Molly Kulesz-Martin

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles
    Molly Kulesz-Martin
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Investig Dermatol Symp Proc 10:142-52. 2005
  2. pmc A molecular case report: functional assay of tyrosine kinase inhibitors in cells from a patient's primary renal cell carcinoma
    Molly F Kulesz-Martin
    Knight Cancer Institute and Department of Dermatology, Oregon Health and Science University, Portland, OR, USA and ryanc ohsu edu
    Cancer Biol Ther 14:95-9. 2013
  3. ncbi request reprint RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties
    Elizabeth J Horn
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    Carcinogenesis 25:157-67. 2004
  4. ncbi request reprint P53 family activities in development and cancer: relationship to melanocyte and keratinocyte carcinogenesis
    Jodi Johnson
    Department of Dermatology, Oregon Health and Science University, School of Medicine, Portland, Oregon, USA
    J Invest Dermatol 125:857-64. 2005
  5. ncbi request reprint p73 loss triggers conversion to squamous cell carcinoma reversible upon reconstitution with TAp73alpha
    Jodi Johnson
    Department of Dermatology, OHSU Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Cancer Res 67:7723-30. 2007
  6. ncbi request reprint Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification
    Chad D Knights
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 278:52890-900. 2003
  7. ncbi request reprint Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine model
    Daniel S Gareau
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 10022, USA
    J Invest Dermatol 127:2184-90. 2007
  8. pmc Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
    Gangwen Han
    Department of Otolaryngology, Oregon Health and Science University, Portland, OR, USA
    J Clin Invest 115:1714-23. 2005
  9. ncbi request reprint Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    Shi Long Lu
    Department of Otolaryngology, Oregon Health and Science University, Portland, USA
    Cancer Res 64:4405-10. 2004
  10. ncbi request reprint Novel initiation genes in squamous cell carcinomagenesis: a role for substrate-specific ubiquitylation in the control of cell survival
    Amador Albor
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Mol Carcinog 46:585-90. 2007

Research Grants

  1. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2007
  2. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2009
  3. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly Kulesz Martin; Fiscal Year: 2009
  4. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz Martin; Fiscal Year: 2010
  5. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz Martin; Fiscal Year: 2010
  6. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz Martin; Fiscal Year: 2010
  7. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2009
  8. Training in Molecular Basis of Skin Pathobiology
    Molly Kulesz Martin; Fiscal Year: 2007
  9. Montagna Symposium on the Biology of Skin
    Molly Kulesz Martin; Fiscal Year: 2007
  10. QUANTITATIVE CARCINOGENESIS IN CULTURED EPITHELIAL CELLS
    Molly Kulesz Martin; Fiscal Year: 2002

