Research Topics
Species | Patricia HurnSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
Adult or perinatal brain injury: does sex matter?Patricia D Hurn
Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
Stroke 36:193-5. 2005
Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemiaWenri Zhang
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 29:1475-81. 2009..We conclude that sEH is an important mechanism underlying sex-linked differences in blood flow and brain damage after cerebral ischemia...- T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammationPatricia D Hurn
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
J Cereb Blood Flow Metab 27:1798-805. 2007.... - Estradiol attenuates neuroprotective benefits of isoflurane preconditioning in ischemic mouse brainLan Wang
Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 28:1824-34. 2008..In OVX+ERbeta agonist, IsoPC increased cortical infarct volume. Estradiol depresses the brain's protective response to IsoPC and may exacerbate cortical ischemic injury mainly through an ERbeta-dependent mechanism... - Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemiaJulia Kofler
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 26:135-41. 2006..We conclude that PARP-2 is a novel executioner of cell death pathways in focal cerebral ischemia, but might be a necessary survival factor after global ischemia to mitigate hippocampal delayed cell death... - Gender and the injured brainKamila Vagnerova
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
Anesth Analg 107:201-14. 2008..Lastly, implications for current and future perioperative and intensive care are identified... - Recombinant T cell receptor ligand treats experimental strokeSandhya Subramanian
Neuroimmunology Research, Portland VA Medical Center, Portland, OR 97239, USA
Stroke 40:2539-45. 2009..We tested the hypothesis that RTL would improve ischemic outcome in the brain without exacerbating defects in the peripheral immune system function... - Sex, sex steroids, and brain injuryPaco S Herson
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
Semin Reprod Med 27:229-39. 2009..This review evaluates key evidence and highlights the importance of the platform on which brain injury occurs (i.e., genetic sex and hormonal modulators)... - Estradiol after cardiac arrest and cardiopulmonary resuscitation is neuroprotective and mediated through estrogen receptor-betaRuediger R Noppens
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon, USA
J Cereb Blood Flow Metab 29:277-86. 2009..05). Injury was not different in hippocampal CA1 between vehicle and ER-alpha agonist-treated animals. We conclude that long-term E2 administration after CA/CPR is neuroprotective and that this effect is most likely mediated via ER-beta... - Estradiol and G1 reduce infarct size and improve immunosuppression after experimental strokeBing Zhang
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
J Immunol 184:4087-94. 2010..These results demonstrate for the first time that E2 replacement in ovariectomized female mice improves stroke-induced peripheral immunosuppression... - Gender-specific response to isoflurane preconditioning in focal cerebral ischemiaHideto Kitano
Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 27:1377-86. 2007..Male IsoPC neuroprotection was lost in Akt1-deficient male mice. We conclude that IsoPC is beneficial only in ischemic male brain and that sex differences in IsoPC are mediated through Akt activation and basal NIPK expression... - Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male miceMasayoshi Uchida
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 29:1454-62. 2009..We conclude that testosterone exhibits dose-dependent and time-sensitive effects after ischemia and that testosterone is likely to be an important factor in sex-linked differences in cerebrovascular disease... - Estrogen and selective estrogen receptor modulators: neuroprotection in the Women's Health Initiative eraStephanie Murphy
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Endocrine 21:17-26. 2003..This review critiques estrogen and SERMs' neuroprotective potential in experimental and clinical studies of stroke and cerebrovascular disease... - Evidence of the peripheral inflammatory response in patients with transient ischemic attackAmy Miner Ross
School of Nursing, Oregon Health and Science University, Ashland, Oregon 97520, USA
J Stroke Cerebrovasc Dis 16:203-7. 2007.... - A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte cultureMingyue Liu
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR, 97239 3098, USA
J Neurosci Methods 171:214-7. 2008..This innovative technique may also be applied to other in vitro studies of sex-related functional differences... - Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemiaInes P Koerner
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Front Biosci 13:2833-41. 2008..While estradiol suppresses cerebral sEH expression, and sEH suppression diminishes inflammation after MCAO, our findings suggest that the effect of estrogen on inflammation is complex, and only partially explained by sEH suppression... - Role of P450 aromatase in sex-specific astrocytic cell deathMingyue Liu
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 27:135-41. 2007..We conclude that astrocytes isolated from neonatal cortex exhibit marked sex differences in sensitivity to OGD, in part because of enhanced aromatization and estradiol formation in female cells... - Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophagesHalina Offner
Neuroimmunology Research, Veterans Affairs Medical Center, Portland, OR 97239, USA
J Immunol 176:6523-31. 2006.... - Experimental stroke induces massive, rapid activation of the peripheral immune systemHalina Offner
Neuroimmunology Research, Veterans Affairs Medical Center, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 26:654-65. 2006..These data show for the first time that focal cerebral ischemia results in dynamic and widespread activation of inflammatory cytokines, chemokines, and CCR in the peripheral immune system... - Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitationMichael P Hutchens
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, United States
Resuscitation 76:89-94. 2008..0001 versus WT). We conclude that sEH plays an important role in cardiovascular regulation, and that reduced sEH levels or function reduces survival from cardiac arrest... 
