Patricia Hurn

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Adult or perinatal brain injury: does sex matter?
    Patricia D Hurn
    Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Stroke 36:193-5. 2005
  2. pmc Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1475-81. 2009
  3. pmc T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
    Patricia D Hurn
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
    J Cereb Blood Flow Metab 27:1798-805. 2007
  4. pmc Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain
    Lan Wang
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 28:1824-34. 2008
  5. ncbi request reprint Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia
    Julia Kofler
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:135-41. 2006
  6. pmc Gender and the injured brain
    Kamila Vagnerova
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Anesth Analg 107:201-14. 2008
  7. pmc Recombinant T cell receptor ligand treats experimental stroke
    Sandhya Subramanian
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR 97239, USA
    Stroke 40:2539-45. 2009
  8. pmc Sex, sex steroids, and brain injury
    Paco S Herson
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Semin Reprod Med 27:229-39. 2009
  9. pmc Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-beta
    Ruediger R Noppens
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 29:277-86. 2009
  10. pmc Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke
    Bing Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Immunol 184:4087-94. 2010

Research Grants

  1. ESTROGEN AS NEUROPROTECTANT IN CEREBRAL ISCHEMIA
    Patricia Hurn; Fiscal Year: 2003
  2. CEREBRAL ISCHEMIA IN THE FEMALE
    Patricia Hurn; Fiscal Year: 2003
  3. Cerebral Ischemia in the Female and Male
    Patricia Hurn; Fiscal Year: 2007
  4. Sex, Sex Steroids & Neuroprotection
    Patricia Hurn; Fiscal Year: 2007
  5. Estrogen and Testosterone in Experimental Stroke
    Patricia Hurn; Fiscal Year: 2007
  6. Estrogen and Immunoprotection in Experimental Stroke
    Patricia Hurn; Fiscal Year: 2009
  7. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2010

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Adult or perinatal brain injury: does sex matter?
    Patricia D Hurn
    Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Stroke 36:193-5. 2005
  2. pmc Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia
    Wenri Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1475-81. 2009
    ..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...
  3. pmc T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
    Patricia D Hurn
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
    J Cereb Blood Flow Metab 27:1798-805. 2007
    ....
  4. pmc Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brain
    Lan Wang
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 28:1824-34. 2008
    ..In OVX+ERbeta agonist, IsoPC increased cortical infarct volume. Estradiol depresses the brain's protective response to IsoPC and may exacerbate cortical ischemic injury mainly through an ERbeta-dependent mechanism...
  5. ncbi request reprint Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia
    Julia Kofler
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:135-41. 2006
    ..We conclude that PARP-2 is a novel executioner of cell death pathways in focal cerebral ischemia, but might be a necessary survival factor after global ischemia to mitigate hippocampal delayed cell death...
  6. pmc Gender and the injured brain
    Kamila Vagnerova
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Anesth Analg 107:201-14. 2008
    ..Lastly, implications for current and future perioperative and intensive care are identified...
  7. pmc Recombinant T cell receptor ligand treats experimental stroke
    Sandhya Subramanian
    Neuroimmunology Research, Portland VA Medical Center, Portland, OR 97239, USA
    Stroke 40:2539-45. 2009
    ..We tested the hypothesis that RTL would improve ischemic outcome in the brain without exacerbating defects in the peripheral immune system function...
  8. pmc Sex, sex steroids, and brain injury
    Paco S Herson
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Semin Reprod Med 27:229-39. 2009
    ..This review evaluates key evidence and highlights the importance of the platform on which brain injury occurs (i.e., genetic sex and hormonal modulators)...
  9. pmc Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-beta
    Ruediger R Noppens
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Cereb Blood Flow Metab 29:277-86. 2009
    ..05). Injury was not different in hippocampal CA1 between vehicle and ER-alpha agonist-treated animals. We conclude that long-term E2 administration after CA/CPR is neuroprotective and that this effect is most likely mediated via ER-beta...
