Research Topics
Species | Steven L JacquesSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
Tutorial on diffuse light transportSteven L Jacques
Oregon Health and Science University, Portland, Oregon 97239, USA
J Biomed Opt 13:041302. 2008..Finite mesh-based numerical methods are introduced to calculate the diffuse light field in complex tissues with arbitrary boundaries. Applications in tissue spectroscopy and imaging illustrate these theoretical and computational tools...- Optical assessment of cutaneous blood volume depends on the vessel size distribution: a computer simulation studySteven L Jacques
Oregon Health and Science University Dermatology Biomedical Engineering, Portland, 97239, USA
J Biophotonics 3:75-81. 2010..The coefficient of variation was about 10% due to random placement. R varies with size, even with small vessels, and does not simply apply to large vessels... 
How tissue optics affect dosimetry of photodynamic therapySteven L Jacques
Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97239 4501, USA
J Biomed Opt 15:051608. 2010..The lessons illustrate how tissue optics play a dominant role in specifying the treatment zone during PDT...- In vivo outer hair cell length changes expose the active process in the cochleaDingjun Zha
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS ONE 7:e32757. 2012..These length changes, which have not previously been measured in vivo, must be correctly timed with the acoustic stimulus to produce amplification... - In vivo measurement of epidermal thickness changes associated with tumor promotion in murine modelsKevin G Phillips
Oregon Health and Science University, Department of Dermatology, Portland, Oregon 97201, USA
J Biomed Opt 15:041514. 2010..Our results demonstrate that in vivo rCSLM imaging provides epithelial biologists an accurate noninvasive means to monitor cutaneous pathogenesis... - Quantitative characterization of developing collagen gels using optical coherence tomographyDavid Levitz
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Avenue, Mailcode CH13B, Portland, Oregon 97239, USA
J Biomed Opt 15:026019. 2010..In summary, the increased turbidity of SMC gels that develops over time is due to a change in the structure of collagen, which affects g, and not simply due to a change in number density of collagen fibers due to contraction... - A differentially amplified motion in the ear for near-threshold sound detectionFangyi Chen
Oregon Hearing Research Center, Oregon Health and Science University, Portland, Oregon, USA
Nat Neurosci 14:770-4. 2011..These effects depend nonlinearly on the stimulus sound pressure level. The timing difference and enhancement of vibrations are important for explaining how the noise problem is circumvented... - Non-destructive label-free monitoring of collagen gel remodeling using optical coherence tomographyDavid Levitz
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Mailcode CH13B, Portland, OR 97239, USA
Biomaterials 31:8210-7. 2010..These results suggest that the decrease in scattering anisotropy in the collagen-SMC gels was due to MMP activity that degrades collagen fibrils into smaller fragments... - Solution of transport equations in layered media with refractive index mismatch using the PN-methodKevin G Phillips
Department of Dermatology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L468R Portland, Oregon 97201, USA
J Opt Soc Am A Opt Image Sci Vis 26:2147-62. 2009..The stability, convergence, and accuracy of the method are established. Example calculations demonstrating the flexibility of the method are performed... - Dermal reflectivity determined by optical coherence tomography is an indicator of epidermal hyperplasia and dermal edema within inflamed skinKevin G Phillips
J Biomed Opt 16:040503. 2011..86). Our results suggest that dermal reflectivity as measured by OCT can be utilized to quantify a psoriasis-like disease in mice, and thus has the potential to aid in the quantitative assessment of psoriasis in humans... - Automated detection of malignant features in confocal microscopy on superficial spreading melanoma versus neviDan Gareau
Oregon Health and Science University, Department of Dermatology, Portland, OR, USA
J Biomed Opt 15:061713. 2010..0035). Quantitative endpoint metrics for malignant characteristics make digital RCM data an attractive diagnostic asset for pathologists, augmenting studies thus far, which have relied largely on visual assessment... - Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear vibrometryHrebesh M Subhash
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Ave, Portland, Oregon 97239
J Biomed Opt 17:060505. 2012..5 nm at 1 kHz of acoustic stimulation. To the best of our knowledge, this is the first demonstration of depth-resolved vibration imaging of ossicles with a PS-OCT system at a nanometer scale... - Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM)Ravikant Samatham
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 13:041309. 2008..The decrease in g (toward more isotropic scattering) is likely due to the failure of the mutant fibrils to assemble into the larger collagen fiber bundles that yield forward scattering... 
