Research Topics
Genomes and Genes | Richard GoodmanSummaryAffiliation: Oregon Health and Science University Country: USA Publications
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Publications
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesisNgan Vo
Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 102:16426-31. 2005..These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues...
Activation and repression in the nervous systemR H Goodman
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Curr Opin Neurobiol 8:413-7. 1998..Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated...- CBP/p300 in cell growth, transformation, and developmentR H Goodman
Vollum Institute, Oregon Health Sciences University, Portland 97201 USA
Genes Dev 14:1553-77. 2000 - Phosphorylated CREB binds specifically to the nuclear protein CBPJ C Chrivia
Vollum Institute, Oregon Health Sciences University, Portland 97201
Nature 365:855-9. 1993..We propose that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB... - Nuclear protein CBP is a coactivator for the transcription factor CREBR P Kwok
Vollum Institute, Oregon Health Sciences University, Portland 97201
Nature 370:223-6. 1994..8). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes... - Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBPJ R Lundblad
Vollum Institute, Oregon Health Sciences University, Portland 97201
Nature 374:85-8. 1995..Our results indicate that the gene repression and cell immortalization functions associated with E1A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression... - Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signalingY Chen
Vollum Institute and Department of Cell and Developmental Biology L 215, Oregon Health Sciences University, Portland, OR 97201, USA
Development 126:3607-16. 1999..Taken together, our results suggest that positive hh and negative PKA regulation of wg gene expression converge on the regulation of CI phosphorylation... - Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryoY Chen
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Cell Biol 20:1616-25. 2000..Taken together, our data suggest that dCBP function is necessary for ci-mediated transactivation of wg during Drosophila embryogenesis... - The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA bindingM A Schumacher
Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
J Biol Chem 275:35242-7. 2000.... - Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiersF Bantignies
Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Cell Biol 20:9317-30. 2000..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure... - CREB signaling--timing is everythingS Impey
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
Sci STKE 2001:pe1. 2001..The continuing debate about the involvement of calmodulin kinase IV is also described... - The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor grooveJ R Lundblad
Division of Molecular Medicine, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Biol Chem 273:19251-9. 1998..These data indicate that Tax does not regulate DNA binding of CREB by altering dimerization, but rather enhances DNA binding by additionally interacting with the minor groove of flanking DNA sequences... - The beta-adrenergic receptor kinase interacts with the amino terminus of the G protein beta subunitP S Goldman
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Biochem Biophys Res Commun 240:425-9. 1997..In addition, we show that amino acids 1 to 145 of G beta 2 are sufficient for beta ARK binding... - Protein kinase A directly regulates the activity and proteolysis of cubitus interruptusY Chen
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
Proc Natl Acad Sci U S A 95:2349-54. 1998..In summary, we show that the modulation of the hh signaling pathway by PKA occurs directly at the level of CI phosphorylation... - Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREBQ Zhang
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Cell Biol 20:4970-8. 2000..These data indicate that the association of phosphorylated CREB with CBP promotes the binding of RbAp48 and its homologue RbAp46, allowing the formation of a complex that facilitates histone acetylation during transcriptional activation... - The multifunctional role of the co-activator CBP in transcriptional regulationP S Goldman
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Recent Prog Horm Res 52:103-19; discussion 119-20. 1997..In addition, we will outline the various transcription factor pathways that CBP has been proposed to activate. Finally, we will discuss the possible role of CBP in cellular transformation and differentiation... - Consensus and variant cAMP-regulated enhancers have distinct CREB-binding propertiesJ C Craig
Vollum Institute and Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
J Biol Chem 276:11719-28. 2001..We suggest that CREB binds the consensus and variant CRE sequences through fundamentally distinct mechanisms... - Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding proteinD M Fass
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Biol Chem 276:2992-7. 2001..Thus, we propose that the C/EBP sites in the PEPCK promoter allow CREMalpha to activate transcription despite its lack of Q regions... - Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoformsM E Laurance
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Biol Chem 272:2646-51. 1997..Tax activation of the cellular CRE depends on the KID and its ability to interact with CBP in a phosphorylation-dependent manner... - The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase AR P Rehfuss
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
J Biol Chem 266:18431-4. 1991..These findings indicate that CREB is not unique in its ability to mediate cAMP-dependent transcriptional regulation... - The CRE-binding protein dCREB-A is required for Drosophila embryonic developmentR E Rose
Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
Genetics 146:595-606. 1997..The absolute requirement of dCREB-A for embryogenesis demonstrates a nonredundant function for a CRE-binding protein that will be useful in studying the role of specific signal transduction cascades in development... - Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBPN Vo
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Cell Biol 21:6181-8. 2001..We suggest that p300/CBP-mediated acetylation disrupts the RIP140-CtBP complex and derepresses nuclear hormone receptor-regulated genes. Disruption of repressor-CtBP interactions by acetylation may be a general mode of gene activation... - Isolation of Drosophila CREB-B: a novel CRE-binding proteinT Usui
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
DNA Cell Biol 12:589-95. 1993..Northern blot analysis shows that multiple transcripts of the dCREB-B gene are expressed in embryonic and adult tissues and that these transcripts arise from both strands of the DNA.(ABSTRACT TRUNCATED AT 250 WORDS).. - Epigenetic mechanisms and gene networks in the nervous systemChristine M Colvis
Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
J Neurosci 25:10379-89. 2005 - Redox sensor CtBP mediates hypoxia-induced tumor cell migrationQinghong Zhang
Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 103:9029-33. 2006..We propose that CtBP senses levels of free NADH to control expression of cell adhesion genes, thereby promoting tumor cell migration under hypoxic stress... - An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4Gregory S Yochum
