Research Topics
| M HelfandSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Detail Information
Publications
Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task ForceLinda L Humphrey
Oregon Health and Science University and Portland Veterans Affairs Medical Center, Mailcode BICC, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA
Ann Intern Med 137:347-60. 2002..Because these results incorporate several rounds of screening, the actual number of mammograms needed to prevent one death from breast cancer is higher. In addition, each screening has associated risks and costs...- Incorporating information about cost-effectiveness into evidence-based decision-making: the evidence-based practice center (EPC) modelMark Helfand
Portland VA Medical Center and the Oregon Evidence Based Practice Center, Oregon Health and Sciences University, Portland, Oregon 97239, USA
Med Care 43:33-43. 2005..There is a pressing need for guidance on how to incorporate economic information into evidence-based decision-making. Such guidance should take account of the quality and relevance of economic evaluations... 
Comparative effectiveness research: challenges for medical journalsHarold C Sox
Dartmouth Institute, Dartmouth Medical School, Hanover, New Hampshire, USA
Trials 11:45. 2010....- Clinical outcomes resulting from telemedicine interventions: a systematic reviewW R Hersh
Division of Medical Informatics and Outcomes Research, Oregon Health and Science University, BICC, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
BMC Med Inform Decis Mak 1:5. 2001..The objective of this systematic review was to evaluate the efficacy of telemedicine interventions for health outcomes in two classes of application: home-based and office/hospital-based... 
A CTSA agenda to advance methods for comparative effectiveness researchMark Helfand
Oregon Clinical and Translational Research Center, Oregon Health and Sciences University, and Department of Hospital and Specialty Medicine, The Portland VA Medical Center, Portland, OR, USA
Clin Transl Sci 4:188-98. 2011..Insights generated by this work should be of enormous value to PCORI and to the broad range of organizations that will be funding and implementing CER...- Using evidence reports: progress and challenges in evidence-based decision makingMark Helfand
Oregon Health and Science University, Portland, USA
Health Aff (Millwood) 24:123-7. 2005..GRADE, an international consortium of systematic-review developers and users, is seeking to improve the process of incorporating considerations other than the strength of evidence in making decisions that are evidence based... - Screening for skin cancerM Helfand
Division of Medical Informatics and Outcomes Research, Evidence Based Practice Center, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
Am J Prev Med 20:47-58. 2001..Current recommendations from professional societies regarding screening for skin cancer vary... - Screening for chlamydial infectionH D Nelson
Division of Medical Informatics and Outcomes Research and Evidence based Practice Center, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
Am J Prev Med 20:95-107. 2001..This review updates the literature since the last recommendation of the U.S. Preventive Services Task Force published in 1996... - Rural hospital transfer patterns before and after implementation of a statewide trauma system. OHSU Rural Trauma Research GroupN C Mann
Oregon Health Sciences University, School of Medicine, Portland 97201, USA
Acad Emerg Med 4:764-71. 1997..To evaluate trauma transfer practices in rural Oregon before and after implementation of a statewide trauma system... - Screening high-risk populations for thyroid cancerK Eden
Oregon Health Sciences University, Evidence Based Practice Center, Portland, Oregon
Med Pediatr Oncol 36:583-91. 2001..We systematically reviewed evidence on the accuracy of ultrasound and palpation to detect thyroid nodules and of fine needle aspiration (FNA), a confirmatory test, to diagnose thyroid cancer... - Adequacy of hospital discharge status as a measure of outcome among injured patientsR J Mullins
Department of Surgery, Oregon Health Sciences University, Portland 97201, USA
JAMA 279:1727-31. 1998..Crude mortality rates at the time of hospital discharge are commonly used to assess the quality of care provided to patients hospitalized following trauma... - Effectiveness of Helicobacter pylori therapies in a clinical practice settingM B Fennerty
Department of Medicine, Oregon Health Sciences University, Portland 97201 3098, USA
Arch Intern Med 159:1562-6. 1999.... - Patterns of endoscopy use in the United StatesD A Lieberman
Division of Gastroenterology, Department of Medicine, Oregon Health Sciences University, Portland, Oregon 97207, USA
Gastroenterology 118:619-24. 2000..The aim of this study was to use a large national endoscopic database to determine why routine endoscopy is performed in diverse practice settings... - Hyperbaric oxygen therapy for stroke: a systematic review of the evidenceSusan Carson
