Urszula T Iwaniec

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage
    Urszula T Iwaniec
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA
    Alcohol Clin Exp Res 37:1271-7. 2013
  2. pmc Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia
    Urszula T Iwaniec
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
    Bone 53:145-53. 2013
  3. pmc Body mass influences cortical bone mass independent of leptin signaling
    U T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Bone 44:404-12. 2009
  4. pmc Consumption of green tea extract results in osteopenia in growing male mice
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 139:1914-9. 2009
  5. pmc Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 26:1506-16. 2011
  6. pmc Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse
    U T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Bone 42:695-701. 2008
  7. pmc Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Peptides 28:1012-9. 2007
  8. ncbi request reprint PTH stimulates bone formation in mice deficient in Lrp5
    Urszula T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, USA
    J Bone Miner Res 22:394-402. 2007
  9. ncbi request reprint A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized rats
    U T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
    Osteoporos Int 18:351-62. 2007
  10. ncbi request reprint Strain-dependent variations in the response of cancellous bone to ovariectomy in mice
    Urszula T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, USA
    J Bone Miner Res 21:1068-74. 2006

Collaborators

Detail Information

Publications40

  1. pmc Intraperitoneal injection of ethanol results in drastic changes in bone metabolism not observed when ethanol is administered by oral gavage
    Urszula T Iwaniec
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA
    Alcohol Clin Exp Res 37:1271-7. 2013
    ..However, it is unclear whether the latter 2 methods produce comparable results. The purpose of this investigation was to determine the skeletal response to alcohol delivered daily by oral gavage or ip injection...
  2. pmc Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopenia
    Urszula T Iwaniec
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
    Bone 53:145-53. 2013
    ..In conclusion, our findings do not support a causal role for increased bone marrow fat as a mediator of ovx-induced osteopenia in mice...
  3. pmc Body mass influences cortical bone mass independent of leptin signaling
    U T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Bone 44:404-12. 2009
    ..Taken together, these findings suggest that increased body mass has a positive effect on femur cortical bone mass that is independent of leptin signaling...
  4. pmc Consumption of green tea extract results in osteopenia in growing male mice
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 139:1914-9. 2009
    ....
  5. pmc Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 26:1506-16. 2011
    ..We conclude that increased hypothalamic leptin, sufficient to prevent weight gain, has minimal specific effects (rAAV-Lep versus rAAV-GFP) on bone metabolism in normal female rats...
  6. pmc Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuse
    U T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Bone 42:695-701. 2008
    ..Based on the animal model, our findings suggest that alcohol consumption could impair the beneficial effects of PTH therapy in osteoporosis...
  7. pmc Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Peptides 28:1012-9. 2007
    ..No further skeletal changes in either the femur or lumbar vertebra were observed at 30 weeks post-rAAV-lep administration. The results suggest that hypothalamic leptin functions as an essential permissive factor for normal bone growth...
  8. ncbi request reprint PTH stimulates bone formation in mice deficient in Lrp5
    Urszula T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, USA
    J Bone Miner Res 22:394-402. 2007
    ..This study evaluated the bone anabolic response to intermittent PTH treatment in Lrp5-deficient mice. Our results indicate that Lrp5 is not essential for the stimulatory effect of PTH on cancellous and cortical bone formation...
  9. ncbi request reprint A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized rats
    U T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
    Osteoporos Int 18:351-62. 2007
    ....
  10. ncbi request reprint Strain-dependent variations in the response of cancellous bone to ovariectomy in mice
    Urszula T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, USA
    J Bone Miner Res 21:1068-74. 2006
    ....
  11. pmc Growth hormone regulates the balance between bone formation and bone marrow adiposity
    Philip J Menagh
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 25:757-68. 2010
    ..Rather, GH enhances adipocyte as well as osteoblast precursor pool size. However, GH increases osteoblast differentiation while suppressing bone marrow lipid accumulation...
  12. pmc Peripheral leptin regulates bone formation
    Russell T Turner
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 28:22-34. 2013
