Robert J Hitzemann

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Genes Brain Behav 1:214-22. 2002
  2. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
  3. doi request reprint Genes, behavior and next-generation RNA sequencing
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 12:1-12. 2013
  4. pmc Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 11:585. 2010
  5. pmc High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs
    Nicole A R Walter
    Research and Development Service, Portland VA Medical Center, Portland, OR, USA
    BMC Genomics 10:379. 2009
  6. doi request reprint Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 203:713-22. 2009
  7. pmc Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines
    Robert Hitzemann
    Department of Behavioral Neuroscience Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 90:525-33. 2008
  8. ncbi request reprint On the integration of alcohol-related quantitative trait loci and gene expression analyses
    Robert Hitzemann
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 28:1437-48. 2004
  9. pmc Effects of sodium butyrate on methamphetamine-sensitized locomotor activity
    John H Harkness
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR 97239 3098, USA
    Behav Brain Res 239:139-47. 2013
  10. pmc Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains
    Suzanne S Fei
    Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Proteome Res 10:2905-12. 2011

Research Grants

  1. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
  2. Mapping the Genes for Complex Behavioral Traits
    Robert Hitzemann; Fiscal Year: 2007
  3. Mapping the Genes for Ethanol Related Phenotypes
    Robert Hitzemann; Fiscal Year: 2007
  4. Neurocircuitry Mapping and Genotyping Core
    Robert Hitzemann; Fiscal Year: 2007
  5. Mapping the Genes for Complex Behavioral Traits
    Robert J Hitzemann; Fiscal Year: 2010
  6. Mapping the Genes for Ethanol-Related Phenotypes
    Robert J Hitzemann; Fiscal Year: 2010
  7. MAPPING THE GENES FOR NEUROLEPTIC RESPONSE
    Robert Hitzemann; Fiscal Year: 2002
  8. MAPPING THE GENES FOR ETHANOL AND DOPAMINE PHENOTYPES
    Robert Hitzemann; Fiscal Year: 2003
  9. Mapping the Genes for Complex Behavioral Traits
    Robert J Hitzemann; Fiscal Year: 2011

