Improvements in the ability to detect latent infection with Mtb, disease associated with Mtb, and strains resistant to commonly used antibiotics are reviewed...
  19. ncbi Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation
    Marielle C Gold
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Pediatr Res 60:34-7. 2006
    ..These results are consistent with the observation that vaccines that effect strong adjuvant activity on dendritic cells can induce protective responses in neonates...
  20. ncbi Immunologic susceptibility of young children to Mycobacterium tuberculosis
    Deborah A Lewinsohn
    Pediatr Res 63:115. 2008

Research Grants6

  1. EVALUATION OF ADOPTIVE T CELL THERAPY FOR HIV
    DEBORAH LEWINSOHN; Fiscal Year: 2002
    ..My long-term goal is to work in an academic medical center as a physician scientist with a primary focus on the immunopathogenesis of HIV infection. ..
  2. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2005
    ..These studies may contribute to a more complete understanding of TB immunity in young children, and hence facilitate the development of an improved TB vaccine for this vulnerable population. ..
  3. Tuberculosis Immunity in Young Children
    DEBORAH LEWINSOHN; Fiscal Year: 2006
    ..These studies may contribute to a more complete understanding of TB immunity in young children, and hence 'facilitate the development of an improved TB vaccine for this vulnerable population. ..