Research Topics
Genomes and GenesSpecies | Emily L HoSummaryAffiliation: Oregon State University Country: USA Publications
Research Grants
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Publications
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cellsMelinda C Myzak
Linus Pauling Institute, Molecular and Cellular Biology Program, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 27:811-9. 2006....- Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsPraveen Rajendran
Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
Clin Epigenetics 3:4. 2011.... - Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cellsAnna Hsu
School of Biological and Population Health Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
Clin Epigenetics 3:3. 2011..Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent... - Dietary factors and epigenetic regulation for prostate cancer preventionEmily Ho
Linus Pauling Institute, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
Adv Nutr 2:497-510. 2011..In particular, we focus on epigenetic dysregulation and the impact of specific nutrients and food components on DNA methylation and histone modifications that can alter gene expression and influence prostate cancer progression... - Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassemblyPraveen Rajendran
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Mol Cancer 10:68. 2011..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells... - Dietary sulforaphane, a histone deacetylase inhibitor for cancer preventionEmily Ho
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA
J Nutr 139:2393-6. 2009..These studies also will provide a strong scientific foundation for future large-scale human clinical intervention studies... 
Overview to symposium "Nutrients and epigenetic regulation of gene expression"Emily Ho
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA and
J Nutr 139:2387-8. 2009..All 4 presentations were videotaped and can be viewed online (www.nutrition.org)...- Zinc and prostatic cancerEmily Ho
Department of Nutrition and Exercise Science, Linus Pauling Institute, Oregon State University, 103 Milam Hall, Corvallis, Oregon 97330, USA
Curr Opin Clin Nutr Metab Care 12:640-5. 2009..To summarize the recent findings related to the functions of zinc in prostate cancer prevention... 
Zinc deficiency, DNA damage and cancer riskEmily Ho
Department of Nutrition and Food Management and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr Biochem 15:572-8. 2004..This review will focus on potential mechanisms by which zinc deficiency impairs host protective mechanisms designed to protect against DNA damage, enhances susceptibility to DNA-damaging agents and ultimately increases risk for cancer...- Zinc transporter expression in zebrafish (Danio rerio) during developmentEmily Ho
Department of Nutrition and Exercise Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
Comp Biochem Physiol C Toxicol Pharmacol 155:26-32. 2012.... - Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cellsAnna Hsu
Department of Nutrition and Exercise Sciences, 103 Milam Hall, Oregon State University, Corvallis OR 97331, USA
Exp Biol Med (Maywood) 235:90-7. 2010..This 'whole-food'-based approach is significant for the development of public health recommendations for prostate cancer prevention... - Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cellsMichelle Yan
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Nutr 138:667-73. 2008..Thus, zinc deficiency may compromise DNA integrity in the prostate by impairing the function of zinc-containing proteins... - Multi-targeted prevention of cancer by sulforaphaneJohn D Clarke
Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
Cancer Lett 269:291-304. 2008..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability... - Consumption of green tea extract results in osteopenia in growing male miceUrszula T Iwaniec
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Nutr 139:1914-9. 2009.... - Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus miceMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
FASEB J 20:506-8. 2006.... - Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in ratsYang Song
Department of Nutrition and Exercise Science and 5Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 139:1626-31. 2009..These results suggest interactions among zinc deficiency, DNA integrity, oxidative stress, and DNA repair and suggested a role for zinc in maintaining DNA integrity... - Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exerciseYang Song
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97330, USA
Free Radic Biol Med 48:82-8. 2010..Overall, this study suggests that marginal zinc deficiency sensitizes the prostate to oxidative stress and demonstrates the importance of maintaining optimal zinc nutrition in physically active populations... - Dietary zinc restriction and repletion affects DNA integrity in healthy menYang Song
