Research Topics
Species | Maureen E HoatlinSummaryAffiliation: Oregon Health and Science University Country: USA Publications
Research Grants
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Detail Information
Publications
A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZFM E Hoatlin
Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
Blood 94:3737-47. 1999..These results suggest that the function of FANCC may be linked to a transcriptional repression pathway involved in chromatin remodeling...
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathwaysAlexandra Sobeck
Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 284:25560-8. 2009..Our results indicate that functions of FANCM are controlled by FA- and non-FA pathways in the DNA damage response...- Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitorsIgor Landais
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, USA
Mol Cancer 8:133. 2009..Curcumin was previously identified as a weak inhibitor of FANCD2-Ub. The aim of this study is to identify derivatives of curcumin with better activity and specificity... 
A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathwayIgor Landais
Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
Int J Cancer 124:783-92. 2009....- The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cellsM E Hoatlin
Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
Blood 91:1418-25. 1998..Therefore, while cytoplasmic localization of this protein appears to be functionally important, it may also exert some essential nuclear function... - Identification, developmental expression and regulation of the Xenopus ortholog of human FANCG/XRCC9Stacie Stone
Division of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA
Genes Cells 12:841-51. 2007..Our data demonstrate that interactions between FANCA and FANCG occur at the earliest stage of vertebrate development and raise the possibility that functionally different isoforms of xFANCG may play a role in early development... - Posttranscriptional cell cycle-dependent regulation of human FANCC expressionM C Heinrich
Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, OR 97207, USA
Blood 95:3970-7. 2000..Our observation of dynamic control of FANCC expression by the proteasome has important implications for understanding the molecular regulation of the multiprotein complex. (Blood. 2000;95:3970-3977).. - Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksAlexandra Sobeck
Division of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, USA
Mol Cell Biol 26:425-37. 2006.... - The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specificMu Shui Dai
Division of Molecular Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
J Biol Chem 277:26327-34. 2002..These results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins... - DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2A Sobeck
Biochemistry and Molecular Biology and Molecular and Medical Genetics, Oregon Health and Science University, Medical Research Building, Portland, OR 97239, USA
Mol Cell Biol 27:4283-92. 2007..Our results provide new evidence that the FA pathway discriminates among DNA structures and demonstrate that triggering the FA pathway can be uncoupled from DNA replication and ATRIP-dependent activation... - Amplified and tissue-directed expression of retroviral vectors using ping-pong techniquesM E Hoatlin
Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
J Mol Med 73:113-20. 1995..Factors that limit tissue-specific expression are reviewed... - Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transportTanja Y Reuter
Department of Biochemistry, University of Wuerzburg, D-97074 Wuerzburg, Germany
Exp Cell Res 289:211-21. 2003..Taken together, our data strongly support the hypothesis that FA proteins are functionally involved in several complex cellular pathways including transcription regulation, cell signaling, oxidative metabolism, and cellular transport... - Characterization, expression and complex formation of the murine Fanconi anaemia gene product FancgHenri J van de Vrugt
Department of Clinical Genetics and Human Genetics, VU University Medical Centre, Van der Boechorststraat 7, NL 1081 BT Amsterdam, The Netherlands
Genes Cells 7:333-42. 2002..Comparison of FA gene characteristics in different species may help to unravel the molecular function of the FA pathway... - Fanconi anemia protein complex is a novel target of the IKK signalsomeTetsuya Otsuki
Hematology Branch, NHLBI Bldg, Bethesda, Maryland 20892, USA
J Cell Biochem 86:613-23. 2002..When exposed to mitomycin C, cells expressing IKK2 K > M develop a cell cycle abnormality characteristic of FA. Thus, FANCA may function to recruit IKK2, thus providing the cell a means of rapidly responding to stress... - A novel ubiquitin ligase is deficient in Fanconi anemiaAmom Ruhikanta Meetei
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, Maryland 21224, USA
Nat Genet 35:165-70. 2003..Our data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2... - A multiprotein nuclear complex connects Fanconi anemia and Bloom syndromeAmom Ruhikanta Meetei
Laboratory of Genetics Mass Spectrometry Unit, National Institute on Aging NIH, TRIAD Center Room 3000, 333 Cassell Drive, Baltimore, MD 21224, USA
Mol Cell Biol 23:3417-26. 2003..The findings that FA proteins are part of a DNA-unwinding complex imply that FA proteins may participate in DNA repair... - Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2Hideyuki Ikeda
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160-8582, Japan
Cancer Res 63:2688-94. 2003..This finding suggests a novel mechanistic principle of tumor progression based on the genetic correction of an early caretaker gene defect... - FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathwayChen Ling
Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
EMBO J 26:2104-14. 2007..Our study identifies FAAP100 as a new critical component of the FA-BRCA DNA damage response network... - The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCCFrance Léveillé
Department of Clinical Genetics and Human Genetics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
DNA Repair (Amst) 5:556-65. 2006..This strengthens the idea that FANCE recruits FANCD2 to the core complex, without interfering with the binding of FANCC... - The Fanconi anemia gene product FANCF is a flexible adaptor proteinFrance Léveillé
Department of Clinical Genetics and Human Genetics, VU University Medical Center, Van der Boechorststraat 7, NL 1081BT Amsterdam, The Netherlands
J Biol Chem 279:39421-30. 2004..Our data demonstrate that FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex... - Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypesMarieke Levitus
Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
Blood 103:2498-503. 2004..Our results suggest that the FA pathway of genome stabilization may be controlled by at least 11 different genes, including FANCI and FANCJ... - FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemiaMichael Hölzel
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Pathol 201:198-203. 2003..FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki-67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication...
Research Grants
- FANCONI ANEMIA--ROLE OF THE C PROTEINMaureen Hoatlin; Fiscal Year: 2003..abstract_text> ..
- Functional Analysis of the Fanconi PathwayMaureen Hoatlin; Fiscal Year: 2009..We will examine replication in the presence and absence of XFANCD2 to determine if it is required for normal progress of DNA replication, or removal of DNA double strand breaks that arise naturally during replication. ..