Research Topics
Genomes and Genes | Urszula T IwaniecSummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Failure to generate bone marrow adipocytes does not protect mice from ovariectomy-induced osteopeniaUrszula T Iwaniec
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA Electronic address
Bone 53:145-53. 2013..In conclusion, our findings do not support a causal role for increased bone marrow fat as a mediator of ovx-induced osteopenia in mice...- Effects of low-dose parathyroid hormone on bone mass, turnover, and ectopic osteoinduction in a rat model for chronic alcohol abuseU T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
Bone 42:695-701. 2008..Based on the animal model, our findings suggest that alcohol consumption could impair the beneficial effects of PTH therapy in osteoporosis... - Consumption of green tea extract results in osteopenia in growing male miceUrszula T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Nutr 139:1914-9. 2009.... - Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob miceUrszula T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Peptides 28:1012-9. 2007..No further skeletal changes in either the femur or lumbar vertebra were observed at 30 weeks post-rAAV-lep administration. The results suggest that hypothalamic leptin functions as an essential permissive factor for normal bone growth... - Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female ratsUrszula T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Bone Miner Res 26:1506-16. 2011..We conclude that increased hypothalamic leptin, sufficient to prevent weight gain, has minimal specific effects (rAAV-Lep versus rAAV-GFP) on bone metabolism in normal female rats... 
PTH stimulates bone formation in mice deficient in Lrp5Urszula T Iwaniec
Department of Physiological Sciences, University of Florida, Gainesville, USA
J Bone Miner Res 22:394-402. 2007..This study evaluated the bone anabolic response to intermittent PTH treatment in Lrp5-deficient mice. Our results indicate that Lrp5 is not essential for the stimulatory effect of PTH on cancellous and cortical bone formation...- A comparative study of the bone-restorative efficacy of anabolic agents in aged ovariectomized ratsU T Iwaniec
Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
Osteoporos Int 18:351-62. 2007.... - Body mass influences cortical bone mass independent of leptin signalingU T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Bone 44:404-12. 2009..Taken together, these findings suggest that increased body mass has a positive effect on femur cortical bone mass that is independent of leptin signaling... - Strain-dependent variations in the response of cancellous bone to ovariectomy in miceUrszula T Iwaniec
Department of Physiological Sciences, University of Florida, Gainesville, USA
J Bone Miner Res 21:1068-74. 2006.... - Growth hormone regulates the balance between bone formation and bone marrow adiposityPhilip J Menagh
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Bone Miner Res 25:757-68. 2010..Rather, GH enhances adipocyte as well as osteoblast precursor pool size. However, GH increases osteoblast differentiation while suppressing bone marrow lipid accumulation... 
Moderate alcohol intake lowers biochemical markers of bone turnover in postmenopausal womenJill A Marrone
Nutrition Division, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
Menopause 19:974-9. 2012..This study investigated the hypothesis that moderate alcohol intake attenuates bone turnover after menopause...- The role of mast cells in parathyroid bone diseaseRussell T Turner
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Bone Miner Res 25:1637-49. 2010..Mice, in turn, were resistant to the development of PTH-induced bone marrow fibrosis. These findings suggest that the mast cell may be a novel target for treatment of metabolic bone disease... - Selected extraskeletal effects of systemic treatment with basic fibroblast growth factor in ovariectomized ratsHeather L Wamsley
Department of Pathobiology, College of Veterinary Medicine, Veterinary Medical Teaching Hospital, Clinical Pathology Service, University of Florida, Gainesville, Florida 32610, USA
Toxicol Pathol 33:577-83. 2005..Though bFGF strongly stimulates bone formation at osteopenic skeletal sites, its extraskeletal effects may restrict the long-term use of bFGF in its current form as an osteoporosis therapy... - Histological analysis of boneUrszula T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
Methods Mol Biol 447:325-41. 2008..Specifically detailed are processes for embedding, cutting, staining, and evaluating histological bone specimens with a focus on rodent models... - Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relaySatya P Kalra
Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610 0244, United States
Peptides 30:967-73. 2009.... - Effect of reduced c-Kit signaling on bone marrow adiposityRussell T Turner
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, 97331, USA
Anat Rec (Hoboken) 294:1126-34. 2011..Taken together, our results indicate that c-Kit signaling plays an important but previously unsuspected role in regulating bone marrow adiposity... - Peripheral leptin regulates bone formationRussell T Turner
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA
J Bone Miner Res 28:22-34. 2013..In summary, our results indicate that leptin, acting primarily through peripheral pathways, increases osteoblast number and activity... - Dose-response effects of intermittent PTH on cancellous bone in hindlimb unloaded ratsRussell T Turner
Department of Nutrition and Exercise, Oregon State University, Corvallis, OR 97330, USA
J Bone Miner Res 22:64-71. 2007..HLU suppressed bone formation and resulted in bone loss in the tibial metaphysis of 6-month-old male rats. A human therapeutic dose of intermittent PTH (1 microg/kg/day) prevented the skeletal changes associated with HLU... - Changes in gene expression associated with the bone anabolic effects of basic fibroblast growth factor in aged ovariectomized ratsR A Power