  10. pmc Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke
    Bing Zhang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Immunol 184:4087-94. 2010
    ..These results demonstrate for the first time that E2 replacement in ovariectomized female mice improves stroke-induced peripheral immunosuppression...
  11. pmc Gender-specific response to isoflurane preconditioning in focal cerebral ischemia
    Hideto Kitano
    Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 27:1377-86. 2007
    ..Male IsoPC neuroprotection was lost in Akt1-deficient male mice. We conclude that IsoPC is beneficial only in ischemic male brain and that sex differences in IsoPC are mediated through Akt activation and basal NIPK expression...
  12. pmc Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice
    Masayoshi Uchida
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:1454-62. 2009
    ..We conclude that testosterone exhibits dose-dependent and time-sensitive effects after ischemia and that testosterone is likely to be an important factor in sex-linked differences in cerebrovascular disease...
  13. ncbi request reprint Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative era
    Stephanie Murphy
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Endocrine 21:17-26. 2003
    ..This review critiques estrogen and SERMs' neuroprotective potential in experimental and clinical studies of stroke and cerebrovascular disease...
  14. pmc Evidence of the peripheral inflammatory response in patients with transient ischemic attack
    Amy Miner Ross
    School of Nursing, Oregon Health and Science University, Ashland, Oregon 97520, USA
    J Stroke Cerebrovasc Dis 16:203-7. 2007
    ....
  15. pmc A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte culture
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR, 97239 3098, USA
    J Neurosci Methods 171:214-7. 2008
    ..This innovative technique may also be applied to other in vitro studies of sex-related functional differences...
  16. pmc Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia
    Ines P Koerner
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Front Biosci 13:2833-41. 2008
    ..While estradiol suppresses cerebral sEH expression, and sEH suppression diminishes inflammation after MCAO, our findings suggest that the effect of estrogen on inflammation is complex, and only partially explained by sEH suppression...
  17. ncbi request reprint Role of P450 aromatase in sex-specific astrocytic cell death
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:135-41. 2007
    ..We conclude that astrocytes isolated from neonatal cortex exhibit marked sex differences in sensitivity to OGD, in part because of enhanced aromatization and estradiol formation in female cells...
  18. ncbi request reprint Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
    J Immunol 176:6523-31. 2006
    ....
  19. ncbi request reprint Experimental stroke induces massive, rapid activation of the peripheral immune system
    Halina Offner
    Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 26:654-65. 2006
    ..These data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system...
  20. pmc Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation
    Michael P Hutchens
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, United States
    Resuscitation 76:89-94. 2008
    ..0001 versus WT). We conclude that sEH plays an important role in cardiovascular regulation, and that reduced sEH levels or function reduces survival from cardiac arrest...
  21. doi request reprint Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexes
    Matthias J Merkel
    Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, Portland, OR 97239 3098, USA
    Am J Physiol Heart Circ Physiol 295:H409-15. 2008
    ..We conclude that ME-induced reduction in cell death is abolished by E(2) in a sex-independent manner via activation of estrogen receptors, and this interaction is dependent on iNOS...
  22. doi request reprint Renal ischemia: does sex matter?
    Michael P Hutchens
    OR Health and Science University, Department of Anesthesiology and Peri Operative Medicine, Portland, USA
    Anesth Analg 107:239-49. 2008
    ..Although much work remains to characterize the biological mechanisms involved, the data are sufficient to support consideration of gender and the use of medications that impact steroid availability in the perioperative plan of care...
  23. pmc Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP)
    Sufang Yang
    Department of Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
    Anesth Analg 108:964-70. 2009
    ..We tested the hypothesis that PPBP protects neurons by a mechanism involving activation of the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB)...
  24. pmc Age-dependent effects of testosterone in experimental stroke
    Jian Cheng
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 29:486-94. 2009
    ..Lastly, stroke damage was not different in aging aromatase knockout mice versus wild-type controls. Our findings indicate that testosterone's effects in experimental stroke are age dependent, mediated via AR, but not cerebral aromatase...
