Richard Goodman

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
  2. ncbi request reprint Activation and repression in the nervous system
    R H Goodman
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Curr Opin Neurobiol 8:413-7. 1998
  3. ncbi request reprint CBP/p300 in cell growth, transformation, and development
    R H Goodman
    Vollum Institute, Oregon Health Sciences University, Portland 97201 USA
    Genes Dev 14:1553-77. 2000
  4. ncbi request reprint Phosphorylated CREB binds specifically to the nuclear protein CBP
    J C Chrivia
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 365:855-9. 1993
  5. ncbi request reprint Nuclear protein CBP is a coactivator for the transcription factor CREB
    R P Kwok
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 370:223-6. 1994
  6. ncbi request reprint Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
    J R Lundblad
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 374:85-8. 1995
  7. ncbi request reprint Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
    Y Chen
    Vollum Institute and Department of Cell and Developmental Biology L 215, Oregon Health Sciences University, Portland, OR 97201, USA
    Development 126:3607-16. 1999
  8. pmc Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
    Y Chen
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:1616-25. 2000
  9. ncbi request reprint The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding
    M A Schumacher
    Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Biol Chem 275:35242-7. 2000
  10. pmc Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    F Bantignies
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:9317-30. 2000

Research Grants

  1. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
  2. ECTOPIC HORMONE SYNTHESIS IN PHEOCHROMOCYTOMA CELLS
    Richard Goodman; Fiscal Year: 2007
  3. MULTIDISCIPLINARY TRAINING IN NEUROENDOCRINOLOGY
    Richard Goodman; Fiscal Year: 2007
  4. Regulation of MeCP2 by CREB-induced microRNAs
    Richard Goodman; Fiscal Year: 2009
  5. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
  6. Regulation of MeCP2 by CREB-induced microRNAs
    Richard Goodman; Fiscal Year: 2007
  7. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
  8. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003

