M M Heinricher

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression
    Ryan S Phillips
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurophysiol 108:2393-404. 2012
  2. ncbi Neural basis for improgan antinociception
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 169:1414-20. 2010
  3. ncbi Descending control of nociception: Specificity, recruitment and plasticity
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Brain Res Rev 60:214-25. 2009
  4. ncbi Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor
    Mary M Heinricher
    Department of Neurological Surgery, CR 137, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurophysiol 104:3222-30. 2010
  5. ncbi Nociceptin/orphanin FQ: pain, stress and neural circuits
    Mary M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, Portland, OR 97239, USA
    Life Sci 77:3127-32. 2005
  6. ncbi Prostaglandin E2 in the medial preoptic area produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla
    M M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, Portland 97239, USA
    Neuroscience 128:389-98. 2004
  7. ncbi Prostaglandin E2 in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla
    Mary M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Pain 110:419-26. 2004
  8. ncbi Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla
    Mary M Heinricher
    Dept Neurological Surgery, L 472, Oregon Health and Science Univ, Portland, OR 97239, USA
    J Neurophysiol 92:1982-9. 2004
  9. ncbi Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla
    M M Heinricher
    Department of Neurological Surgery, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurophysiol 85:280-6. 2001
  10. ncbi Orphanin FQ/nociceptin: from neural circuitry to behavior
    Mary M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland 97239, USA
    Life Sci 73:813-22. 2003

Research Grants

  1. Medullary Circuitry of Opioid Analgesia
    Mary Heinricher; Fiscal Year: 2006
  2. Neural circuitry of improgran analgesia
    Mary Heinricher; Fiscal Year: 2007
  3. Supraspinal prostaglandins and descending control
    Mary Heinricher; Fiscal Year: 2007
  4. Neural circuitry of improgran analgesia
    Mary M Heinricher; Fiscal Year: 2010
  5. Migraine headache and central pain facilitating systems
    Mary M Heinricher; Fiscal Year: 2010
  6. MEDULLARY CIRCUITRY INVOLVED IN OPIOID ANALGESIA
    Mary Heinricher; Fiscal Year: 2000
  7. Interleukin-1Beta in Central Pain Modulating Circuits
    Mary Heinricher; Fiscal Year: 2004
  8. Medullary Circuitry of Pain Facilitation
    Mary M Heinricher; Fiscal Year: 2010

