K Matthew Lattal

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero
    K Matthew Lattal
    Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 16:124-9. 2013
  2. pmc A parametric analysis of factors affecting acquisition and extinction of contextual fear in C57BL/6 and DBA/2 mice
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Processes 90:49-57. 2012
  3. pmc Facets of Pavlovian and operant extinction
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Processes 90:1-8. 2012
  4. ncbi request reprint Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, OR 97239 3098, USA
    Behav Neurosci 121:1125-31. 2007
  5. ncbi request reprint Effects of ethanol on encoding, consolidation, and expression of extinction following contextual fear conditioning
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 121:1280-92. 2007
  6. pmc What does it take to demonstrate memory erasure? Theoretical comment on Norrholm et al. (2008)
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Neurosci 122:1186-90. 2008
  7. ncbi request reprint Cellular learning theory: theoretical comment on Cole and McNally (2007)
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Behav Neurosci 121:1140-3. 2007
  8. pmc Extinction: [corrected] does it or doesn't it? The requirement of altered gene activity and new protein synthesis
    K Matthew Lattal
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biol Psychiatry 60:344-51. 2006
  9. pmc Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction
    James M Stafford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239 3098, USA
    Biol Psychiatry 72:25-33. 2012
  10. pmc Modafinil reinstates a cocaine conditioned place preference following extinction in rats
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 204:250-3. 2009