Vollum Institute, Division of Biostatistics, Department of Public Health and Preventative Medicine, OHSU Cancer Institute, Oregon Health and Science University, Portland 97239, USA
J Biol Chem 282:871-8. 2007..We propose that Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism... - Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complexQinghong Zhang
Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 104:829-33. 2007..We propose that the reduction in transcriptional repression mediated by HIC1, due to the decrease of CtBP binding, increases SIRT1 expression. This mechanism allows the specific regulation of SIRT1 in response to nutrient deprivation... - Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulationSunita K Agarwal
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1802, USA
Neoplasia 9:101-7. 2007..These unbiased data also suggest that menin could play a broad role in transcriptional regulation... - Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cellsGregory S Yochum
Department of Public Health and Preventative Medicine, and Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 104:3324-9. 2007..Furthermore, 15 components of the canonical Wnt pathway were identified as beta-catenin target genes, suggesting that feed-forward and feedback mechanisms exist to modulate the Wnt signal in colon cancer cells... - A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functionsStefanie J Otto
Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
J Neurosci 27:6729-39. 2007..Unexpectedly, genes considered exclusively non-neuronal also contained an RE1 motif and were expressed in neurons. This supports the model that REST binding is a critical determinant of neuronal phenotype... - Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancyDavid M Keller
Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 282:32084-92. 2007..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion... - Homeostatic regulation of MeCP2 expression by a CREB-induced microRNAMatthew E Klein
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Nat Neurosci 10:1513-4. 2007..This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression... - An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAPGary A Wayman
Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
Proc Natl Acad Sci U S A 105:9093-8. 2008..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity... - Role reversal: the regulation of neuronal gene expression by microRNAsMatthew E Klein
Reed College and Vollum Institute, Oregon Health and Sciences University, Portland OR, USA
Curr Opin Neurobiol 15:507-13. 2005..The combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone... - Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosisQinghong Zhang
Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 102:2802-7. 2005..Consequently, interference with HIPK2 action in H1299 cells rescued UV-triggered apoptosis... - The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in DrosophilaFrédéric Bantignies
Vollum Institute and Department of Cell and Developmental Biology L 215, Oregon Health Sciences University, Portland, OR 97201, USA
Proc Natl Acad Sci U S A 99:2895-900. 2002..These results imply that, in addition to its histone acetyltransferase activity, dCBP may affect higher-order chromatin structure... - Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IVSoren Impey
The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
Neuron 34:235-44. 2002..Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301... - The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogasterWilliam H Ludlam
Department of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
Mol Cell Biol 22:3832-41. 2002..Furthermore, the effects of CBP AT activity are not limited to a few specific promoters, but rather CBT AT activity may play a role in regulating global histone acetylation throughout the developing organism... - C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programsMadeleine Grooteclaes
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:4568-73. 2003..The results presented herein establish two functional roles of CtBP: to corepress epithelial genes, thus permitting epithelial-to-mesenchymal transitions, and to modulate the cellular threshold for apoptotic responses... - Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensorClark C Fjeld
Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
Proc Natl Acad Sci U S A 100:9202-7. 2003..These findings support the possibility that changes in nuclear nicotinamide adenine dinucleotides could regulate the functions of CtBP in cell differentiation, development, or transformation... - Deacetylase activity is required for cAMP activation of a subset of CREB target genesDaniel M Fass
Vollum Institute L474, Oregon Health and Science University, Portland, Oregon 97239, USA
J Biol Chem 278:43014-9. 2003..These data indicate that histone deacetylases differentially regulate CREB target genes by contributing to either activation or cessation of transcription... - Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBPQinghong Zhang
Vollum Institute, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
Cell 115:177-86. 2003..Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53... - Cell-type-specific binding of the transcription factor CREB to the cAMP-response elementHyunjoo Cha-Molstad
Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 101:13572-7. 2004..We conclude that the family of CREB target genes differs from one cell type to another and that the ability of CREB to bind to a particular CRE represents an important component of gene regulation... - Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regionsSoren Impey
Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Cell 119:1041-54. 2004..A large fraction of the SACO loci delineated bidirectional promoters and novel antisense transcripts. This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species... - Regulation of corepressor function by nuclear NADHQinghong Zhang
Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
Science 295:1895-7. 2002..We propose that this ability to detect changes in nuclear NAD+/NADH ratio allows CtBP to serve as a redox sensor for transcription...
Research Grants
- Regulation of MeCP2 by CREB-induced microRNAsRichard H Goodman; Fiscal Year: 2010..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
- ECTOPIC HORMONE SYNTHESIS IN PHEOCHROMOCYTOMA CELLSRichard Goodman; Fiscal Year: 2007..abstract_text> ..
- MULTIDISCIPLINARY TRAINING IN NEUROENDOCRINOLOGYRichard Goodman; Fiscal Year: 2007..The concentration of researchers in Oregon in the field of neuroendocrinology provides a unique environment for trainees. ..
- Regulation of MeCP2 by CREB-induced microRNAsRichard Goodman; Fiscal Year: 2009..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
- Identification of gene targets for morphine and other drugs of abuseRichard Goodman; Fiscal Year: 2009..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
- Regulation of MeCP2 by CREB-induced microRNAsRichard Goodman; Fiscal Year: 2007..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
- RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMSRichard Goodman; Fiscal Year: 2006..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
- TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATIONRichard Goodman; Fiscal Year: 2003..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..