Research Topics
| C L KliethermesSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in miceChristopher L Kliethermes
Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, VAMC Research R and D 12, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
Psychopharmacology (Berl) 169:190-7. 2003..Anxiety is a common disorder in humans that exists in many forms, and animal models of human anxiety are typically employed for the discovery of anxiolytic drugs with human therapeutic potential...
Selection for pentobarbital withdrawal severity: correlated differences in withdrawal from other sedative drugsChristopher L Kliethermes
Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, Veterans Affairs Medical Center, c o Portland VA Medical Center, Portland, OR 97239, USA
Brain Res 1009:17-25. 2004..These results indicate that some of the same genes that affect the severity of withdrawal from pentobarbital also influence ethanol and zolpidem withdrawal, but that diazepam withdrawal may be less influenced by these genes...
Anxiety-like behavior in mice in two apparatuses during withdrawal from chronic ethanol vapor inhalationC L Kliethermes
Department of Behavioral Neuroscience, Oregon Health and Science University and the Portland Alcohol Research Center, VA Medical Center, Portland, Oregon 97239, USA
Alcohol Clin Exp Res 28:1012-9. 2004..Ethanol vapor inhalation offers an advantage over liquid diet consumption in that the onset of withdrawal can be temporally controlled more precisely, allowing studies of the development of withdrawal symptoms...
Anxiety-like behaviors following chronic ethanol exposureChristopher L Kliethermes
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
Neurosci Biobehav Rev 28:837-50. 2005..In addition, standard anxiolytic drugs should ameliorate the anxiogenic-like effects of withdrawal, preferably in multiple tests of anxiety-like behavior...
Home cage activity and ingestive behaviors in mice following chronic ethanol vapor inhalationChristopher L Kliethermes
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Physiol Behav 85:479-88. 2005..Further, even in a relatively severe mouse model of alcohol withdrawal, any decreases in general home cage activity are short-lived...
Genetic independence of mouse measures of some aspects of novelty seekingChristopher L Kliethermes
Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, OR 97239 3098, USA
Proc Natl Acad Sci U S A 103:5018-23. 2006....
Pharmacological and genetic influences on hole-board behaviors in miceChristopher L Kliethermes
Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, CA 94608, USA
Pharmacol Biochem Behav 85:57-65. 2006..However, the results with the genetically heterogeneous mice and HEB and LEB mice suggest that some aspects of the dopaminergic system are involved in head dipping...
