S L Jacques
Affiliation: Oregon Health and Science University
- Tutorial on diffuse light transportSteven L Jacques
Oregon Health and Science University, Portland, Oregon 97239, USA
J Biomed Opt 13:041302. 2008..Finite mesh-based numerical methods are introduced to calculate the diffuse light field in complex tissues with arbitrary boundaries. Applications in tissue spectroscopy and imaging illustrate these theoretical and computational tools...
- Imaging superficial tissues with polarized lightS L Jacques
Oregon Medical Laser Center, Providence St Vincent Medical Center, Portland, Oregon 97225, USA
Lasers Surg Med 26:119-29. 2000..This study presents a study of the transition of linearly polarized light into randomly polarized light during light propagation through tissues...
- Modeling photon transport in transabdominal fetal oximetryS L Jacques
Oregon Medical Laser Center, Portland 97225, USA
J Biomed Opt 5:277-82. 2000..The perturbation P=(Tf - Tm)/Tm is -53% due to the fetal brain. The model illustrates the challenge and feasibility of transabdominal oximetry of the fetal brain...
- Imaging skin pathology with polarized lightSteven L Jacques
Oregon Health and Science University, Department of Dermatology, Portland, Oregon and Providence St Vincent Medical Center, Oregon Medical Laser Center, Portland, Oregon, USA
J Biomed Opt 7:329-40. 2002..This result suggests that the point spread function in skin for cross-talk between Pol pixels has a half-width-half-max of about 390 microm...
- Light distributions from point, line and plane sources for photochemical reactions and fluorescence in turbid biological tissuesS L Jacques
Oregon Medical Laser Center, Providence St Vincent Medical Center, Portland 97225, USA
Photochem Photobiol 67:23-32. 1998..Analytic expressions that mimic accurate Monte Carlo simulations are presented. Application to fluorescence measurements and prediction of necrotic zones in photodynamic therapy are outlined...
- Ratio of entropy to enthalpy in thermal transitions in biological tissuesSteven L Jacques
Oregon Health and Science University, Department of Dermatology, 20000 NW Walker Road, Beaverton, Oregon 97006, USA
J Biomed Opt 11:041108. 2006..8 J(mol K) to DeltaS. Hence, the dynamics of irreversible thermal transitions can be described in terms of one free parameter, the apparent number of cooperative hydrogen bonds broken during the transition...
- In vivo determination of optical properties of normal and tumor tissue with white light reflectance and an empirical light transport model during endoscopyP R Bargo
Oregon Health and Science University, Biomedical Engineering Department, 20000 NW Walker Road, Beaverton, Oregon 97006, USA
J Biomed Opt 10:034018. 2005..87+/-1.10 cm(-1) and 8.4+/-2.3 cm(-1), respectively. These values are similar to data presented by other authors. Blood perfusion was the main variable accounting for differences in the absorption coefficient between the studied tissues...
- Solution of transport equations in layered media with refractive index mismatch using the PN-methodKevin G Phillips
Department of Dermatology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L468R Portland, Oregon 97201, USA
J Opt Soc Am A Opt Image Sci Vis 26:2147-62. 2009..The stability, convergence, and accuracy of the method are established. Example calculations demonstrating the flexibility of the method are performed...
- Noninvasive imaging of melanoma with reflectance mode confocal scanning laser microscopy in a murine modelDaniel S Gareau
Department of Dermatology, Oregon Health and Science University, Portland, Oregon 10022, USA
J Invest Dermatol 127:2184-90. 2007..The rCSLM images illustrate the difference between normal skin and sites with apparent melanoma. This imaging modality shows promise to track the progression of melanoma lesions in animal models...
- Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM)Ravikant Samatham
Oregon Health and Science University, Department of Biomedical Engineering, 3303 SW Bond Avenue, Portland, Oregon 97239, USA
J Biomed Opt 13:041309. 2008..The decrease in g (toward more isotropic scattering) is likely due to the failure of the mutant fibrils to assemble into the larger collagen fiber bundles that yield forward scattering...
- Optical assessment of cutaneous blood volume depends on the vessel size distribution: a computer simulation studySteven L Jacques
Oregon Health and Science University Dermatology Biomedical Engineering, Portland, 97239, USA
J Biophotonics 3:75-81. 2010..The coefficient of variation was about 10% due to random placement. R varies with size, even with small vessels, and does not simply apply to large vessels...
- Design, testing, and clinical studies of a handheld polarized light cameraJessica C Ramella-Roman
Oregon Medical Laser Center, Providence St Vincent Medical Center, Portland, Oregon, USA
J Biomed Opt 9:1305-10. 2004..In both cases, the 16-bit camera outperforms the USB cameras. Despite these limitations, the results obtained with this USB prototype are very satisfactory. Examples of polarized images of lesions taken prior to surgery are presented...
- Confocal fluorescence spectroscopy of subcutaneous cartilage expressing green fluorescent protein versus cutaneous collagen autofluorescenceDaniel S Gareau
Oregon Health and Science University, Department of Biomedical Engineering and Dermatology, Shriners Hospital for Crippled Children, Portland, Oregon 97239, USA
J Biomed Opt 9:254-8. 2004..13 and 0.48, respectively. The study demonstrates that a topical optical fiber measurement is affected by collagen autofluorescence, while a confocal microscope can detect subdermal fluorescence while rejecting collagen autofluorescence...
- Simultaneous compensation for spatial and temporal dispersion of acousto-optical deflectors for two-dimensional scanning with a single prismShaoqun Zeng
National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
Opt Lett 31:1091-3. 2006..14 with compensation. The insertion loss was 37%. Two-photon fluorescence microscopy used the compensated 2D AOD scanner to image a fluorescent microsphere, which improves signal intensity -15-fold compared with the uncompensated scanner...
- Analysis of the dispersion compensation of acousto-optic deflectors used for multiphoton imagingShaoqun Zeng
Huazhong University of Science and Technology, Key Laboratory of Biomedical Photonics, Ministry of Education, Wuhan National Laboratory for Optoelectronics, Wuhan 430074 China
J Biomed Opt 12:024015. 2007..Fluorescence images of beads and cells are shown to demonstrate the performance of two-photon microscopy when applying this compensated 2-D AOD as scanner...
- Relationship between damaged fraction and reflected spectra of denaturing tissuesHiroyuki Yoshimura
Faculty of Engineering, Chiba University, Chiba, Japan
Lasers Surg Med 37:308-13. 2005..The relationship between the damaged fraction and reflected spectra of denaturing tissues was investigated for a variation of the temperature of the tissues...
- Correlation of static speckle with sample properties in optical coherence tomographyTimothy R Hillman
Optical Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia
Opt Lett 31:190-2. 2006..The observed contrast ratios vary in value from the Rayleigh limit of 0.52 to in excess of 2, suggesting that the contrast ratio could be useful in optical coherence tomography, particularly when imaging in ultrahigh-resolution regimes...