Emily L Ho

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    Melinda C Myzak
    Linus Pauling Institute, Molecular and Cellular Biology Program, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 27:811-9. 2006
  2. pmc A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Clin Epigenetics 4:16. 2012
  3. pmc Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
    Praveen Rajendran
    Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
    Clin Epigenetics 3:4. 2011
  4. pmc Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
    Anna Hsu
    School of Biological and Population Health Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Clin Epigenetics 3:3. 2011
  5. pmc Dietary factors and epigenetic regulation for prostate cancer prevention
    Emily Ho
    Linus Pauling Institute, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Adv Nutr 2:497-510. 2011
  6. pmc Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Cancer 10:68. 2011
  7. pmc Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    Emily Ho
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA
    J Nutr 139:2393-6. 2009
  8. doi request reprint Overview to symposium "Nutrients and epigenetic regulation of gene expression"
    Emily Ho
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA and
    J Nutr 139:2387-8. 2009
  9. doi request reprint Zinc and prostatic cancer
    Emily Ho
    Department of Nutrition and Exercise Science, Linus Pauling Institute, Oregon State University, 103 Milam Hall, Corvallis, Oregon 97330, USA
    Curr Opin Clin Nutr Metab Care 12:640-5. 2009
  10. ncbi request reprint Zinc deficiency, DNA damage and cancer risk
    Emily Ho
    Department of Nutrition and Food Management and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 15:572-8. 2004