  25. pmc Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia
    Jian Cheng
    Department of Anesthesiology and Peri Operative Medicine, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 31:339-50. 2011
    ..Our finding suggests that SIK1 contributes to neuroprotection by androgens within physiological ranges by inhibiting histone deacetylation...
  26. pmc Mechanisms of gender-linked ischemic brain injury
    Mingyue Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR 97239 3098, USA
    Restor Neurol Neurosci 27:163-79. 2009
    ....
  27. pmc Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo
    Michael P Hutchens
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHN 2, Portland, Oregon 97239, USA
    Anesthesiology 112:395-405. 2010
    ..In this study, cardiac arrest and cardiopulmonary resuscitation were used to assess whether estradiol is renoprotective via an estrogen receptor (ER)-dependent mechanism...
  28. ncbi request reprint Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy
    Agata Matejuk
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 174:2387-95. 2005
    ..These data are the first to define age-dependent differences in EAE expression and response to hormone therapy...
  29. pmc Brain aromatization: classic roles and new perspectives
    Charles E Roselli
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Semin Reprod Med 27:207-17. 2009
    ..A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies...
  30. pmc Mitochondrial mechanism of neuroprotection by CART
    Peizhong Mao
    Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Eur J Neurosci 26:624-32. 2007
    ..The findings suggest that CART's neuroprotective mechanism of action may be linked to preservation of mitochondrial function and prevention of energy failure after ischemia-reperfusion injury...
  31. pmc Dietary soy may not confound acute experimental stroke infarct volume outcomes in ovariectomized female rats
    Kamm D Prongay
    Department of Comparative Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Lab Anim 44:238-46. 2010
    ..More studies addressing the potential confounding effects of dietary soy in 'oestrogen-sensitive' stroke models are needed if investigators are to make informed choices regarding diets used in experimental stroke research...
  32. ncbi request reprint Dose-dependent neuroprotection by 17beta-estradiol after cardiac arrest and cardiopulmonary resuscitation
    Ruediger R Noppens
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
    Crit Care Med 33:1595-602. 2005
    ..The present study determined whether E2 also improves neuronal survival after experimental cardiac arrest and cardiopulmonary resuscitation and if any protection is dose-dependent...
  33. pmc Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke
    Xiaoqin Liu
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 28:1898-906. 2008
    ....
  34. pmc Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt
    Zhiping Cao
    Anesthesiology Service, Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239 2999, USA
    Am J Physiol Heart Circ Physiol 294:H302-10. 2008
    ..The incomplete loss of protection in females following the blockade of PI3K suggests that additional factors may facilitate the maintenance or function of activated Akt...
  35. pmc Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization
    Melissa H Kelley
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Neurochem 107:668-78. 2008
    ..Thus, interventions which prevent ischemia-induced decline in GABA(A) receptors may represent a novel neuroprotective strategy...
  36. pmc Deleterious effects of dihydrotestosterone on cerebral ischemic injury
    Jian Cheng
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Cereb Blood Flow Metab 27:1553-62. 2007
    ..Our data suggest that androgens are important mediators of ischemic damage in male brain and that transcriptional mechanisms should be considered as we seek to understand innate male sensitivity to cerebral ischemia...
  37. ncbi request reprint Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase
    Kamila Vagnerova
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHS 2, Portland, Oregon 97239, USA
    Anesth Analg 103:430-4, table of contents. 2006
    ..Because AG provides no additional benefit to P(+) treatment and iNOSKOs do not benefit from P(+), we speculate that P(+) acts by suppressing cell death resulting from iNOS toxicity...
  38. ncbi request reprint Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats
    Zhizheng Zhang
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
    Anesth Analg 97:1776-83. 2003
    ..6% +/- 5.3%; CP, 40.9% +/- 6.2%) conferred by BRL 52537. BRL 52537 did not produce postischemic hypothermia. These data demonstrate that KORs may provide a therapeutic target during early reperfusion after ischemic stroke...