Collaborators

Detail Information

Publications45

  1. pmc A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
    Ngan Vo
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:16426-31. 2005
    ..These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues...
  2. ncbi request reprint Activation and repression in the nervous system
    R H Goodman
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Curr Opin Neurobiol 8:413-7. 1998
    ..Their association with histone acetylases, to mediate activation, or deacetylases, to mediate repression, provide a model for explaining how gene expression is regulated...
  3. ncbi request reprint CBP/p300 in cell growth, transformation, and development
    R H Goodman
    Vollum Institute, Oregon Health Sciences University, Portland 97201 USA
    Genes Dev 14:1553-77. 2000
  4. ncbi request reprint Phosphorylated CREB binds specifically to the nuclear protein CBP
    J C Chrivia
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 365:855-9. 1993
    ..We propose that CBP may participate in cAMP-regulated gene expression by interacting with the activated phosphorylated form of CREB...
  5. ncbi request reprint Nuclear protein CBP is a coactivator for the transcription factor CREB
    R P Kwok
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 370:223-6. 1994
    ..8). Consistent with its role as a coactivator, CBP augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes...
  6. ncbi request reprint Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
    J R Lundblad
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 374:85-8. 1995
    ..Our results indicate that the gene repression and cell immortalization functions associated with E1A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression...
  7. ncbi request reprint Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
    Y Chen
    Vollum Institute and Department of Cell and Developmental Biology L 215, Oregon Health Sciences University, Portland, OR 97201, USA
    Development 126:3607-16. 1999
    ..Taken together, our results suggest that positive hh and negative PKA regulation of wg gene expression converge on the regulation of CI phosphorylation...
  8. pmc Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
    Y Chen
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:1616-25. 2000
    ..Taken together, our data suggest that dCBP function is necessary for ci-mediated transactivation of wg during Drosophila embryogenesis...
  9. ncbi request reprint The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding
    M A Schumacher
    Department of Biochemistry and Molecular Biology and the Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201 3098, USA
    J Biol Chem 275:35242-7. 2000
    ....
  10. pmc Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    F Bantignies
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:9317-30. 2000
    ..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure...
  11. ncbi request reprint CREB signaling--timing is everything
    S Impey
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Sci STKE 2001:pe1. 2001
    ..The continuing debate about the involvement of calmodulin kinase IV is also described...
  12. ncbi request reprint The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove
    J R Lundblad
    Division of Molecular Medicine, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 273:19251-9. 1998
    ..These data indicate that Tax does not regulate DNA binding of CREB by altering dimerization, but rather enhances DNA binding by additionally interacting with the minor groove of flanking DNA sequences...
  13. ncbi request reprint The beta-adrenergic receptor kinase interacts with the amino terminus of the G protein beta subunit
    P S Goldman
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Biochem Biophys Res Commun 240:425-9. 1997
    ..In addition, we show that amino acids 1 to 145 of G beta 2 are sufficient for beta ARK binding...
  14. pmc Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
    Y Chen
    Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 95:2349-54. 1998
    ..In summary, we show that the modulation of the hh signaling pathway by PKA occurs directly at the level of CI phosphorylation...
  15. pmc Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB
    Q Zhang
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:4970-8. 2000
    ..These data indicate that the association of phosphorylated CREB with CBP promotes the binding of RbAp48 and its homologue RbAp46, allowing the formation of a complex that facilitates histone acetylation during transcriptional activation...
  16. ncbi request reprint The multifunctional role of the co-activator CBP in transcriptional regulation
    P S Goldman
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Recent Prog Horm Res 52:103-19; discussion 119-20. 1997
    ..In addition, we will outline the various transcription factor pathways that CBP has been proposed to activate. Finally, we will discuss the possible role of CBP in cellular transformation and differentiation...
  17. ncbi request reprint Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties
    J C Craig
    Vollum Institute and Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA
    J Biol Chem 276:11719-28. 2001
    ..We suggest that CREB binds the consensus and variant CRE sequences through fundamentally distinct mechanisms...
  18. ncbi request reprint Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein
    D M Fass
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 276:2992-7. 2001
    ..Thus, we propose that the C/EBP sites in the PEPCK promoter allow CREMalpha to activate transcription despite its lack of Q regions...
  19. ncbi request reprint Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms
    M E Laurance
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 272:2646-51. 1997
    ..Tax activation of the cellular CRE depends on the KID and its ability to interact with CBP in a phosphorylation-dependent manner...
  20. ncbi request reprint The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A
    R P Rehfuss
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    J Biol Chem 266:18431-4. 1991
    ..These findings indicate that CREB is not unique in its ability to mediate cAMP-dependent transcriptional regulation...
  21. pmc The CRE-binding protein dCREB-A is required for Drosophila embryonic development
    R E Rose
    Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Genetics 146:595-606. 1997
    ..The absolute requirement of dCREB-A for embryogenesis demonstrates a nonredundant function for a CRE-binding protein that will be useful in studying the role of specific signal transduction cascades in development...
  22. pmc Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP
    N Vo
    Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 21:6181-8. 2001
    ..We suggest that p300/CBP-mediated acetylation disrupts the RIP140-CtBP complex and derepresses nuclear hormone receptor-regulated genes. Disruption of repressor-CtBP interactions by acetylation may be a general mode of gene activation...
  23. ncbi request reprint Isolation of Drosophila CREB-B: a novel CRE-binding protein
    T Usui
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201
    DNA Cell Biol 12:589-95. 1993
    ..Northern blot analysis shows that multiple transcripts of the dCREB-B gene are expressed in embryonic and adult tissues and that these transcripts arise from both strands of the DNA.(ABSTRACT TRUNCATED AT 250 WORDS)..
  24. ncbi request reprint Epigenetic mechanisms and gene networks in the nervous system
    Christine M Colvis
    Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 25:10379-89. 2005
  25. pmc Redox sensor CtBP mediates hypoxia-induced tumor cell migration
    Qinghong Zhang
    Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 103:9029-33. 2006
    ..We propose that CtBP senses levels of free NADH to control expression of cell adhesion genes, thereby promoting tumor cell migration under hypoxic stress...
  26. ncbi request reprint An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4
    Gregory S Yochum
    Vollum Institute, Division of Biostatistics, Department of Public Health and Preventative Medicine, OHSU Cancer Institute, Oregon Health and Science University, Portland 97239, USA
    J Biol Chem 282:871-8. 2007
    ..We propose that Wnt/beta-catenin signaling may contribute to colorectal carcinogenesis by reducing the level of the E2F4 cell cycle repressor via an antisense mechanism...
  27. pmc Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
    Qinghong Zhang
    Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 104:829-33. 2007
    ..We propose that the reduction in transcriptional repression mediated by HIC1, due to the decrease of CtBP binding, increases SIRT1 expression. This mechanism allows the specific regulation of SIRT1 in response to nutrient deprivation...
  28. pmc Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1802, USA
    Neoplasia 9:101-7. 2007
    ..These unbiased data also suggest that menin could play a broad role in transcriptional regulation...
  29. pmc Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells
    Gregory S Yochum
    Department of Public Health and Preventative Medicine, and Oregon Health and Science University Cancer Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 104:3324-9. 2007
    ..Furthermore, 15 components of the canonical Wnt pathway were identified as beta-catenin target genes, suggesting that feed-forward and feedback mechanisms exist to modulate the Wnt signal in colon cancer cells...
  30. ncbi request reprint A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions
    Stefanie J Otto
    Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 27:6729-39. 2007
    ..Unexpectedly, genes considered exclusively non-neuronal also contained an RE1 motif and were expressed in neurons. This supports the model that REST binding is a critical determinant of neuronal phenotype...
  31. ncbi request reprint Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy
    David M Keller
    Vollum Institute, and Division of Biostatistics, Department of Public Health and Preventative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 282:32084-92. 2007
    ..We additionally show that many Pdx-1 targets also interact with NeuroD1/BETA2, including the micro-RNA miR-375, a known regulator of insulin secretion...
  32. ncbi request reprint Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
    Matthew E Klein
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nat Neurosci 10:1513-4. 2007
    ..This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression...
  33. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  34. ncbi request reprint Role reversal: the regulation of neuronal gene expression by microRNAs
    Matthew E Klein
    Reed College and Vollum Institute, Oregon Health and Sciences University, Portland OR, USA
    Curr Opin Neurobiol 15:507-13. 2005
    ..The combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone...
  35. pmc Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis
    Qinghong Zhang
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 102:2802-7. 2005
    ..Consequently, interference with HIPK2 action in H1299 cells rescued UV-triggered apoptosis...
  36. pmc The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila
    Frédéric Bantignies
    Vollum Institute and Department of Cell and Developmental Biology L 215, Oregon Health Sciences University, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 99:2895-900. 2002
    ..These results imply that, in addition to its histone acetyltransferase activity, dCBP may affect higher-order chromatin structure...
  37. ncbi request reprint Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV
    Soren Impey
    The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
    Neuron 34:235-44. 2002
    ..Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301...
  38. pmc The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster
    William H Ludlam
    Department of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    Mol Cell Biol 22:3832-41. 2002
    ..Furthermore, the effects of CBP AT activity are not limited to a few specific promoters, but rather CBT AT activity may play a role in regulating global histone acetylation throughout the developing organism...
  39. pmc C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs
    Madeleine Grooteclaes
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:4568-73. 2003
    ..The results presented herein establish two functional roles of CtBP: to corepress epithelial genes, thus permitting epithelial-to-mesenchymal transitions, and to modulate the cellular threshold for apoptotic responses...
  40. pmc Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor
    Clark C Fjeld
    Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Proc Natl Acad Sci U S A 100:9202-7. 2003
    ..These findings support the possibility that changes in nuclear nicotinamide adenine dinucleotides could regulate the functions of CtBP in cell differentiation, development, or transformation...
  41. ncbi request reprint Deacetylase activity is required for cAMP activation of a subset of CREB target genes
    Daniel M Fass
    Vollum Institute L474, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 278:43014-9. 2003
    ..These data indicate that histone deacetylases differentially regulate CREB target genes by contributing to either activation or cessation of transcription...
  42. ncbi request reprint Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    Qinghong Zhang
    Vollum Institute, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239, USA
    Cell 115:177-86. 2003
    ..Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53...
  43. pmc Cell-type-specific binding of the transcription factor CREB to the cAMP-response element
    Hyunjoo Cha-Molstad
    Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 101:13572-7. 2004
    ..We conclude that the family of CREB target genes differs from one cell type to another and that the ability of CREB to bind to a particular CRE represents an important component of gene regulation...
  44. ncbi request reprint Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions
    Soren Impey
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Cell 119:1041-54. 2004
    ..A large fraction of the SACO loci delineated bidirectional promoters and novel antisense transcripts. This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species...
  45. ncbi request reprint Regulation of corepressor function by nuclear NADH
    Qinghong Zhang
    Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    Science 295:1895-7. 2002
    ..We propose that this ability to detect changes in nuclear NAD+/NADH ratio allows CtBP to serve as a redox sensor for transcription...

