R Komers

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. doi request reprint Renin inhibition in the treatment of diabetic kidney disease
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Clin Sci (Lond) 124:553-66. 2013
  2. doi request reprint Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Sci (Lond) 123:635-47. 2012
  3. pmc Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays
    Jingjing Yu
    UW Medicine Lake Union, University of Washington, Seattle, WA 98109, USA
    BMC Mol Biol 12:49. 2011
  4. ncbi request reprint Effect of hyperinsulinaemia on renal function and nitrate/nitrite excretion in healthy subjects
    R Komers
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Clin Exp Pharmacol Physiol 26:336-41. 1999
  5. ncbi request reprint Cyclo-oxygenase-2 inhibition attenuates the progression of nephropathy in uninephrectomized diabetic rats
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Potland, Oregon 97239 2940, USA
    Clin Exp Pharmacol Physiol 34:36-41. 2007
  6. ncbi request reprint Renal p38 MAP kinase activity in experimental diabetes
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Lab Invest 87:548-58. 2007
  7. ncbi request reprint Effects of p38 mitogen-activated protein kinase inhibition on blood pressure, renal hemodynamics, and renal vascular reactivity in normal and diabetic rats
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Ore 97239, USA
    Transl Res 150:343-9. 2007
  8. ncbi request reprint What is the role of renin inhibition in the treatment of diabetic kidney disease?
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Curr Diab Rep 9:447-52. 2009
  9. pmc Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats
    R Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Br J Pharmacol 162:163-74. 2011
  10. doi request reprint Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239 2940, USA
    Kidney Int 79:432-42. 2011

