Takatoshi Karasawa

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e66220. 2013
  2. pmc Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Sci 124:378-87. 2011
  3. pmc CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    T Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, 97239, USA
    Cell Death Dis 1:e102. 2010
  4. pmc Intracellular mechanisms of aminoglycoside-induced cytotoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Integr Biol (Camb) 3:879-86. 2011
  5. pmc Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels
    Tian Wang
    Oregon Hearing Research Center, NRC04, Department of Otolaryngology, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Biochem Biophys 65:381-98. 2013
  6. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008
  7. pmc Diverse kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
    Yuqin Yang
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR, 97239, United States of America
    PLoS ONE 10:e0125266. 2015
  8. pmc Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides
    Meiyan Jiang
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 9:e108941. 2014

Research Grants

  1. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. pmc Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e66220. 2013
    ....
  2. pmc Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Sci 124:378-87. 2011
    ..Therefore, we conclude that CRT binding to gentamicin is protective against gentamicin-induced cytotoxicity...
  3. pmc CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    T Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, 97239, USA
    Cell Death Dis 1:e102. 2010
    ..Gentamicin also enhanced the binding between CLIMP-63 and 14-3-3 proteins, and we also identified that 14-3-3 proteins are involved in gentamicin-induced cytotoxicity, likely by binding to CLIMP-63...
  4. pmc Intracellular mechanisms of aminoglycoside-induced cytotoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Integr Biol (Camb) 3:879-86. 2011
    ..We also discuss potential strategies to reduce aminoglycoside cytotoxicity, which are necessary for greater bactericidal efficacy during aminoglycoside pharmacotherapy...
  5. pmc Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels
    Tian Wang
    Oregon Hearing Research Center, NRC04, Department of Otolaryngology, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Biochem Biophys 65:381-98. 2013
    ....
  6. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008
    ..In an endolymph-like extracellular environment, clearance of GTTR was attenuated from KPT2-TRPV4 cells in a TRPV4-dependent fashion. We propose that TRPV4 has a role in aminoglycoside uptake and retention in the cochlea...
  7. pmc Diverse kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles
    Yuqin Yang
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR, 97239, United States of America
    PLoS ONE 10:e0125266. 2015
    ..The fast Kir-based regenerative shifts between two RP states could form a critical mechanism for conduction/spread of vasomotion along the arteriole axis. ..
  8. pmc Sodium-glucose transporter-2 (SGLT2; SLC5A2) enhances cellular uptake of aminoglycosides
    Meiyan Jiang
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 9:e108941. 2014
    ..Phlorizin did not protect wild-type mice from kanamycin-induced ototoxicity. We conclude that SGLT2 can traffic gentamicin and contribute to gentamicin-induced cytotoxicity. ..

Research Grants1

  1. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007
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