Estradiol abolishes reduction in cell death by the opioid agonist Met5-enkephalin after oxygen glucose deprivation in isolated cardiomyocytes from both sexesMatthias J Merkel
Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, Portland, OR 97239 3098, USA
Am J Physiol Heart Circ Physiol 295:H409-15. 2008..We conclude that ME-induced reduction in cell death is abolished by E(2) in a sex-independent manner via activation of estrogen receptors, and this interaction is dependent on iNOS...- Renal ischemia: does sex matter?Michael P Hutchens
OR Health and Science University, Department of Anesthesiology and Peri Operative Medicine, Portland, USA
Anesth Analg 107:239-49. 2008..Although much work remains to characterize the biological mechanisms involved, the data are sufficient to support consideration of gender and the use of medications that impact steroid availability in the perioperative plan of care... - Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP)Sufang Yang
Department of Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 3098, USA
Anesth Analg 108:964-70. 2009..We tested the hypothesis that PPBP protects neurons by a mechanism involving activation of the transcription factor cyclic adenosine monophosphate response element-binding protein (CREB)... - Age-dependent effects of testosterone in experimental strokeJian Cheng
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 29:486-94. 2009..Lastly, stroke damage was not different in aging aromatase knockout mice versus wild-type controls. Our findings indicate that testosterone's effects in experimental stroke are age dependent, mediated via AR, but not cerebral aromatase... - Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemiaJian Cheng
Department of Anesthesiology and Peri Operative Medicine, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 31:339-50. 2011..Our finding suggests that SIK1 contributes to neuroprotection by androgens within physiological ranges by inhibiting histone deacetylation... - Mechanisms of gender-linked ischemic brain injuryMingyue Liu
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR 97239 3098, USA
Restor Neurol Neurosci 27:163-79. 2009.... - Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivoMichael P Hutchens
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHN 2, Portland, Oregon 97239, USA
Anesthesiology 112:395-405. 2010..In this study, cardiac arrest and cardiopulmonary resuscitation were used to assess whether estradiol is renoprotective via an estrogen receptor (ER)-dependent mechanism... - Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapyAgata Matejuk
Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 174:2387-95. 2005..These data are the first to define age-dependent differences in EAE expression and response to hormone therapy... - Brain aromatization: classic roles and new perspectivesCharles E Roselli
Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
Semin Reprod Med 27:207-17. 2009..A better understanding of brain aromatization could shed new light on its physiologic and pathologic functions and someday lead to new, centrally acting drug therapies... - Mitochondrial mechanism of neuroprotection by CARTPeizhong Mao
Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
Eur J Neurosci 26:624-32. 2007..The findings suggest that CART's neuroprotective mechanism of action may be linked to preservation of mitochondrial function and prevention of energy failure after ischemia-reperfusion injury... - Dietary soy may not confound acute experimental stroke infarct volume outcomes in ovariectomized female ratsKamm D Prongay
Department of Comparative Medicine, Oregon Health and Science University, Portland, OR 97239, USA
Lab Anim 44:238-46. 2010..More studies addressing the potential confounding effects of dietary soy in 'oestrogen-sensitive' stroke models are needed if investigators are to make informed choices regarding diets used in experimental stroke research... - Dose-dependent neuroprotection by 17beta-estradiol after cardiac arrest and cardiopulmonary resuscitationRuediger R Noppens
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA
Crit Care Med 33:1595-602. 2005.... - Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental strokeXiaoqin Liu
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 28:1898-906. 2008.... - Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/AktZhiping Cao
Anesthesiology Service, Veterans Affairs Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97239 2999, USA
Am J Physiol Heart Circ Physiol 294:H302-10. 2008..The incomplete loss of protection in females following the blockade of PI3K suggests that additional factors may facilitate the maintenance or function of activated Akt... - Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilizationMelissa H Kelley
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
J Neurochem 107:668-78. 2008..Thus, interventions which prevent ischemia-induced decline in GABA(A) receptors may represent a novel neuroprotective strategy... - Deleterious effects of dihydrotestosterone on cerebral ischemic injuryJian Cheng