    ..In summary, our results indicate that leptin, acting primarily through peripheral pathways, increases osteoblast number and activity...
  13. pmc Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal women
    Jill A Marrone
    Nutrition Division, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
    Menopause 19:974-9. 2012
    ..This study investigated the hypothesis that moderate alcohol intake attenuates bone turnover after menopause...
  14. doi request reprint Histological analysis of bone
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Methods Mol Biol 447:325-41. 2008
    ..Specifically detailed are processes for embedding, cutting, staining, and evaluating histological bone specimens with a focus on rodent models...
  15. doi request reprint Effect of reduced c-Kit signaling on bone marrow adiposity
    Russell T Turner
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, 97331, USA
    Anat Rec (Hoboken) 294:1126-34. 2011
    ..Taken together, our results indicate that c-Kit signaling plays an important but previously unsuspected role in regulating bone marrow adiposity...
  16. pmc The role of mast cells in parathyroid bone disease
    Russell T Turner
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 25:1637-49. 2010
    ..Mice, in turn, were resistant to the development of PTH-induced bone marrow fibrosis. These findings suggest that the mast cell may be a novel target for treatment of metabolic bone disease...
  17. ncbi request reprint Acute exposure to high dose γ-radiation results in transient activation of bone lining cells
    Russell T Turner
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR, USA Center for Healthy Aging Research, Oregon State University, Corvallis, OR, USA Electronic address
    Bone 57:164-73. 2013
    ..Bone marrow transplantation is effective in mitigating the detrimental effects of acute exposure to high dose whole body γ-radiation on bone turnover. ..
  18. ncbi request reprint Selected extraskeletal effects of systemic treatment with basic fibroblast growth factor in ovariectomized rats
    Heather L Wamsley
    Department of Pathobiology, College of Veterinary Medicine, Veterinary Medical Teaching Hospital, Clinical Pathology Service, University of Florida, Gainesville, Florida 32610, USA
    Toxicol Pathol 33:577-83. 2005
    ..Though bFGF strongly stimulates bone formation at osteopenic skeletal sites, its extraskeletal effects may restrict the long-term use of bFGF in its current form as an osteoporosis therapy...
  19. pmc Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay
    Satya P Kalra
    Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610 0244, United States
    Peptides 30:967-73. 2009
    ....
  20. ncbi request reprint Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss
    Russell T Turner
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
    Menopause 20:677-86. 2013
    ....
  21. ncbi request reprint Dose-response effects of intermittent PTH on cancellous bone in hindlimb unloaded rats
    Russell T Turner
    Department of Nutrition and Exercise, Oregon State University, Corvallis, OR 97330, USA
    J Bone Miner Res 22:64-71. 2007
    ..HLU suppressed bone formation and resulted in bone loss in the tibial metaphysis of 6-month-old male rats. A human therapeutic dose of intermittent PTH (1 microg/kg/day) prevented the skeletal changes associated with HLU...
  22. ncbi request reprint Sequential treatment with basic fibroblast growth factor and PTH is more efficacious than treatment with PTH alone for increasing vertebral bone mass and strength in osteopenic ovariectomized rats
    U T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville 32610 0144, USA
    Endocrinology 143:2515-26. 2002
    ..These findings indicate that sequential treatment with bFGF and PTH is more efficacious than treatment with PTH alone for increasing bone mass and strength and improving trabecular microarchitecture in osteopenic OVX rats...
  23. ncbi request reprint Changes in gene expression associated with the bone anabolic effects of basic fibroblast growth factor in aged ovariectomized rats
    R A Power
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
    Bone 31:143-8. 2002
    ..These in vivo results suggest that bFGF treatment upregulates gene expression for IGF-I, which may mediate, at least in part, the increased gene expression for bone matrix proteins and the bone anabolic effects of bFGF in aged ovx rats...
  24. pmc Effects of alcohol on skeletal response to growth hormone in hypophysectomized rats
    Russell T Turner
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Bone 46:806-12. 2010
    ..We conclude that the detrimental skeletal effects of alcohol abuse observed in this experiment are mediated, at least in part, by skeletal resistance to GH...
  25. pmc Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism
    Malcolm B Lowry
    Department of Microbiology, Oregon State University, Corvallis, Oregon 97331, USA
    Endocrinology 149:5735-46. 2008
    ....
  26. pmc MicroRNAs control neurobehavioral development and function in zebrafish
    Tamara L Tal
