Jeffrey A Kaye

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Unobtrusive measurement of daily computer use to detect mild cognitive impairment
    Jeffrey Kaye
    Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR, USA Department of Neurology, Oregon Health and Science University, Portland, OR, USA Neurology Service, Portland Veteran Affairs Medical Center, Portland, OR, USA Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA Electronic address
    Alzheimers Dement 10:10-7. 2014
  2. pmc One walk a year to 1000 within a year: continuous in-home unobtrusive gait assessment of older adults
    Jeffrey Kaye
    Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Gait Posture 35:197-202. 2012
  3. ncbi request reprint Factors associated with brain donation among optimally healthy elderly people
    J A Kaye
    Veterans Affairs Medical Center, Portland, Oregon, USA
    J Gerontol A Biol Sci Med Sci 54:M560-4. 1999
  4. ncbi request reprint Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults
    J A Kaye
    Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurology 69:196-9. 2007
  5. ncbi request reprint Asynchronous regional brain volume losses in presymptomatic to moderate AD
    J A Kaye
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Alzheimers Dis 8:51-6. 2005
  6. pmc Intelligent Systems For Assessing Aging Changes: home-based, unobtrusive, and continuous assessment of aging
    Jeffrey A Kaye
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239 3098, USA
    J Gerontol B Psychol Sci Soc Sci 66:i180-90. 2011
  7. doi request reprint Home-based technologies: a new paradigm for conducting dementia prevention trials
    Jeffrey Kaye
    NIA Layton Aging and Alzheimer s Disease Center and ORCATECH, the Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 4:S60-6. 2008
  8. doi request reprint Trajectory of mild cognitive impairment onset
    Diane B Howieson
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Int Neuropsychol Soc 14:192-8. 2008
  9. pmc Unobtrusive assessment of activity patterns associated with mild cognitive impairment
    Tamara L Hayes
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 4:395-405. 2008
  10. pmc Neuropathologic basis of age-associated brain atrophy
    Deniz Erten-Lyons
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    JAMA Neurol 70:616-22. 2013

Research Grants

Detail Information

Publications73

  1. pmc Unobtrusive measurement of daily computer use to detect mild cognitive impairment
    Jeffrey Kaye
    Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR, USA Department of Neurology, Oregon Health and Science University, Portland, OR, USA Neurology Service, Portland Veteran Affairs Medical Center, Portland, OR, USA Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA Electronic address
    Alzheimers Dement 10:10-7. 2014
    ..We sought to determine whether long-term changes in remotely monitored computer use differ in persons with MCI in comparison with cognitively intact volunteers...
  2. pmc One walk a year to 1000 within a year: continuous in-home unobtrusive gait assessment of older adults
    Jeffrey Kaye
    Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Gait Posture 35:197-202. 2012
    ..Unobtrusive home walking assessments are ecologically valid measures of walking function. They provide previously unattainable metrics (periodicity, variability, range of minimum and maximum speeds) of everyday motor function...
  3. ncbi request reprint Factors associated with brain donation among optimally healthy elderly people
    J A Kaye
    Veterans Affairs Medical Center, Portland, Oregon, USA
    J Gerontol A Biol Sci Med Sci 54:M560-4. 1999
    ..Subjects were initially selected for good health. The study population had a relatively high education level, a high socioeconomic status, and were predominantly white...
  4. ncbi request reprint Brain volumes in Guam dementia vs Parkinson dementia complex vs aging Chamorro adults
    J A Kaye
    Departments of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurology 69:196-9. 2007
    ..Chamorros with a family history of PDC or dementia may have increased brain atrophy, suggesting a hereditary susceptibility to neurodegenerative disorders...
  5. ncbi request reprint Asynchronous regional brain volume losses in presymptomatic to moderate AD
    J A Kaye
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Alzheimers Dis 8:51-6. 2005
    ..These regional and phase-specific volume changes form targets for monitoring disease-modifying therapies at clinically relevant, defined stages of dementia...
