BALZ B FREI

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults
    Brian M Dixon
    USANA Health Sciences, Inc, 3838 West Parkway Boulevard, Salt Lake City UT 84120, USA
    BMC Res Notes 5:575. 2012
  2. doi request reprint Authors' perspective: What is the optimum intake of vitamin C in humans?
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 52:815-29. 2012
  3. ncbi request reprint Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 133:3275S-84S. 2003
  4. ncbi request reprint Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Nutr 134:3196S-3198S. 2004
  5. pmc Vitamin C and cancer revisited
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 105:11037-8. 2008
  6. ncbi request reprint Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
  7. ncbi request reprint Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity
    Lixin Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Arterioscler Thromb Vasc Biol 26:2638-43. 2006
  8. ncbi request reprint Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 34:674-82. 2003
  9. ncbi request reprint Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Cardiovasc Res 55:820-9. 2002
  10. ncbi request reprint Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide
    Jung Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 34:1306-14. 2003

Research Grants

  1. 10th Annual SFRBM Meeting
    Balz Frei; Fiscal Year: 2004
  2. 11th Annual SFRBM Meeting
    Balz Frei; Fiscal Year: 2005
  3. CER on CAM Antioxidant Therapies (CERCAT)
    Balz Frei; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. pmc Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults
    Brian M Dixon
    USANA Health Sciences, Inc, 3838 West Parkway Boulevard, Salt Lake City UT 84120, USA
    BMC Res Notes 5:575. 2012
    ..Only three studies have shown a positive correlation between circulating 25-hydroxyvitamin D and hCAP18 levels. Here we provide additional evidence for such a correlation in healthy, middle-aged adults...
  2. doi request reprint Authors' perspective: What is the optimum intake of vitamin C in humans?
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 52:815-29. 2012
    ....
  3. ncbi request reprint Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 133:3275S-84S. 2003
    ..To determine whether tea polyphenols act as effective antioxidants in vivo, future studies in animals and humans should employ sensitive and specific biomarkers of oxidative damage to lipids, proteins and DNA...
  4. ncbi request reprint Efficacy of dietary antioxidants to prevent oxidative damage and inhibit chronic disease
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Nutr 134:3196S-3198S. 2004
  5. pmc Vitamin C and cancer revisited
    Balz Frei
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 105:11037-8. 2008
  6. ncbi request reprint Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 43:89-143. 2003
    ..Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed...
  7. ncbi request reprint Iron chelation inhibits NF-kappaB-mediated adhesion molecule expression by inhibiting p22(phox) protein expression and NADPH oxidase activity
    Lixin Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Arterioscler Thromb Vasc Biol 26:2638-43. 2006
    ..Here we determined whether the iron chelator, desferrioxamine (DFO), ameliorates oxidative stress and cellular adhesion molecule expression in a murine model of local inflammation...
  8. ncbi request reprint Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Free Radic Biol Med 34:674-82. 2003
    ..Our data suggest that intracellular, but not extracellular, transition metal ions mediate inflammatory cytokine-induced SP-1 activation and adhesion molecule expression in endothelial cells...
  9. ncbi request reprint Albumin selectively inhibits TNF alpha-induced expression of vascular cell adhesion molecule-1 in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Cardiovasc Res 55:820-9. 2002
    ..We hypothesized that albumin, the major plasma protein, acts as an anti-inflammatory agent towards endothelial cells...
  10. ncbi request reprint Ascorbate does not act as a pro-oxidant towards lipids and proteins in human plasma exposed to redox-active transition metal ions and hydrogen peroxide
    Jung Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331 6512, USA
    Free Radic Biol Med 34:1306-14. 2003
    ..Our data show that even in the presence of redox-active iron or copper and H(2)O(2), ascorbate acts as an antioxidant that prevents lipid peroxidation and does not promote protein oxidation in human plasma in vitro...
  11. ncbi request reprint Thiourea protects against copper-induced oxidative damage by formation of a redox-inactive thiourea-copper complex
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
    Free Radic Biol Med 32:1333-8. 2002
    ....
  12. pmc Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine
    Lixin Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Arterioscler Thromb Vasc Biol 29:732-8. 2009
    ..The objective of the present study was to investigate whether and how LPS and iron enhance, and DFO inhibits, NADPH oxidase activity in human aortic endothelial cells (HAECs)...
  13. ncbi request reprint Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Circulation 117:421-8. 2008
    ..Here, we investigated whether LA inhibits atherosclerosis in apolipoprotein E-deficient (apoE-/-) and apoE/low-density lipoprotein receptor-deficient mice, 2 well-established animal models of human atherosclerosis...
  14. ncbi request reprint Coffee and health: a review of recent human research
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Crit Rev Food Sci Nutr 46:101-23. 2006
    ....
  15. ncbi request reprint Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
    Anal Biochem 350:41-51. 2006
    ..Ours is the first validated quantitative assay using HPLC-tandem MS applied to plasma total 15-PGFs...
  16. pmc Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 46:791-8. 2009
    ..Our findings suggest that NADPH oxidase-mediated ROS production and cellular redox signaling do not promote, but instead limit, LPS-induced acute inflammatory responses in vivo...
  17. pmc Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512
    Proc Natl Acad Sci U S A 104:4077-82. 2007
    ..Lipoic acid may be useful in the prevention of sepsis and inflammatory vascular diseases...
  18. doi request reprint Vitamin E revisited: do new data validate benefits for chronic disease prevention?
    Maret G Traber
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Curr Opin Lipidol 19:30-8. 2008