Collaborators

Detail Information

Publications32

  1. pmc Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero
    K Matthew Lattal
    Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 16:124-9. 2013
    ..We discuss evidence from behavioral epigenetic approaches that forces a re-evaluation of widely used behavioral definitions of extinction and reconsolidation...
  2. pmc A parametric analysis of factors affecting acquisition and extinction of contextual fear in C57BL/6 and DBA/2 mice
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Processes 90:49-57. 2012
    ..We describe the implications of our results for behavioral and neurobiological approaches to extinction, and we examine the general challenges in studying extinction in subjects that differ in learning or performance prior to extinction...
  3. pmc Facets of Pavlovian and operant extinction
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Processes 90:1-8. 2012
    ..We consider the different roles that theory has played in the development of research on extinction in these preparations and conclude with some attention to applications of extinction...
  4. ncbi request reprint Systemic or intrahippocampal delivery of histone deacetylase inhibitors facilitates fear extinction
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, OR 97239 3098, USA
    Behav Neurosci 121:1125-31. 2007
    ..Molecular and behavioral mechanisms through which this enhanced extinction effect may occur are discussed...
  5. ncbi request reprint Effects of ethanol on encoding, consolidation, and expression of extinction following contextual fear conditioning
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 121:1280-92. 2007
    ..Together, these results indicate that ethanol affects extinction by acting on multiple learning and performance processes, including attention, memory encoding, and memory expression...
  6. pmc What does it take to demonstrate memory erasure? Theoretical comment on Norrholm et al. (2008)
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Behav Neurosci 122:1186-90. 2008
    ..These findings and others discussed in this article demonstrate some of the challenges in making inferences about memory erasure during extinction...
  7. ncbi request reprint Cellular learning theory: theoretical comment on Cole and McNally (2007)
    K Matthew Lattal
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Behav Neurosci 121:1140-3. 2007
    ..This commentary discusses some of the implications of these findings for theoretical and neurobiological approaches to memory, as well as current thinking about the cellular circuitry involved in reward learning and drug abuse...
  8. pmc Extinction: [corrected] does it or doesn't it? The requirement of altered gene activity and new protein synthesis
    K Matthew Lattal
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Biol Psychiatry 60:344-51. 2006
    ..We suggest that extinction occurs through the interaction of multiple behavioral and molecular mechanisms...
  9. pmc Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction
    James M Stafford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239 3098, USA
    Biol Psychiatry 72:25-33. 2012
    ....
  10. pmc Modafinil reinstates a cocaine conditioned place preference following extinction in rats
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 204:250-3. 2009
    ....
  11. pmc Direct comparisons of the size and persistence of anisomycin-induced consolidation and reconsolidation deficits
    James M Stafford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Learn Mem 16:494-503. 2009
    ..These experiments showed that when experiences and performance are matched prior to anisomycin injections, consolidation deficits are generally larger and more persistent compared to reconsolidation deficits...
  12. pmc The histone deacetylase inhibitor sodium butyrate modulates acquisition and extinction of cocaine-induced conditioned place preference
    Jonathan D Raybuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Mail code L470 Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 106:109-16. 2013
    ....
  13. pmc Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits
    James M Stafford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Learn Mem 20:156-63. 2013
    ..These findings demonstrate that behavioral experiences during periods of heightened fear prevent extinction and prolong the conditioned fear response...
  14. pmc Double dissociation of amygdala and hippocampal contributions to trace and delay fear conditioning
    Jonathan D Raybuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e15982. 2011
    ..We discuss the implications of this surprising finding for current models of the neural circuitry involved in fear conditioning...
  15. pmc Post-retrieval disruption of a cocaine conditioned place preference by systemic and intrabasolateral amygdala beta2- and alpha1-adrenergic antagonists
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA
    Learn Mem 16:777-89. 2009
    ..These systemic and site-specific injections, as well as the FOS immunohistochemical analyses, implicate the importance of specific noradrenergic signaling mechanisms within the BLA in post-retrieval plasticity...
  16. pmc A role for alpha-adrenergic receptors in extinction of conditioned fear and cocaine conditioned place preference
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 124:204-10. 2010
    ..These results confirm the involvement of the alpha-adrenergic receptor in extinction processes in both appetitive and aversive preparations...
  17. doi request reprint Prazosin differentially affects extinction of cocaine conditioned place preference on the basis of dose and initial preference
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Neuroreport 23:1048-51. 2012
    ....
  18. pmc Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival
    Jianming Wang
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 33:1574-81. 2013
    ..Switching microglial gene expression toward a neuroprotective phenotype is a promising new therapeutic approach for ischemic brain injury. ..
  19. pmc Methylphenidate enhances extinction of contextual fear
    Antony D Abraham
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239, USA
    Learn Mem 19:67-72. 2012
    ..Because MPH is widely used in clinical treatments, these experiments suggest that the drug could be used in combination with behavioral therapies for patients with fear disorders...
  20. ncbi request reprint Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm
    Rick E Bernardi
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Neurosci 121:156-63. 2007
    ....
  21. pmc Is an epigenetic switch the key to persistent extinction?
    James M Stafford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Neurobiol Learn Mem 96:35-40. 2011
    ..We will review evidence demonstrating extinction enhancements by drugs that target epigenetic mechanisms and will describe some of the challenges that epigenetic approaches face in promoting persistent suppression of memories...
  22. pmc Post-conditioning propranolol disrupts cocaine sensitization
    Rick E Bernardi
    Oregon Health and Science University, Department of Behavioral Neuroscience, L470, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, United States
    Pharmacol Biochem Behav 102:515-9. 2012
    ..Rats that failed to show a locomotor response to cocaine during conditioning were not affected by propranolol. We discuss the implications of these findings as they relate to drug conditioning and memory consolidation studies...
  23. doi request reprint Bridging the interval: theory and neurobiology of trace conditioning
    Jonathan D Raybuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, United States Electronic address
    Behav Processes 101:103-11. 2014
    ....
  24. doi request reprint Dopamine and extinction: a convergence of theory with fear and reward circuitry
    Antony D Abraham
    Department of Behavioral Neuroscience, Oregon Health and Science University, United States
    Neurobiol Learn Mem 108:65-77. 2014
    ..At a behavioral level, we describe theories of learning and dopamine function that could describe the fundamental rules underlying how dopamine modulates different aspects of learning and memory processes. ..
  25. doi request reprint Cue configuration effects in acquisition and extinction of a cocaine-induced place preference
    Leah N Hitchcock
    Department of Behavioral Neuroscience, Oregon Health and Science University
    Behav Neurosci 128:217-27. 2014
    ..The use of different CPP configurations may distinguish the underlying substrates and relevant cues for acquisition and extinction processes in cocaine abuse. (PsycINFO Database Record (c) 2014 APA, all rights reserved). ..
  26. pmc Effects of D-cycloserine on extinction and reconditioning of ethanol-seeking behavior in mice
    Peter A Groblewski
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon
    Alcohol Clin Exp Res 33:772-82. 2009
    ..Thus, the current experiments examined the effects of DCS on the extinction and subsequent reconditioning of ethanol-induced CPP in mice...
  27. pmc Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation
    Christopher G Vecsey
    Neuroscience Graduate Group, University of Pennsylvania, 19104, USA
    J Neurosci 27:6128-40. 2007
    ..Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex...
  28. pmc Transgenic inhibition of neuronal protein kinase A activity facilitates fear extinction
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:12700-7. 2006
    ..Further, these experiments represent the first genetic evidence that protein kinases may be constraints for the extinction of fear...
  29. ncbi request reprint Effects of post-session injections of anisomycin on the extinction of a spatial preference and on the acquisition of a spatial reversal preference
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Behav Brain Res 153:327-39. 2004
    ..These findings suggest that acquisition and extinction may involve different molecular processes, and they do not support the idea that brief extinction trials induce a protein synthesis-dependent reconsolidation phase of spatial memory...
  30. pmc Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:4667-72. 2004
    ..These results suggest that anisomycin injections after retrieval do not retroactively affect the memory from conditioning...
  31. ncbi request reprint Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training
    Matthew T Scharf
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104 6018, USA
    J Neurophysiol 87:2770-7. 2002
    ....
  32. ncbi request reprint Extinction, renewal, and spontaneous recovery of a spatial preference in the water maze
    K Matthew Lattal
    Department of Biology, University of Pennsylvania, 3740 Hamilton Walk, Philadelphia, PA 19104, USA
    Behav Neurosci 117:1017-28. 2003
    ..Implications of these findings for theories of spatial learning and hippocampal function are discussed...

Research Grants9

  1. Mechanisms of Appetitive and Aversive Context Learning
    KENNON LATTAL; Fiscal Year: 2005
    ..These experiments will lay the groundwork for a research program that is focused on asking questions about the nature of specific contextual associations in learning and memory. ..
  2. Temporal factors in extinction and spontaneous recovery
    KENNON LATTAL; Fiscal Year: 2007
    ....
  3. Behavioral and Epigenetic Mechanisms in Extinction of Cocaine-Induced Memories
    MARCELO ANDRES WOOD; Fiscal Year: 2010
    ..In this project, we examine behavioral and pharmacological interventions in a mouse model of cocaine seeking that may help reverse cocaine seeking and reduce relapse. ..
  4. Temporal factors in extinction and spontaneous recovery
    KENNON MATTHEW LATTAL; Fiscal Year: 2010
    ....