M P Kavanaugh

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint ASCT-1 is a neutral amino acid exchanger with chloride channel activity
    N Zerangue
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 271:27991-4. 1996
  2. ncbi request reprint Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family
    M P Kavanaugh
    Vollum Institute, Oregon Health Sciences University, Portland, USA
    Kidney Int 49:959-63. 1996
  3. ncbi request reprint Localization and function of five glutamate transporters cloned from the salamander retina
    S Eliasof
    Vollum Institute L 474, Oregon Health Sciences University, Portland 97210, USA
    Vision Res 38:1443-54. 1998
  4. pmc Interaction of L-cysteine with a human excitatory amino acid transporter
    N Zerangue
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Physiol 493:419-23. 1996
  5. pmc Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97210, USA
    Proc Natl Acad Sci U S A 94:4155-60. 1997
  6. ncbi request reprint Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons
    C S Tailor
    Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 87201 3098, USA
    J Biol Chem 276:27221-30. 2001
  7. ncbi request reprint Cloning and expression of a family of inward rectifier potassium channels
    C T Bond
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Receptors Channels 2:183-91. 1994
  8. pmc gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5
    N Madani
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Proc Natl Acad Sci U S A 95:8005-10. 1998
  9. ncbi request reprint Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants
    M S Sonders
    Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
    J Neurosci 17:960-74. 1997
  10. pmc The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species
    S L Kozak
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    J Virol 69:3433-40. 1995

Collaborators

Detail Information

Publications18

  1. ncbi request reprint ASCT-1 is a neutral amino acid exchanger with chloride channel activity
    N Zerangue
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 271:27991-4. 1996
    ..The properties of ASCT-1 suggest that it may function to equilibrate different pools of neutral amino acids and provide a mechanism to link amino acid concentration gradients...
  2. ncbi request reprint Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family
    M P Kavanaugh
    Vollum Institute, Oregon Health Sciences University, Portland, USA
    Kidney Int 49:959-63. 1996
    ..The distinct structural and functional properties of these molecules establishes them as members of a new family of phosphate transporters which may play a major role in phosphate uptake in a wide variety of cell types...
  3. ncbi request reprint Localization and function of five glutamate transporters cloned from the salamander retina
    S Eliasof
    Vollum Institute L 474, Oregon Health Sciences University, Portland 97210, USA
    Vision Res 38:1443-54. 1998
    ....
  4. pmc Interaction of L-cysteine with a human excitatory amino acid transporter
    N Zerangue
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    J Physiol 493:419-23. 1996
    ..5. Because the EAAT3 transporter is also expressed in tissues including kidney and intestine, the results suggest the possibility of a heretofore unrecognized mechanism of L-cysteine uptake in peripheral tissues as well as in brain...
  5. pmc Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97210, USA
    Proc Natl Acad Sci U S A 94:4155-60. 1997
    ..These properties of EAAT5 are similar to the glutamate-elicited chloride conductances previously described in retinal neurons, suggesting that the EAAT5-associated chloride conductance may participate in visual processing...
  6. ncbi request reprint Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons
    C S Tailor
    Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 87201 3098, USA
    J Biol Chem 276:27221-30. 2001
    ..We conclude that ASCT2 isoforms with truncated amino termini are synthesized in mammalian cells by a leaky scanning mechanism that employs multiple alternative CUG and GUG initiation codons...
  7. ncbi request reprint Cloning and expression of a family of inward rectifier potassium channels
    C T Bond
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Receptors Channels 2:183-91. 1994
    ..The results demonstrate the existence of a large and widely expressed family of inward rectifier potassium channel subunits with distinct tissue distributions and functional properties...
  8. pmc gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5
    N Madani
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Proc Natl Acad Sci U S A 95:8005-10. 1998
    ..The gp120-mediated disruption of CXCR4 and CCR5 signaling may contribute to AIDS pathogenesis...
  9. ncbi request reprint Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants
    M S Sonders
    Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
    J Neurosci 17:960-74. 1997
    ..In addition, the voltage dependence of DA uptake suggests a mechanism through which presynaptic DA autoreceptor activation may accelerate the termination of dopaminergic neurotransmission in vivo...
  10. pmc The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species
    S L Kozak
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    J Virol 69:3433-40. 1995
    ..We conclude that amphotropic gp70 binds more strongly to rRam-1 than to the homologous hamster protein and that this stable attachment is necessary for infection, interference, membrane fusion, and pathogenesis...
  11. ncbi request reprint An excitatory amino-acid transporter with properties of a ligand-gated chloride channel
    W A Fairman
    Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
    Nature 375:599-603. 1995
    ..Thus EAAT4 combines the re-uptake of neurotransmitter with a mechanism for increasing chloride permeability, both of which could regulate excitatory neurotransmission...
  12. ncbi request reprint 1,3-Di(2-tolyl)guanidine blocks nicotinic response in guinea pig myenteric neurons
    J J Galligan
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    J Pharmacol Exp Ther 251:169-74. 1989
    ..0 and 12.3 microM, respectively) whereas DTG but not Bridge-DPG inhibited 5-HT-induced contractions of the longitudinal muscle-myenteric plexus noncompetitively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. pmc Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters
    M P Kavanaugh
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    Proc Natl Acad Sci U S A 91:7071-5. 1994
    ..Accordingly, depletion of extracellular phosphate increased Ram-1 and Glvr-1 expression 3- to 5-fold. These results suggest simple methods to modulate retroviral receptor expression, with possible applications to human gene therapy...
  14. ncbi request reprint Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 268:15329-32. 1993
    ..Northern blot analyses revealed ubiquitous expression of this gene, termed ASCT1, consistent with the general metabolic role ascribed to system ASC...
  15. ncbi request reprint Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition
    Y Bismuth
    Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel
    J Biol Chem 272:16096-102. 1997
    ..The total conservation of the residue throughout the family suggests that tyrosine 140 may be involved in the liganding of the amino group, the moiety common to all of the neurotransmitters...
  16. ncbi request reprint Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family
    M P Kavanaugh
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201 3098
    J Biol Chem 269:15445-50. 1994
    ..These results demonstrate that domains of these transporters can function in chimeric combinations to control viral receptor and transport functions...
  17. ncbi request reprint Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex
    J L Arriza
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Neurosci 14:5559-69. 1994
    ..These studies provide a foundation for understanding the role of glutamate transporters in human excitatory neurotransmission and in neuropathology...
  18. ncbi request reprint Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters
    H P Koch
    Department of Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA
    Mol Pharmacol 56:1095-104. 1999
    ....