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Genomes and Genes | M P KavanaughSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
ASCT-1 is a neutral amino acid exchanger with chloride channel activityN Zerangue
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Biol Chem 271:27991-4. 1996..The properties of ASCT-1 suggest that it may function to equilibrate different pools of neutral amino acids and provide a mechanism to link amino acid concentration gradients...- Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor familyM P Kavanaugh
Vollum Institute, Oregon Health Sciences University, Portland, USA
Kidney Int 49:959-63. 1996..The distinct structural and functional properties of these molecules establishes them as members of a new family of phosphate transporters which may play a major role in phosphate uptake in a wide variety of cell types... - Localization and function of five glutamate transporters cloned from the salamander retinaS Eliasof
Vollum Institute L 474, Oregon Health Sciences University, Portland 97210, USA
Vision Res 38:1443-54. 1998.... 
Interaction of L-cysteine with a human excitatory amino acid transporterN Zerangue
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
J Physiol 493:419-23. 1996..5. Because the EAAT3 transporter is also expressed in tissues including kidney and intestine, the results suggest the possibility of a heretofore unrecognized mechanism of L-cysteine uptake in peripheral tissues as well as in brain...- Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductanceJ L Arriza
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97210, USA
Proc Natl Acad Sci U S A 94:4155-60. 1997..These properties of EAAT5 are similar to the glutamate-elicited chloride conductances previously described in retinal neurons, suggesting that the EAAT5-associated chloride conductance may participate in visual processing... - Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codonsC S Tailor
Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 87201 3098, USA
J Biol Chem 276:27221-30. 2001..We conclude that ASCT2 isoforms with truncated amino termini are synthesized in mammalian cells by a leaky scanning mechanism that employs multiple alternative CUG and GUG initiation codons... - Cloning and expression of a family of inward rectifier potassium channelsC T Bond
Vollum Institute, Oregon Health Sciences University, Portland 97201
Receptors Channels 2:183-91. 1994..The results demonstrate the existence of a large and widely expressed family of inward rectifier potassium channel subunits with distinct tissue distributions and functional properties... - gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5N Madani
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
Proc Natl Acad Sci U S A 95:8005-10. 1998..The gp120-mediated disruption of CXCR4 and CCR5 signaling may contribute to AIDS pathogenesis... - Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulantsM S Sonders
Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
J Neurosci 17:960-74. 1997..In addition, the voltage dependence of DA uptake suggests a mechanism through which presynaptic DA autoreceptor activation may accelerate the termination of dopaminergic neurotransmission in vivo... - The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible speciesS L Kozak
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
J Virol 69:3433-40. 1995..We conclude that amphotropic gp70 binds more strongly to rRam-1 than to the homologous hamster protein and that this stable attachment is necessary for infection, interference, membrane fusion, and pathogenesis... - An excitatory amino-acid transporter with properties of a ligand-gated chloride channelW A Fairman
Howard Hughes Medical Institute, Oregon Health Sciences University, Portland 97201, USA
Nature 375:599-603. 1995..Thus EAAT4 combines the re-uptake of neurotransmitter with a mechanism for increasing chloride permeability, both of which could regulate excitatory neurotransmission... - 1,3-Di(2-tolyl)guanidine blocks nicotinic response in guinea pig myenteric neuronsJ J Galligan
Vollum Institute, Oregon Health Sciences University, Portland 97201
J Pharmacol Exp Ther 251:169-74. 1989..0 and 12.3 microM, respectively) whereas DTG but not Bridge-DPG inhibited 5-HT-induced contractions of the longitudinal muscle-myenteric plexus noncompetitively.(ABSTRACT TRUNCATED AT 250 WORDS).. - Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symportersM P Kavanaugh
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
Proc Natl Acad Sci U S A 91:7071-5. 1994..Accordingly, depletion of extracellular phosphate increased Ram-1 and Glvr-1 expression 3- to 5-fold. These results suggest simple methods to modulate retroviral receptor expression, with possible applications to human gene therapy... - Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene familyJ L Arriza
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
J Biol Chem 268:15329-32. 1993..Northern blot analyses revealed ubiquitous expression of this gene, termed ASCT1, consistent with the general metabolic role ascribed to system ASC... - Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognitionY Bismuth
Department of Biochemistry, Hadassah Medical School, The Hebrew University, Jerusalem 91120, Israel
J Biol Chem 272:16096-102. 1997..The total conservation of the residue throughout the family suggests that tyrosine 140 may be involved in the liganding of the amino group, the moiety common to all of the neurotransmitters... - Control of cationic amino acid transport and retroviral receptor functions in a membrane protein familyM P Kavanaugh
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201 3098
J Biol Chem 269:15445-50. 1994..These results demonstrate that domains of these transporters can function in chimeric combinations to control viral receptor and transport functions... - Functional comparisons of three glutamate transporter subtypes cloned from human motor cortexJ L Arriza
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
J Neurosci 14:5559-69. 1994..These studies provide a foundation for understanding the role of glutamate transporters in human excitatory neurotransmission and in neuropathology... - Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transportersH P Koch
Department of Pharmaceutical Sciences, University of Montana, Missoula, Montana, USA
Mol Pharmacol 56:1095-104. 1999....