Soren Impey

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    Soren Impey
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Cell 119:1041-54. 2004
  2. ncbi request reprint CREB signaling--timing is everything
    S Impey
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Sci STKE 2001:pe1. 2001
  3. ncbi request reprint Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
    Soren Impey
    The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
    Neuron 34:235-44. 2002
  4. pmc An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling
    Soren Impey
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA
    Mol Cell Neurosci 43:146-56. 2010
  5. ncbi request reprint A histone deacetylase regulates addiction
    Soren Impey
    Department of Cell and Developmental Biology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neuron 56:415-7. 2007
  6. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
  7. pmc Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
    Hyunjoo Cha-Molstad
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 101:13572-7. 2004
  8. pmc The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation
    Adam Lesiak
    Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164, Department of Molecular Biosciences, University of California, Davis, California 95616, and Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239
    J Neurosci 34:717-25. 2014
  9. ncbi request reprint Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006
  10. ncbi request reprint Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
    Matthew E Klein
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Neurosci 10:1513-4. 2007

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    Soren Impey
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Cell 119:1041-54. 2004
    ..A large fraction of the SACO loci delineated bidirectional promoters and novel antisense transcripts. This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species...
  2. ncbi request reprint CREB signaling--timing is everything
    S Impey
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Sci STKE 2001:pe1. 2001
    ..The continuing debate about the involvement of calmodulin kinase IV is also described...
  3. ncbi request reprint Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
    Soren Impey
    The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
    Neuron 34:235-44. 2002
    ..Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301...
  4. pmc An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling
    Soren Impey
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA
    Mol Cell Neurosci 43:146-56. 2010
    ..These data suggest that neuronal activity regulates spine formation, in part, by increasing miR132 transcription, which in turn activates a Rac1-Pak actin remodeling pathway...
  5. ncbi request reprint A histone deacetylase regulates addiction
    Soren Impey
    Department of Cell and Developmental Biology, Oregon Health and Sciences University, Portland, OR 97239, USA
    Neuron 56:415-7. 2007
    ..In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine...
  6. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
    ..These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues...
  7. pmc Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
    Hyunjoo Cha-Molstad
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 101:13572-7. 2004
    ..We conclude that the family of CREB target genes differs from one cell type to another and that the ability of CREB to bind to a particular CRE represents an important component of gene regulation...
  8. pmc The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation
    Adam Lesiak
    Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164, Department of Molecular Biosciences, University of California, Davis, California 95616, and Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239
    J Neurosci 34:717-25. 2014
    ..In light of recent evidence implicating miR132 dysregulation in Rett syndrome and schizophrenia, these findings identify NDL PCBs as potential environmental risk factors for neurodevelopmental disorders. ..
  9. ncbi request reprint Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006
    ..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
  10. ncbi request reprint Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
    Matthew E Klein
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Neurosci 10:1513-4. 2007
    ..This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression...
  11. pmc KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription
    Liangqi Xie
    Oregon Stem Cell Center, Department of Pediatrics, Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR, USA
    EMBO J 30:1473-84. 2011
    ..We propose that KDM5B activates self-renewal-associated gene expression by repressing cryptic initiation and maintaining an H3K4me3 gradient important for productive transcriptional elongation...
  12. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  13. pmc Leptin Induces Hippocampal Synaptogenesis via CREB-Regulated MicroRNA-132 Suppression of p250GAP
    Matasha Dhar
    Department of Integrative Physiology and Neuroscience M D, M Z, T J L, T B, I N K, S M A, G A W, Program in Neuroscience, Washington State University, Pullman, Washington 99164 Oregon Stem Cell Center S I, Oregon Health and Sciences University, Portland, Oregon 97239 and Department of Neurophysiology T N, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033 Japan
    Mol Endocrinol 28:1073-87. 2014
    ....
  14. ncbi request reprint Role reversal: the regulation of neuronal gene expression by microRNAs
    Matthew E Klein
    Reed College and Vollum Institute, Oregon Health and Sciences University, Portland OR, USA
    Curr Opin Neurobiol 15:507-13. 2005
    ..The combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone...
  15. ncbi request reprint CREB-mediated Bcl-2 protein expression after ischemic preconditioning
    Robert Meller
    RS Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
    J Cereb Blood Flow Metab 25:234-46. 2005