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Cereb Blood Flow Metab 27:1553-62. 2007..Our data suggest that androgens are important mediators of ischemic damage in male brain and that transcriptional mechanisms should be considered as we seek to understand innate male sensitivity to cerebral ischemia... - Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthaseKamila Vagnerova
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road UHS-2, Portland, Oregon 97239, USA
Anesth Analg 103:430-4, table of contents. 2006..Because AG provides no additional benefit to P(+) treatment and iNOSKOs do not benefit from P(+), we speculate that P(+) acts by suppressing cell death resulting from iNOS toxicity... - Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in ratsZhizheng Zhang
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon, USA
Anesth Analg 97:1776-83. 2003..IMPLICATIONS: The neuroprotective effect of selective kappa-opioid agonists in transient focal ischemia is via a selective action at the kappa-opioid receptors... - Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotectionSuzan Dziennis
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
J Neurosci 27:7268-74. 2007..We conclude that estradiol increases STAT3 phosphorylation in neurons after MCAO and that STAT3 activation plays an important role in estradiol-mediated neuroprotection... - Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult ratsSuzan Dziennis
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
Environ Health Perspect 116:474-80. 2008..Subsequently, it has been expanded to include developmental exposures to environmental contaminants as risk factors for adult onset disease... - Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2Sufang Yang
Department of Anesthesiology and Peri Operative Medicine, Oregon Health Sciences University, Portland, Oregon 97239 3098, USA
Anesth Analg 104:1179-84, tables of contents. 2007..We tested the hypothesis that the potent, prototypical sigma(1)-receptor agonist, 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP), protects neurons by a mechanism involving the antiapoptotic protein bcl-2... - Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brainHideto Kitano
Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Cereb Blood Flow Metab 27:1108-28. 2007..Mechanisms underlying volatile anesthetic neuroprotection and preconditioning will also be examined. Lastly, future directions for inhalational anesthetics and ischemic brain injury will be briefly discussed... - Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotectionYun Xu
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Proc Natl Acad Sci U S A 103:14489-94. 2006..The findings suggest that CART is an important player in estrogen-mediated neuroprotection and a potential therapeutic agent for stroke and other neurodegenerative diseases... - Neonatal factors influence adult stroke outcomeTara K S Craft
Department of Psychology, The Ohio State University, 51 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA
Psychoneuroendocrinology 31:601-13. 2006..Taken together, these data provide the first direct evidence that neonatal environment can substantially influence adult cerebrovascular health... - Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in miceJulia Kofler
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Neurosci Methods 136:33-44. 2004..A dissociation between functional and histological outcome was found emphasizing the importance of combining both outcome measures for evaluation of neuroprotective strategies... - Chronic behavioral testing after focal ischemia in the mouse: functional recovery and the effects of genderXiaoling Li
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
Exp Neurol 187:94-104. 2004..This suggests that a short battery of tests including the neurological score, cylinder, and corner test may be adequate to rapidly and repeatedly assess sensorimotor dysfunction in mice of both genders... - Postischemic angiogenic factor expression in stroke-prone ratsMichael M Wang
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Exp Neurol 173:283-8. 2002..Thus, the SHRSP brain elaborates a unique and specific pattern of angiopoietin system gene expression after stroke which may underlie stroke susceptibility of these rats... - Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotectionLouise D McCullough
Department of Neurology and Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland 21287 4961, USA
J Neurosci 23:8701-5. 2003.... - Neuronal overexpression of cyclooxygenase-2 increases cerebral infarctionSYLVAIN DORE
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Ann Neurol 54:155-62. 2003.... - Mechanisms of ischemic brain damageAnish Bhardwaj
Meyer 8 140, Neuroscience Critical Care Division, Johns Hopkins Hospital, 600 N Wolfe Street, Baltimore, MD 21287, USA