  39. pmc Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection
    Suzan Dziennis
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 27:7268-74. 2007
    ..We conclude that estradiol increases STAT3 phosphorylation in neurons after MCAO and that STAT3 activation plays an important role in estradiol-mediated neuroprotection...
  40. pmc Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats
    Suzan Dziennis
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Environ Health Perspect 116:474-80. 2008
    ..Subsequently, it has been expanded to include developmental exposures to environmental contaminants as risk factors for adult onset disease...
  41. pmc Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2
    Sufang Yang
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health Sciences University, Portland, Oregon 97239 3098, USA
    Anesth Analg 104:1179-84, tables of contents. 2007
    ..We tested the hypothesis that the potent, prototypical sigma(1)-receptor agonist, 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), protects neurons by a mechanism involving the antiapoptotic protein bcl-2...
  42. pmc Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain
    Hideto Kitano
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Cereb Blood Flow Metab 27:1108-28. 2007
    ..Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed...
  43. pmc Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection
    Yun Xu
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:14489-94. 2006
    ..The findings suggest that CART is an important player in estrogen-mediated neuroprotection and a potential therapeutic agent for stroke and other neurodegenerative diseases...
  44. ncbi request reprint Neonatal factors influence adult stroke outcome
    Tara K S Craft
    Department of Psychology, The Ohio State University, 51 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA
    Psychoneuroendocrinology 31:601-13. 2006
    ..Taken together, these data provide the first direct evidence that neonatal environment can substantially influence adult cerebrovascular health...
  45. ncbi request reprint Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice
    Julia Kofler
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Neurosci Methods 136:33-44. 2004
    ..A dissociation between functional and histological outcome was found emphasizing the importance of combining both outcome measures for evaluation of neuroprotective strategies...
  46. ncbi request reprint Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of gender
    Xiaoling Li
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Exp Neurol 187:94-104. 2004
    ..This suggests that a short battery of tests including the neurological score, cylinder, and corner test may be adequate to rapidly and repeatedly assess sensorimotor dysfunction in mice of both genders...
  47. ncbi request reprint Postischemic angiogenic factor expression in stroke-prone rats
    Michael M Wang
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Exp Neurol 173:283-8. 2002
    ..Thus, the SHRSP brain elaborates a unique and specific pattern of angiopoietin system gene expression after stroke which may underlie stroke susceptibility of these rats...
  48. ncbi request reprint Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection
    Louise D McCullough
    Department of Neurology and Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4961, USA
    J Neurosci 23:8701-5. 2003
    ....
  49. ncbi request reprint Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction
    SYLVAIN DORE
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Ann Neurol 54:155-62. 2003
    ....
  50. ncbi request reprint Mechanisms of ischemic brain damage
    Anish Bhardwaj
    Meyer 8 140, Neuroscience Critical Care Division, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
    Curr Cardiol Rep 5:160-7. 2003
    ..This article discusses several important cell death and salvage pathways that are important in experimental cerebral ischemia that may be critical to outcome in clinical brain injury...
  51. ncbi request reprint Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack
    Nabil J Alkayed
    Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Stroke 33:1677-84. 2002
    ..We tested the hypothesis that experimental TIA induces expression of P450 2C11, an arachidonic acid epoxygenase that produces vasodilator epoxyeicosatrienoic acids, leading to increased tissue perfusion and reduced stroke damage...
  52. ncbi request reprint Social stress exacerbates focal cerebral ischemia in mice
    Nobuo Sugo
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 33:1660-4. 2002
    ..The purpose of the present study was to determine whether exposure to stress or elevated corticosterone concentrations in the days preceding cerebral ischemia exacerbates ischemic injury as assessed by histological and behavioral outcomes...
  53. ncbi request reprint Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery
    Shozo Goto
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Schools of Medicine, Baltimore, MD 21287, USA
    Stroke 33:1101-6. 2002
    ..PARP-/- mice were also treated with viral transfection of wild-type PARP-1 to determine whether protection from MCA occlusion is lost with restoration of the gene product...