Detail Information

Publications15

  1. ncbi request reprint Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Genes Brain Behav 1:214-22. 2002
    ..In addition, the MCM data set can be used to interrogate gene expression data to estimate which polymorphisms within the interval of interest are relevant to the QTL...
  2. pmc Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis
    Megan K Mulligan
    Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6368-73. 2006
    ..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
  3. doi request reprint Genes, behavior and next-generation RNA sequencing
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Genes Brain Behav 12:1-12. 2013
    ..RNA-Seq embraces the complexity of the transcriptome and provides a mechanism to understand the underlying regulatory code; the potential to inform the brain-behavior relationship is substantial...
  4. pmc Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse
    Ovidiu D Iancu
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    BMC Genomics 11:585. 2010
    ..Brain (striatum) gene expression data were obtained using the Illumina Mouse WG 6.1 array, and the data sets were interrogated using a weighted gene co-expression network analysis (WGCNA)...
  5. pmc High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPs
    Nicole A R Walter
    Research and Development Service, Portland VA Medical Center, Portland, OR, USA
    BMC Genomics 10:379. 2009
    ..With the advent of next-generation, high-throughput sequencing, we are now in a position to determine to what extent polymorphisms are currently cryptic in such models and their impact on downstream analyses...
  6. doi request reprint Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock mice
    R Hitzemann
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 203:713-22. 2009
    ..Previous studies have suggested that there is an inverse genetic relationship between ethanol consumption (two-bottle choice, continuous access) and ethanol withdrawal (e.g., Metten et al., Behav Brain Res 95:113-122, 1998a)...
  7. pmc Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected lines
    Robert Hitzemann
    Department of Behavioral Neuroscience Oregon Health and Science University, Portland, OR 97239 3098, USA
    Pharmacol Biochem Behav 90:525-33. 2008
    ..Overall, the current study illustrates that the heritability of PPI is sufficient for shortterm selective breeding and that the lines which are developed can be used to characterize the factors associated with the regulation of PPI...
  8. ncbi request reprint On the integration of alcohol-related quantitative trait loci and gene expression analyses
    Robert Hitzemann
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97201, USA
    Alcohol Clin Exp Res 28:1437-48. 2004
    ..This study was undertaken to determine whether the process of moving from QTL to quantitative trait gene (QTG) could be accelerated by the integration of functional genomics (gene expression) into the analysis strategy...
  9. pmc Effects of sodium butyrate on methamphetamine-sensitized locomotor activity
    John H Harkness
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR 97239 3098, USA
    Behav Brain Res 239:139-47. 2013
    ....
  10. pmc Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strains
    Suzanne S Fei
    Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Proteome Res 10:2905-12. 2011
    ....
  11. ncbi request reprint QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits
    J K Belknap
    Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    Behav Genet 31:5-15. 2001
    ..We argue that these two complementary genetic methods have much to offer in efforts to highlight genes and pathways most likely to influence the susceptibility and progression of common diseases in human populations...
  12. ncbi request reprint Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J mice
    Ronnie Dhaher
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
    Pharmacol Biochem Behav 92:335-42. 2009
    ..These results suggest that the MNAc shell is a component of the underlying neural circuitry contributing to limited access alcohol consumption in the B6 mouse...
  13. ncbi request reprint Neuropsychological function and delay discounting in methamphetamine-dependent individuals
    William F Hoffman
    Mental Health and Clinical Neurosciences Division and Methamphetamine Abuse Research Center P35C, Veterans Affairs Medical Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 188:162-70. 2006
    ..Methamphetamine (MA) dependence accounts for substantial neuropsychiatric morbidity. Furthermore, there is evidence in the literature of psychiatric and cognitive impairment in chronic users...
  14. ncbi request reprint How replicable are mRNA expression QTL?
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mamm Genome 17:643-56. 2006
    ..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets...
  15. ncbi request reprint Complex genetics of interactions of alcohol and CNS function and behavior
    Douglas B Matthews
    Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
    Alcohol Clin Exp Res 29:1706-19. 2005
    ..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...

Research Grants25

  1. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
    ..We believe the second conference will be even more successful than the first. ..
  2. Mapping the Genes for Complex Behavioral Traits
    Robert Hitzemann; Fiscal Year: 2007
    ..Finally, the strategy outlined in aims 1-5, provides interlocking levels of proof on several levels, in keeping with the recommendations of a recent "white" paper on QTL analysis (Flaherty et al. 2003). ..
  3. Mapping the Genes for Ethanol Related Phenotypes
    Robert Hitzemann; Fiscal Year: 2007
    ..We argue that such multiple sources of evidence will exclude the possibility of a false positive result. Aim 5 will test this hypothesis ..
  4. Neurocircuitry Mapping and Genotyping Core
    Robert Hitzemann; Fiscal Year: 2007
    ..The core will also provide (aim 4) tissue for gene array and proteomics analyses and a high thoughput SNP genotyping facility for all INIA-West investigators. ..
  5. Mapping the Genes for Complex Behavioral Traits
    Robert J Hitzemann; Fiscal Year: 2010
    ..With this information in hand, it should be possible to develop new therapeutic strategies and interventions. . ..
  6. Mapping the Genes for Ethanol-Related Phenotypes
    Robert J Hitzemann; Fiscal Year: 2010
    ..The eventual goal is to determine which gene or genes make some individuals more prone to develop alcoholism than others. With this information in hand, it should be possible to develop new therapeutic strategies. ..
  7. MAPPING THE GENES FOR NEUROLEPTIC RESPONSE
    Robert Hitzemann; Fiscal Year: 2002
    ....
  8. MAPPING THE GENES FOR ETHANOL AND DOPAMINE PHENOTYPES
    Robert Hitzemann; Fiscal Year: 2003
    ....
  9. Mapping the Genes for Complex Behavioral Traits
    Robert J Hitzemann; Fiscal Year: 2011
    ..With this information in hand, it should be possible to develop new therapeutic strategies and interventions. . ..