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles
    Molly Kulesz-Martin
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Investig Dermatol Symp Proc 10:142-52. 2005
    ..Thus, clonal lineage mouse models representing early through late cancer progression stages may inform the focus on early, potentially causal events from microarray studies of human cancers, facilitating prognosis and molecular therapy...
  2. pmc A molecular case report: functional assay of tyrosine kinase inhibitors in cells from a patient's primary renal cell carcinoma
    Molly F Kulesz-Martin
    Knight Cancer Institute and Department of Dermatology, Oregon Health and Science University, Portland, OR, USA and ryanc ohsu edu
    Cancer Biol Ther 14:95-9. 2013
    ..Immunostaining of the original primary tumor revealed strong positivity for VHL and Src protein expression. Functional evaluation of a patient's tumor cells appears feasible in the setting of RCC...
  3. ncbi request reprint RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties
    Elizabeth J Horn
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    Carcinogenesis 25:157-67. 2004
    ..We propose a model in which Trim32 activities as an E3-ubiquitin ligase favor initiated cell survival in carcinogenesis by blocking UVB-induced TNFalpha apoptotic signaling...
  4. ncbi request reprint P53 family activities in development and cancer: relationship to melanocyte and keratinocyte carcinogenesis
    Jodi Johnson
    Department of Dermatology, Oregon Health and Science University, School of Medicine, Portland, Oregon, USA
    J Invest Dermatol 125:857-64. 2005
  5. ncbi request reprint p73 loss triggers conversion to squamous cell carcinoma reversible upon reconstitution with TAp73alpha
    Jodi Johnson
    Department of Dermatology, OHSU Cancer Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Cancer Res 67:7723-30. 2007
    ..The results support the activation of TAp73alpha as a rational mechanism for cancer therapy in solid tumors of the epithelium...
  6. ncbi request reprint Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification
    Chad D Knights
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 278:52890-900. 2003
    ..These findings suggest therapeutic strategies that address both p53/Mdm2 interaction and associated p53 protein defects in human tumors that have amplified mdm2 genes...
  7. ncbi request reprint Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine model
    Daniel S Gareau
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 10022, USA
    J Invest Dermatol 127:2184-90. 2007
    ..The rCSLM images illustrate the difference between normal skin and sites with apparent melanoma. This imaging modality shows promise to track the progression of melanoma lesions in animal models...
  8. pmc Distinct mechanisms of TGF-beta1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis
    Gangwen Han
    Department of Otolaryngology, Oregon Health and Science University, Portland, OR, USA
    J Clin Invest 115:1714-23. 2005
    ..TGF-beta1-mediated EMT requires functional TGF-(beta)RII, whereas TGF-beta1-mediated tumor invasion cooperates with reduced TGF-(beta)RII signaling in tumor epithelia...
  9. ncbi request reprint Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    Shi Long Lu
    Department of Otolaryngology, Oregon Health and Science University, Portland, USA
    Cancer Res 64:4405-10. 2004
    ..These phenotypes correlated with enhanced Smad signaling in transgenic epithelia and stroma. Our study suggests that TGF-beta1 overexpression at early stages of HNSCC formation provides a tumor promoting microenvironment...
  10. ncbi request reprint Novel initiation genes in squamous cell carcinomagenesis: a role for substrate-specific ubiquitylation in the control of cell survival
    Amador Albor
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Mol Carcinog 46:585-90. 2007
    ..Our hypothesis is that increased expression of Trim32 may enhance epidermal carcinogenesis, by increasing the threshold of NF-kappaB activity through Piasy downmodulation...
  11. ncbi request reprint The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB
    Amador Albor
    Department of Dermatology and Program in Cell and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:25850-66. 2006
    ..Our results indicate that, by controlling Piasy stability, Trim32 regulates UVB-induced keratinocyte apoptosis through induction of NFkappaB and suggests loss of function of Trim32 in LGMD2H...
  12. ncbi request reprint Induction of gene amplification as a gain-of-function phenotype of mutant p53 proteins
    Sally El-Hizawi
    Department of Dermatology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Cancer Res 62:3264-70. 2002
    ..Additional studies are needed to assess the potential of targeting mutant p53 interaction with topoisomerase I for the reduction of drug resistance development during chemotherapy...
  13. pmc NF-κB repression by PIAS3 mediated RelA SUMOylation
    Yuangang Liu
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e37636. 2012
    ..These results support a novel negative feedback mechanism for NF-κB regulation by PIAS3-mediated RelA SUMOylation...
  14. pmc Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
    Kristina E Hoot
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon 97239 2999, USA
    J Clin Invest 118:2722-32. 2008
    ..Our data suggest that enhanced Smad3/Smad4-mediated Snail transcription contributed to Smad2 loss-associated EMT during skin carcinogenesis...
  15. ncbi request reprint Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4
    Yuangang Liu
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Cancer Res 67:10711-9. 2007
    ..Thus, microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP and implies a novel therapeutic strategy through combined MAPK inhibitions that mimic the function of MKP4...
  16. ncbi request reprint Facilitated search for specific genomic targets by p53 C-terminal basic DNA binding domain
    Yuangang Liu
    Department of Dermatology, Oregon Health and Science University, Portland, Oregan 97239, USA
    Cancer Biol Ther 3:1102-8. 2004
    ....
  17. doi request reprint 56th annual Montagna Symposium on the Biology of Skin: Epidermal T-cell interactions--clinicopathological and basic mechanisms
    Kevin D Cooper
    Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA
    J Invest Dermatol 128:1351-3. 2008
  18. pmc Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin
    Kevin G Phillips
    J Biomed Opt 16:040503. 2011
    ..86). Our results suggest that dermal reflectivity as measured by OCT can be utilized to quantify a psoriasis-like disease in mice, and thus has the potential to aid in the quantitative assessment of psoriasis in humans...
  19. pmc Global rank-invariant set normalization (GRSN) to reduce systematic distortions in microarray data
    Carl R Pelz
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239 3098, USA
    BMC Bioinformatics 9:520. 2008
    ..Therefore, methods to correct this kind of technical variation are critical. Here we consider a method to reduce this type of variation applied after three common procedures for processing microarray data: MAS 5.0, RMA, and dChip...
  20. ncbi request reprint Imaging melanoma in a murine model using reflectance-mode confocal scanning laser microscopy and polarized light imaging
    Daniel S Gareau
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Investig Dermatol Symp Proc 10:164-9. 2005
    ..PLI could distinguish superficial from deeper melanoma lesions because the melanin of the superficial lesions attenuated the PAR-PER image, whereas deeper lesions failed to attenuate the PAR-PER image...
  21. ncbi request reprint Current view of the role of transforming growth factor beta 1 in skin carcinogenesis
    Allen Guanqun Li
    Department of Otolaryngology, Oregon Health and Science University, Portland, Oregon, USA
    J Investig Dermatol Symp Proc 10:110-7. 2005
    ..This notion is further suggested by our recent study that Smad3 knockout mice were resistant to skin chemical carcinogenesis at least in part via abrogation of endogenous TGFbeta1-induced inflammation...
  22. ncbi request reprint Gene expression profiling of initiated epidermal cells with benign or malignant tumor fates
    Zhiping Wang
    Department of Dermatology, Oregon Health and Science University and Biostatistics and Bioinformatics Shared Resource, OHSU Cancer Institute, Portland, OR 97201, USA
    Carcinogenesis 23:635-43. 2002
    ..The cloned epidermal cell lineages allowed detection of putative early cancer genes in a model that is conducive to testing their direct role in epithelial multistep carcinogenesis in vitro and in vivo...