  6. pmc Intelligent Systems For Assessing Aging Changes: home-based, unobtrusive, and continuous assessment of aging
    Jeffrey A Kaye
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239 3098, USA
    J Gerontol B Psychol Sci Soc Sci 66:i180-90. 2011
    ..To describe a longitudinal community cohort study, Intelligent Systems for Assessing Aging Changes, that has deployed an unobtrusive home-based assessment platform in many seniors homes in the existing community...
  7. doi request reprint Home-based technologies: a new paradigm for conducting dementia prevention trials
    Jeffrey Kaye
    NIA Layton Aging and Alzheimer s Disease Center and ORCATECH, the Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 4:S60-6. 2008
    ..Clinical studies identifying the optimal ways of using these methods are needed...
  8. doi request reprint Trajectory of mild cognitive impairment onset
    Diane B Howieson
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Int Neuropsychol Soc 14:192-8. 2008
    ..Aging transitions leading to MCI and dementia are characterized by unique linear and nonlinear cognitive changes in several domains that precede the diagnosis of MCI and dementia by at least several years...
  9. pmc Unobtrusive assessment of activity patterns associated with mild cognitive impairment
    Tamara L Hayes
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 4:395-405. 2008
    ..We evaluated the use of continuous, long-term, and unobtrusive in-home monitoring to assess neurologic function in healthy and cognitively impaired elders...
  10. pmc Neuropathologic basis of age-associated brain atrophy
    Deniz Erten-Lyons
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    JAMA Neurol 70:616-22. 2013
    ..This study aims to clarify the neuropathologic correlates of longitudinal brain atrophy...
  11. pmc Executive function predicts risk of falls in older adults without balance impairment
    Teresa J Buracchio
    Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97239 USA
    BMC Geriatr 11:74. 2011
    ..The aim of this study is to investigate the association between executive dysfunction and risk of falling and to determine if this association is independent of balance...
  12. pmc Medication adherence in healthy elders: small cognitive changes make a big difference
    Tamara L Hayes
    Division of Biomedical Engineering, Oregon Health and Sciences University, 3303 SW Bond Avenue, Portland, OR 97239, USA
    J Aging Health 21:567-80. 2009
    ..Participants were divided into a group with High Cognitive Function (HCF) or Low Cognitive Function (LCF) based on their scores on the ADAS-Cog...
  13. pmc Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study
    Patricia L Kramer
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neurobiol Aging 32:2113-22. 2011
    ..Our findings suggest that up-regulation of reelin may be a compensatory response to tau-related or beta-amyloid stress associated with AD even prior to the onset of dementia...
  14. pmc Ascorbic acid and rates of cognitive decline in Alzheimer's disease
    Gene L Bowman
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    J Alzheimers Dis 16:93-8. 2009
    ..This relationship may indicate that the CSF: plasma AA ratio is an index of AA availability to the brain or may be an artifact of a relationship between blood-brain barrier impairment and neurodegeneration...
  15. pmc Cognitive impairment risk: white matter hyperintensity progression matters
    Lisa C Silbert
    Layton Aging and Alzheimer s Disease Center, Department of Neurology, CR 131, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd, Portland, OR 97239, USA
    Neurology 73:120-5. 2009
    ..To determine whether white matter hyperintensity (WMH) progression rate is a better predictor of cognitive impairment risk than baseline WMH volume in healthy elderly individuals...
  16. pmc Uric acid as a CNS antioxidant
    Gene L Bowman
    Department of Neurology, Layton Center for Aging and Alzheimer s Disease Research, Oregon Health and Science University, Portland, OR 97239, USA
    J Alzheimers Dis 19:1331-6. 2010
    ..Adequately powered prospective studies would help assess any role for UA in primary and secondary prevention of AD...