Department of Nutrition and Exercise Sciences and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Am J Clin Nutr 90:321-8. 2009..Zinc plays an important role in antioxidant defense and the maintenance of cellular DNA integrity. However, no experimental human studies have been performed to examine the role of zinc status on DNA damage... - Dietary histone deacetylase inhibitors: from cells to mice to manRoderick H Dashwood
Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Semin Cancer Biol 17:363-9. 2007..In a broader context, there is growing interest in dietary HDAC inhibitors and their impact on epigenetic mechanisms affecting other chronic conditions, such as cardiovascular disease, neurodegeneration and aging... - Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?Roderick H Dashwood
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
Carcinogenesis 27:344-9. 2006.... - Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cellsEmily C Colgate
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Cancer Lett 246:201-9. 2007.... - Zinc transporter expression profiles in the rat prostate following alterations in dietary zincYang Song
Department of Nutrition and Exercise Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR 97331, USA
Biometals 23:51-8. 2010..No correlations were found between zinc transporter expression and zinc concentrations in the ventral lobes. These results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate... - Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compoundsHui Nian
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
Environ Mol Mutagen 50:213-21. 2009..Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention... - Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in miceDebbie J Mustacich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr Biochem 20:469-76. 2009.... - Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophagesCarmen P Wong
Department of Nutrition and Exercise Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR 97331, USA
Cancer Lett 276:38-46. 2009.... - Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cellsMichelle Yan
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
J Nutr Biochem 21:687-94. 2010..The differential response to zinc in PC-3 and BPH-1 cells suggests that zinc may serve an important role in regulating cell growth and apoptosis in prostate cancer and hyperplasia cells... - Zinc supplementation increases zinc status and thymopoiesis in aged miceCarmen P Wong
Department of Nutrition and Exercise Sciences, Oregon State University, OR 97331, USA
J Nutr 139:1393-7. 2009..Taken together, our results showed that in mice, zinc supplementation can reverse some age-related thymic defects and may be of considerable benefit in improving immune function and overall health in elderly populations... - Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjectsMelinda C Myzak
Linus Pauling Institute, Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
Exp Biol Med (Maywood) 232:227-34. 2007..Moreover, the data suggest that HDAC activity in PBMC may be used as a biomarker for assessing exposure to novel dietary HDAC inhibitors in human subjects... - Dietary agents as histone deacetylase inhibitorsMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331-6512, USA
Mol Carcinog 45:443-6. 2006.... - Protection by dietary zinc in ALS mutant G93A SOD transgenic miceIrina P Ermilova
Linus Pauling Institute, Environmental Health Sciences Center, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Neurosci Lett 379:42-6. 2005..These data support a role for moderate levels of dietary zinc potentially protecting against the toxicity of ALS-associated SOD and the protection does not result from depleting copper... - Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine productionCarmen P Wong
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Exp Gerontol 45:163-9. 2010..Taken together, our results suggested that aging was associated with dysregulation in splenic DC activation and subset differentiation, and may represent one of the factors contributing to the decline in immune function with age... - Anti-inflammatory activity of soy and tea in prostate cancer preventionAnna Hsu
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Exp Biol Med (Maywood) 235:659-67. 2010..Finally, we propose that dietary strategies that incorporate these bioactive food components as whole foods may be a more effective means to target pathways that contribute to prostate cancer development...
Research Grants
- Dietary histone deactylase inhibitors in prostate cancer preventionEmily Ho; Fiscal Year: 2010..The working hypothesis is that high cruciferous vegetable intake will be associated with lower HDAC activity in peripheral blood and increase acetylated histone levels in prostate tissue of men at high risk for prostate cancer. ..
- Dietary histone deactylase inhibitors in prostate cancer preventionEmily Ho; Fiscal Year: 2009..The working hypothesis is that high cruciferous vegetable intake will be associated with lower HDAC activity in peripheral blood and increase acetylated histone levels in prostate tissue of men at high risk for prostate cancer. ..
- Dietary histone deactylase inhibitors in prostate cancer preventionEmily Ho; Fiscal Year: 2010..abstract_text> ..