Collaborators

Detail Information

Publications33

  1. pmc Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    Melinda C Myzak
    Linus Pauling Institute, Molecular and Cellular Biology Program, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 27:811-9. 2006
    ....
  2. pmc A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Clin Epigenetics 4:16. 2012
    ..abstract:..
  3. pmc Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
    Praveen Rajendran
    Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
    Clin Epigenetics 3:4. 2011
    ....
  4. pmc Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
    Anna Hsu
    School of Biological and Population Health Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Clin Epigenetics 3:3. 2011
    ..Our results demonstrated the ability of SFN to epigenetically modulate cyclin D2 expression, and provide novel insights into the mechanisms by which SFN may regulate gene expression as a prostate cancer chemopreventive agent...
  5. pmc Dietary factors and epigenetic regulation for prostate cancer prevention
    Emily Ho
    Linus Pauling Institute, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR, USA
    Adv Nutr 2:497-510. 2011
    ..In particular, we focus on epigenetic dysregulation and the impact of specific nutrients and food components on DNA methylation and histone modifications that can alter gene expression and influence prostate cancer progression...
  6. pmc Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Cancer 10:68. 2011
    ..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells...
  7. pmc Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    Emily Ho
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA
    J Nutr 139:2393-6. 2009
    ..These studies also will provide a strong scientific foundation for future large-scale human clinical intervention studies...
  8. doi request reprint Overview to symposium "Nutrients and epigenetic regulation of gene expression"
    Emily Ho
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA and
    J Nutr 139:2387-8. 2009
    ..All 4 presentations were videotaped and can be viewed online (www.nutrition.org)...
  9. doi request reprint Zinc and prostatic cancer
    Emily Ho
    Department of Nutrition and Exercise Science, Linus Pauling Institute, Oregon State University, 103 Milam Hall, Corvallis, Oregon 97330, USA
    Curr Opin Clin Nutr Metab Care 12:640-5. 2009
    ..To summarize the recent findings related to the functions of zinc in prostate cancer prevention...
  10. ncbi request reprint Zinc deficiency, DNA damage and cancer risk
    Emily Ho
    Department of Nutrition and Food Management and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 15:572-8. 2004
    ..This review will focus on potential mechanisms by which zinc deficiency impairs host protective mechanisms designed to protect against DNA damage, enhances susceptibility to DNA-damaging agents and ultimately increases risk for cancer...
  11. pmc Zinc transporter expression in zebrafish (Danio rerio) during development
    Emily Ho
    Department of Nutrition and Exercise Sciences, 103 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Comp Biochem Physiol C Toxicol Pharmacol 155:26-32. 2012
    ....
  12. ncbi request reprint Zinc deficiency alters DNA damage response genes in normal human prostate epithelial cells
    Michelle Yan
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 138:667-73. 2008
    ..Thus, zinc deficiency may compromise DNA integrity in the prostate by impairing the function of zinc-containing proteins...
  13. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    ..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability...
  14. doi request reprint Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells
    Anna Hsu
    Department of Nutrition and Exercise Sciences, 103 Milam Hall, Oregon State University, Corvallis OR 97331, USA
    Exp Biol Med (Maywood) 235:90-7. 2010
    ..This 'whole-food'-based approach is significant for the development of public health recommendations for prostate cancer prevention...
  15. pmc Consumption of green tea extract results in osteopenia in growing male mice
    Urszula T Iwaniec
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 139:1914-9. 2009
    ....
  16. pmc Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats
    Yang Song
    Department of Nutrition and Exercise Science and 5Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 139:1626-31. 2009
    ..These results suggest interactions among zinc deficiency, DNA integrity, oxidative stress, and DNA repair and suggested a role for zinc in maintaining DNA integrity...
  17. pmc Dietary histone deacetylase inhibitors: from cells to mice to man
    Roderick H Dashwood
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Semin Cancer Biol 17:363-9. 2007
    ..In a broader context, there is growing interest in dietary HDAC inhibitors and their impact on epigenetic mechanisms affecting other chronic conditions, such as cardiovascular disease, neurodegeneration and aging...
  18. pmc Dietary zinc restriction and repletion affects DNA integrity in healthy men
    Yang Song
    Department of Nutrition and Exercise Sciences and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Am J Clin Nutr 90:321-8. 2009
    ..Zinc plays an important role in antioxidant defense and the maintenance of cellular DNA integrity. However, no experimental human studies have been performed to examine the role of zinc status on DNA damage...
  19. pmc Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    FASEB J 20:506-8. 2006
    ....
  20. pmc Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Carcinogenesis 27:344-9. 2006
    ....
  21. doi request reprint Marginal zinc deficiency increases oxidative DNA damage in the prostate after chronic exercise
    Yang Song
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97330, USA
    Free Radic Biol Med 48:82-8. 2010
    ..Overall, this study suggests that marginal zinc deficiency sensitizes the prostate to oxidative stress and demonstrates the importance of maintaining optimal zinc nutrition in physically active populations...
  22. pmc Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds
    Hui Nian
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Environ Mol Mutagen 50:213-21. 2009
    ..Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention...
  23. doi request reprint Zinc transporter expression profiles in the rat prostate following alterations in dietary zinc
    Yang Song
    Department of Nutrition and Exercise Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR 97331, USA
    Biometals 23:51-8. 2010
    ..No correlations were found between zinc transporter expression and zinc concentrations in the ventral lobes. These results indicate that ZnT2 may play a significant role in the maintenance of zinc homeostasis in the prostate...
  24. ncbi request reprint Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells
    Emily C Colgate
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 246:201-9. 2007
    ....
  25. pmc Dietary agents as histone deacetylase inhibitors
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Mol Carcinog 45:443-6. 2006
    ....
  26. pmc Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    Melinda C Myzak
    Linus Pauling Institute, Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Exp Biol Med (Maywood) 232:227-34. 2007
    ..Moreover, the data suggest that HDAC activity in PBMC may be used as a biomarker for assessing exposure to novel dietary HDAC inhibitors in human subjects...
  27. pmc Zinc supplementation increases zinc status and thymopoiesis in aged mice
    Carmen P Wong
    Department of Nutrition and Exercise Sciences, Oregon State University, OR 97331, USA
    J Nutr 139:1393-7. 2009
    ..Taken together, our results showed that in mice, zinc supplementation can reverse some age-related thymic defects and may be of considerable benefit in improving immune function and overall health in elderly populations...
  28. pmc Induction of proinflammatory response in prostate cancer epithelial cells by activated macrophages
    Carmen P Wong
    Department of Nutrition and Exercise Sciences, Oregon State University, 103 Milam Hall, Corvallis, OR 97331, USA
    Cancer Lett 276:38-46. 2009
    ....
  29. pmc Alpha-tocopherol modulates genes involved in hepatic xenobiotic pathways in mice
    Debbie J Mustacich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 20:469-76. 2009
    ....
  30. doi request reprint Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cells
    Michelle Yan
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Nutr Biochem 21:687-94. 2010
    ..The differential response to zinc in PC-3 and BPH-1 cells suggests that zinc may serve an important role in regulating cell growth and apoptosis in prostate cancer and hyperplasia cells...
  31. ncbi request reprint Protection by dietary zinc in ALS mutant G93A SOD transgenic mice
    Irina P Ermilova
    Linus Pauling Institute, Environmental Health Sciences Center, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Neurosci Lett 379:42-6. 2005
    ..These data support a role for moderate levels of dietary zinc potentially protecting against the toxicity of ALS-associated SOD and the protection does not result from depleting copper...
  32. doi request reprint Aging is associated with altered dendritic cells subset distribution and impaired proinflammatory cytokine production
    Carmen P Wong
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Exp Gerontol 45:163-9. 2010
    ..Taken together, our results suggested that aging was associated with dysregulation in splenic DC activation and subset differentiation, and may represent one of the factors contributing to the decline in immune function with age...
  33. doi request reprint Anti-inflammatory activity of soy and tea in prostate cancer prevention
    Anna Hsu
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Exp Biol Med (Maywood) 235:659-67. 2010
    ..Finally, we propose that dietary strategies that incorporate these bioactive food components as whole foods may be a more effective means to target pathways that contribute to prostate cancer development...

Research Grants7

  1. Dietary histone deactylase inhibitors in prostate cancer prevention
    Emily Ho; Fiscal Year: 2010
    ..The working hypothesis is that high cruciferous vegetable intake will be associated with lower HDAC activity in peripheral blood and increase acetylated histone levels in prostate tissue of men at high risk for prostate cancer. ..
  2. Dietary histone deactylase inhibitors in prostate cancer prevention
    Emily Ho; Fiscal Year: 2009
    ..The working hypothesis is that high cruciferous vegetable intake will be associated with lower HDAC activity in peripheral blood and increase acetylated histone levels in prostate tissue of men at high risk for prostate cancer. ..
  3. Dietary histone deactylase inhibitors in prostate cancer prevention
    Emily Ho; Fiscal Year: 2010
    ..abstract_text> ..