Curr Cardiol Rep 5:160-7. 2003..This article discusses several important cell death and salvage pathways that are important in experimental cerebral ischemia that may be critical to outcome in clinical brain injury... - Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attackNabil J Alkayed
Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Stroke 33:1677-84. 2002..We tested the hypothesis that experimental TIA induces expression of P450 2C11, an arachidonic acid epoxygenase that produces vasodilator epoxyeicosatrienoic acids, leading to increased tissue perfusion and reduced stroke damage... - Social stress exacerbates focal cerebral ischemia in miceNobuo Sugo
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 33:1660-4. 2002..The mechanism underlying the effects of stress on stroke outcome likely involves corticosterone acting through glucocorticoid receptors to increase subsequent ischemia-induced neuronal death... - Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recoveryShozo Goto
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Schools of Medicine, Baltimore, MD 21287, USA
Stroke 33:1101-6. 2002..CONCLUSIONS: PARP-1 deficiency provides both early and prolonged protection from experimental focal stroke. The mechanism is not linked to preservation of ADC and mitigation of secondary energy depletion during early reperfusion... - Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke modelAgnieszka A Ardelt
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Stroke 36:337-41. 2005..We hypothesized that E2 protects brain in stroke through modulation of angiogenesis. We quantified molecular markers of angiogenesis and capillary density before and after unilateral middle cerebral artery occlusion (MCAO)... - Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protectionLouise D McCullough
Department of Neurology, University of Connecticut Health Center, Farmington, Connecticut 06030 1840, USA
J Cereb Blood Flow Metab 25:502-12. 2005.... - Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABAHung Dong Joh
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 26:518-26. 2006..It may be that estradiol under ischemic conditions is attenuating GABA metabolism rather than enhancing synthesis or is augmenting other aspects of GABAergic transmission such as GABA transporters and receptors... - Neuroprotective effect of selective kappa opioid receptor agonist is gender specific and linked to reduced neuronal nitric oxideEmil Zeynalov
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Cereb Blood Flow Metab 26:414-20. 2006..Neuroprotective effects of BRL 52537 are lost in the male when nNOS is not present; therefore, BRL 52537 likely acts upstream from NO generation and its subsequent neurotoxicity... - Social interaction improves experimental stroke outcomeTara K S Craft
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
Stroke 36:2006-11. 2005..CONCLUSIONS: Affiliative interaction during the peri-ischemic period reduces intraischemic CRP concentration, decreases ischemic damage in male and female mice, and improves behavioral outcome... - Ischemic neuroprotection with selective kappa-opioid receptor agonist is gender specificChih-Hung Chen
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 36:1557-61. 2005.... - SOD1 overexpression and female sex exhibit region-specific neuroprotection after global cerebral ischemia due to cardiac arrestJulia Kofler
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Cereb Blood Flow Metab 25:1130-7. 2005..However, no additive neuroprotection was observed, and these beneficial effects were restricted to specific brain regions... - Lack of correlation of vaginal impedance measurements with hormone levels in the ratSylvia J Singletary
Department of Comparative Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
Contemp Top Lab Anim Sci 44:37-42. 2005..Vaginal impedance may be useful in distinguishing estrus from nonestrus rats but may be limited for chronic estrous cycle monitoring because of the possible risk of inducing pseudopregnancy... - Effects of estrogen on platelet reactivity after transient forebrain ischemia in ratsMarguerite T Littleton-Kearney
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Biol Res Nurs 7:135-45. 2005..In this rodent global cerebral ischemic model, physiologic doses of estrogen are not deleterious to platelet reactivity and may initially reduce postischemic platelet reactivity... - Global brain water increases after experimental focal cerebral ischemia: effect of hypertonic salineThomas J K Toung
Department of Anesthesiology/Critcal Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 30:644-9. 2002..5% hypertonic saline treatment begun at 24 hrs postischemia and to standard diuretic/osmotic agents. These results may have implications for diuretic and osmotic therapy in clinical ischemic stroke... - Estrogen and stroke: a balanced analysisPatricia D Hurn
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Stroke 34:338-41. 2003 - An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brainMahmood Amiry-Moghaddam
