Maureen E Hoatlin

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF
    M E Hoatlin
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
    Blood 94:3737-47. 1999
  2. pmc The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways
    Alexandra Sobeck
    Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 284:25560-8. 2009
  3. pmc Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
    Igor Landais
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, USA
    Mol Cancer 8:133. 2009
  4. doi request reprint A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway
    Igor Landais
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Int J Cancer 124:783-92. 2009
  5. ncbi request reprint The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cells
    M E Hoatlin
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
    Blood 91:1418-25. 1998
  6. ncbi request reprint Identification, developmental expression and regulation of the Xenopus ortholog of human FANCG/XRCC9
    Stacie Stone
    Division of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA
    Genes Cells 12:841-51. 2007
  7. ncbi request reprint Posttranscriptional cell cycle-dependent regulation of human FANCC expression
    M C Heinrich
    Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, OR 97207, USA
    Blood 95:3970-7. 2000
  8. pmc Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks
    Alexandra Sobeck
    Division of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, USA
    Mol Cell Biol 26:425-37. 2006
  9. ncbi request reprint The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific
    Mu Shui Dai
    Division of Molecular Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 277:26327-34. 2002
  10. pmc DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2
    A Sobeck
    Biochemistry and Molecular Biology and Molecular and Medical Genetics, Oregon Health and Science University, Medical Research Building, Portland, OR 97239, USA
    Mol Cell Biol 27:4283-92. 2007

Research Grants

  1. FANCONI ANEMIA--ROLE OF THE C PROTEIN
    Maureen Hoatlin; Fiscal Year: 2003
  2. Functional Analysis of the Fanconi Pathway
    Maureen Hoatlin; Fiscal Year: 2009

Collaborators

  • Igor Landais
  • M C Heinrich
  • Chao Yang
  • Vincenzo Costanzo
  • S Arai
  • Mu Shui Dai
  • Nathalie Chevallier
  • Aiming Sun
  • A Melnick
  • A Zelent
  • W Wang
  • Salvatore Sechi
  • Arleen D Auerbach
  • KARLENE CIMPRICH
  • Hal Broxmeyer
  • C G Mathew
  • Jan Christian
  • Hans Joenje
  • Alexandra Sobeck
  • Johan P de Winter
  • Stacie Stone
  • Annette L Medhurst
  • Amom Ruhikanta Meetei
  • Quinten Waisfisz
  • France Léveillé
  • Anneke B Oostra
  • Martin A Rooimans
  • Michael Wallisch
  • Bendert de Graaf
  • Chen Ling
  • Patrick Bier
  • Fre Arwert
  • Henri J van de Vrugt
  • A Sobeck
  • El Houari Laghmani
  • Zhijiang Yan
  • Jurgen Steltenpool
  • Marieke Levitus
  • Michael Hölzel
  • Tanja Y Reuter
  • Eric Blom
  • Hideyuki Ikeda
  • Tetsuya Otsuki
  • S Stone
  • Abdullah Mahmood Ali
  • Yutong Xue
  • Reinhard Kalb
  • Margriet van Kogelenberg
  • Minoru Takata
  • Kornelia Neveling
  • Masamichi Ishiai
  • Detlev Schindler
  • Miriam Ferrer
  • Susan Olson
  • John H Postlethwait
  • Patrick J Lupardus
  • Yassmine Akkari
  • Tanja Reuter
  • Tom A Titus
  • Jean Gautier
  • Johan de Winter
  • Mark Johnson
  • K J Patel
  • Nicolle F C Cool
  • Yutaka Kawakami
  • Maiko Matsushita
  • Aggie W M Nieuwint
  • Pia A J Huber
  • Colin E Bishop
  • Hans J Gross
  • Holger Hoehn
  • Paul J van Diest
  • Yohko Kawai
  • Akitoshi Kinoshita
  • Masao S Sasaki
  • Mary K Young
  • ALAN D D'ANDREA
  • Sabine Herterich
  • Yu Zhi
  • Dafeng Yang
  • Yne de Vries
  • Frank Mercurio
  • Johnson M Liu
  • Mireille Koomen
  • Ngan Ching Cheng
  • Merl Hoekstra
  • Anthony Manning
  • Mariska A D Berns
  • Jan de Groot
  • Rik J Schepers