    ..Vitamin E benefits in human health and chronic disease prevention are evaluated with respect to established alpha-tocopherol functions during vitamin E deficiency, adequacy, and excess...
  19. doi request reprint Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation
    Lixin Li
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Ann N Y Acad Sci 1203:151-9. 2010
    ..Furthermore, LA reversed the age-dependent changes in aortic SOD activity and plasma MCP-1 levels. Hence, vascular oxidative stress and inflammation increase with age and are ameliorated by LA supplementation...
  20. ncbi request reprint Pyrrolidine dithiocarbamate is a potent antioxidant against hypochlorous acid-induced protein damage
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    FEBS Lett 532:80-4. 2002
    ..These data demonstrate that PDTC is a potent antioxidant against HOCl-induced protein oxidative damage, suggesting that PDTC might be useful in the prevention and treatment of inflammatory conditions...
  21. ncbi request reprint Inhibition of peroxynitrite-mediated LDL oxidation by prenylated flavonoids: the alpha,beta-unsaturated keto functionality of 2'-hydroxychalcones as a novel antioxidant pharmacophore
    Jan F Stevens
    Department of Chemistry, Oregon State University, Corvallis, Oregon 97331 7301, USA
    Chem Res Toxicol 16:1277-86. 2003
    ..Taken together, our results suggest that the alpha,beta-unsaturated keto functionality of chalcones is most reactive toward superoxide and peroxynitrite anions...
  22. ncbi request reprint Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vitro and in vivo effects
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 36:201-11. 2004
    ....
  23. pmc The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Exp Biol Med (Maywood) 235:633-41. 2010
    ..Whether eliminating excess iron is a useful adjunct for the prevention or treatment of atherosclerosis in humans remains to be investigated...
  24. ncbi request reprint Endurance exercise results in DNA damage as detected by the comet assay
    Angela Mastaloudis
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 36:966-75. 2004
    ..Thus, endurance exercise resulted in DNA damage as shown by the comet assay and AO seemed to enhance recovery in women but not in men...
  25. ncbi request reprint Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 281:37102-10. 2006
    ..We conclude that the effect of dietary flavonoids on endothelial adhesion molecule expression depends on their molecular structure, concentration, and metabolic transformation but not their antioxidant activity...
  26. pmc Vitamin C conjugates of genotoxic lipid peroxidation products: structural characterization and detection in human plasma
    John Sowell
    Linus Pauling Institute and Department of Chemistry, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 101:17964-9. 2004
    ....
  27. ncbi request reprint Is there a gender difference in the effect of antioxidants on cancer risk?
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Br J Nutr 94:139-40. 2005
  28. ncbi request reprint Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
    Francesco Visioli
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Redox Rep 7:223-7. 2002
    ..Thus, vitamin C and lipoic acid potentiate endothelial NO synthesis and bioactivity by mechanisms that appear to be independent of cellular GSH levels and redox environment...
  29. ncbi request reprint Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Free Radic Biol Med 41:1727-46. 2006
    ..We conclude that the large increase in plasma total antioxidant capacity observed after the consumption of flavonoid-rich foods is not caused by the flavonoids themselves, but is likely the consequence of increased uric acid levels...
  30. ncbi request reprint Ascorbylated 4-hydroxy-2-nonenal as a potential biomarker of oxidative stress response
    John Sowell
    Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 827:139-45. 2005
    ..In the present study, we utilize liquid chromatography coupled with tandem mass spectrometry for investigation into the use of a novel compound, ascorbylated 4-hydroxy-2-nonenal, as a potential biomarker of oxidative stress...
  31. ncbi request reprint The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids
    Silvina B Lotito
    Linus Pauling Institute, Oregon State University, Corvallis 97331, USA
    Free Radic Biol Med 37:251-8. 2004
    ..Taken together, our data show that the increase in plasma antioxidant capacity in humans after apple consumption is due mainly to the well-known metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids...
  32. ncbi request reprint Human neutrophils oxidize low-density lipoprotein by a hypochlorous acid-dependent mechanism: the role of vitamin C
    Anitra C Carr
    Linus Pauling Institute, Oregon State University, Corvallis 97331 6512, USA
    Biol Chem 383:627-36. 2002
    ....
  33. ncbi request reprint Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes
    Jung H Suh
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Redox Rep 9:57-61. 2004
    ..Our results suggest that DHLA chelates and inactivates redox-active transition metal ions in small-molecular, biological complexes without affecting iron- or copper-dependent enzyme activities...
  34. ncbi request reprint Metal-independent production of hydroxyl radicals by halogenated quinones and hydrogen peroxide: an ESR spin trapping study
    Ben Zhan Zhu
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 32:465-73. 2002
    ..Metal-independent production of *OH from H(2)O(2) was also observed with several other halogenated quinones...
  35. pmc Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo
    Hao Wei
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Heart Circ Physiol 301:H712-20. 2011
    ..Therefore, copper appears to play an important role in vascular inflammation, and TTM may have value as an anti-inflammatory or anti-atherogenic agent...
  36. ncbi request reprint Lack of inhibitory effect of HDL on TNFalpha-induced adhesion molecule expression in human aortic endothelial cells
    Wei Jian Zhang
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331, USA
    Atherosclerosis 165:241-9. 2002
    ..The ability of polyunsaturated phospholipids in HDL to affect endothelial activation remains to be further investigated...

Research Grants3

  1. 10th Annual SFRBM Meeting
    Balz Frei; Fiscal Year: 2004
    ....
  2. 11th Annual SFRBM Meeting
    Balz Frei; Fiscal Year: 2005
    ....
  3. CER on CAM Antioxidant Therapies (CERCAT)
    Balz Frei; Fiscal Year: 2007
    ..abstract_text> ..