Alec J Hirsch

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc The Src family kinase c-Yes is required for maturation of West Nile virus particles
    Alec J Hirsch
    Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, 505 N W 185th Avenue, Beaverton, Oregon 97006, USA
    J Virol 79:11943-51. 2005
  2. pmc The use of RNAi-based screens to identify host proteins involved in viral replication
    Alec J Hirsch
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Future Microbiol 5:303-11. 2010
  3. pmc West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    J Virol 81:10849-60. 2007
  4. pmc West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Virol 83:6125-34. 2009
  5. pmc Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors
    Jessica L Smith
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    J Virol 86:5278-87. 2012
  6. pmc West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 N W 185th Ave, Beaverton, OR 97006, USA
    J Virol 82:5212-9. 2008
  7. pmc Flaviviruses are sensitive to inhibition of thymidine synthesis pathways
    Matthew A Fischer
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    J Virol 87:9411-9. 2013
  8. pmc Sultam thiourea inhibition of West Nile virus
    Eric Barklis
    Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Antimicrob Agents Chemother 51:2642-5. 2007
  9. pmc Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence
    David A Stein
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA
    J Virol 85:10154-66. 2011
  10. pmc Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12
    Ryan M Melnychuk
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Virol 78:8382-91. 2004

Collaborators

Detail Information

Publications10

  1. pmc The Src family kinase c-Yes is required for maturation of West Nile virus particles
    Alec J Hirsch
    Vaccine and Gene Therapy Institute, Oregon Health and Sciences University, 505 N W 185th Avenue, Beaverton, Oregon 97006, USA
    J Virol 79:11943-51. 2005
    ..These results identify c-Yes as a cellular protein that is involved in WNV assembly and egress...
  2. pmc The use of RNAi-based screens to identify host proteins involved in viral replication
    Alec J Hirsch
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Future Microbiol 5:303-11. 2010
    ..This review summarizes the methods used in RNAi-based screening for host factors involved in virus replication, and discusses published examples of such screens...
  3. pmc West Nile virus infection activates the unfolded protein response, leading to CHOP induction and apoptosis
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    J Virol 81:10849-60. 2007
    ....
  4. pmc West nile virus capsid degradation of claudin proteins disrupts epithelial barrier function
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Virol 83:6125-34. 2009
    ..Since epithelial cells are frequent sites of WNV infection, these observations imply a potential mechanism for virus dissemination and extraneural pathogenesis...
  5. pmc Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors
    Jessica L Smith
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    J Virol 86:5278-87. 2012
    ....
  6. pmc West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of alphavbeta3 integrin
    Guruprasad R Medigeshi
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, 505 N W 185th Ave, Beaverton, OR 97006, USA
    J Virol 82:5212-9. 2008
    ..These data suggest that WNV utilizes lipid rafts during initial stages of internalization and that the lipid rafts may contain a factor(s) that may enhance WNV endocytosis...
  7. pmc Flaviviruses are sensitive to inhibition of thymidine synthesis pathways
    Matthew A Fischer
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA
    J Virol 87:9411-9. 2013
    ..Our data reveal thymidine synthesis pathways as new and unexpected therapeutic targets for antiflaviviral drug development. ..
  8. pmc Sultam thiourea inhibition of West Nile virus
    Eric Barklis
    Vollum Institute and Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Mail Code L220, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
    Antimicrob Agents Chemother 51:2642-5. 2007
    ..7 microM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication...
  9. pmc Inhibition of dengue virus infections in cell cultures and in AG129 mice by a small interfering RNA targeting a highly conserved sequence
    David A Stein
    Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA
    J Virol 85:10154-66. 2011
    ..Overall, the data indicate that DC-3 siRNA represents a useful research reagent and has potential as a novel approach to therapeutic intervention against the genetically diverse dengue viruses...
  10. pmc Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Galpha12
    Ryan M Melnychuk
    Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201, USA
    J Virol 78:8382-91. 2004
    ..The data presented here suggest that US28 functionally signals through Galpha12 family G proteins and RhoA in a ligand-dependent manner and these signaling molecules are important for the ability of US28 to induce cellular migration...