Detail Information

Publications22

  1. ncbi request reprint A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF
    M E Hoatlin
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
    Blood 94:3737-47. 1999
    ..These results suggest that the function of FANCC may be linked to a transcriptional repression pathway involved in chromatin remodeling...
  2. pmc The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways
    Alexandra Sobeck
    Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 284:25560-8. 2009
    ..Our results indicate that functions of FANCM are controlled by FA- and non-FA pathways in the DNA damage response...
  3. pmc Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
    Igor Landais
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, USA
    Mol Cancer 8:133. 2009
    ..Curcumin was previously identified as a weak inhibitor of FANCD2-Ub. The aim of this study is to identify derivatives of curcumin with better activity and specificity...
  4. doi request reprint A novel cell-free screen identifies a potent inhibitor of the Fanconi anemia pathway
    Igor Landais
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Int J Cancer 124:783-92. 2009
    ....
  5. ncbi request reprint The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cells
    M E Hoatlin
    Division of Hematology and Medical Oncology, Oregon Health Sciences University, Portland, OR 97201, USA
    Blood 91:1418-25. 1998
    ..Therefore, while cytoplasmic localization of this protein appears to be functionally important, it may also exert some essential nuclear function...
  6. ncbi request reprint Identification, developmental expression and regulation of the Xenopus ortholog of human FANCG/XRCC9
    Stacie Stone
    Division of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA
    Genes Cells 12:841-51. 2007
    ..Our data demonstrate that interactions between FANCA and FANCG occur at the earliest stage of vertebrate development and raise the possibility that functionally different isoforms of xFANCG may play a role in early development...
  7. ncbi request reprint Posttranscriptional cell cycle-dependent regulation of human FANCC expression
    M C Heinrich
    Department of Medicine, Division of Hematology and Medical Oncology, Oregon Health Sciences University and Portland Veterans Affairs Medical Center, Portland, OR 97207, USA
    Blood 95:3970-7. 2000
    ..Our observation of dynamic control of FANCC expression by the proteasome has important implications for understanding the molecular regulation of the multiprotein complex. (Blood. 2000;95:3970-3977)..
  8. pmc Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks
    Alexandra Sobeck
    Division of Biochemistry and Molecular Biology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, USA
    Mol Cell Biol 26:425-37. 2006
    ....
  9. ncbi request reprint The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific
    Mu Shui Dai
    Division of Molecular Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Biol Chem 277:26327-34. 2002
    ..These results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins...
  10. pmc DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2
    A Sobeck
    Biochemistry and Molecular Biology and Molecular and Medical Genetics, Oregon Health and Science University, Medical Research Building, Portland, OR 97239, USA
    Mol Cell Biol 27:4283-92. 2007
    ..Our results provide new evidence that the FA pathway discriminates among DNA structures and demonstrate that triggering the FA pathway can be uncoupled from DNA replication and ATRIP-dependent activation...
  11. ncbi request reprint Amplified and tissue-directed expression of retroviral vectors using ping-pong techniques
    M E Hoatlin
    Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201 3098, USA
    J Mol Med 73:113-20. 1995
    ..Factors that limit tissue-specific expression are reviewed...
  12. ncbi request reprint Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport
    Tanja Y Reuter
    Department of Biochemistry, University of Wuerzburg, D 97074 Wuerzburg, Germany
    Exp Cell Res 289:211-21. 2003
    ..Taken together, our data strongly support the hypothesis that FA proteins are functionally involved in several complex cellular pathways including transcription regulation, cell signaling, oxidative metabolism, and cellular transport...