    ..H89, KN62, and U0126 reduced CREB activation and Bcl-2 expression. Taken together, these data suggest that after ischemic preconditioning CREB activation regulates the expression of the prosurvival protein Bcl-2...
  16. pmc Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis
    Amy S Farrell
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
    Mol Cell Biol 33:2930-49. 2013
    ....
  17. ncbi request reprint Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3011, USA
    J Neurosci 24:3786-94. 2004
    ..These results identify CaMKI as a positive transducer of growth cone motility and axon outgrowth and provide a new physiological role for the CaMKK-CaMKI pathway...
  18. ncbi request reprint Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein
    D M Fass
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 276:2992-7. 2001
    ..Thus, we propose that the C/EBP sites in the PEPCK promoter allow CREMalpha to activate transcription despite its lack of Q regions...
  19. ncbi request reprint cAMP response element-mediated gene expression in transgenic reporter gene mouse strain
    Karl Obrietan
    Neuroscience Department, Ohio State University, Columbus, Ohio 43210, USA
    Methods Enzymol 345:570-84. 2002
  20. ncbi request reprint Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal
    Tamara Z Shaw-Lutchman
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 22:3663-72. 2002
    ..CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions...
  21. ncbi request reprint Hippocampal CRE-mediated gene expression is required for contextual memory formation
    Jaime Athos
    Department of Pharmacology, Box 357280, Health Sciences Building, University of Washington, Seattle, Washington 98195 7280, USA
    Nat Neurosci 5:1119-20. 2002
  22. ncbi request reprint Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP
    Steven Poser
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 23:4420-7. 2003
    ..This study indicates that cAMP may inhibit some forms of neurotrophin-mediated neuronal survival and suggests that a number of PI3-kinase-regulated processes in neurons may be inhibited by cAMP...
  23. ncbi request reprint A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions
    Stefanie J Otto
    Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 27:6729-39. 2007
    ..Unexpectedly, genes considered exclusively non-neuronal also contained an RE1 motif and were expressed in neurons. This supports the model that REST binding is a critical determinant of neuronal phenotype...
  24. pmc microRNA modulation of circadian-clock period and entrainment
    Hai Ying M Cheng
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Neuron 54:813-29. 2007
    ..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
  25. pmc Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1802, USA
    Neoplasia 9:101-7. 2007
    ..These unbiased data also suggest that menin could play a broad role in transcriptional regulation...
  26. ncbi request reprint Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERK
    Laura Cancedda
    Institute of Neuroscience of Consiglio Nazionale delle Ricerche, 56100 Pisa, Italy
    J Neurosci 23:7012-20. 2003
    ..Finally, because CRE-mediated gene expression was totally dependent on ERK activation, we suggest that PKA action on CRE-mediated gene expression is mediated by ERK...
  27. ncbi request reprint Epigenetic mechanisms and gene networks in the nervous system
    Christine M Colvis
    Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 25:10379-89. 2005
  28. pmc Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons
    Hoon Ryu
    Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, Bedford, MA 01730, USA
    Proc Natl Acad Sci U S A 102:13915-20. 2005
    ..These results suggest that the regulation of mitochondrial function via the mitochondrial PKA and CREB pathways may underlie some of the salutary effects of DFO in neurons...
  29. ncbi request reprint Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins
    J Simon C Arthur
    Medical Research Council Protein Phosphorylation Unit, MSI WTB complex, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Neurosci 24:4324-32. 2004
    ..These results indicate that MSK1 is the major neurotrophin-activated Ser133 kinase in CNS neurons...
  30. ncbi request reprint Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133
    Boyoung Lee
    Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:1137-48. 2005
    ..Together these data provide a framework to begin to understand how the neuroprotective and excitotoxic effects of NMDA receptor activity function in an antagonistic manner at the level of the CREB/CRE transcriptional pathway...
  31. ncbi request reprint Regulation of CRE-mediated transcription in mouse brain by amphetamine
    Tamara Z Shaw-Lutchman
    Deparment of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    Synapse 48:10-7. 2003
    ..This study identifies several brain regions where CRE-mediated transcription may play a key role in the development of neuronal plasticity associated with amphetamine administration...
  32. pmc CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli
    Michel Barrot
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 99:11435-40. 2002
    ..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...

Research Grants6

  1. Regulation of CBP by Synaptic Activity
    Soren Impey; Fiscal Year: 2005
    ..This will be accomplished by conducting the above described research, attending and presenting at local and national seminars and meetings, and participating in courses teaching molecular biology and neurophysiology techniques. ..
  2. Genomic-wide Analysis of Oct 3/4 and Nanog Targets
    Soren Impey; Fiscal Year: 2006
    ..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..
  3. Genomic-wide Analysis of Oct 3/4 and Nanog Targets
    Soren Impey; Fiscal Year: 2007
    ..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..
  4. Genomic-wide Analysis of Oct 3/4 and Nanog Targets
    Soren Impey; Fiscal Year: 2009
    ..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..
  5. Genomic-wide Analysis of Oct 3/4 and Nanog Targets
    Soren Impey; Fiscal Year: 2010
    ..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..