Patricia L Kramer

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
    Patricia L Kramer
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurobiol Aging 32:2113-22. 2011
  2. ncbi request reprint A new locus for autosomal dominant congenital cataracts maps to chromosome 3
    P L Kramer
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Invest Ophthalmol Vis Sci 41:36-9. 2000
  3. pmc Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population
    Mary K Wirtz
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:3055-60. 2010
  4. pmc Functional screening of Alzheimer pathology genome-wide association signals in Drosophila
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 88:232-8. 2011
  5. ncbi request reprint GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36
    M K Wirtz
    Casey Eye Institute, Oregon Health Sciences University, Portland 97201, USA
    Arch Ophthalmol 117:237-41. 1999
  6. pmc Review of selected databases of longitudinal aging studies
    Deniz Erten-Lyons
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 8:584-9. 2012
  7. pmc Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q
    M K Wirtz
    Department of Ophthalmology, Oregon Health Sciences University, Portland 97201 4197, USA
    Am J Hum Genet 60:296-304. 1997
  8. pmc A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
  9. pmc Translational gene mapping of cognitive decline
    Beth Wilmot
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Aging 29:524-41. 2008
  10. ncbi request reprint The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region
    Patricia L Kramer
    Departments of Neurology, Molecular and Medical Genetics, and Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
    Arch Ophthalmol 124:1328-31. 2006

Research Grants

  1. Genetic Associations with Alzheimer-free Survival
    Patricia Kramer; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
    Patricia L Kramer
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurobiol Aging 32:2113-22. 2011
    ..Our findings suggest that up-regulation of reelin may be a compensatory response to tau-related or beta-amyloid stress associated with AD even prior to the onset of dementia...
  2. ncbi request reprint A new locus for autosomal dominant congenital cataracts maps to chromosome 3
    P L Kramer
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Invest Ophthalmol Vis Sci 41:36-9. 2000
    ..To map a gene for cataracts in a family with congenital nuclear and sutural cataracts and to examine candidate genes in the linked region...
  3. pmc Association of POAG risk factors and the Thr377Met MYOC mutation in an isolated Greek population
    Mary K Wirtz
    Department of Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:3055-60. 2010
    ..To characterize the MYOC genotype correlation with phenotypes in an isolated Greek population with a high incidence of glaucoma...
  4. pmc Functional screening of Alzheimer pathology genome-wide association signals in Drosophila
    Joshua M Shulman
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 88:232-8. 2011
    ..Our strategy of coupling genome-wide association in humans with functional screening in a model organism is likely to be a powerful approach for gene discovery in AD and other complex genetic disorders...
  5. ncbi request reprint GLC1F, a new primary open-angle glaucoma locus, maps to 7q35-q36
    M K Wirtz
    Casey Eye Institute, Oregon Health Sciences University, Portland 97201, USA
    Arch Ophthalmol 117:237-41. 1999
    ..A large family with adult-onset primary open-angle glaucoma (POAG) was identified...
  6. pmc Review of selected databases of longitudinal aging studies
    Deniz Erten-Lyons
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 8:584-9. 2012
    ..In this article, we review selected databases of longitudinal aging studies. We also make recommendations on future steps to create a comprehensive database. Additionally, we discuss issues related to data harmonization...
  7. pmc Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q
    M K Wirtz
    Department of Ophthalmology, Oregon Health Sciences University, Portland 97201 4197, USA
    Am J Hum Genet 60:296-304. 1997
    ..1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult-onset POAG gene to chromosome 3q, gene symbol GLC1C...
  8. pmc A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia
    Wei Tian
    Department of Medicine, Divisions of Nephrology and Hypertension, and Endocrinology and Metabolism, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 106:14034-9. 2009
    ..These data suggest that this polymorphism affects TRPV4 function in vivo and likely influences systemic water balance on a population-wide basis...
  9. pmc Translational gene mapping of cognitive decline
    Beth Wilmot
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Aging 29:524-41. 2008
    ....
  10. ncbi request reprint The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region
    Patricia L Kramer
    Departments of Neurology, Molecular and Medical Genetics, and Ophthalmology, Casey Eye Institute, Oregon Health and Sciences University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
    Arch Ophthalmol 124:1328-31. 2006
    ..To determine whether mutations in the WD40-repeat 36 (WDR36) gene are responsible for primary open-angle glaucoma (POAG) that maps to the GLC1G locus in a family with 16 affected family members...
  11. ncbi request reprint Weill-Marchesani syndrome--possible linkage of the autosomal dominant form to 15q21.1
    M K Wirtz
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Am J Med Genet 65:68-75. 1996
    ..1, are candidate genes for Weill-Marchesani syndrome. Immunohistochemistry staining of skin sections from family 1 showed an apparent decrease in fibrillin staining compared to control individuals...
  12. ncbi request reprint Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q
    P L Kramer
    Department of Neurology, Oregon Health Sciences University, Portland 97201
    Genomics 13:904-5. 1992
  13. ncbi request reprint Rapid-onset dystonia-parkinsonism: linkage to chromosome 19q13
    P L Kramer
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Ann Neurol 46:176-82. 1999
    ..Identification of the genetic defect in RDP holds promise for understanding the underlying disease processes of both of these more common diseases...
  14. doi request reprint Childhood-onset restless legs syndrome: clinical and genetic features of 22 families
    Hiltrud Muhle
    Department of Neuropediatrics, University of Kiel, Kiel, Germany
    Mov Disord 23:1113-21; quiz 1203. 2008
    ..RLS symptoms can occur in early childhood. The positive family history suggests a genetic cause in most families with at least one additional RLS gene locus...
  15. ncbi request reprint Co-occurrence of restless legs syndrome and Parkin mutations in two families
    Susanna Adel
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Mov Disord 21:258-63. 2006
    ..The clinical phenotype did not differ between RLS patients with and without a Parkin mutation. Inheritance of RLS was consistent with autosomal dominant transmission, and linkage analysis excluded all three known loci for RLS...

Research Grants4

  1. Genetic Associations with Alzheimer-free Survival
    Patricia Kramer; Fiscal Year: 2007
    ..These data will be available primarily through the NACC website for dissemination to the AD and aging research community. Access will also be available through the OHSU ADC Genetics Core. ..