Research Grants23

  1. Regulation of MeCP2 by CREB-induced microRNAs
    Richard H Goodman; Fiscal Year: 2010
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  2. ECTOPIC HORMONE SYNTHESIS IN PHEOCHROMOCYTOMA CELLS
    Richard Goodman; Fiscal Year: 2007
    ..abstract_text> ..
  3. MULTIDISCIPLINARY TRAINING IN NEUROENDOCRINOLOGY
    Richard Goodman; Fiscal Year: 2007
    ..The concentration of researchers in Oregon in the field of neuroendocrinology provides a unique environment for trainees. ..
  4. Regulation of MeCP2 by CREB-induced microRNAs
    Richard Goodman; Fiscal Year: 2009
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  5. Identification of gene targets for morphine and other drugs of abuse
    Richard Goodman; Fiscal Year: 2009
    ..The concept that CREB signaling induces mediators of translational arrest has profound implications for the understanding of drug action. ..
  6. Regulation of MeCP2 by CREB-induced microRNAs
    Richard Goodman; Fiscal Year: 2007
    ..The studies described in this proposal address a completely novel mechanism of gene regulation that has implications for the understanding of MeCP2 biology and neural development in general. ..
  7. RECEPTORS AND SIGNALING IN NEUROENDOCRINE SYSTEMS
    Richard Goodman; Fiscal Year: 2006
    ..Core laboratories for cell culture, protein chemistry, and administration are designed to allow the proposed studies to be performed in an efficient and cost-effective manner. ..
  8. TRANSCRIPTIONAL COACTIVATORS IN ENDOCRINE REGULATION
    Richard Goodman; Fiscal Year: 2003
    ..Finally, we will characterize the ability of the "CREB binding domain" of CBP to interact with other transcription factors activated or inhibited by Ser/Thr phosphorylation. ..