Collaborators

Detail Information

Publications31

  1. ncbi Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression
    Ryan S Phillips
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurophysiol 108:2393-404. 2012
    ..These findings show that pain relief can be separated pharmacologically from respiratory depression and identify RVM OFF-cells as important central targets for continued development of potent analgesics with fewer side effects...
  2. ncbi Neural basis for improgan antinociception
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 169:1414-20. 2010
    ..This common basis for improgan, opioid, and cannabinoid antinociception in the RVM supports the idea that improgan functions as a specific analgesic agent...
  3. ncbi Descending control of nociception: Specificity, recruitment and plasticity
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Brain Res Rev 60:214-25. 2009
    ....
  4. ncbi Physiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor
    Mary M Heinricher
    Department of Neurological Surgery, CR 137, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurophysiol 104:3222-30. 2010
    ..A presynaptic P450 epoxygenase may therefore be an important target for development of clinically useful nonopioid analgesic drugs...
  5. ncbi Nociceptin/orphanin FQ: pain, stress and neural circuits
    Mary M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, Portland, OR 97239, USA
    Life Sci 77:3127-32. 2005
    ..Although the likelihood of interactions between stress and analgesia systems must be considered in interpreting these data, they suggest that N/OFQ antagonists have potential as clinically useful analgesic drugs...
  6. ncbi Prostaglandin E2 in the medial preoptic area produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla
    M M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, Portland 97239, USA
    Neuroscience 128:389-98. 2004
    ..The present study indicates that the MPO also contributes to the hyperalgesic component of the illness response, most likely by recruiting the nociceptive modulating circuitry of the RVM...
  7. ncbi Prostaglandin E2 in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla
    Mary M Heinricher
    Department of Neurological Surgery, L 472, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Pain 110:419-26. 2004
    ..These data demonstrate a prostaglandin-sensitive descending facilitation from the PAG, and suggest that this is mediated by on- and off-cells in the RVM...
  8. ncbi Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla
    Mary M Heinricher
    Dept Neurological Surgery, L 472, Oregon Health and Science Univ, Portland, OR 97239, USA
    J Neurophysiol 92:1982-9. 2004
    ....
  9. ncbi Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla
    M M Heinricher
    Department of Neurological Surgery, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurophysiol 85:280-6. 2001
    ..CCK thus differs from another antiopioid peptide, orphanin FQ/nociceptin, which interferes with opioid analgesia by potently suppressing all OFF-cell firing...
  10. ncbi Orphanin FQ/nociceptin: from neural circuitry to behavior
    Mary M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland 97239, USA
    Life Sci 73:813-22. 2003
    ..It is simply inhibitory. For this reason, the effects seen in functional studies will only be fully understood when examined in the context of identified neural circuits...
  11. ncbi The role of excitatory amino acid transmission within the rostral ventromedial medulla in the antinociceptive actions of systemically administered morphine
    M M Heinricher
    Department of Neurological Surgery, Oregon Health Sciences University, Portland 97201, USA
    Pain 81:57-65. 1999
    ....
  12. ncbi Activation of brainstem N-methyl-D-aspartate receptors is required for the analgesic actions of morphine given systemically
    M M Heinricher
    Department of Neurological Surgery, Oregon Health Sciences University, OR, Portland 97201, USA
    Pain 92:129-38. 2001
    ..Excitatory amino acid-mediated excitation thus has at least two distinct roles within the RVM, activating off-cells and on-cells under different conditions...
  13. ncbi Analysis of excitatory amino acid transmission within the rostral ventromedial medulla: implications for circuitry
    M M Heinricher
    Division of Neurosurgery, Oregon Health Sciences University, Portland 97201, USA
    Pain 75:247-55. 1998
    ..This suggests that, under the conditions of these experiments, on-cell discharge is not a potent regulator of moment-to-moment variations in nociceptive responsiveness...
  14. ncbi Are opioid-sensitive neurons in the rostral ventromedial medulla inhibitory interneurons?
    D R Cleary
    Department of Neurological Surgery, Mail Stop CR137, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 151:564-71. 2008
    ..These data also support an independent role for on-cells in pain modulation...
  15. ncbi Noradrenergic agonist administration into the central nucleus of the amygdala increases the tail-flick latency in lightly anesthetized rats
    J P Ortiz
    Department of Neurological Surgery, Oregon Health and Science University, Mail code CH8N, 3303 Southwest Bond Avenue, Portland, OR 97239, USA
    Neuroscience 148:737-43. 2007
    ..These results demonstrate that anatomically and pharmacologically specific activation of alpha(2)-receptors in the CeA in lightly anesthetized rats results in behaviorally measurable antinociception...
  16. ncbi Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury
    Jonathan D Carlson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:13222-31. 2007
    ..These data demonstrate that both on- and off-cells in the RVM are sensitized to innocuous and noxious mechanical stimuli after nerve injury. This sensitization likely contributes to allodynia and hyperalgesia of neuropathic pain states...
  17. ncbi Purinergic receptor immunoreactivity in the rostral ventromedial medulla
    L N Close
    Department of Neurological Surgery, Oregon Health and Science University, Mail code CH8N, 3303 Southwest Bond Avenue, Portland, OR 97239, USA
    Neuroscience 158:915-21. 2009
    ..Purinergic neurotransmission in this region may play an important role in nociception and/or nociceptive modulation, as at other levels of the neuraxis...
  18. ncbi Alpha(2)-noradrenergic antagonist administration into the central nucleus of the amygdala blocks stress-induced hypoalgesia in awake behaving rats
    J P Ortiz
    Department of Neurological Surgery, Oregon Health and Science University, 3303 Southwest Bond Avenue, Portland, OR 97239, USA
    Neuroscience 157:223-8. 2008
    ..alpha(2)-Adrenoceptor function in the CeA is necessary for restraint-induced SIH...
  19. ncbi Lesions of the periaqueductal gray disrupt input to the rostral ventromedial medulla following microinjections of morphine into the medial or basolateral nuclei of the amygdala
    Steve McGaraughty
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97201, USA
    Brain Res 1009:223-7. 2004
    ..These results demonstrate that the influences from both the BLa and MEa to the RVM are relayed via the PAG...
  20. ncbi Role for medullary pain facilitating neurons in secondary thermal hyperalgesia
    Wendy Kincaid
    Department Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurophysiol 95:33-41. 2006
    ..These experiments support a pronociceptive role for on cells and suggest that these neurons contribute to secondary hyperalgesia in inflammation...
  21. ncbi Nociceptive facilitating neurons in the rostral ventromedial medulla
    Miranda J Neubert
    Department of Neurological Surgery, L-472, Oregon Health and Science University, Portland, OR 97239, USA
    Pain 110:158-65. 2004
    ..Activation of on-cells likely contributes to enhanced sensitivity to noxious stimulation or reduced sensitivity to analgesic drugs in a variety of conditions...
  22. ncbi Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more
    T Darland
    Dept of Cell and Developmental Biology, Oregon Health Sciences University, Portland, USA
    Trends Neurosci 21:215-21. 1998
    ..The number and diversity of papers focused on OFQ/N1-17 at the recent meeting of the Society for Neuroscience augur an exciting future for this new peptide...
  23. ncbi Purinergic actions on neurons that modulate nociception in the rostral ventromedial medulla
    N R Selden
    Department of Neurological Surgery, Oregon Health and Science University, Mail code CH8N, 3303 Southwest Bond Avenue, Portland, OR 97239, USA
    Neuroscience 146:1808-16. 2007
    ..The differential responses of on-, off- and neutral-cells to purinergic ligands highlight the value of pharmacological signatures in further delineation of the anatomy, connectivity and function of this therapeutically important system...
  24. ncbi Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity
    Steve McGaraughty
    Department of Neurological Surgery, Oregon Health Sciences University, Portland, OR 97201, USA
    Pain 96:153-62. 2002
    ..One way in which the modulatory circuitry of the RVM might be engaged physiologically in behaving animals is via opioid-mediated activation of the basolateral nucleus...
  25. ncbi NMDA receptor-mediated activation of medullary pro-nociceptive neurons is required for secondary thermal hyperalgesia
    Mei Xu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    Pain 127:253-62. 2007
    ..The present experiments demonstrate that a novel, NMDA-mediated activation of on-cells is required for secondary thermal hyperalgesia in acute inflammation...
  26. ncbi The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla
    K M Wagner
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Neuroscience 238:29-38. 2013
    ..Taken as a whole, these findings establish an anatomical and functional connection between the DMH and RVM by which stress can facilitate pain...
  27. ncbi Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage
    J S Cetas
    Department of Neurological Surgery, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Neuroscience 163:719-29. 2009
    ..Failure of this brainstem compensatory mechanism could be significant for acute perfusion deficits seen in patients following subarachnoid hemorrhage...
  28. ncbi Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients
    Jonathan D Carlson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA
    J Neurophysiol 103:962-7. 2010
    ....
  29. ncbi A possible neural basis for stress-induced hyperalgesia
    Melissa E Martenson
    Department of Neurological Surgery, CR 137, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Pain 142:236-44. 2009
    ..These data demonstrate a top-down activation of brainstem pain-facilitating neurons, and suggest a possible neural circuit for stress-induced hyperalgesia...
  30. ncbi Ronald Tasker Award: nociceptive on- and off-cells in the mesopontine tegmentum
    Jonathan D Carlson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, USA
    Clin Neurosurg 52:366-70. 2005
  31. ncbi Simultaneous analysis of the time course for changes in core body temperature, activity, and nociception following systemic administration of interleukin-1beta in the rat
    Michael M Morgan
    Department of Psychology, Washington State University Vancouver, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, USA
    Brain Res 996:187-92. 2004
    ..The results of this study demonstrate that, two phases of hyperalgesia occur and coincide with the periods of altered thermoregulation produced by systemic administration of IL-1beta...