  13. ncbi request reprint Characterization, expression and complex formation of the murine Fanconi anaemia gene product Fancg
    Henri J van de Vrugt
    Department of Clinical Genetics and Human Genetics, VU University Medical Centre, Van der Boechorststraat 7, NL 1081 BT Amsterdam, The Netherlands
    Genes Cells 7:333-42. 2002
    ..Comparison of FA gene characteristics in different species may help to unravel the molecular function of the FA pathway...
  14. ncbi request reprint Fanconi anemia protein complex is a novel target of the IKK signalsome
    Tetsuya Otsuki
    Hematology Branch, NHLBI Bldg, Bethesda, Maryland 20892, USA
    J Cell Biochem 86:613-23. 2002
    ..When exposed to mitomycin C, cells expressing IKK2 K > M develop a cell cycle abnormality characteristic of FA. Thus, FANCA may function to recruit IKK2, thus providing the cell a means of rapidly responding to stress...
  15. ncbi request reprint A novel ubiquitin ligase is deficient in Fanconi anemia
    Amom Ruhikanta Meetei
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, 333 Cassell Drive, TRIAD Center Room 3000, Baltimore, Maryland 21224, USA
    Nat Genet 35:165-70. 2003
    ..Our data suggest that PHF9 has a crucial role in the Fanconi anemia pathway as the likely catalytic subunit required for monoubiquitination of FANCD2...
  16. pmc A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome
    Amom Ruhikanta Meetei
    Laboratory of Genetics Mass Spectrometry Unit, National Institute on Aging NIH, TRIAD Center Room 3000, 333 Cassell Drive, Baltimore, MD 21224, USA
    Mol Cell Biol 23:3417-26. 2003
    ..The findings that FA proteins are part of a DNA-unwinding complex imply that FA proteins may participate in DNA repair...
  17. ncbi request reprint Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2
    Hideyuki Ikeda
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Cancer Res 63:2688-94. 2003
    ..This finding suggests a novel mechanistic principle of tumor progression based on the genetic correction of an early caretaker gene defect...
  18. pmc FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway
    Chen Ling
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    EMBO J 26:2104-14. 2007
    ..Our study identifies FAAP100 as a new critical component of the FA-BRCA DNA damage response network...
  19. ncbi request reprint The nuclear accumulation of the Fanconi anemia protein FANCE depends on FANCC
    France Léveillé
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    DNA Repair (Amst) 5:556-65. 2006
    ..This strengthens the idea that FANCE recruits FANCD2 to the core complex, without interfering with the binding of FANCC...
  20. ncbi request reprint The Fanconi anemia gene product FANCF is a flexible adaptor protein
    France Léveillé
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Van der Boechorststraat 7, NL 1081BT Amsterdam, The Netherlands
    J Biol Chem 279:39421-30. 2004
    ..Our data demonstrate that FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex...
  21. ncbi request reprint Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes
    Marieke Levitus
    Department of Clinical Genetics and Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
    Blood 103:2498-503. 2004
    ..Our results suggest that the FA pathway of genome stabilization may be controlled by at least 11 different genes, including FANCI and FANCJ...
  22. ncbi request reprint FANCD2 protein is expressed in proliferating cells of human tissues that are cancer-prone in Fanconi anaemia
    Michael Hölzel
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 201:198-203. 2003
    ..FANCD2 expression is frequently expressed in proliferating cells as demonstrated by Ki-67 immunofluorescence double staining, consistent with a function of FANCD2 in DNA replication...

Research Grants9

  1. FANCONI ANEMIA--ROLE OF THE C PROTEIN
    Maureen Hoatlin; Fiscal Year: 2003
    ..abstract_text> ..
  2. Functional Analysis of the Fanconi Pathway
    Maureen Hoatlin; Fiscal Year: 2009
    ..We will examine replication in the presence and absence of XFANCD2 to determine if it is required for normal progress of DNA replication, or removal of DNA double strand breaks that arise naturally during replication. ..