Genomes and Genes
Robert J Hitzemann
Affiliation: Oregon Health and Science University
- Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activationR Hitzemann
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97201 3098, USA
Genes Brain Behav 1:214-22. 2002..In addition, the MCM data set can be used to interrogate gene expression data to estimate which polymorphisms within the interval of interest are relevant to the QTL...
- Toward understanding the genetics of alcohol drinking through transcriptome meta-analysisMegan K Mulligan
Waggoner Center for Alcohol and Addiction Research and Sections of Neurobiology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 103:6368-73. 2006..The present study demonstrates the use of (i) a microarray meta-analysis to analyze a behavioral phenotype (in this case, alcohol preference) and (ii) a congenic strain for identification of cis regulation...
- Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouseOvidiu D Iancu
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
BMC Genomics 11:585. 2010..Brain (striatum) gene expression data were obtained using the Illumina Mouse WG 6.1 array, and the data sets were interrogated using a weighted gene co-expression network analysis (WGCNA)...
- High throughput sequencing in mice: a platform comparison identifies a preponderance of cryptic SNPsNicole A R Walter
Research and Development Service, Portland VA Medical Center, Portland, OR, USA
BMC Genomics 10:379. 2009..With the advent of next-generation, high-throughput sequencing, we are now in a position to determine to what extent polymorphisms are currently cryptic in such models and their impact on downstream analyses...
- On the integration of alcohol-related quantitative trait loci and gene expression analysesRobert Hitzemann
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97201, USA
Alcohol Clin Exp Res 28:1437-48. 2004..This study was undertaken to determine whether the process of moving from QTL to quantitative trait gene (QTG) could be accelerated by the integration of functional genomics (gene expression) into the analysis strategy...
- Detection of reciprocal quantitative trait loci for acute ethanol withdrawal and ethanol consumption in heterogeneous stock miceR Hitzemann
Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
Psychopharmacology (Berl) 203:713-22. 2009..Previous studies have suggested that there is an inverse genetic relationship between ethanol consumption (two-bottle choice, continuous access) and ethanol withdrawal (e.g., Metten et al., Behav Brain Res 95:113-122, 1998a)...
- Short-term selective breeding for high and low prepulse inhibition of the acoustic startle response; pharmacological characterization and QTL mapping in the selected linesRobert Hitzemann
Department of Behavioral Neuroscience Oregon Health and Science University, Portland, OR 97239 3098, USA
Pharmacol Biochem Behav 90:525-33. 2008..Overall, the current study illustrates that the heritability of PPI is sufficient for shortterm selective breeding and that the lines which are developed can be used to characterize the factors associated with the regulation of PPI...
- Protein database and quantitative analysis considerations when integrating genetics and proteomics to compare mouse strainsSuzanne S Fei
Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
J Proteome Res 10:2905-12. 2011....
- QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traitsJ K Belknap
Research Service, Veterans Affairs Medical Center, Portland, Oregon 97201, USA
Behav Genet 31:5-15. 2001..We argue that these two complementary genetic methods have much to offer in efforts to highlight genes and pathways most likely to influence the susceptibility and progression of common diseases in human populations...
- Electrolytic lesions of the medial nucleus accumbens shell selectively decrease ethanol consumption without altering preference in a limited access procedure in C57BL/6J miceRonnie Dhaher
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, United States
Pharmacol Biochem Behav 92:335-42. 2009..These results suggest that the MNAc shell is a component of the underlying neural circuitry contributing to limited access alcohol consumption in the B6 mouse...
- Neuropsychological function and delay discounting in methamphetamine-dependent individualsWilliam F Hoffman
Mental Health and Clinical Neurosciences Division and Methamphetamine Abuse Research Center P35C, Veterans Affairs Medical Center, and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
Psychopharmacology (Berl) 188:162-70. 2006..Methamphetamine (MA) dependence accounts for substantial neuropsychiatric morbidity. Furthermore, there is evidence in the literature of psychiatric and cognitive impairment in chronic users...
- How replicable are mRNA expression QTL?Jeremy L Peirce
Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Mamm Genome 17:643-56. 2006..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets...
- Complex genetics of interactions of alcohol and CNS function and behaviorDouglas B Matthews
Department of Psychology, University of Memphis, Memphis, Tennessee 38152, USA
Alcohol Clin Exp Res 29:1706-19. 2005..J. Hitzemann, and (5) The use of gene arrays in conjunction with transgenic and selected animals to understand anxiety in alcoholism, by. B. Tabakoff...
- 2006 Genes & Behavior ConferenceRobert Hitzemann; Fiscal Year: 2006..We believe the second conference will be even more successful than the first. ..
- Mapping the Genes for Complex Behavioral TraitsRobert Hitzemann; Fiscal Year: 2007..Finally, the strategy outlined in aims 1-5, provides interlocking levels of proof on several levels, in keeping with the recommendations of a recent "white" paper on QTL analysis (Flaherty et al. 2003). ..
- Mapping the Genes for Ethanol Related PhenotypesRobert Hitzemann; Fiscal Year: 2007..We argue that such multiple sources of evidence will exclude the possibility of a false positive result. Aim 5 will test this hypothesis ..
- Neurocircuitry Mapping and Genotyping CoreRobert Hitzemann; Fiscal Year: 2007..The core will also provide (aim 4) tissue for gene array and proteomics analyses and a high thoughput SNP genotyping facility for all INIA-West investigators. ..
- Mapping the Genes for Complex Behavioral TraitsRobert J Hitzemann; Fiscal Year: 2010..With this information in hand, it should be possible to develop new therapeutic strategies and interventions. . ..
- Mapping the Genes for Ethanol-Related PhenotypesRobert J Hitzemann; Fiscal Year: 2010..The eventual goal is to determine which gene or genes make some individuals more prone to develop alcoholism than others. With this information in hand, it should be possible to develop new therapeutic strategies. ..
- MAPPING THE GENES FOR NEUROLEPTIC RESPONSERobert Hitzemann; Fiscal Year: 2002....
- MAPPING THE GENES FOR ETHANOL AND DOPAMINE PHENOTYPESRobert Hitzemann; Fiscal Year: 2003....
- Mapping the Genes for Complex Behavioral TraitsRobert J Hitzemann; Fiscal Year: 2011..With this information in hand, it should be possible to develop new therapeutic strategies and interventions. . ..