In vivo imaging and low-coherence interferometry of organ of Corti vibrationFangyi Chen
Oregon Health and Science University, Oregon Hearing Research Center, 3181 Southwest Sam Jackson Park Road, NRC04, Portland, Oregon 97239 3098, USA
J Biomed Opt 12:021006. 2007..The tunnel of Corti and the inner sulcus are also visible in the images. Vibrations of +/-2 and +/-22 nm are recorded in the BM in response to low and high sound levels at 14 kHz above a noise floor of 0.2 nm...- IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17AHeather L Rizzo
Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 186:1495-502. 2011..IL-17A may represent an attractive therapeutic target in individuals with psoriasis by blocking downstream effects of IL-23... - Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscopeKevin G Phillips
Department of Biomedical Engineering and Cell and Developmental Biology, Oregon Health and Science University, 3303 S W Bond Avenue, Portland, Oregon 97239, USA
Phys Rev Lett 109:118105. 2012..This optical technique enables a simple and robust means to perform quantitative investigations of engineered and biological specimens in three dimensions using standard optical microscopes... - Reflectance confocal microscopy of optical phantomsSteven L Jacques
Department of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave, Portland, OR 97239, USA
Biomed Opt Express 3:1162-72. 2012..Results show that μ(s) varies as 58, 8-24, and 130-200 cm(-1) for phantom types (1), (2) and (3), respectively. The g varies as 0.112, 0.53-0.67, and 0.003-0.26, respectively... - Optical fiber probe spectroscopy for laparoscopic monitoring of tissue oxygenation during esophagectomiesDaniel S Gareau
Oregon Health and Science University, Department of Biomedical Engineering, Portland, OR 97239, USA
J Biomed Opt 15:061712. 2010..71 when the specificity equaled 0.71... - Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine modelDaniel S Gareau
Department of Dermatology, Oregon Health and Science University, Portland, Oregon 10022, USA
J Invest Dermatol 127:2184-90. 2007..The rCSLM images illustrate the difference between normal skin and sites with apparent melanoma. This imaging modality shows promise to track the progression of melanoma lesions in animal models... - Imaging skin pathology with polarized lightSteven L Jacques
Oregon Health and Science University, Department of Dermatology, Portland, Oregon and Providence St Vincent Medical Center, Oregon Medical Laser Center, Portland, Oregon, USA
J Biomed Opt 7:329-40. 2002..This result suggests that the point spread function in skin for cross-talk between Pol pixels has a half-width-half-max of about 390 microm... - Ratio of entropy to enthalpy in thermal transitions in biological tissuesSteven L Jacques
Oregon Health and Science University, Department of Dermatology, 20000 NW Walker Road, Beaverton, Oregon 97006, USA
J Biomed Opt 11:041108. 2006..8 J(mol K) to DeltaS. Hence, the dynamics of irreversible thermal transitions can be described in terms of one free parameter, the apparent number of cooperative hydrogen bonds broken during the transition... - Confocal fluorescence spectroscopy of subcutaneous cartilage expressing green fluorescent protein versus cutaneous collagen autofluorescenceDaniel S Gareau
Oregon Health and Science University, Department of Biomedical Engineering and Dermatology, Shriners Hospital for Crippled Children, Portland, Oregon 97239, USA
J Biomed Opt 9:254-8. 2004..13 and 0.48, respectively. The study demonstrates that a topical optical fiber measurement is affected by collagen autofluorescence, while a confocal microscope can detect subdermal fluorescence while rejecting collagen autofluorescence... - Collection efficiency of a single optical fiber in turbid mediaPaulo R Bargo
Oregon Medical Laser Center, Providence St. Vincent Hospital, 9205 S.W. Barnes Road, Portland, Oregon 97225, USA
Appl Opt 42:3187-97. 2003..For lower scattering, such as in soft tissues, photons arrive at the fiber from deeper depths, and the coupling efficiency could increase twofold to threefold above that predicted by the NA...