Research Topics
Species | BALZ B FREISummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Authors' perspective: What is the optimum intake of vitamin C in humans?Balz Frei
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Crit Rev Food Sci Nutr 52:815-29. 2012....
Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic diseaseBalz Frei
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
J Nutr 134:3196S-3198S. 2004
Vitamin C and cancer revisitedBalz Frei
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Proc Natl Acad Sci U S A 105:11037-8. 2008- Antioxidant activity of tea polyphenols in vivo: evidence from animal studiesBalz Frei
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 133:3275S-84S. 2003..To determine whether tea polyphenols act as effective antioxidants in vivo, future studies in animals and humans should employ sensitive and specific biomarkers of oxidative damage to lipids, proteins and DNA... - Tea catechins and polyphenols: health effects, metabolism, and antioxidant functionsJane V Higdon
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Crit Rev Food Sci Nutr 43:89-143. 2003..Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed... - Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activityLixin Li
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Arterioscler Thromb Vasc Biol 26:2638-43. 2006..Here we determined whether the iron chelator, desferrioxamine (DFO), ameliorates oxidative stress and cellular adhesion molecule expression in a murine model of local inflammation... - Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cellsWei Jian Zhang
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
Free Radic Biol Med 34:674-82. 2003..Our data suggest that intracellular, but not extracellular, transition metal ions mediate inflammatory cytokine-induced SP-1 activation and adhesion molecule expression in endothelial cells... - Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cellsWei-Jian Zhang
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Cardiovasc Res 55:820-9. 2002.... - Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamineLixin Li
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Arterioscler Thromb Vasc Biol 29:732-8. 2009..The objective of the present study was to investigate whether and how LPS and iron enhance, and DFO inhibits, NADPH oxidase activity in human aortic endothelial cells (HAECs)... - Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxideJung Suh
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331-6512, USA
Free Radic Biol Med 34:1306-14. 2003..Our data show that even in the presence of redox-active iron or copper and H(2)O(2), ascorbate acts as an antioxidant that prevents lipid peroxidation and does not promote protein oxidation in human plasma in vitro... - Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complexBen-Zhan Zhu
Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
Free Radic Biol Med 32:1333-8. 2002.... - Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient miceWei Jian Zhang
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Circulation 117:421-8. 2008..Here, we investigated whether LA inhibits atherosclerosis in apolipoprotein E-deficient (apoE-/-) and apoE/low-density lipoprotein receptor-deficient mice, 2 well-established animal models of human atherosclerosis... - Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathwayWei Jian Zhang
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512
Proc Natl Acad Sci U S A 104:4077-82. 2007..Lipoic acid may be useful in the prevention of sepsis and inflammatory vascular diseases... - Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanesAlan W Taylor
Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
Anal Biochem 350:41-51. 2006..Ours is the first validated quantitative assay using HPLC-tandem MS applied to plasma total 15-PGFs... - Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damageBen-Zhan Zhu
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
FEBS Lett 532:80-4. 2002..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions... - Coffee and health: a review of recent human researchJane V Higdon
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Crit Rev Food Sci Nutr 46:101-23. 2006.... - Vitamin E revisited: do new data validate benefits for chronic disease prevention?Maret G Traber
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Curr Opin Lipidol 19:30-8. 2008..Vitamin E benefits in human health and chronic disease prevention are evaluated with respect to established alpha-tocopherol functions during vitamin E deficiency, adequacy, and excess... - Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementationLixin Li
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
Ann N Y Acad Sci 1203:151-9. 2010..Furthermore, LA reversed the age-dependent changes in aortic SOD activity and plasma MCP-1 levels. Hence, vascular oxidative stress and inflammation increase with age and are ameliorated by LA supplementation... - Endurance exercise results in DNA damage as detected by the comet assayAngela Mastaloudis
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Free Radic Biol Med 36:966-75. 2004..Thus, endurance exercise resulted in DNA damage as shown by the comet assay and AO seemed to enhance recovery in women but not in men... - Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivoWei Jian Zhang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Free Radic Biol Med 46:791-8. 2009..Our findings suggest that NADPH oxidase-mediated ROS production and cellular redox signaling do not promote, but instead limit, LPS-induced acute inflammatory responses in vivo... - Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effectsSilvina B Lotito
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Free Radic Biol Med 36:201-11. 2004.... - The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental miceWei Jian Zhang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Exp Biol Med (Maywood) 235:633-41. 2010..Whether eliminating excess iron is a useful adjunct for the prevention or treatment of atherosclerosis in humans remains to be investigated... - Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophoreJan F Stevens
Department of Chemistry, Oregon State University, Corvallis, Oregon 97331-7301, USA
Chem Res Toxicol 16:1277-86. 2003..Taken together, our results suggest that the alpha,beta-unsaturated keto functionality of chalcones is most reactive toward superoxide and peroxynitrite anions... - Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolismSilvina B Lotito
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
J Biol Chem 281:37102-10. 2006..We conclude that the effect of dietary flavonoids on endothelial adhesion molecule expression depends on their molecular structure, concentration, and metabolic transformation but not their antioxidant activity... - Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasmaJohn Sowell
Linus Pauling Institute and Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA
Proc Natl Acad Sci U S A 101:17964-9. 2004.... - Is there a gender difference in the effect of antioxidants on cancer risk?Jane V Higdon
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Br J Nutr 94:139-40. 2005 - Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione statusFrancesco Visioli
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
Redox Rep 7:223-7. 2002..Thus, vitamin C and lipoic acid potentiate endothelial NO synthesis and bioactivity by mechanisms that appear to be independent of cellular GSH levels and redox environment... - Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?Silvina B Lotito
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Free Radic Biol Med 41:1727-46. 2006..We conclude that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels... - Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress responseJohn Sowell
Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
J Chromatogr B Analyt Technol Biomed Life Sci 827:139-45. 2005..In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress... - The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoidsSilvina B Lotito
Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
Free Radic Biol Med 37:251-8. 2004..Taken together, our data show that the increase in plasma antioxidant capacity in humans after apple consumption is due mainly to the well-known metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids... - Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin CAnitra C Carr
Linus Pauling Institute, Oregon State University, Corvallis 97331-6512, USA
Biol Chem 383:627-36. 2002.... - Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymesJung H Suh
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
Redox Rep 9:57-61. 2004..Our results suggest that DHLA chelates and inactivates redox-active transition metal ions in small-molecular, biological complexes without affecting iron- or copper-dependent enzyme activities... - Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping studyBen-Zhan Zhu
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Free Radic Biol Med 32:465-73. 2002..Metal-independent production of *OH from H(2)O(2) was also observed with several other halogenated quinones... - Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivoHao Wei
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Am J Physiol Heart Circ Physiol 301:H712-20. 2011..Therefore, copper appears to play an important role in vascular inflammation, and TTM may have value as an anti-inflammatory or anti-atherogenic agent... - Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cellsWei Jian Zhang
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
Atherosclerosis 165:241-9. 2002..The ability of polyunsaturated phospholipids in HDL to affect endothelial activation remains to be further investigated...
Research Grants
- 10th Annual SFRBM MeetingBalz Frei; Fiscal Year: 2004....
- 11th Annual SFRBM MeetingBalz Frei; Fiscal Year: 2005....
- CER on CAM Antioxidant Therapies (CERCAT)Balz Frei; Fiscal Year: 2007..abstract_text> ..