  17. ncbi request reprint Parkinson's disease is associated with hippocampal atrophy
    Richard Camicioli
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Mov Disord 18:784-90. 2003
    ..In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD...
  18. pmc Wechsler Memory Scale-III Faces test performance in patients with mild cognitive impairment and mild Alzheimer's disease
    Adriana M Seelye
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    J Clin Exp Neuropsychol 31:682-8. 2009
    ..Data suggest that brain areas specialized for face recognition memory may be less affected by MCI and mild AD than regions specialized for verbal memory...
  19. pmc Computer-related self-efficacy and anxiety in older adults with and without mild cognitive impairment
    Katherine V Wild
    Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 8:544-52. 2012
    ..This study examines differences in computer-related self-efficacy and anxiety in subgroups of older adults, and changes in those measures after exposure to a systematic training program and subsequent computer use...
  20. pmc Reactions to a remote-controlled video-communication robot in seniors' homes: a pilot study of feasibility and acceptance
    Adriana M Seelye
    Layton Aging and Alzheimer s Disease Center, Oregon Health and Science University, Portland, OR 97239, USA
    Telemed J E Health 18:755-9. 2012
    ..In this study we tested the feasibility of use and acceptance of a remotely controlled robot with video-communication capability in independently living, cognitively intact older adults...
  21. pmc Review of selected databases of longitudinal aging studies
    Deniz Erten-Lyons
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 8:584-9. 2012
    ..In this article, we review selected databases of longitudinal aging studies. We also make recommendations on future steps to create a comprehensive database. Additionally, we discuss issues related to data harmonization...
  22. pmc Trajectory of white matter hyperintensity burden preceding mild cognitive impairment
    Lisa C Silbert
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    Neurology 79:741-7. 2012
    ..To determine the time of acceleration in white matter hyperintensity (WMH) burden, a common indicator of cerebrovascular pathology, in relation to conversion to mild cognitive impairment (MCI) in the elderly...
  23. pmc Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study
    Hiroko H Dodge
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Gerontol A Biol Sci Med Sci 65:1060-7. 2010
    ....
  24. ncbi request reprint Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease
    Joseph F Quinn
    Department Neurology, Oregon Health and Sciences University, Portland, OR, USA
    J Alzheimers Dis 6:93-7. 2004
    ....
  25. pmc Estimation of rest-activity patterns using motion sensors
    Tamara L Hayes
    Biomedical Engineering Department BME and the Oregon Center for Aging and Technology ORCATECH, Oregon Health and Science University OHSU, 3303 SW Bond Avenue, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:2147-50. 2010
    ..Data from this algorithm were highly correlated to ground truth measures (bed mats) and were surprisingly robust to variability in sensor layout and sleep habits...
  26. pmc Sleep habits in mild cognitive impairment
    Tamara L Hayes
    Departments of Biomedical Engineering Neurology Oregon Center for Aging and Technology, Oregon Health and Science University, Portland, OR
    Alzheimer Dis Assoc Disord 28:145-50. 2014
    ..These differences in sleep disruption between aMCI and naMCI may be related to differences in the pathology underlying these MCI subtypes. ..
  27. pmc SVM to detect the presence of visitors in a smart home environment
    Johanna Petersen
    Department of Biomedical Engineering, OHSU, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:5850-3. 2012
    ..These preliminary data demonstrate the feasibility of detecting visitors with in-home sensor data, but highlight the need for more advanced modeling techniques so the model performs well for all subjects and all types of visitors...
  28. pmc Patterns of dietary supplement usage in demographically diverse older people
    Shirley S Kishiyama
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Altern Ther Health Med 11:48-53. 2005
    ..To analyze dietary supplement usage data from 494 older adults, aged 65 to 101 years...
  29. pmc A study of medication-taking and unobtrusive, intelligent reminding
    Tamara L Hayes
    Division of Biomedical Engineering Oregon Health and Sciences University, Portland, Oregon 97239, USA
    Telemed J E Health 15:770-6. 2009
    ..This study indicates that context-aware prompting may provide improved adherence over standard time-based reminders...
