Research Topics
| Sharon K KruegerSummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolismSharon K Krueger
Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, USA
Pharmacol Ther 106:357-87. 2005..The consequences of these FMO genetic polymorphisms in drug metabolism and human health are areas of research requiring further exploration...
C-Terminal truncation of rabbit flavin-containing monooxygenase isoform 2 enhances solubilitySharon K Krueger
Department of Environmental and Molecular Toxicology, Oregon State University, USA
Arch Biochem Biophys 450:149-56. 2006..His-fusion proteins, while active and useful for purification, did not affect solubility. Delta26 variants should prove useful for identifying conditions suitable for production of an FMO crystal...- Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413KSharon K Krueger
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Drug Metab Dispos 37:1785-91. 2009..Although these allelic variants are expected to occur infrequently as mutations to the FMO2*1 allele, they contribute to our overall understanding of mammalian FMO structure and function... - Fetal mouse Cyp1b1 and transplacental carcinogenesis from maternal exposure to dibenzo(a,l)pyreneDavid J Castro
Department of Environmental and Molecular Toxicology, Oregon State University, ALS 1007, Corvallis, OR 97331 7301, USA
Cancer Prev Res (Phila) 1:128-34. 2008..0). These data confirm that cyp1b1 bioactivation of DBP occurs in fetal target tissues, following transplacental exposure, with the thymus and lung as primary and secondary targets, respectively... - Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in HispanicsSharon K Krueger
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Pharmacogenet Genomics 15:245-56. 2005..23,238C (p.Q472) and 124 previously genotyped as homozygous g.23,238 T (p.X472); (2) determine FMO2 haplotypes in this population; and (3) assess the functional impact of SNPs in expressed proteins... - Indole-3-carbinol in the maternal diet provides chemoprotection for the fetus against transplacental carcinogenesis by the polycyclic aromatic hydrocarbon dibenzo[a,l]pyreneZhen Yu
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Carcinogenesis 27:2116-23. 2006..Addition of chemoprotective agents to the maternal diet during pregnancy and nursing may be an effective new approach in reducing the incidence of cancers in children and young adults... - Differences in FMO2*1 allelic frequency between Hispanics of Puerto Rican and Mexican descentSharon K Krueger
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
Drug Metab Dispos 32:1337-40. 2004..0066) that FMO2*1 is more common among Puerto Ricans (7%) than among individuals of Mexican descent (2%). The overall occurrence of FMO2*1 among Hispanics of all origins is estimated to be between 2 and 7%... - Characterization of mouse flavin-containing monooxygenase transcript levels in lung and liver, and activity of expressed isoformsLisbeth K Siddens
Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States
Biochem Pharmacol 75:570-9. 2008..Measurement of activity in heated and unheated lung and liver microsomes verified relative transcript abundance. Our results show that dual Fmo1/2 knockouts will be required to model the human lung FMO profile... - S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2Marilyn C Henderson
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA
Biochem Pharmacol 68:959-67. 2004.... - Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathioneMarilyn C Henderson
Department of Environmental and Molecular Toxicology, and The Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Chem Res Toxicol 17:633-40. 2004..5-1.0 mM completely eliminated the sulfenic acid with resultant production of GSSG. These results indicate that individuals with the FMO21 allele may be at enhanced risk of pulmonary damage upon exposure to thioureas... - Metabolism of the anti-tuberculosis drug ethionamide by mouse and human FMO1, FMO2 and FMO3 and mouse and human lung microsomesMarilyn C Henderson
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Toxicol Appl Pharmacol 233:420-7. 2008..Additionally, there may be therapeutic implications of efficacy and toxicity in human lung based on the FMO2 genetic polymorphism, though further studies are needed to confirm that suggestion... 
Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skinAndrew Larkin
Department of Environmental and Molecular Toxicology, Oregon State University, USA
Toxicol Appl Pharmacol 267:192-9. 2013..The aryl hydrocarbon receptor repressor (Ahrr) was determined to be the most significant input variable for model predictions using back-propagation and normalization of FNN weights...- Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed proteinSharon K Krueger
Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, 571 Weniger, Corvallis, OR 97331 6512, USA
Drug Metab Dispos 30:34-41. 2002..1 may partially explain why activity in post mortem human lung samples has previously been unreported. Individuals that have the FMO2*1 allele-encoding full-length hFMO2.1 may exhibit altered drug metabolism in the lung... - Genetic polymorphisms of flavin-containing monooxygenase (FMO)Sharon K Krueger
Department of Environmental and Molecular Toxicology and The Linus Pauling Institute, Oregon State University, Corvallis, USA
Drug Metab Rev 34:523-32. 2002..Polymorphic expression of functional FMO2 in the individuals of African and Hispanic descent may markedly influence drug metabolism and/or xenobiotic toxicity in the lung... - Alpha-tocopherol modulates Cyp3a expression, increases gamma-CEHC production, and limits tissue gamma-tocopherol accumulation in mice fed high gamma-tocopherol dietsMaret G Traber
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Free Radic Biol Med 38:773-85. 2005..These data support the hypothesis that alpha-tocopherol modulates xenobiotic metabolism by increasing Cyp3a expression, gamma-CEHC formation, and the excretion of both gamma-tocopherol and gamma-CEHC... - Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbitsShelley A Larsen-Su
Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, 1007 ALS, Corvallis, OR 97331, USA
Biochem Pharmacol 63:1353-9. 2002..The early developmental appearance of FMO1 suggests a possible role in the metabolism of xenobiotics through transplacental or lactational exposures... - Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouseLisbeth K Siddens
Department of Environmental and Molecular Toxicology, Oregon State University, USA
Toxicol Appl Pharmacol 264:377-86. 2012..BaP and mixtures up-regulated phase 1 and phase 2 metabolizing enzymes while DBC did not. The carcinogenicity with DBC and two of the mixtures was much greater than would be predicted based on published Relative Potency Factors (RPFs)... - The role of flavin-containing monooxygenase (FMO) in the metabolism of tamoxifen and other tertiary aminesSharon K Krueger
Department of Environmental and Molecular Toxicology, The Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
Drug Metab Rev 38:139-47. 2006..We collaborated with Dr. Kupfer's laboratory and recently determined that the low level of tamoxifen N-oxide production in human liver microsomes may be explained by the kinetics of FMO1 versus FMO3... - In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptorZhen Yu
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Cancer Res 66:755-62. 2006.... - Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidasesPiyush M Vyas
Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA
J Pharmacol Exp Ther 319:497-505. 2006..Thus, our results suggest an important role for FMO3 and yet-to-be identified peroxidases in the bioactivation of sulfonamides in NHEKs... - Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variantsSevasti B Koukouritaki
Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
J Pharmacol Exp Ther 320:266-73. 2007.... - The FMO2 gene of laboratory rats, as in most humans, encodes a truncated proteinVirginie Lattard
Unité de Toxicologie et de Métabolisme Comparés des Xénobiotiques, UMR INRA et DGER, Ecole Nationale Veterinaire de Lyon, Marcy l Etoile, France
Biochem Biophys Res Commun 292:558-63. 2002..Heterologous expression of the cDNA revealed that the truncated protein was catalytically inactive. By Western blotting, FMO2 was faintly detected at approximately 50 kDa in laboratory rat lung...