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0144, USA
Bone 31:143-8. 2002..These in vivo results suggest that bFGF treatment upregulates gene expression for IGF-I, which may mediate, at least in part, the increased gene expression for bone matrix proteins and the bone anabolic effects of bFGF in aged ovx rats... - Sequential treatment with basic fibroblast growth factor and PTH is more efficacious than treatment with PTH alone for increasing vertebral bone mass and strength in osteopenic ovariectomized ratsU T Iwaniec
Department of Physiological Sciences, University of Florida, Gainesville 32610 0144, USA
Endocrinology 143:2515-26. 2002..These findings indicate that sequential treatment with bFGF and PTH is more efficacious than treatment with PTH alone for increasing bone mass and strength and improving trabecular microarchitecture in osteopenic OVX rats... - MicroRNAs control neurobehavioral development and function in zebrafishTamara L Tal
Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, 28645 East HWY 34, Corvallis, OR 97333, USA
FASEB J 26:1452-61. 2012..Together, these data support an integral role for miRNAs in the establishment of vertebrate neurobehavioral and skeletal systems... - Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidismMalcolm B Lowry
Department of Microbiology, Oregon State University, Corvallis, Oregon 97331, USA
Endocrinology 149:5735-46. 2008.... - Bone anabolic effects of subcutaneous treatment with basic fibroblast growth factor alone and in combination with estrogen in osteopenic ovariectomized ratsU T Iwaniec
Department of Physiological Sciences, University of Florida, Gainesville, FL 32610 0144, USA
Bone 33:380-6. 2003..The anabolic effects of bFGF on bone are not enhanced by concurrent treatment with estrogen at the replacement dose used in this study... - Effects of disrupted beta1-integrin function on the skeletal response to short-term hindlimb unloading in miceU T Iwaniec
Dept of Physiological Sciences, Box 100144, JHMHC, Univ of Florida, Gainesville, FL 32610, USA
J Appl Physiol 98:690-6. 2005.... - Whole-body vibration slows the acquisition of fat in mature female ratsG F Maddalozzo
Bone Research Laboratory, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Int J Obes (Lond) 32:1348-54. 2008..To evaluate the effects of whole-body vibration on fat, bone, leptin and muscle mass... - Detrimental effects of reloading recovery on force, shortening velocity, and power of soleus muscles from hindlimb-unloaded ratsJ J Widrick
Dept of Nutrition and Exercise Sciences, Oregon State Univ, Corvallis, OR 97331, USA
Am J Physiol Regul Integr Comp Physiol 295:R1585-92. 2008..HU-induced reductions in fiber length indicate that sarcomere hyperextension upon the resumption of weight-bearing activity may be an important mechanism underlying this response... - Alcohol alters whole body composition, inhibits bone formation, and increases bone marrow adiposity in ratsG F Maddalozzo
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Osteoporos Int 20:1529-38. 2009..The present investigation in growing rats was designed to determine the effects of alcohol consumption on body composition, muscle mass, and bone mass, architecture, and turnover... - Effects of alcohol on skeletal response to growth hormone in hypophysectomized ratsRussell T Turner
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Bone 46:806-12. 2010..We conclude that the detrimental skeletal effects of alcohol abuse observed in this experiment are mediated, at least in part, by skeletal resistance to GH... - Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight lossRussell T Turner
Skeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA
Bone 48:726-32. 2011..Taken together, the results suggest that the energy cost of bone formation in adult rats is low and PTH therapy is effective in preventing the reduced bone formation associated with rapid weight loss... - Impaired osteoinduction in a rat model for chronic alcohol abuseC H Trevisiol
Department of Chemical Engineering, Oregon State University, Corvallis, OR 97331, USA
Bone 41:175-80. 2007..Taken together, these results show that alcohol abuse resulted in decreased bone formation within the DABM implant. We conclude that reduced osteoinduction may contribute to impaired bone healing in alcoholics... - Voluntary Wheel Running in Growing Rats Does Not Protect Against Doxorubicin-induced OsteopeniaReid Hayward
School of Sport and Exercise Science, University of Northern Colorado Rocky Mountain Cancer Rehabilitation Institute, Greeley, CO Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR Athletic Department, National Taiwan University, Taipei, Taiwan Slippery Rock University, Slippery Rock, PA
J Pediatr Hematol Oncol 35:e144-8. 2013..Exercise failed to protect bones from the damaging effects of DOX. Other modalities may be necessary to mitigate the deleterious skeletal effects that occur in juveniles undergoing treatment with anthracyclines... - Bone growth and turnover in progesterone receptor knockout miceDavid J Rickard
Mayo Clinic, Rochester, Minnesota 55905, USA
Endocrinology 149:2383-90. 2008..However, at some skeletal sites, PR signaling attenuates the accumulation of cortical and cancellous bone mass during adolescence... - Effects of parathyroid hormone (1-34) on tibia in an adult rat model for chronic alcohol abuseJean D Sibonga
Division of Space Life Sciences, Universities Space Research Association, Houston, TX 77058, USA
Bone 40:1013-20. 2007..These results suggest that alcohol consumption, in addition to inducing bone loss, may reduce the efficacy of PTH therapy to reverse osteoporosis... - 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivoMuzaffer Cicek
Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Res 67:10106-11. 2007..Our data support the conclusion that 2ME(2) could be an important new therapy in the arsenal to fight metastatic breast cancer... - Treatment of experimental renal osteodystrophy with pamidronateJarkko Jokihaara
Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada
Kidney Int 74:319-27. 2008....