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, 28645 East HWY 34, Corvallis, OR 97333, USA
    FASEB J 26:1452-61. 2012
    ..Together, these data support an integral role for miRNAs in the establishment of vertebrate neurobehavioral and skeletal systems...
  27. ncbi request reprint Bone anabolic effects of subcutaneous treatment with basic fibroblast growth factor alone and in combination with estrogen in osteopenic ovariectomized rats
    U T Iwaniec
    Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
    Bone 33:380-6. 2003
    ..The anabolic effects of bFGF on bone are not enhanced by concurrent treatment with estrogen at the replacement dose used in this study...
  28. ncbi request reprint Effects of disrupted beta1-integrin function on the skeletal response to short-term hindlimb unloading in mice
    U T Iwaniec
    Dept of Physiological Sciences, Box 100144, JHMHC, Univ of Florida, Gainesville, FL 32610, USA
    J Appl Physiol (1985) 98:690-6. 2005
    ....
  29. doi request reprint Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in rats
    G F Maddalozzo
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Osteoporos Int 20:1529-38. 2009
    ..The present investigation in growing rats was designed to determine the effects of alcohol consumption on body composition, muscle mass, and bone mass, architecture, and turnover...
  30. doi request reprint Detrimental effects of reloading recovery on force, shortening velocity, and power of soleus muscles from hindlimb-unloaded rats
    J J Widrick
    Dept of Nutrition and Exercise Sciences, Oregon State Univ, Corvallis, OR 97331, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1585-92. 2008
    ..HU-induced reductions in fiber length indicate that sarcomere hyperextension upon the resumption of weight-bearing activity may be an important mechanism underlying this response...
  31. pmc Whole-body vibration slows the acquisition of fat in mature female rats
    G F Maddalozzo
    Bone Research Laboratory, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Int J Obes (Lond) 32:1348-54. 2008
    ..To evaluate the effects of whole-body vibration on fat, bone, leptin and muscle mass...
  32. ncbi request reprint Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats
    Teresa L Johnson
    Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon
    Alcohol Clin Exp Res 38:1365-72. 2014
    ....
  33. pmc Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss
    Russell T Turner
    Skeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA
    Bone 48:726-32. 2011
    ..Taken together, the results suggest that the energy cost of bone formation in adult rats is low and PTH therapy is effective in preventing the reduced bone formation associated with rapid weight loss...
  34. ncbi request reprint Impaired osteoinduction in a rat model for chronic alcohol abuse
    C H Trevisiol
    Department of Chemical Engineering, Oregon State University, Corvallis, OR 97331, USA
    Bone 41:175-80. 2007
    ..Taken together, these results show that alcohol abuse resulted in decreased bone formation within the DABM implant. We conclude that reduced osteoinduction may contribute to impaired bone healing in alcoholics...
  35. pmc Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents
    Urszula T Iwaniec
    Skeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA Center for Healthy Aging Research, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 65:1209-14. 2013
    ....
  36. doi request reprint Voluntary wheel running in growing rats does not protect against doxorubicin-induced osteopenia
    Reid Hayward
    School of Sport and Exercise Science, University of Northern Colorado, Greeley, CO 80639, USA
    J Pediatr Hematol Oncol 35:e144-8. 2013
    ..Exercise failed to protect bones from the damaging effects of DOX. Other modalities may be necessary to mitigate the deleterious skeletal effects that occur in juveniles undergoing treatment with anthracyclines...
  37. ncbi request reprint Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuse
    Jean D Sibonga
    Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
    Bone 40:1013-20. 2007
    ..These results suggest that alcohol consumption, in addition to inducing bone loss, may reduce the efficacy of PTH therapy to reverse osteoporosis...
  38. pmc Bone growth and turnover in progesterone receptor knockout mice
    David J Rickard
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocrinology 149:2383-90. 2008
    ..However, at some skeletal sites, PR signaling attenuates the accumulation of cortical and cancellous bone mass during adolescence...
  39. ncbi request reprint 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo
    Muzaffer Cicek
    Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Cancer Res 67:10106-11. 2007
    ..Our data support the conclusion that 2ME(2) could be an important new therapy in the arsenal to fight metastatic breast cancer...
  40. doi request reprint Treatment of experimental renal osteodystrophy with pamidronate
    Jarkko Jokihaara
    Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 74:319-27. 2008
    ....