DONALD JUMP

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. ncbi Omega-3 fatty acid supplementation and cardiovascular disease
    Donald B Jump
    Nutrition Program, School of Biological and Population Health Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Lipid Res 53:2525-45. 2012
  2. ncbi Docosahexaenoic acid (DHA) and hepatic gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, MI 48824, United States
    Chem Phys Lipids 153:3-13. 2008
  3. ncbi Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation
    Donald B Jump
    Department of Nutrition and Exercise Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States
    Biochem Pharmacol 81:649-60. 2011
  4. ncbi Fatty acid regulation of hepatic lipid metabolism
    Donald B Jump
    Department of Nutrition and Exercise Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Curr Opin Clin Nutr Metab Care 14:115-20. 2011
  5. ncbi N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 5109, USA
    Curr Opin Lipidol 19:242-7. 2008
  6. ncbi Fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Nutr 135:2503-6. 2005
  7. ncbi Dietary polyunsaturated fatty acids and regulation of gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Opin Lipidol 13:155-64. 2002
  8. ncbi Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes
    Anjali Pawar
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:35931-9. 2003
  9. ncbi Fatty acid regulation of gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Crit Rev Clin Lab Sci 41:41-78. 2004
  10. ncbi The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression
    Anjali Pawar
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:40736-43. 2003

Research Grants

  1. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2003
  2. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 1993
  3. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009

Collaborators

  • Y Wang
  • Jeffrey Peters
  • N Parameswaran
  • Anjali Pawar
  • Daniela Botolin
  • Weiqin Chen
  • Jinghua Xu
  • Julia V Busik
  • Barbara Christian
  • Walter J Esselman
  • Darrell R Boverhof
  • David J Mangelsdorf
  • Lyle D Burgoon
  • Colleen Tashiro
  • Timothy R Zacharewski
  • Jack R Harkema
  • Brock Chittim
  • Erik Jerks