Oregon Evidence Based Practice Center, Oregon Health and Science University, Department of Medical Informatics and Clinical Epidemiology, Portland, OR 97239, USA
Clin Rehabil 19:819-33. 2005..To identify the benefits and harms of using hyperbaric oxygen therapy to treat acute or subacute stroke or the chronic effects of a stroke. We aimed to identify any gaps in the evidence to provide guidance for future research... - Challenges in systematic reviews that assess treatment harmsRoger Chou
Oregon Evidence Based Practice Center, Oregon Health and Science University, and Portland Veterans Affairs Medical Center, Portland, Oregon, USA
Ann Intern Med 142:1090-9. 2005..This article highlights examples of approaches to methodologic issues associated with performing systematic reviews of harms from 96 Evidence-based Practice Center evidence reports... - Methodological shortcomings predicted lower harm estimates in one of two sets of studies of clinical interventionsRoger Chou
Oregon Evidence Based Practice Center, Portland, OR, USA
J Clin Epidemiol 60:18-28. 2007..Little is known, however, about whether perceived methodological shortcomings are associated with lower estimates of harms... - Economic comparison of diagnostic approaches for evaluating osteoporosis in older womenDale F Kraemer
Department of Medical Informatics and Clinical Epidemiology and Evidence based Practice Center, Oregon Health and Science University, Portland, OR 97230, USA
Osteoporos Int 17:68-76. 2006..Compared to other approaches for diagnosing osteoporosis, sequential use of QUS followed by DXA resulted in fewer women treated and lower total costs... - Screening for developmental dysplasia of the hip: a systematic literature review for the US Preventive Services Task ForceScott A Shipman
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
Pediatrics 117:e557-76. 2006..Developmental dysplasia of the hip (DDH) represents a spectrum of anatomic abnormalities that can result in permanent disability... - Diagnosis, access and outcomes: Update of a systematic review of telemedicine servicesWilliam R Hersh
Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, Oregon 97239, USA
J Telemed Telecare 12:S3-31. 2006..Further well-designed research is necessary to understand how best to deploy telemedicine services in health care... - Screening for elevated lead levels in childhood and pregnancy: an updated summary of evidence for the US Preventive Services Task ForceGary Rischitelli
Oregon Evidence Based Practice Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
Pediatrics 118:e1867-95. 2006..This review updates the evidence for the benefits and harms of screening and intervention for elevated blood lead in asymptomatic children and pregnant women... - Estimating risk of breast cancer in carriers of BRCA1 and BRCA2 mutations: a meta-analytic approachRongwei Fu
Oregon Evidence Based Practice Center, Oregon Health and Science University, Portland, OR 97239, USA
Stat Med 26:1775-87. 2007..45 per cent (37.39, 57.72 per cent) and 31.85 per cent (23.72, 41.26 per cent) by 75 years old, respectively. For those with family history, risks of breast cancer conferred by BRCA mutations appear to be higher... - Cost-effectiveness of echocardiography to identify intracardiac thrombus among patients with first stroke or transient ischemic attackRichard T Meenan
Oregon Health and Science University Evidence based Practice Center, Portland, USA
Med Decis Making 27:161-77. 2007..The authors' objective was to evaluate the cost-effectiveness of imaging strategies that use transthoracic (TTE) and transesophageal (TEE) echocardiography for identifying intracardiac thrombus in new stroke patients... - Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysisLinda L Humphrey
Oregon Evidence Based Practice Center, Veterans Affairs Medical Center, Portland, OR, USA
J Gen Intern Med 23:2079-86. 2008..Periodontal disease is common among adults in the US and is a potential source of chronic inflammation. Recent data have suggested an important role for chronic inflammation in the development of coronary heart disease (CHD)... - Intensive insulin therapy in hospitalized patients: a systematic reviewDevan Kansagara
Oregon Health and Science University, Portland Veterans Affairs Medical Center, USA
Ann Intern Med 154:268-82. 2011..The benefits and harms of intensive insulin therapy (IIT) titrated to strict glycemic targets in hospitalized patients remain uncertain... - GRADE guidelines: 3. Rating the quality of evidenceHoward Balshem
Oregon Evidence Based Practice Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
J Clin Epidemiol 64:401-6. 2011..GRADE separates the process of assessing quality of evidence from the process of making recommendations. Judgments about the strength of a recommendation depend on more than just the quality of evidence... - The evaluation of rectal bleeding in adults. A cost-effectiveness analysis comparing four diagnostic strategiesElizabeth Allen