  30. pmc Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease
    Randall L Woltjer
    Department of Pathology, Oregon Health and Sciences Univ, Portland, Oregon, USA
    J Neuropathol Exp Neurol 69:667-76. 2010
    ..These findings lend further support to the idea that dysregulation of the glutamatergic system may play a significant role in AD pathogenesis...
  31. pmc Technology use by rural and urban oldest old
    James F Calvert
    Department of Family Medicine, Oregon Health and Science University, Cascades East Family Medicine, Klamath Falls, OR, USA
    Technol Health Care 17:1-11. 2009
    ..The goal of this study was to determine the extent that community-dwelling elderly at highest risk of losing independence, the oldest old, use common electronic devices found in residential urban or rural settings...
  32. pmc The FAS gene, brain volume, and disease progression in Alzheimer's disease
    Deniz Erten-Lyons
    Veterans Affairs Medical Center, Portland, OR, USA
    Alzheimers Dement 6:118-24. 2010
    ..We sought to identify single-nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD) progression and brain volume...
  33. pmc Status of computerized cognitive testing in aging: a systematic review
    Katherine Wild
    Layton Aging and Alzheimer Center, Oregon Health and Science University, Portland, OR, USA
    Alzheimers Dement 4:428-37. 2008
    ..We present here a systematic review of the status of computer-based cognitive testing, focusing on detection of cognitive decline in the aging population...
  34. pmc The trajectory of gait speed preceding mild cognitive impairment
    Teresa Buracchio
    Layton Aging and Alzheimer s Disease Center, Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Mail Code CR 131, Portland, OR 97239, USA
    Arch Neurol 67:980-6. 2010
    ..We also sought to determine the approximate time at which the decline in motor function accelerated in persons who developed MCI...
  35. pmc Neuroimaging and cognition in Parkinson's disease dementia
    Lisa C Silbert
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Pathol 20:646-53. 2010
    ....
  36. ncbi request reprint A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
    Clifford Singer
    Department of Psychiatry, Oregon Health and Science University, Portland, USA
    Sleep 26:893-901. 2003
    ..To determine the safety and efficacy of 2 dose formulations of melatonin for the treatment of insomnia in patients with Alzheimer's disease...
  37. ncbi request reprint MRS in relation to hippocampal volume in the oldest old
    David C Spencer
    Oregon Health and Science University, Department of Neurology, Portland, OR 97201, USA
    Neurology 60:1194-6. 2003
    ..Neuropsychological tests and APOE genotype did not correlate with MRS ratios. MRS measures are candidate biomarkers for dementia risk...
  38. ncbi request reprint Age at onset of Parkinson disease and apolipoprotein E genotypes
    Sepideh Zareparsi
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Am J Med Genet 107:156-61. 2002
    ..There was a trend for earlier onset of PD in varepsilon2varepsilon3 patients than in varepsilon3varepsilon3 patients only in the Oregon sample. In conclusion, APOE is associated with age at onset of PD...
  39. ncbi request reprint Unobtrusive assessment of mobility
    Misha Pavel
    Biomed Eng Dept, Oregon Health and Sci Univ, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 1:6277-80. 2006
    ..The assessed mobility can be used to characterize the elder's speed of walking and can serve as one of the predictors of future cognitive functionality and the ability of elders to live independently in their home environment...
  40. ncbi request reprint Differential loss of synaptic proteins in Alzheimer's disease: implications for synaptic dysfunction
    P Hemachandra Reddy
    Neurogenetics Laboratory, Neurological Sciences Institute, Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    J Alzheimers Dis 7:103-17; discussion 173-80. 2005
    ..Our study suggests that postsynaptic proteins and presynaptic proteins are important for synaptic function and may be related to cognitive impairments in AD...
