Steven L Jacques

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Reflectance confocal microscopy of optical phantoms
    Steven L Jacques
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Biomed Opt Express 3:1162-72. 2012
  2. doi request reprint Optical properties of biological tissues: a review
    Steven L Jacques
    Department of Biomedical Engineering, Oregon Health Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Phys Med Biol 58:R37-61. 2013
  3. doi request reprint Tutorial on diffuse light transport
    Steven L Jacques
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biomed Opt 13:041302. 2008
  4. pmc How tissue optics affect dosimetry of photodynamic therapy
    Steven L Jacques
    Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97239 4501, USA
    J Biomed Opt 15:051608. 2010
  5. doi request reprint Optical assessment of cutaneous blood volume depends on the vessel size distribution: a computer simulation study
    Steven L Jacques
    Oregon Health and Science University Dermatology Biomedical Engineering, Portland, 97239, USA
    J Biophotonics 3:75-81. 2010
  6. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
  7. pmc Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
    Hrebesh M Subhash
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 18:036003. 2013
  8. pmc In vivo measurement of epidermal thickness changes associated with tumor promotion in murine models
    Kevin G Phillips
    Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97201, USA
    J Biomed Opt 15:041514. 2010
  9. pmc Filtering of Acoustic Signals within the Hearing Organ
    Sripriya Ramamoorthy
    Oregon Health and Science University, Oregon Hearing Research Center, Portland, Oregon 97239 3098
    J Neurosci 34:9051-8. 2014
  10. pmc Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography
    David Levitz
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Mailcode CH13B, Portland, OR 97239, USA
    Biomaterials 31:8210-7. 2010