Centre for Molecular Biology and Neuroscience and Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
Proc Natl Acad Sci U S A 100:2106-11. 2003..The anchoring of AQP4 to alpha-syntrophin may be a target for treatment of brain edema, but therapeutic manipulations of AQP4 must consider the bidirectional water flux through this molecule... - Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in ratsToru Goyagi
Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Anesth Analg 96:532-8, table of contents. 2003..Therefore, PPBP provides significant ischemic neuroprotection in the CP complex without altering the acute accumulation of dopamine in vivo during transient focal ischemia in the rat... - High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in ratsDavid F Antezana
Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
J Neurosurg 98:860-6. 2003.... - Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in ratsToru Goyagi
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 34:1533-8. 2003.... - Estrogen and ischemic neuroprotection: an integrated viewLouise D McCullough
Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe St, Pathology 509, Baltimore, MD 21287, USA
Trends Endocrinol Metab 14:228-35. 2003..This apparent dichotomy between the limitation of HRT in ameliorating complex disease development vs the excellent performance of estradiol in containing experimental brain damage remains to be understood... - Membrane restraint of estrogen receptor alpha enhances estrogen-dependent nuclear localization and genomic functionYun Xu
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
Mol Endocrinol 18:86-96. 2004..Furthermore, these experiments provide evidence that under certain circumstances, membrane proteins are capable of nuclear function without detectable nucleoplasmic localization... - Testosterone as a modulator of vascular behaviorMarguerite Littleton-Kearney
Johns Hopkins Schools of Nursing and Medicine, 525 N Wolfe Street, Room 460, Baltimore, MD 21205 2110, USA
Biol Res Nurs 5:276-85. 2004..This review focuses on current understanding of testosterone's physiological effects on vascular behavior and of testosterone's putative role in vascular health and disease... - Estrogen restores postischemic sensitivity to the thromboxane mimetic U46619 in rat pial arteryXinyue Qin
Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 25:1041-6. 2005..Restoration of normal constriction to vascular agonists may be an important mechanism by which E2 protects the vasculature and diminishes tissue damage after ischemia... - Effects of combined oral conjugated estrogens and medroxyprogesterone acetate on brain infarction size after experimental stroke in ratMarguerite T Littleton-Kearney
Department of Anesthesiology Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Cereb Blood Flow Metab 25:421-6. 2005..It was concluded that CEE alone, or with CEP, is neuroprotective in the cortex, but interactive effects between the hormones may counteract CEE beneficial effects in subcortical brain regions... - Non-classical regulation of estrogen receptor-alpha by ICI182,780Michael M Wang
Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0622, USA
J Steroid Biochem Mol Biol 92:51-62. 2004.... - Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in ratsTsung-Ying Chen
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 35:1180-5. 2004....
Research Grants
- ESTROGEN AS NEUROPROTECTANT IN CEREBRAL ISCHEMIAPatricia Hurn; Fiscal Year: 2003..Findings from this study will provide a physiological rationale for nursing care of women, both pre- and postmenopausal, who sustain brain injury from stroke, circulatory arrest or invasive neurosurgical procedures. ..
- CEREBRAL ISCHEMIA IN THE FEMALEPatricia Hurn; Fiscal Year: 2003....
- Cerebral Ischemia in the Female and MalePatricia Hurn; Fiscal Year: 2007..Our findings will elucidate the mechanisms behind a most fundamental "genetic" aspect of ischemia, biological sex. ..
- Sex, Sex Steroids & NeuroprotectionPatricia Hurn; Fiscal Year: 2007..These projects are supported by 3 core facilities: 1) Administration; 2) Tissue Analysis and 3) Animal Models. ..
- Estrogen and Testosterone in Experimental StrokePatricia Hurn; Fiscal Year: 2007..Our findings will help to elucidate the mechanisms behind a most fundamental "genetic" aspect of ischemia, biological sex. ..
- Estrogen and Immunoprotection in Experimental StrokePatricia Hurn; Fiscal Year: 2009..Our study is focused on developing therapy that will improve brain outcomes and immune system function after stroke in females. We will also explore the effects of estrogen deficiency and restoration on post-stroke immunity. ..
- Estrogen and Immunoprotection in Experimental StrokePatricia D Hurn; Fiscal Year: 2010..Our study is focused on developing therapy that will improve brain outcomes and immune system function after stroke in females. We will also explore the effects of estrogen deficiency and restoration on post-stroke immunity. ..