  41. ncbi request reprint Dementia assessment in primary care: results from a study in three managed care systems
    Linda Boise
    Layton Aging and Alzheimer Disease Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    J Gerontol A Biol Sci Med Sci 59:M621-6. 2004
    ..Prior research has found that dementia is often undiagnosed in primary care, but there has been limited research on whether physicians respond to symptoms, behaviors, or other events that may be indicators of dementia...
  42. ncbi request reprint Antioxidants in Alzheimer's disease-vitamin C delivery to a demanding brain
    Joseph Quinn
    Department of Neurology, the Portland Veteran s Affairs Medical Center and Oregon Health and Science University, Portland OR 97201, USA
    J Alzheimers Dis 5:309-13. 2003
    ..717; p=0.016). We conclude that oral vitamin C supplements are delivered to the brain, and speculate that the increased CSF: plasma ratio of vitamin C in AD reflects increased antioxidant consumption by the AD brain...
  43. ncbi request reprint Dementia-free survival among centenarians: an evidence-based review
    James F Calvert
    Department of Family Medicine, Oregon Health and Science University, Portland, USA
    J Gerontol A Biol Sci Med Sci 61:951-6. 2006
    ..The goal of this review was to identify research describing centenarians to find the prevalence of dementia-free survival...
  44. ncbi request reprint Magnetic resonance approaches to brain aging and Alzheimer disease-associated neuropathology
    Valerie C Anderson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Top Magn Reson Imaging 16:439-52. 2005
    ..These newer techniques continue to expand our understanding of neuropathology in the aging brain and are likely to play an important clinical role in the future...
  45. ncbi request reprint Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease
    John C Adair
    Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Stroke 35:e159-62. 2004
    ....
  46. pmc Physical activity and the risk of dementia in oldest old
    Aleksandra Sumic
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Rd Campus Services Building 669, Mail Code CB 669, Portland, Oregon 97201 3098, USA
    J Aging Health 19:242-59. 2007
    ..This study evaluated the protective role of physical activity (PA) against cognitive impairment (CI) in the oldest old (age >/= 85)...
  47. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  48. ncbi request reprint apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice
    Jennifer Robertson
    Department of Behavioral Neuroscience, L470, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Neurobiol Aging 26:637-43. 2005
    ..Consistent with the mouse data, male and female PRAD patients with epsilon4/epsilon4 showed higher anxiety scores than those with epsilon3/epsilon3. We conclude that human apoE isoforms have differential effects on measures of anxiety...
  49. pmc Unobtrusive and ubiquitous in-home monitoring: a methodology for continuous assessment of gait velocity in elders
    Stuart Hagler
    Division of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    IEEE Trans Biomed Eng 57:813-20. 2010
    ..1 cm/s (SD = 9.1 cm/s) after a simple calibration procedure. Based on the average measured walking speed of 102 cm/s, our system had an average error of less than 7% without calibration and 1.1% with calibration...
  50. pmc Trends in the prevalence of dementia in Japan
    Hiroko H Dodge
    Department of Neurology, Oregon Health and Science University, CR131, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, USA Department of Neurology, University of Michigan, Ann Arbor, MI 48190, USA
    Int J Alzheimers Dis 2012:956354. 2012
    ..Further studies, for example, comparing the population attributable risk of vascular diseases to the prevalence and incidence of dementia could help to clarify the regional variations in etiological subtypes...
  51. pmc Dyslipidemia and blood-brain barrier integrity in Alzheimer's disease
    Gene L Bowman
    Department of Neurology, Oregon Health and Science University, 3181 Southwest Samuel Jackson Park Road, Portland, OR 97239, USA
    Curr Gerontol Geriatr Res 2012:184042. 2012
    ..Conclusion. Dyslipidemia is more prevalent in AD subjects with BBB impairment. Plasma triglyceride and HDL cholesterol may have a role in maintaining BBB integrity in mild-to-moderate Alzheimer's disease...
