Christa M Helms

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Diurnal pituitary-adrenal activity during schedule-induced polydipsia of water and ethanol in cynomolgus monkeys (Macaca fascicularis)
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 228:541-9. 2013
  2. pmc Ovarian hormones and the heterogeneous receptor mechanisms mediating the discriminative stimulus effects of ethanol in female rats
    Christa M Helms
    Oregon National Primate Research Center, Division of Neuroscience, Oregon Health and Science University, Beaverton, Oregon 97006 6448, USA
    Behav Pharmacol 24:95-104. 2013
  3. pmc Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 224:133-43. 2012
  4. pmc A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006 3448, USA
    Alcohol Clin Exp Res 36:995-1003. 2012
  5. ncbi request reprint Impact of strain and D-amphetamine on impulsivity (delay discounting) in inbred mice
    Christa M Helms
    Department of Behavioral Neuroscience L 470, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 188:144-51. 2006
  6. pmc The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006 6448, USA
    Psychopharmacology (Berl) 216:333-43. 2011
  7. pmc Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006 6448, USA
    J Pharmacol Exp Ther 331:142-52. 2009
  8. pmc Basolateral amygdala lesions and sensitivity to reinforcer magnitude in concurrent chains schedules
    Christa M Helms
    Oregon Health and Science University, Oregon National Primate Research Center, Division of Neuroscience, L 584, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Behav Brain Res 191:210-8. 2008
  9. pmc Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006 6448, USA
    Alcohol Clin Exp Res 32:1197-206. 2008
  10. pmc Gamma-hydroxybutyric acid in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Behav Pharmacol 19:317-24. 2008

Research Grants

Detail Information

Publications13

  1. pmc Diurnal pituitary-adrenal activity during schedule-induced polydipsia of water and ethanol in cynomolgus monkeys (Macaca fascicularis)
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 228:541-9. 2013
    ....
  2. pmc Ovarian hormones and the heterogeneous receptor mechanisms mediating the discriminative stimulus effects of ethanol in female rats
    Christa M Helms
    Oregon National Primate Research Center, Division of Neuroscience, Oregon Health and Science University, Beaverton, Oregon 97006 6448, USA
    Behav Pharmacol 24:95-104. 2013
    ..Ovarian hormones appear to contribute to 5-HT receptor mediation of the discriminative stimulus effects of ethanol in rats...
  3. pmc Social rank, chronic ethanol self-administration, and diurnal pituitary-adrenal activity in cynomolgus monkeys
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Psychopharmacology (Berl) 224:133-43. 2012
    ..Excessive ethanol intake disrupts circadian rhythms. Diurnal rhythms of the hypothalamic-pituitary-adrenal axis have not been characterized in the context of ethanol self-administration with regard to social rank...
  4. pmc A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006 3448, USA
    Alcohol Clin Exp Res 36:995-1003. 2012
    ..A longitudinal analysis of chronic ethanol intake on homeostatic mechanisms is, however, incompletely characterized in primates...
  5. ncbi request reprint Impact of strain and D-amphetamine on impulsivity (delay discounting) in inbred mice
    Christa M Helms
    Department of Behavioral Neuroscience L 470, Oregon Health and Science University, Portland, OR 97239, USA
    Psychopharmacology (Berl) 188:144-51. 2006
    ..C57BL/6J (B6) and DBA/2J (D2) mouse strains differ in sensitivity to the associative effects and in self-administration of several drugs of abuse...
  6. pmc The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006 6448, USA
    Psychopharmacology (Berl) 216:333-43. 2011
    ..Excessive alcohol consumption is less common among aged compared to young adults, with aged adults showing greater sensitivity to many behavioral effects of ethanol...
  7. pmc Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006 6448, USA
    J Pharmacol Exp Ther 331:142-52. 2009
    ..GABA(A) receptors with high affinity for Ro15-4513 (i.e., containing alpha(4/6) and alpha(5) subunits) may be particularly important mediators of the multiple discriminative stimulus effects of ethanol through GABA(A) receptor systems...
  8. pmc Basolateral amygdala lesions and sensitivity to reinforcer magnitude in concurrent chains schedules
    Christa M Helms
    Oregon Health and Science University, Oregon National Primate Research Center, Division of Neuroscience, L 584, 505 N W 185th Avenue, Beaverton, OR 97006, USA
    Behav Brain Res 191:210-8. 2008
    ..Impaired learning about the tone-reinforcer magnitude relationships may have disrupted discrimination of the reinforcer magnitude reversal...
  9. pmc Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006 6448, USA
    Alcohol Clin Exp Res 32:1197-206. 2008
    ....
  10. pmc Gamma-hydroxybutyric acid in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Behav Pharmacol 19:317-24. 2008
    ..Furthermore, the data do not strongly support shared discriminative stimulus effects as the rationale for gamma-hydroxybutyric acid pharmacotherapy for alcoholism...
  11. pmc Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys
    Kathleen A Grant
    Department of Behavioral Neuroscience, Oregon Health and Science University, Beaverton, OR 97006 6448, USA
    J Pharmacol Exp Ther 326:354-61. 2008
    ..0 g/kg). Furthermore, the discriminative stimulus effects of ethanol appear to be mediated by activity at binding sites that are particularly sensitive to 3alpha,5alpha-P...
  12. doi request reprint The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR, 97006, USA
    Psychopharmacology (Berl) 231:1853-61. 2014
    ..Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age...
  13. pmc Neurosteroid influences on sensitivity to ethanol
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center Beaverton, OR, USA
    Front Endocrinol (Lausanne) 3:10. 2012
    ..It is currently difficult to assign a specific mechanism by which neuroactive steroids could modulate the effects of ethanol in particular behavioral tasks...

Research Grants2

  1. Areas of Amygdala and Frontal Cortex in Outcome Learning
    CHRISTA HELMS; Fiscal Year: 2006
    ..Understanding how these brain regions are involved in learning about rewards will provide information about the processes disrupted in drug abusers. ..