  54. ncbi request reprint Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model
    Agnieszka A Ardelt
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Stroke 36:337-41. 2005
    ..We hypothesized that E2 protects brain in stroke through modulation of angiogenesis. We quantified molecular markers of angiogenesis and capillary density before and after unilateral middle cerebral artery occlusion (MCAO)...
  55. ncbi request reprint Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection
    Louise D McCullough
    Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030 1840, USA
    J Cereb Blood Flow Metab 25:502-12. 2005
    ....
  56. pmc Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA
    Hung Dong Joh
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 26:518-26. 2006
    ..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors...
  57. ncbi request reprint Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxide
    Emil Zeynalov
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Cereb Blood Flow Metab 26:414-20. 2006
    ..Neuroprotective effects of BRL 52537 are lost in the male when nNOS is not present; therefore, BRL 52537 likely acts upstream from NO generation and its subsequent neurotoxicity...
  58. ncbi request reprint Social interaction improves experimental stroke outcome
    Tara K S Craft
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Stroke 36:2006-11. 2005
    ..The purpose of the present study was to determine whether affiliative social interactions before and after stroke improve ischemic outcomes as assessed through histological analysis and behavioral assays...
  59. ncbi request reprint Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specific
    Chih Hung Chen
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 36:1557-61. 2005
    ..We tested the hypothesis that BRL provides significant neuroprotection from transient focal ischemia in male but not in female rats...
  60. ncbi request reprint SOD1 overexpression and female sex exhibit region-specific neuroprotection after global cerebral ischemia due to cardiac arrest
    Julia Kofler
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 25:1130-7. 2005
    ..However, no additive neuroprotection was observed, and these beneficial effects were restricted to specific brain regions...
  61. pmc Lack of correlation of vaginal impedance measurements with hormone levels in the rat
    Sylvia J Singletary
    Department of Comparative Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Contemp Top Lab Anim Sci 44:37-42. 2005
    ..Vaginal impedance may be useful in distinguishing estrus from nonestrus rats but may be limited for chronic estrous cycle monitoring because of the possible risk of inducing pseudopregnancy...
  62. pmc Effects of estrogen on platelet reactivity after transient forebrain ischemia in rats
    Marguerite T Littleton-Kearney
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biol Res Nurs 7:135-45. 2005
    ..In this rodent global cerebral ischemic model, physiologic doses of estrogen are not deleterious to platelet reactivity and may initially reduce postischemic platelet reactivity...
  63. ncbi request reprint Global brain water increases after experimental focal cerebral ischemia: effect of hypertonic saline
    Thomas J K Toung
    Department of Anesthesiology Critcal Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Crit Care Med 30:644-9. 2002
    ....
  64. ncbi request reprint Estrogen and stroke: a balanced analysis
    Patricia D Hurn
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Stroke 34:338-41. 2003
  65. pmc An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain
    Mahmood Amiry-Moghaddam
    Centre for Molecular Biology and Neuroscience and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
    Proc Natl Acad Sci U S A 100:2106-11. 2003
    ..The anchoring of AQP4 to alpha-syntrophin may be a target for treatment of brain edema, but therapeutic manipulations of AQP4 must consider the bidirectional water flux through this molecule...
  66. ncbi request reprint Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats
    Toru Goyagi
    Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Anesth Analg 96:532-8, table of contents. 2003
    ..Therefore, PPBP provides significant ischemic neuroprotection in the CP complex without altering the acute accumulation of dopamine in vivo during transient focal ischemia in the rat...
  67. ncbi request reprint High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats
    David F Antezana
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg 98:860-6. 2003
    ..Ibuprofen treatment was compared with mild systemic hypothermia, which is known to be neuroprotective and is commonly used during neurosurgical procedures...
  68. ncbi request reprint Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats
    Toru Goyagi
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 34:1533-8. 2003
    ....