Collaborators

Detail Information

Publications35

  1. doi request reprint Renin inhibition in the treatment of diabetic kidney disease
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Clin Sci (Lond) 124:553-66. 2013
    ....
  2. doi request reprint Enhanced phosphorylation of Na(+)-Cl- co-transporter in experimental metabolic syndrome: role of insulin
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Clin Sci (Lond) 123:635-47. 2012
    ..Together, these findings indicate that hyperinsulinaemia is an important driving force of NCC activity in the metabolic syndrome with possible consequences for BP regulation...
  3. pmc Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays
    Jingjing Yu
    UW Medicine Lake Union, University of Washington, Seattle, WA 98109, USA
    BMC Mol Biol 12:49. 2011
    ..Although a critical component of chromatin structure, DNA methylation has often been studied independently of other chromatin events and transcription...
  4. ncbi request reprint Effect of hyperinsulinaemia on renal function and nitrate/nitrite excretion in healthy subjects
    R Komers
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Clin Exp Pharmacol Physiol 26:336-41. 1999
    ..In contrast, mild volume expansion with insulin-free vehicle resulted in increased excretion of NO metabolites. This insulin-induced attenuation of renal NO synthesis may contribute to the anti-natriuretic actions of insulin...
  5. ncbi request reprint Cyclo-oxygenase-2 inhibition attenuates the progression of nephropathy in uninephrectomized diabetic rats
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Potland, Oregon 97239 2940, USA
    Clin Exp Pharmacol Physiol 34:36-41. 2007
    ..4. In conclusion, long-term COX-2 inhibition is associated with modest nephroprotection in uninephrectomized diabetic rats when administered as late intervention. These effects are independent of metabolic control and blood pressure...
  6. ncbi request reprint Renal p38 MAP kinase activity in experimental diabetes
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Lab Invest 87:548-58. 2007
    ..p38 activation in diabetes is likely to occur via multiple pathways and cannot be explained by downregulation of MKP-1...
  7. ncbi request reprint Effects of p38 mitogen-activated protein kinase inhibition on blood pressure, renal hemodynamics, and renal vascular reactivity in normal and diabetic rats
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Ore 97239, USA
    Transl Res 150:343-9. 2007
    ..The observed effects of p38 inhibition could be mediated at least in part by enhancement of endothelium-dependent vasodilation...
  8. ncbi request reprint What is the role of renin inhibition in the treatment of diabetic kidney disease?
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Curr Diab Rep 9:447-52. 2009
    ..This article focuses on experimental and clinical studies evaluating the two principal approaches to renin inhibition: direct renin inhibition with competitive inhibitors (eg, aliskiren) and inhibition of the (pro)renin receptor...
  9. pmc Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats
    R Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239 2940, USA
    Br J Pharmacol 162:163-74. 2011
    ..Early stages of diabetes are associated with renal haemodynamic changes, contributing to later development of DN. However, the role of RhoA/ROCK, known regulators of vascular tone, in this process has not been studied...
  10. doi request reprint Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239 2940, USA
    Kidney Int 79:432-42. 2011
    ..The combination of both treatments was no different than losartan alone. Thus, ROCK inhibition protected the kidney from diabetic nephropathy even though it did not reduce the blood pressure...
  11. doi request reprint Rho kinase inhibition in diabetic nephropathy
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239 2940, USA
    Curr Opin Nephrol Hypertens 20:77-83. 2011
    ..The review discusses recent studies exploring the consequences of diabetes-induced Rho-ROCK activation in the kidney and the effects of ROCK inhibition (ROCKi) in experimental diabetic nephropathy...
  12. ncbi request reprint Altered endothelial nitric oxide synthase targeting and conformation and caveolin-1 expression in the diabetic kidney
    Radko Komers
    Division of NephrologyHypertension PP262, Oregon Health and Science University, 3314 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    Diabetes 55:1651-9. 2006
    ..In summary, we observed diabetes-mediated alterations in eNOS and CAV-1 expression that are consistent with the view of decreased bioavailability of renal eNOS-derived NO...
  13. ncbi request reprint Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans
    R Komers
    Institute for Clinical and Experimental Medicine, Diabetes Center, Prague, Czech Republic
    J Hypertens 18:51-9. 2000
    ..However, recent experimental findings suggest that AT1B actions may be also partly mediated by NO. In this study, we explored whether ACE inhibitors and AT1B modulate hemodynamic responses to L-arginine (L-arg), a NO precursor...
  14. ncbi request reprint Therapeutic potential of ACE inhibitors for the treatment of hypertension in Type 2 diabetes
    R Komers
    Division of Nephrology and Hypertension, Oregon Health Sciences University, PP262, 3314 SW US Veterans Hospital Road, Portland, Oregon, 97201 2940, USA
    Expert Opin Investig Drugs 9:2601-17. 2000
    ..This goal is more likely to be achieved by multifactorial intervention, reflecting the complexity of metabolic syndrome. ACEI should be viewed as an important, but not the only, part of this complex approach...
  15. pmc Immunohistochemical and functional correlations of renal cyclooxygenase-2 in experimental diabetes
    R Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health Sciences University, Portland, Oregon 97201-2940, USA
    J Clin Invest 107:889-98. 2001
    ....
  16. ncbi request reprint Renal activity of Akt kinase in experimental Type 1 diabetes
    J Zdychova
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 57:709-15. 2008
    ..In addition to Akt, other signaling pathways likely contribute to regulation of renal mTOR activity in diabetes...
  17. ncbi request reprint Renal and cardiovascular effects of selective cyclooxygenase-2 inhibitors
    R Komers
    Division of Nephrology, Hypertension, and Clinical Pharmacology, Oregon Health Sciences University, Portland, OR, USA
    Am J Kidney Dis 38:1145-57. 2001
    ..This suggests that COX-2 inhibitors may confer a renoprotective effect in diverse renal disorders. These intriguing formulations must be delineated further in appropriately designed prospective clinical trials...