Detail Information

Publications27

  1. pmc Reflectance confocal microscopy of optical phantoms
    Steven L Jacques
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Biomed Opt Express 3:1162-72. 2012
    ..Results show that μ(s) varies as 58, 8-24, and 130-200 cm(-1) for phantom types (1), (2) and (3), respectively. The g varies as 0.112, 0.53-0.67, and 0.003-0.26, respectively...
  2. doi request reprint Optical properties of biological tissues: a review
    Steven L Jacques
    Department of Biomedical Engineering, Oregon Health Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
    Phys Med Biol 58:R37-61. 2013
    ....
  3. doi request reprint Tutorial on diffuse light transport
    Steven L Jacques
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biomed Opt 13:041302. 2008
    ..Finite mesh-based numerical methods are introduced to calculate the diffuse light field in complex tissues with arbitrary boundaries. Applications in tissue spectroscopy and imaging illustrate these theoretical and computational tools...
  4. pmc How tissue optics affect dosimetry of photodynamic therapy
    Steven L Jacques
    Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97239 4501, USA
    J Biomed Opt 15:051608. 2010
    ..The lessons illustrate how tissue optics play a dominant role in specifying the treatment zone during PDT...
  5. doi request reprint Optical assessment of cutaneous blood volume depends on the vessel size distribution: a computer simulation study
    Steven L Jacques
    Oregon Health and Science University Dermatology Biomedical Engineering, Portland, 97239, USA
    J Biophotonics 3:75-81. 2010
    ..The coefficient of variation was about 10% due to random placement. R varies with size, even with small vessels, and does not simply apply to large vessels...
  6. pmc In vivo outer hair cell length changes expose the active process in the cochlea
    Dingjun Zha
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 7:e32757. 2012
    ..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification...
  7. pmc Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
    Hrebesh M Subhash
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 18:036003. 2013
    ..The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane...
  8. pmc In vivo measurement of epidermal thickness changes associated with tumor promotion in murine models
    Kevin G Phillips
    Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97201, USA
    J Biomed Opt 15:041514. 2010
    ..Our results demonstrate that in vivo rCSLM imaging provides epithelial biologists an accurate noninvasive means to monitor cutaneous pathogenesis...
  9. pmc Filtering of Acoustic Signals within the Hearing Organ
    Sripriya Ramamoorthy
    Oregon Health and Science University, Oregon Hearing Research Center, Portland, Oregon 97239 3098
    J Neurosci 34:9051-8. 2014
    ..These observations show that additional processing and filtering of acoustic signals occur within the organ of Corti before inner hair cell excitation, representing a departure from established theories. ..
  10. pmc Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomography
    David Levitz
    Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Mailcode CH13B, Portland, OR 97239, USA
    Biomaterials 31:8210-7. 2010
    ..These results suggest that the decrease in scattering anisotropy in the collagen-SMC gels was due to MMP activity that degrades collagen fibrils into smaller fragments...
  11. doi request reprint Quantitative characterization of developing collagen gels using optical coherence tomography
    David Levitz
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Avenue, Mailcode CH13B, Portland, Oregon 97239, USA
    J Biomed Opt 15:026019. 2010
    ..In summary, the increased turbidity of SMC gels that develops over time is due to a change in the structure of collagen, which affects g, and not simply due to a change in number density of collagen fibers due to contraction...
  12. pmc A differentially amplified motion in the ear for near-threshold sound detection
    Fangyi Chen
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Nat Neurosci 14:770-4. 2011
    ..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented...
  13. doi request reprint Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM)
    Ravikant Samatham
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
    J Biomed Opt 13:041309. 2008
    ..The decrease in g (toward more isotropic scattering) is likely due to the failure of the mutant fibrils to assemble into the larger collagen fiber bundles that yield forward scattering...
  14. pmc Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skin
    Kevin G Phillips
    J Biomed Opt 16:040503. 2011
    ..86). Our results suggest that dermal reflectivity as measured by OCT can be utilized to quantify a psoriasis-like disease in mice, and thus has the potential to aid in the quantitative assessment of psoriasis in humans...
  15. pmc Automated detection of malignant features in confocal microscopy on superficial spreading melanoma versus nevi
    Dan Gareau
    Oregon Health and Science University, Department of Dermatology, Portland, OR, USA
    J Biomed Opt 15:061713. 2010
    ..0035). Quantitative endpoint metrics for malignant characteristics make digital RCM data an attractive diagnostic asset for pathologists, augmenting studies thus far, which have relied largely on visual assessment...
  16. doi request reprint Solution of transport equations in layered media with refractive index mismatch using the PN-method
    Kevin G Phillips
    Department of Dermatology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L468R Portland, Oregon 97201, USA
    J Opt Soc Am A Opt Image Sci Vis 26:2147-62. 2009
    ..The stability, convergence, and accuracy of the method are established. Example calculations demonstrating the flexibility of the method are performed...
  17. pmc Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometry
    Hrebesh M Subhash
    Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Ave, Portland, Oregon 97239
    J Biomed Opt 17:060505. 2012
    ..5  nm at 1 kHz of acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at a nanometer scale...
  18. ncbi request reprint In vivo imaging and low-coherence interferometry of organ of Corti vibration
    Fangyi Chen
    Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239 3098, USA
    J Biomed Opt 12:021006. 2007
    ..The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of +/-2 and +/-22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm...
  19. doi request reprint IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A
    Heather L Rizzo
    Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 186:1495-502. 2011
    ..IL-17A may represent an attractive therapeutic target in individuals with psoriasis by blocking downstream effects of IL-23...
  20. pmc Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope
    Kevin G Phillips
    Department of Biomedical Engineering and Cell and Developmental Biology, Oregon Health and Science University, 3303 S W Bond Avenue, Portland, Oregon 97239, USA
    Phys Rev Lett 109:118105. 2012
    ..This optical technique enables a simple and robust means to perform quantitative investigations of engineered and biological specimens in three dimensions using standard optical microscopes...
  21. pmc Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomies
    Daniel S Gareau
    Oregon Health and Science University, Department of Biomedical Engineering, Portland, OR 97239, USA
    J Biomed Opt 15:061712. 2010
    ..71 when the specificity equaled 0.71...
  22. ncbi request reprint Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine model
    Daniel S Gareau
    Department of Dermatology, Oregon Health and Science University, Portland, Oregon 10022, USA
    J Invest Dermatol 127:2184-90. 2007
    ..The rCSLM images illustrate the difference between normal skin and sites with apparent melanoma. This imaging modality shows promise to track the progression of melanoma lesions in animal models...
  23. ncbi request reprint Imaging skin pathology with polarized light
    Steven L Jacques
    Oregon Health and Science University, Department of Dermatology, Portland, Oregon and Providence St Vincent Medical Center, Oregon Medical Laser Center, Portland, Oregon, USA
    J Biomed Opt 7:329-40. 2002
    ..This result suggests that the point spread function in skin for cross-talk between Pol pixels has a half-width-half-max of about 390 microm...
  24. ncbi request reprint Ratio of entropy to enthalpy in thermal transitions in biological tissues
    Steven L Jacques
    Oregon Health and Science University, Department of Dermatology, 20000 NW Walker Road, Beaverton, Oregon 97006, USA
    J Biomed Opt 11:041108. 2006
    ..8 J(mol K) to DeltaS. Hence, the dynamics of irreversible thermal transitions can be described in terms of one free parameter, the apparent number of cooperative hydrogen bonds broken during the transition...
  25. ncbi request reprint Confocal fluorescence spectroscopy of subcutaneous cartilage expressing green fluorescent protein versus cutaneous collagen autofluorescence
    Daniel S Gareau
    Oregon Health and Science University, Department of Biomedical Engineering and Dermatology, Shriners Hospital for Crippled Children, Portland, Oregon 97239, USA
    J Biomed Opt 9:254-8. 2004
    ..13 and 0.48, respectively. The study demonstrates that a topical optical fiber measurement is affected by collagen autofluorescence, while a confocal microscope can detect subdermal fluorescence while rejecting collagen autofluorescence...
  26. ncbi request reprint Collection efficiency of a single optical fiber in turbid media
    Paulo R Bargo
    Oregon Medical Laser Center, Providence St Vincent Hospital, 9205 S W Barnes Road, Portland, Oregon 97225, USA
    Appl Opt 42:3187-97. 2003
    ..For lower scattering, such as in soft tissues, photons arrive at the fiber from deeper depths, and the coupling efficiency could increase twofold to threefold above that predicted by the NA...