Scott Houghtaling

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Genes Dev 17:2021-35. 2003
  2. ncbi request reprint Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Res 65:85-91. 2005
  3. ncbi request reprint Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, 97239, USA
    Hum Mol Genet 14:3027-33. 2005
  4. doi request reprint Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice
    Qing Shuo Zhang
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Res 68:1601-8. 2008
  5. ncbi request reprint Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
    Rocio Montes De Oca
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Blood 105:1003-9. 2005

Collaborators

Detail Information

Publications5

  1. pmc Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon 97239, USA
    Genes Dev 17:2021-35. 2003
    ..The phenotypic overlap between Fancd2-null and Brca2/Fancd1 hypomorphic mice is consistent with a common function for both proteins in the same pathway, regulating genomic stability...
  2. ncbi request reprint Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Res 65:85-91. 2005
    ..Therefore, Trp53 is required for the S phase checkpoint activation observed in Fancd2 mutant cells. Fancd2(-/-)/Trp53(-/-) cells showed an increase in aneuploidy and had multiple gross chromosomal rearrangements...
  3. ncbi request reprint Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining
    Scott Houghtaling
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, 97239, USA
    Hum Mol Genet 14:3027-33. 2005
    ..The role of Fancd2 in DSB repair may account for the moderate sensitivity of FA cells to irradiation and FA cells sensitivity to ICLs that are repaired via a DSB intermediate...
  4. doi request reprint Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice
    Qing Shuo Zhang
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR 97239, USA
    Cancer Res 68:1601-8. 2008
    ..The reduction in oxidative DNA damage in tempol-treated FA fibroblasts and mice suggests that its tumor-delaying function may be attributed to its antioxidant activity...
  5. ncbi request reprint Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin
    Rocio Montes De Oca
    Dana Farber Cancer Institute, Department of Radiation Oncology, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA
    Blood 105:1003-9. 2005
    ..We hypothesize that the carboxy terminus of FANCD2-44 plays a critical role in sensing or repairing DNA damage...