Research Grants26

  1. Medullary Circuitry of Opioid Analgesia
    Mary Heinricher; Fiscal Year: 2006
    ..The proposed work should advance our understanding of central processes involved in bi-directional pain modulation, and should ultimately lead to improved clinical treatment of pain. ..
  2. Neural circuitry of improgran analgesia
    Mary Heinricher; Fiscal Year: 2007
    ....
  3. Supraspinal prostaglandins and descending control
    Mary Heinricher; Fiscal Year: 2007
    ..Knowledge of the mechanisms through which prostaglandins recruit descending control systems will advance our understanding of the neural basis of pain modulation, and should ultimately lead to improved clinical treatment of pain. ..
  4. Neural circuitry of improgran analgesia
    Mary M Heinricher; Fiscal Year: 2010
    ....
  5. Migraine headache and central pain facilitating systems
    Mary M Heinricher; Fiscal Year: 2010
    ..This idea is attractive because a central dysfunction could potentially explain the multiple triggers for migraine attached, as well as the range of associated symptoms, including nausea and aversion to light and sound. ..
  6. MEDULLARY CIRCUITRY INVOLVED IN OPIOID ANALGESIA
    Mary Heinricher; Fiscal Year: 2000
    ....
  7. Interleukin-1Beta in Central Pain Modulating Circuits
    Mary Heinricher; Fiscal Year: 2004
    ..In providing additional tools to manipulate these systems, this work may ultimately lead to improved clinical treatment of pain. ..
  8. Medullary Circuitry of Pain Facilitation
    Mary M Heinricher; Fiscal Year: 2010
    ..The work proposed in this application will study the properties of pain-modulating neurons in the brainstem to determine how they are altered to support chronic pain. ..