  18. ncbi request reprint Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake
    Ivana Vaneckova
    Center of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Blood Press Res 27:203-10. 2004
    ....
  19. ncbi request reprint Effects of cyclooxygenase-2 (COX-2) inhibition on plasma and renal renin in diabetes
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, and the Portland Veterans Affairs Medical Center, 97201 2940, USA
    J Lab Clin Med 140:351-7. 2002
    ..These findings do not support a significant role for COX-2 in mediating renin status in diabetes...
  20. ncbi request reprint Effect of rofecoxib on the glomerular filtration rate, proteinuria and the renin-angiotensin-aldosterone system in elderly subjects with chronic renal impairment
    M Horackova
    Department of Medicine, 2nd Medical Faculty of Charles University, University Hospital Motol, V Uvalu 84, 150 06 Prague 5, Czech Republic
    Int J Clin Pharmacol Ther 43:413-9. 2005
    ..Considering the increasing popularity and prescribing of specific COX-2 inhibitors, a new class of NSAIDs lacking gastrointestinal side effects, the evaluation of their effects on renal function has become very important...
  21. doi request reprint Effect of orchiectomy on renal function in control and diabetic rats with chronic inhibition of nitric oxide
    Sharon Anderson
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239 2940, USA
    Clin Exp Pharmacol Physiol 37:19-23. 2010
    ..This suggests that testosterone reduction does not attenuate the deleterious impact of the diabetic metabolic milieu in the kidney...
  22. doi request reprint Inhibition of the renin-angiotensin system: is more better?
    Sharon Anderson
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon, USA
    Kidney Int 75:12-4. 2009
    ..They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan...
  23. ncbi request reprint Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes
    Radko Komers
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Renin Angiotensin Aldosterone Syst 5:33-8. 2004
    ..Furthermore, angiotensin receptor blockers (ARBs), another group of inhibitors of the renin-angiotensin system (RAS), have not been studied in this context...
  24. ncbi request reprint Effects of long-term inhibition of neuronal nitric oxide synthase (NOS1) in uninephrectomized diabetic rats
    Radko Komers
    Division of Nephrology and Hypertension, Oregon Health and Science University, PP262, 3314 SW US Veterans Hospital Road, Portland, OR 97239 2940, USA
    Nitric Oxide 11:147-55. 2004
    ..In summary, long-term nNOS inhibition had modest nephroprotective effects in uninephrectomized diabetic rats. These effects may be mediated by renal hemodynamic mechanisms, as well as by lower food (protein) intake...
  25. ncbi request reprint Treatment of hypertension in diabetic patients with nephropathy
    R Komers
    Division of Nephrology and Hypertension, Oregon Health Sciences University, PP262, 3314 SW US Veterans Hospital Road, Portland, OR 97201-2940, USA
    Curr Diab Rep 1:251-60. 2001
    ..Furthermore, multifactorial intervention targeting metabolic derangements and lifestyle, is a necessary complimentary measure that must accompany antihypertensive treatment...
  26. ncbi request reprint Determination of caveolin-1 in renal caveolar and non-caveolar fractions in experimental type 1 diabetes
    H Demova
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 58:563-8. 2009
    ..This suggests applicability of SF in studies focusing on CAV-1 targeting in organs with various cell lines in vivo...
  27. ncbi request reprint Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis
    Dalibor Lecian
    Department of Nephrology, Institute for Clinical and Experimental Medicine, Charles University, Prague, Czech Republic
    Kidney Blood Press Res 29:135-43. 2006
    ....
  28. doi request reprint Renal activity of Akt kinase in obese Zucker rats
    Jana Zdychova
    Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Exp Biol Med (Maywood) 233:1231-41. 2008
    ..These data suggest that DM2 is associated with selective IR in the kidney, allowing pro-growth signaling via mTOR, whereas potentially protective effects mediated by eNOS are blunted...
  29. ncbi request reprint A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy
    J A Hubacek
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 60:377-80. 2011
    ..In conclusion, patients with DM1 display lower freqencies of the protective CC genotype as compared to healthy subjects. However, the study did not reveal associations of -765G > C polymorphism with the risk of DN...
  30. ncbi request reprint Endothelial-derived vasoactive mediators in polycystic kidney disease
    Muna A Al-Nimri
    Division of Nephrology and Hypertension, Oregon Health and Science University, and Portland VA Medical Center, Portland, Oregon 97201, USA
    Kidney Int 63:1776-84. 2003
    ..Mediators of these hemodynamic changes are not well understood, but evidence suggests that endothelial-derived mediators may participate...
  31. ncbi request reprint Paradoxes of nitric oxide in the diabetic kidney
    Radko Komers
    Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon 97201 2940, USA
    Am J Physiol Renal Physiol 284:F1121-37. 2003
    ..Increasing accumulations of advanced glycation end products may be one of the culprits in this process. In addition, this balance is continuously modified by actual metabolic control and the degree of insulinopenia...
  32. ncbi request reprint Gender hormones and the progression of experimental polycystic kidney disease
    Kenneth D Stringer
    Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, Oregon 97239, USA
    Kidney Int 68:1729-39. 2005
    ....
  33. ncbi request reprint Renal cyclooxygenase-2 in obese Zucker (fatty) rats
    Radko Komers
    Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Int 67:2151-8. 2005
    ..Unlike type 1 diabetes, renal COX has not been studied in models of type 2 diabetes...
  34. ncbi request reprint Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications
    J Zdychova
    Diabetes Center, Institute of Clinical and Experimental Medicine, Videnska 1958, 140 00 Prague 4, Czech Republic
    Physiol Res 54:1-16. 2005
    ..Future studies should include the evaluation of therapeutical benefits of pharmacological modulators of Akt activity...
  35. ncbi request reprint Aliskiren combined with losartan in diabetes and nephropathy
    Sharon Anderson
    N Engl J Med 359:1069; author reply 1069-70. 2008