  52. pmc An electronic pillbox for continuous monitoring of medication adherence
    Tamara L Hayes
    Dept of Biomed Eng, Oregon Health and Sci Univ, Portland, OR, USA
    Conf Proc IEEE Eng Med Biol Soc 1:6400-3. 2006
    ..We report on the design of the MedTracker, and on the results of a field trial in 39 homes to evaluate the device...
  53. ncbi request reprint Greater orbital prefrontal volume selectively predicts worse working memory performance in older adults
    David H Salat
    Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Cereb Cortex 12:494-505. 2002
    ..These results suggest that working memory is a sensitive measure of cognitive aging and that regional morphology is associated with specific cognitive abilities in older adults...
  54. pmc Translational gene mapping of cognitive decline
    Beth Wilmot
    Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neurobiol Aging 29:524-41. 2008
    ....
  55. ncbi request reprint Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
    Christopher M Clark
    Departments of Neurology, Center for Neuerodegenerative Disease Research, Alzheimer s Disease Center, Philadelphia, PA 19104, USA
    Arch Neurol 60:1696-702. 2003
    ..To understand their value as predictors of disease-specific pathology, levels determined during life must be correlated with definitive diagnoses in mixed dementia groups and cognitively normal subjects...
  56. pmc Unobtrusive assessment of walking speed in the home using inexpensive PIR sensors
    Tamara L Hayes
    The Biomedical Engineering division, Oregon Health and Science University, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:7248-51. 2009
    ..We discuss the potential of this approach for continuous assessment...
  57. pmc Gender effects on plasma and brain copper
    Joseph F Quinn
    Department of Neurology, Portland VA Medical Center and Oregon Health and Science University, Portland, OR 97239, USA
    Int J Alzheimers Dis 2011:150916. 2011
    ..01) was higher in women than in men, but there was no difference in cerebrospinal fluid copper. We conclude that gender differences in copper status may influence copper-mediated pathological events in the brain...
  58. pmc Exceptional brain aging in a rural population-based cohort
    Jeffrey Kaye
    Department of Neurology, Oregon Health and Science University, Portland, OR, USA
    J Rural Health 25:320-5. 2009
    ..Little is known about the prevalence of dementia and other disabling conditions among rural centenarians although this information is important to clinicians caring for them...
  59. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  60. ncbi request reprint Independent predictors of cognitive decline in healthy elderly persons
    Scott Marquis
    Department of Medicine Neurology, University of Alberta, 2E3 08, 8440 112th St, Edmonton, Alberta, Canada T6G 2B7
    Arch Neurol 59:601-6. 2002
    ..Several studies have shown that individually memory, hippocampal volume, and motor measures presage the onset of dementia. It is unclear if these independently contribute to the prediction of mild cognitive impairment...
  61. ncbi request reprint Quantitative in vivo biomarkers of oxidative damage and their application to the diagnosis and management of Alzheimer's disease
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    J Alzheimers Dis 8:359-67. 2005
    ..In addition, measurement of CSF F2-IsoPs can increase the accuracy of laboratory-based classification of geriatric dementias, and have been used to assess objectively the response to anti-oxidant interventions in AD...
  62. ncbi request reprint Symptoms of sleep disturbance in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Department of Biomathematics and Biostatistics, Georgetown University School of Medicine, Georgetown University Hospital, Washington, DC 20007, USA
    J Sleep Res 14:177-85. 2005
    ..There was no association between subjective perception of 'sleep problems', the number and frequency of sleep disturbance symptoms, and estimated TIB in either group...
  63. ncbi request reprint Corpus callosum in neurodegenerative diseases: findings in Parkinson's disease
    Katie Wiltshire
    University of Alberta, Edmonton, Canada
    Dement Geriatr Cogn Disord 20:345-51. 2005
    ..80, -2.18 to -1.43). We conclude that PD and PDD patients do not have callosal atrophy in contrast to other neurodegenerative diseases, including AD. Callosal atrophy was correlated with dementia severity in patients with AD but not PDD...