Portland Veterans Affairs Medical Center, Portland, OR 97207, USA
J Gen Intern Med 20:81-90. 2005..Though primary care patients commonly present with rectal bleeding, the optimal evaluation strategy remains unknown... - Safety of vaginal birth after cesarean: a systematic reviewJeanne Marie Guise
Department of Obstetrics and Gynecology, Evidence Based Practice Center, Oregon Health and Science University, UHN 50, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
Obstet Gynecol 103:420-9. 2004..To evaluate the benefits and harms of vaginal birth after cesarean compared with repeat cesarean delivery... - Screening for postmenopausal osteoporosis: a review of the evidence for the U.S. Preventive Services Task ForceHeidi D Nelson
Oregon Health and Science University, and Veterans Affairs Medical Center, Mail Code BICC 504, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Ann Intern Med 137:529-41. 2002..The role of risk factor assessment and different bone density techniques, frequency of screening, and identification of subgroups for which screening is most effective remain unclear... - Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the evidenceMarian McDonagh
Department of Medical Informatics and Clinical Epidemiology, Oregon Evidence Based Practice Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Arch Phys Med Rehabil 85:1198-204. 2004..To identify the benefits and harms of hyperbaric oxygen therapy (HBOT) to treat traumatic brain injury (TBI)... - Systematic review of the incidence and consequences of uterine rupture in women with previous caesarean sectionJeanne Marie Guise
Department of Obstetrics and Gynecology, Oregon Health and Science University, UHN 50, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
BMJ 329:19-25. 2004..To evaluate the incidence and consequences of uterine rupture in women who have had a delivery by caesarean section... - The effectiveness of primary care-based interventions to promote breastfeeding: systematic evidence review and meta-analysis for the US Preventive Services Task ForceJeanne Marie Guise
Department of Medical Informatics and Clinical Epidemiology and Evidence based Practice Center, Oregon Health and Science University, Portland, Oregon 97239, USA
Ann Fam Med 1:70-8. 2003..We wanted to systematically review whether primary care-based interventions improve initiation and duration of breastfeeding... - A systematic review of the efficacy of telemedicine for making diagnostic and management decisionsWilliam Hersh
Division of Medical Informatics and Outcomes Research, Evidence Based Practice Center, Oregon Health and Science University, Portland, Oregon 97201, USA
J Telemed Telecare 8:197-209. 2002..Despite the widespread use of telemedicine in most major medical specialties, there is strong evidence in only a few of them that the diagnostic and management decisions provided by telemedicine are comparable to face-to-face care... - Screening for bacterial vaginosis in pregnancyJ M Guise
Department of Obstetrics and Gynecology and Evidence based Practice Center, Oregon Health Sciences University, Portland, Oregon 97201, USA
Am J Prev Med 20:62-72. 2001..Bacterial vaginosis (BV) is a strong independent risk factor for adverse pregnancy outcomes. BV is found in 9% to 23% of pregnant women. Symptoms include vaginal discharge, pruritus, or malodor, but often women with BV are asymptomatic... - Systematic review of the literature on pain in patients with polytrauma including traumatic brain injurySteven K Dobscha
Portland Center for the Study of Chronic, Comorbid Physical and Mental Disorders, Portland Veterans Affairs Medical Center, Portland, OR 97207, USA
Pain Med 10:1200-17. 2009.... - Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task ForceMark Helfand
Oregon Health and Science University, Evidence-based Practice Center, Portland, Oregon 97239, USA
Ann Intern Med 140:128-41. 2004..Data on the adverse effects of broader use of L-thyroxine are sparse. CONCLUSION: It is uncertain whether treatment will improve quality of life in otherwise healthy patients who have abnormal TSH levels and normal free thyroxine levels... - Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task ForceMark Helfand
Oregon Evidence Based Practice Center, Veterans Affairs Medical Center, andOregon Health and Science University, Portland, Oregon 97239, USA
Ann Intern Med 151:496-507. 2009..Traditional risk factors do not explain all of the risk for incident coronary heart disease (CHD) events. Various new or emerging risk factors have the potential to improve global risk assessment for CHD... - Screening for hepatitis C virus infection: a review of the evidence for the U.S. Preventive Services Task ForceRoger Chou
Oregon Health and Science University and the Veterans Affairs Medical Center, Portland, Oregon 97239, USA