Detail Information

Publications22

  1. ncbi Omega-3 fatty acid supplementation and cardiovascular disease
    Donald B Jump
    Nutrition Program, School of Biological and Population Health Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Lipid Res 53:2525-45. 2012
    ..The outcome of our analysis reveals that nonfish sources of ω 3 PUFA vary in their capacity to regulate blood levels of C(20-22) ω 3 PUFA and CVD risk factors...
  2. ncbi Docosahexaenoic acid (DHA) and hepatic gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, MI 48824, United States
    Chem Phys Lipids 153:3-13. 2008
    ..22:6,n-3 control of these same signaling pathways in non-hepatic tissues may help to explain the diverse actions of n-3 PUFA on such complex physiological processes as visual acuity and learning...
  3. ncbi Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation
    Donald B Jump
    Department of Nutrition and Exercise Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, United States
    Biochem Pharmacol 81:649-60. 2011
    ..Pharmacological inhibition of ACC activity will not only attenuate DNL and induce FAO, but will also attenuate the synthesis of very long chain saturated, mono- and polyunsaturated fatty acids...
  4. ncbi Fatty acid regulation of hepatic lipid metabolism
    Donald B Jump
    Department of Nutrition and Exercise Sciences, The Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Curr Opin Clin Nutr Metab Care 14:115-20. 2011
    ..To discuss transcriptional mechanisms regulating hepatic lipid metabolism...
  5. ncbi N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 5109, USA
    Curr Opin Lipidol 19:242-7. 2008
    ..This review brings together metabolic and molecular studies that help explain n-3 (omega-3) polyunsaturated fatty acid regulation of hepatic gene transcription...
  6. ncbi Fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Departments of Physiology, Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA
    J Nutr 135:2503-6. 2005
    ..Many of these mechanisms are regulated by PPARalpha or SREBP-1c. Together, these mechanisms control hepatic lipid composition and affect whole-body lipid composition...
  7. ncbi Dietary polyunsaturated fatty acids and regulation of gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Curr Opin Lipidol 13:155-64. 2002
    ....
  8. ncbi Unsaturated fatty acid regulation of peroxisome proliferator-activated receptor alpha activity in rat primary hepatocytes
    Anjali Pawar
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:35931-9. 2003
    ....
  9. ncbi Fatty acid regulation of gene transcription
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Crit Rev Clin Lab Sci 41:41-78. 2004
    ....
  10. ncbi The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression
    Anjali Pawar
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:40736-43. 2003
    ..The unsaturated fatty acid suppression of SREBP-1 and its targeted lipogenic genes is independent of LXRalpha..
  11. ncbi Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition
    Yun Wang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 49:1538-52. 2008
    ..As such, hepatic Elovl5 activity may affect hepatic glucose production during fasting. In summary, Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition...
  12. ncbi Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity
    Yun Wang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 47:2028-41. 2006
    ..In conclusion, these studies establish a role for PPARalpha, LXR, SREBP-1, ChREBP, and MLX in the control of hepatic fatty acid elongase and desaturase expression and lipid composition...
  13. ncbi Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist
    Jinghua Xu
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 281:18351-62. 2006
    ..In conclusion, n-3 PUFA and WY14643/PPARalpha target different transcription factors to control L-PK gene transcription. MLX, the heterodimer partner for ChREBP, has emerged as a novel target for n-3 PUFA regulation...
  14. ncbi The biochemistry of n-3 polyunsaturated fatty acids
    Donald B Jump
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 277:8755-8. 2002
  15. ncbi Selective proteolytic processing of rat hepatic sterol regulatory element binding protein-1 (SREBP-1) and SREBP-2 during postnatal development
    Daniela Botolin
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 278:6959-62. 2003
    ..This mechanism differs from the hormonal and fatty acid-mediated pre-translational control of SREBP-1c in adult liver...
  16. ncbi Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways
    Daniela Botolin
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 47:181-92. 2006
    ..Thus, 22:6,n-3 suppresses hepatocyte nSREBP-1 through 26S proteasome- and Erk-dependent pathways. These studies reveal a novel mechanism for n-3 PUFA regulation of hepatocyte nSREBP-1 and lipid metabolism...
  17. ncbi Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid
    Weiqin Chen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824, USA
    Invest Ophthalmol Vis Sci 48:18-26. 2007
    ....
  18. ncbi Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity
    Darrell R Boverhof
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing Michigan 48824-1319, USA
    Toxicol Sci 85:1048-63. 2005
    ..Collectively, the data support a proposed mechanism for TCDD-mediated hepatotoxicity, including fatty liver, which involves mobilization of peripheral fat and inappropriate increases in hepatic uptake of fatty acids...
  19. ncbi Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases
    Yun Wang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 46:706-15. 2005
    ..In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver...
  20. ncbi Negative growth effects of ciglitazone on kidney interstitial fibroblasts: role of PPAR-gamma
    Narayanan Parameswaran
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Kidney Blood Press Res 26:2-9. 2003
    ....
  21. ncbi Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells
    Anjali Pawar
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 277:39243-50. 2002
    ..Taken together, these findings demonstrate that the rate of assimilation of exogenously added fatty acids and their metabolites into complex lipids plays an important role in regulating PPARalpha and LXRalpha activity...
  22. ncbi Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells
    Weiqin Chen
    Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, 48824, USA
    Invest Ophthalmol Vis Sci 46:4342-7. 2005
    ..DHA(22:6n3) could be an important anti-inflammatory agent in the face of increased cytokine production and CAM expression in the diabetic retina...

Research Grants16

  1. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2003
    ..Understanding how these factors participate in this process in normal and obese animals will have important implications for human health. ..
  2. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 1993
    ..Finally, it is not unreasonable to expect that the PUFA mechanism of gene control may extend beyond lipogenesis and could explain other metabolic actions of PUFA...
  3. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..Determine how over expression of specific fatty acid elongases affects hepatic function, blood lipid composition and the onset of chronic disease. ..