  64. ncbi request reprint Neural networks for longitudinal studies in Alzheimer's disease
    Reeti Tandon
    Computational Biology and Biostatistics Lab, GE India Technology Center, EPIP Phase II, Hoodi Village, Whitefield Road, Bangalore, Karnataka 560066, India
    Artif Intell Med 36:245-55. 2006
    ..We propose a new type of neural network called the mixed effects neural network (MENN) model that can incorporate this type of longitudinal information...
  65. ncbi request reprint Characterizing sleep problems in persons with Alzheimer's disease and normal elderly
    Rochelle E Tractenberg
    Departments of Biostatistics, Biomathematics and Bioinformatics and Psychiatry, Georgetown University School of Medicine, Washington, DC, USA
    J Sleep Res 15:97-103. 2006
    ..Within-cohort differences reflect a clear distinction between persons with and without sleep problems, regardless of the reporter...
  66. ncbi request reprint Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    Sandip Ray
    Satoris, Inc, 2686 Middlefield Road, Suite E, Redwood City, California 94063, USA
    Nat Med 13:1359-62. 2007
    ..Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease...
  67. pmc Biomarkers for cognitive impairment and dementia in elderly people
    Joshua A Sonnen
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA 98104, USA
    Lancet Neurol 7:704-14. 2008
    ..An approach that efficiently combines independent information from risk-factor assessment, neuroimaging measures, and biomarkers might soon guide clinicians in the early diagnosis and management of cognitive impairment in elderly people...
  68. ncbi request reprint Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition
    Elaine R Peskind
    VA Puget Sound Health Care System, Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Arch Neurol 63:936-9. 2006
    ..Normal aging and the presence of the apolipoprotein E (APOE*4) allele are the most important known risk factors for Alzheimer disease...
  69. ncbi request reprint Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease
    Thomas J Montine
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Ann Neurol 52:175-9. 2002
    ..These results should guide the organization of clinical trials now being planned for patients with Alzheimer's disease...
  70. ncbi request reprint Healthy brain aging
    Jeffrey A Kaye
    Arch Neurol 59:1721-3. 2002
  71. ncbi request reprint Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro
    Simona Vuletic
    Department of Medicine, Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, Washington 98109 4517, USA
    J Neurosci Res 80:406-13. 2005
    ..The findings of reduced PLTP activity in AD CSF, and the observation that PLTP can influence apoE secretion in astrocytes suggest a potential link between alterations in the brain lipid metabolism and AD pathogenesis...
  72. ncbi request reprint Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease
    Jing Zhang
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA
    J Alzheimers Dis 7:125-33; discussion 173-80. 2005
    ....
  73. pmc Multiple SNPs within and surrounding the apolipoprotein E gene influence cerebrospinal fluid apolipoprotein E protein levels
    Lynn M Bekris
    Geriatric Research, Education, and Clinical Center GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:255-66. 2008
    ..Further investigation of the genetic influence of these loci on apoE expression levels in the central nervous system is likely to provide new insight into apoE regulation as well as AD pathogenesis...

Research Grants9

  1. Intelligent Systems for Detection of Aging Changes
    Jeffrey Kaye; Fiscal Year: 2007
    ....
  2. Intelligent Systems for Detection of Aging Changes
    Jeffrey Kaye; Fiscal Year: 2006
    ....
  3. Oregon Roybal Center for Translational Research on Aging
    Jeffrey Kaye; Fiscal Year: 2007
    ..abstract_text> ..
  4. Intelligent Systems for Detection of Aging Changes
    Jeffrey Kaye; Fiscal Year: 2009
    ....
  5. Intelligent Systems for Detection of Aging Changes
    Jeffrey A Kaye; Fiscal Year: 2010
    ....