Research Topics
| K Matthew LattalSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zeroK Matthew Lattal
Oregon Health and Science University, Portland, Oregon, USA
Nat Neurosci 16:124-9. 2013..We discuss evidence from behavioral epigenetic approaches that forces a re-evaluation of widely used behavioral definitions of extinction and reconsolidation...
A parametric analysis of factors affecting acquisition and extinction of contextual fear in C57BL/6 and DBA/2 miceK Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Processes 90:49-57. 2012..We describe the implications of our results for behavioral and neurobiological approaches to extinction, and we examine the general challenges in studying extinction in subjects that differ in learning or performance prior to extinction...- Facets of Pavlovian and operant extinctionK Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Processes 90:1-8. 2012..We consider the different roles that theory has played in the development of research on extinction in these preparations and conclude with some attention to applications of extinction... 
Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinctionK Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, OR 97239 3098, USA
Behav Neurosci 121:1125-31. 2007..Molecular and behavioral mechanisms through which this enhanced extinction effect may occur are discussed...- Effects of ethanol on encoding, consolidation, and expression of extinction following contextual fear conditioningK Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Neurosci 121:1280-92. 2007..Together, these results indicate that ethanol affects extinction by acting on multiple learning and performance processes, including attention, memory encoding, and memory expression... - What does it take to demonstrate memory erasure? Theoretical comment on Norrholm et al. (2008)K Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
Behav Neurosci 122:1186-90. 2008..These findings and others discussed in this article demonstrate some of the challenges in making inferences about memory erasure during extinction... - Cellular learning theory: theoretical comment on Cole and McNally (2007)K Matthew Lattal
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
Behav Neurosci 121:1140-3. 2007..This commentary discusses some of the implications of these findings for theoretical and neurobiological approaches to memory, as well as current thinking about the cellular circuitry involved in reward learning and drug abuse... - Extinction: [corrected] does it or doesn't it? The requirement of altered gene activity and new protein synthesisK Matthew Lattal
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
Biol Psychiatry 60:344-51. 2006..We suggest that extinction occurs through the interaction of multiple behavioral and molecular mechanisms... - Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinctionJames M Stafford
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239 3098, USA
Biol Psychiatry 72:25-33. 2012.... - Direct comparisons of the size and persistence of anisomycin-induced consolidation and reconsolidation deficitsJames M Stafford
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Learn Mem 16:494-503. 2009..These experiments showed that when experiences and performance are matched prior to anisomycin injections, consolidation deficits are generally larger and more persistent compared to reconsolidation deficits... - Modafinil reinstates a cocaine conditioned place preference following extinction in ratsRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Brain Res 204:250-3. 2009.... - Double dissociation of amygdala and hippocampal contributions to trace and delay fear conditioningJonathan D Raybuck
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 6:e15982. 2011..We discuss the implications of this surprising finding for current models of the neural circuitry involved in fear conditioning... - Post-retrieval disruption of a cocaine conditioned place preference by systemic and intrabasolateral amygdala beta2- and alpha1-adrenergic antagonistsRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
Learn Mem 16:777-89. 2009..These systemic and site-specific injections, as well as the FOS immunohistochemical analyses, implicate the importance of specific noradrenergic signaling mechanisms within the BLA in post-retrieval plasticity... - A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preferenceRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Neurosci 124:204-10. 2010..These results confirm the involvement of the alpha-adrenergic receptor in extinction processes in both appetitive and aversive preparations... - Methylphenidate enhances extinction of contextual fearAntony D Abraham
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
Learn Mem 19:67-72. 2012..Because MPH is widely used in clinical treatments, these experiments suggest that the drug could be used in combination with behavioral therapies for patients with fear disorders... - Is an epigenetic switch the key to persistent extinction?James M Stafford
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
Neurobiol Learn Mem 96:35-40. 2011..We will review evidence demonstrating extinction enhancements by drugs that target epigenetic mechanisms and will describe some of the challenges that epigenetic approaches face in promoting persistent suppression of memories... - Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigmRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Behav Neurosci 121:156-63. 2007.... - Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuitsJames M Stafford
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
Learn Mem 20:156-63. 2013..These findings demonstrate that behavioral experiences during periods of heightened fear prevent extinction and prolong the conditioned fear response... - Post-conditioning propranolol disrupts cocaine sensitizationRick E Bernardi
Oregon Health and Science University, Department of Behavioral Neuroscience, L470, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States
Pharmacol Biochem Behav 102:515-9. 2012..Rats that failed to show a locomotor response to cocaine during conditioning were not affected by propranolol. We discuss the implications of these findings as they relate to drug conditioning and memory consolidation studies... - Prazosin differentially affects extinction of cocaine conditioned place preference on the basis of dose and initial preferenceRick E Bernardi
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
Neuroreport 23:1048-51. 2012.... - Effects of D-cycloserine on extinction and reconditioning of ethanol-seeking behavior in micePeter A Groblewski
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon
Alcohol Clin Exp Res 33:772-82. 2009..Thus, the current experiments examined the effects of DCS on the extinction and subsequent reconditioning of ethanol-induced CPP in mice... - Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with timeK Matthew Lattal
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:4667-72. 2004..These results suggest that anisomycin injections after retrieval do not retroactively affect the memory from conditioning... - Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preferenceK Matthew Lattal
Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
Behav Brain Res 153:327-39. 2004..These findings suggest that acquisition and extinction may involve different molecular processes, and they do not support the idea that brief extinction trials induce a protein synthesis-dependent reconsolidation phase of spatial memory... - Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinctionCarolina Isiegas
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 26:12700-7. 2006..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear... - Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activationChristopher G Vecsey
Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
J Neurosci 27:6128-40. 2007..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex... - Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced trainingMatthew T Scharf
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA
J Neurophysiol 87:2770-7. 2002.... - Extinction, renewal, and spontaneous recovery of a spatial preference in the water mazeK Matthew Lattal
Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
Behav Neurosci 117:1017-28. 2003..Implications of these findings for theories of spatial learning and hippocampal function are discussed...
Research Grants
- Mechanisms of Appetitive and Aversive Context LearningKENNON LATTAL; Fiscal Year: 2005..These experiments will lay the groundwork for a research program that is focused on asking questions about the nature of specific contextual associations in learning and memory. ..
- Temporal factors in extinction and spontaneous recoveryKENNON LATTAL; Fiscal Year: 2007....
- Behavioral and Epigenetic Mechanisms in Extinction of Cocaine-Induced MemoriesMARCELO ANDRES WOOD; Fiscal Year: 2010..In this project, we examine behavioral and pharmacological interventions in a mouse model of cocaine seeking that may help reverse cocaine seeking and reduce relapse. ..
- Temporal factors in extinction and spontaneous recoveryKENNON MATTHEW LATTAL; Fiscal Year: 2010....