Ann Intern Med 140:465-79. 2004.... - The art and science of incorporating cost effectiveness into evidence-based recommendations for clinical preventive servicesS Saha
Evidence Based Practice Center, Oregon Health Sciences University, Portland, Oregon, USA
Am J Prev Med 20:36-43. 2001..While this paper focuses on clinical preventive services (i.e., screening, counseling, immunizations, and chemoprevention), the framework we have developed should be broadly portable to other health care services... - C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task ForceDavid I Buckley
Oregon Evidence Based Practice Center, Oregon Health and Science University, Portland, Oregon 97239, USA
Ann Intern Med 151:483-95. 2009..C-reactive protein (CRP) may help to refine global risk assessment for coronary heart disease (CHD), particularly among persons who are at intermediate risk on the basis of traditional risk factors alone... - AHRQ series paper 2: principles for developing guidance: AHRQ and the effective health-care programMark Helfand
Oregon Evidence Based Practice Center, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
J Clin Epidemiol 63:484-90. 2010..This article describes some of the fundamental principles that have been developed to guide the work of producing comparative effectiveness reviews (CERs)... - Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysisLinda L Humphrey
Department of Medical Informatics and Clinical Epidemiology, Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
Mayo Clin Proc 83:1203-12. 2008..To determine whether an elevated homocysteine level is an independent risk factor for the development of coronary heart disease (CHD) to aid the US Preventive Services Task Force in its evaluation of novel risk factors for incident CHD... - Assessment and management of acute pain in adult medical inpatients: a systematic reviewMark Helfand
Evidence Based Synthesis Program, Portland Veterans Affairs Medical Center, Portland, OR 97239, USA
Pain Med 10:1183-99. 2009..To review the literature addressing effective care for acute pain in inpatients on medical wards... - Comparative efficacy and safety of long-acting oral opioids for chronic non-cancer pain: a systematic reviewRoger Chou
Department of Medicine, Oregon Health and Science University, and Oregon Evidence-Based Practice Center, Portland, Oregon, USA
J Pain Symptom Manage 26:1026-48. 2003..A subgroup of three studies on long-acting versus short-acting oxycodone was more homogeneous and provided fair evidence that these formulations are equally effective for pain control... - Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: a systematic reviewRoger Chou
Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
J Pain Symptom Manage 28:140-75. 2004..Dantrolene, and to a lesser degree chlorzoxazone, have been associated with rare serious hepatotoxicity... - Quality of adverse event assessment in randomized controlled trials and observational studiesRoger Chou
Mayo Clin Proc 78:119; author reply 119. 2003 - Incorporating considerations of resources use into grading recommendationsGordon H Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 336:1170-3. 2008 - The cost-effectiveness of screening mammography beyond age 65 years: a systematic review for the U.S. Preventive Services Task ForceJeanne Mandelblatt
Georgetown University Medical Center, Lombardi Cancer Center, Washington, DC 20007, USA
Ann Intern Med 139:835-42. 2003..The authors performed a review to determine the costs and benefits of mammography screening after age 65 years... - Challenges in systematic reviews that evaluate drug efficacy or effectivenessP Lina Santaguida
McMaster University Evidence-based Practice Centre, Hamilton, Ontario, Canada
Ann Intern Med 142:1066-72. 2005.... - Policy rounds: a new series and a call for papersMark Helfand
Med Decis Making 28:169-71. 2008 - What is "quality of evidence" and why is it important to clinicians?Gordon H Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 336:995-8. 2008 - Grading quality of evidence and strength of recommendations for diagnostic tests and strategiesHolger J Schunemann
Department of Epidemiology, Italian National Cancer Institute Regina Elena, 00144 Rome, Italy
BMJ 336:1106-10. 2008 - Going from evidence to recommendationsGordon H Guyatt
CLARITY Research Group, Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 336:1049-51. 2008 - Projected cost-effectiveness of statewide universal newborn hearing screeningRon Keren
Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
Pediatrics 110:855-64. 2002.... - GRADE: an emerging consensus on rating quality of evidence and strength of recommendationsGordon H Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada L8N 3Z5
BMJ 336:924-6. 2008 - Shared decision making, decision aids, and risk communicationMark Helfand
Med Decis Making 27:516-7. 2007 - A look back...and aheadMark Helfand
Med Decis Making 25:8-10. 2005