Takatoshi Karasawa

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e66220. 2013
  2. pmc Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Sci 124:378-87. 2011
  3. pmc CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    T Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, 97239, USA
    Cell Death Dis 1:e102. 2010
  4. pmc Intracellular mechanisms of aminoglycoside-induced cytotoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Integr Biol (Camb) 3:879-86. 2011
  5. pmc Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels
    Tian Wang
    Oregon Hearing Research Center, NRC04, Department of Otolaryngology, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Biochem Biophys 65:381-98. 2013
  6. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008

Research Grants

  1. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007

Collaborators

  • Q Wang
  • Zhi Gen Jiang
  • Tian Wang
  • Yu Qin Yang
  • Ke tao Ma
  • Meiyan Jiang
  • Peter S Steyger
  • Ding hua Xie
  • Amanda Phillips
  • Bing Cai Guan

Detail Information

Publications6

  1. pmc Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 8:e66220. 2013
    ....
  2. pmc Calreticulin binds to gentamicin and reduces drug-induced ototoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Toxicol Sci 124:378-87. 2011
    ..Therefore, we conclude that CRT binding to gentamicin is protective against gentamicin-induced cytotoxicity...
  3. pmc CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity
    T Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, 97239, USA
    Cell Death Dis 1:e102. 2010
    ..Gentamicin also enhanced the binding between CLIMP-63 and 14-3-3 proteins, and we also identified that 14-3-3 proteins are involved in gentamicin-induced cytotoxicity, likely by binding to CLIMP-63...
  4. pmc Intracellular mechanisms of aminoglycoside-induced cytotoxicity
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Integr Biol (Camb) 3:879-86. 2011
    ..We also discuss potential strategies to reduce aminoglycoside cytotoxicity, which are necessary for greater bactericidal efficacy during aminoglycoside pharmacotherapy...
  5. pmc Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels
    Tian Wang
    Oregon Hearing Research Center, NRC04, Department of Otolaryngology, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Biochem Biophys 65:381-98. 2013
    ....
  6. pmc TRPV4 enhances the cellular uptake of aminoglycoside antibiotics
    Takatoshi Karasawa
    Oregon Hearing Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, OR 97239, USA
    J Cell Sci 121:2871-9. 2008
    ..In an endolymph-like extracellular environment, clearance of GTTR was attenuated from KPT2-TRPV4 cells in a TRPV4-dependent fashion. We propose that TRPV4 has a role in aminoglycoside uptake and retention in the cochlea...

Research Grants2

  1. Aminoglycoside uptake and clearance in mammalian cells
    Takatoshi Karasawa; Fiscal Year: 2007
    ..Finally, we will conduct in vivo gentamicin injection experiments and determine if strial endothelial cells uptake gentamicin, allowing the drug to pass through stria vascularis, and if this process is also dependent on TRPV4 channel. ..