Research Grants24

  1. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2007
    ..Trim32 protein activities in initiation and malignancy may provide a new molecular identifier of initiated epithelium and leads for reversing survival mechanisms in precancers and malignant cells. ..
  2. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2009
    ....
  3. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly Kulesz Martin; Fiscal Year: 2009
    ..Understanding how Trim32 and Piasy control skin cell survival and skin inflammation promises new ways to treat psoriasis and other human diseases of the skin, as well as inflammatory diseases in other organs of the body. ..
  4. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz Martin; Fiscal Year: 2010
    ....
  5. Trim32 Regulation of Piasy in Skin Homeostasis
    Molly F Kulesz Martin; Fiscal Year: 2010
    ..Understanding how Trim32 and Piasy control skin cell survival and skin inflammation promises new ways to treat psoriasis and other human diseases of the skin, as well as inflammatory diseases in other organs of the body. ..
  6. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz Martin; Fiscal Year: 2010
    ..Cancer Biomedical Informatics Grid ..
  7. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2009
    ..abstract_text> ..
  8. Training in Molecular Basis of Skin Pathobiology
    Molly Kulesz Martin; Fiscal Year: 2007
    ....
  9. Montagna Symposium on the Biology of Skin
    Molly Kulesz Martin; Fiscal Year: 2007
    ..The complex nature of disease makes it essential that there are comprehensive approaches recognizing the separate but interacting elements tying molecular events to the pathophysiological, tissue and clinical presentations. ..
  10. QUANTITATIVE CARCINOGENESIS IN CULTURED EPITHELIAL CELLS
    Molly Kulesz Martin; Fiscal Year: 2002
    ..Knowledge of different functional p53 protein forms in cells and cooperating factors may improve the resolution, prognosis or treatment plan for human tumors with selective loss of distinct p53 functions. ..
  11. Mechanisms of SPAF and AS-FGF-2 in malignant conversion
    Molly Kulesz Martin; Fiscal Year: 2005
    ..The characterization of this bi-directional gene may provide useful prognosis markers as well as new targets for cancer therapy. ..
  12. Mechanisms of cancer initiation by TRIM32
    Molly Kulesz Martin; Fiscal Year: 2006
    ..Trim32 protein activities in initiation and malignancy may provide a new molecular identifier of initiated epithelium and leads for reversing survival mechanisms in precancers and malignant cells. ..
  13. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz Martin; Fiscal Year: 2010
    ..abstract_text> ..