Elaine Johnson

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Chronology of optic nerve head and retinal responses to elevated intraocular pressure
    E C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 41:431-42. 2000
  2. pmc Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?
    Ying Guo
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Exp Eye Res 89:921-33. 2009
  3. pmc Friend or foe? Resolving the impact of glial responses in glaucoma
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, 3375 S W Terwilliger Blvd, Portland, OR 97239, USA
    J Glaucoma 18:341-53. 2009
  4. pmc Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models
    Elaine C Johnson
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Ceres, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Eye Res 88:808-15. 2009
  5. pmc Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 52:504-18. 2011
  6. pmc Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 48:3161-77. 2007
  7. ncbi request reprint The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health Sciences University, 3375 S W Terwilliger Blvd, Portland, OR 97201, USA
    Exp Eye Res 83:51-60. 2006
  8. pmc Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats
    John C Morrison
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4146, USA
    Invest Ophthalmol Vis Sci 50:2802-8. 2009
  9. pmc Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer
    Ying Guo
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 51:3003-18. 2010
  10. doi request reprint Rat models for glaucoma research
    John C Morrison
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Prog Brain Res 173:285-301. 2008

Research Grants

  1. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2007

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Chronology of optic nerve head and retinal responses to elevated intraocular pressure
    E C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 41:431-42. 2000
    ..To determine the chronology of optic nerve head and retinal responses to elevated intraocular pressure (IOP)...
  2. pmc Does elevated intraocular pressure reduce retinal TRKB-mediated survival signaling in experimental glaucoma?
    Ying Guo
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Exp Eye Res 89:921-33. 2009
    ..A better understanding of the roles of these proteins in IOP-induced injury is likely to suggest informed strategies for neuroprotection in glaucoma...
  3. pmc Friend or foe? Resolving the impact of glial responses in glaucoma
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, 3375 S W Terwilliger Blvd, Portland, OR 97239, USA
    J Glaucoma 18:341-53. 2009
    ..With these unresolved issues in mind, this review will summarize recent progress in our understanding of the process of glial activation in the glaucomatous optic nerve head and retina...
  4. pmc Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models
    Elaine C Johnson
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Ceres, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Eye Res 88:808-15. 2009
    ..The examination of these studies in this review reveals a number of consistent observations and provides direction for further investigations of this hypothesis...
  5. pmc Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 52:504-18. 2011
    ..However, the initial responses of the ONH to elevated IOP are unknown. Here the authors use a rat glaucoma model to characterize ONH gene expression changes associated with early optic nerve injury...
  6. pmc Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Department of Ophthalmology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Invest Ophthalmol Vis Sci 48:3161-77. 2007
    ..In glaucoma, the optic nerve head (ONH) is the likely site of initial injury and elevated intraocular pressure (IOP) is the best-known risk factor. This study determines global gene expression changes in the pressure-injured ONH...
  7. ncbi request reprint The use of cyclodialysis to limit exposure to elevated intraocular pressure in rat glaucoma models
    Elaine C Johnson
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health Sciences University, 3375 S W Terwilliger Blvd, Portland, OR 97201, USA
    Exp Eye Res 83:51-60. 2006
    ..This tool offers new opportunities for identifying and studying the molecular processes associated with glaucomatous progression and for testing potential neuroprotective therapies in a clinically relevant situation...
  8. pmc Reliability and sensitivity of the TonoLab rebound tonometer in awake Brown Norway rats
    John C Morrison
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4146, USA
    Invest Ophthalmol Vis Sci 50:2802-8. 2009
    ..To compare the sensitivity of the TonoLab rebound tonometer with the Tono-Pen in awake Brown Norway rats and to compare their ability to predict optic nerve damage induced by experimental IOP elevation...
  9. pmc Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer
    Ying Guo
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Invest Ophthalmol Vis Sci 51:3003-18. 2010
    ..To determine and compare gene expression patterns in the whole retina and retinal ganglion cell layer (RGCL) in a rodent glaucoma model...
  10. doi request reprint Rat models for glaucoma research
    John C Morrison
    Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Prog Brain Res 173:285-301. 2008
    ..Continued use of these models will lead to a better understanding of cellular mechanisms of pressure-induced optic nerve damage and POAG...
  11. pmc Comparison of anterior segment structures in two rat glaucoma models: an ultrasound biomicroscopic study
    Nikolaos Nissirios
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Invest Ophthalmol Vis Sci 49:2478-82. 2008
    ..This study was undertaken to investigate whether anterior chamber (AC) changes develop in two popular models in vivo and whether the changes are related to IOP...
  12. ncbi request reprint Age related optic nerve axonal loss in adult Brown Norway rats
    William O Cepurna
    The Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239, USA
    Exp Eye Res 80:877-84. 2005
    ..Therefore, the impact of animal age must be considered when modeling the course and pathophysiology of experimental glaucomatous optic nerve damage in rats...
  13. ncbi request reprint Selective ganglion cell functional loss in rats with experimental glaucoma
    Brad Fortune
    Discoveries in Sight, Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA
    Invest Ophthalmol Vis Sci 45:1854-62. 2004
    ..To characterize retinal functional consequences of elevated intraocular pressure (IOP) in a rat model of experimental glaucoma...
  14. ncbi request reprint Understanding mechanisms of pressure-induced optic nerve damage
    John C Morrison
    Kenneth C Swan Ocular Neurobiology Laboratory, Casey Eye Institute, Oregon Health and Sciences University, 3375 S W Terwilliger Blvd, Portland, OR 97239, USA
    Prog Retin Eye Res 24:217-40. 2005
    ..Ultimately, this knowledge may lead to the development of new treatments designed to preserve vision in these difficult patients...
  15. ncbi request reprint Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas, USA
    Invest Ophthalmol Vis Sci 46:1313-21. 2005
    ..To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy...
  16. ncbi request reprint Microarray analysis of changes in mRNA levels in the rat retina after experimental elevation of intraocular pressure
    Farid Ahmed
    Laboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, Maryland 20814 9692, USA
    Invest Ophthalmol Vis Sci 45:1247-58. 2004
    ..The goal of this study was to identify altered patterns of retinal mRNA expression after experimental elevation of intraocular pressure (IOP) in a rat glaucoma model...

Research Grants4

  1. The Optic Nerve Head in Glaucoma
    Elaine Johnson; Fiscal Year: 2007
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