  69. ncbi request reprint Estrogen and ischemic neuroprotection: an integrated view
    Louise D McCullough
    Department of Neurology, Johns Hopkins School of Medicine, 600 N Wolfe St, Pathology 509, Baltimore, MD 21287, USA
    Trends Endocrinol Metab 14:228-35. 2003
    ..This apparent dichotomy between the limitation of HRT in ameliorating complex disease development vs the excellent performance of estradiol in containing experimental brain damage remains to be understood...
  70. ncbi request reprint Membrane restraint of estrogen receptor alpha enhances estrogen-dependent nuclear localization and genomic function
    Yun Xu
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Mol Endocrinol 18:86-96. 2004
    ..Furthermore, these experiments provide evidence that under certain circumstances, membrane proteins are capable of nuclear function without detectable nucleoplasmic localization...
  71. ncbi request reprint Testosterone as a modulator of vascular behavior
    Marguerite Littleton-Kearney
    Johns Hopkins Schools of Nursing and Medicine, 525 N Wolfe Street, Room 460, Baltimore, MD 21205 2110, USA
    Biol Res Nurs 5:276-85. 2004
    ..This review focuses on current understanding of testosterone's physiological effects on vascular behavior and of testosterone's putative role in vascular health and disease...
  72. ncbi request reprint Estrogen restores postischemic sensitivity to the thromboxane mimetic U46619 in rat pial artery
    Xinyue Qin
    Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 25:1041-6. 2005
    ..Restoration of normal constriction to vascular agonists may be an important mechanism by which E2 protects the vasculature and diminishes tissue damage after ischemia...
  73. ncbi request reprint Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in rat
    Marguerite T Littleton-Kearney
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Cereb Blood Flow Metab 25:421-6. 2005
    ..It was concluded that CEE alone, or with CEP, is neuroprotective in the cortex, but interactive effects between the hormones may counteract CEE beneficial effects in subcortical brain regions...
  74. ncbi request reprint Non-classical regulation of estrogen receptor-alpha by ICI182,780
    Michael M Wang
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0622, USA
    J Steroid Biochem Mol Biol 92:51-62. 2004
    ....
  75. ncbi request reprint Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats
    Tsung Ying Chen
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Stroke 35:1180-5. 2004
    ....

Research Grants35

  1. ESTROGEN AS NEUROPROTECTANT IN CEREBRAL ISCHEMIA
    Patricia Hurn; Fiscal Year: 2003
    ..Findings from this study will provide a physiological rationale for nursing care of women, both pre- and postmenopausal, who sustain brain injury from stroke, circulatory arrest or invasive neurosurgical procedures. ..
  2. CEREBRAL ISCHEMIA IN THE FEMALE
    Patricia Hurn; Fiscal Year: 2003
    ....
  3. Cerebral Ischemia in the Female and Male
    Patricia Hurn; Fiscal Year: 2007
    ..Our findings will elucidate the mechanisms behind a most fundamental "genetic" aspect of ischemia, biological sex. ..
  4. Sex, Sex Steroids & Neuroprotection
    Patricia Hurn; Fiscal Year: 2007
    ..These projects are supported by 3 core facilities: 1) Administration; 2) Tissue Analysis and 3) Animal Models. ..
  5. Estrogen and Testosterone in Experimental Stroke
    Patricia Hurn; Fiscal Year: 2007
    ..Our findings will help to elucidate the mechanisms behind a most fundamental "genetic" aspect of ischemia, biological sex. ..
  6. Estrogen and Immunoprotection in Experimental Stroke
    Patricia Hurn; Fiscal Year: 2009
    ..Our study is focused on developing therapy that will improve brain outcomes and immune system function after stroke in females. We will also explore the effects of estrogen deficiency and restoration on post-stroke immunity. ..
  7. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2010
    ..Our study is focused on developing therapy that will improve brain outcomes and immune system function after stroke in females. We will also explore the effects of estrogen deficiency and restoration on post-stroke immunity. ..