Peter J Francis

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Hered 63:212-8. 2007
  2. pmc Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 2:e1197. 2007
  3. doi CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Ophthalmology 115:1019-25. 2008
  4. pmc Rhesus monkeys and humans share common susceptibility genes for age-related macular disease
    Peter J Francis
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Mol Genet 17:2673-80. 2008
  5. pmc Update on the role of genetics in the onset of age-related macular degeneration
    Peter James Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Clin Ophthalmol 5:1127-33. 2011
  6. pmc Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function
    Peter J Francis
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 50:3425-31. 2009
  7. doi Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    P J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    J Med Genet 46:300-7. 2009
  8. pmc Progression of geographic atrophy and genotype in age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, and Devers Eye Institute, Portland, Oregon 97239, USA
    Ophthalmology 117:1554-9, 1559.e1. 2010
  9. pmc Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Vis 14:1395-400. 2008
  10. doi Risk assessment model for development of advanced age-related macular degeneration
    Michael L Klein
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Arch Ophthalmol 129:1543-50. 2011

Collaborators

Detail Information

Publications24

  1. ncbi The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Hered 63:212-8. 2007
    ....
  2. pmc Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 2:e1197. 2007
    ..We aimed to better understand the functional role of this gene in the AMD disease process and assess whether it is associated with earlier forms of the disease...
  3. doi CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Ophthalmology 115:1019-25. 2008
    ..To determine if CFH and LOC387715/ARMS2 genotypes influence treatment response to AREDS-type nutritional supplementation with antioxidants and zinc...
  4. pmc Rhesus monkeys and humans share common susceptibility genes for age-related macular disease
    Peter J Francis
    Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Hum Mol Genet 17:2673-80. 2008
    ..This is the first evidence that humans and macaques share the same genetic susceptibility factors for a common complex disease...
  5. pmc Update on the role of genetics in the onset of age-related macular degeneration
    Peter James Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Clin Ophthalmol 5:1127-33. 2011
    ..In this article, contemporary commentary is provided on rapidly progressing efforts to elucidate the genetic pathogenesis of AMD as the field stands at the end of the first decade of the 21st century...
  6. pmc Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function
    Peter J Francis
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Invest Ophthalmol Vis Sci 50:3425-31. 2009
    ..The authors explored donor cell behavior using human cortical neural progenitor cells (hNPC(ctx)) introduced into the subretinal space of normal rhesus macaques...
  7. doi Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss
    P J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    J Med Genet 46:300-7. 2009
    ..This paper examines other AMD susceptibility genes to determine if these genotypes influenced disease progression and treatment response...
  8. pmc Progression of geographic atrophy and genotype in age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, and Devers Eye Institute, Portland, Oregon 97239, USA
    Ophthalmology 117:1554-9, 1559.e1. 2010
    ..We sought to determine whether genotype is associated with rate of growth of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD)...
  9. pmc Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population
    Peter J Francis
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA
    Mol Vis 14:1395-400. 2008
    ....
  10. doi Risk assessment model for development of advanced age-related macular degeneration
    Michael L Klein
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239, USA
    Arch Ophthalmol 129:1543-50. 2011
    ..To design a risk assessment model for development of advanced age-related macular degeneration (AMD) incorporating phenotypic, demographic, environmental, and genetic risk factors...
  11. doi Cell transplantation to arrest early changes in an ush2a animal model
    Bin Lu
    Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Invest Ophthalmol Vis Sci 51:2269-76. 2010
    ..Cell transplantation prevented functional deterioration for at least 10 weeks and reversed the mislocalization of cone pigment...
  12. ncbi Intravitreal bevacizumab (Avastin) treatment of neovascular age-related macular degeneration
    M Vaughn Emerson
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
    Retina 27:439-44. 2007
    ..To report the change in visual acuity and central retinal thickness by optical coherence tomography (OCT) after intravitreal injections of bevacizumab for the treatment of neovascular age-related macular degeneration (AMD)...
  13. doi Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy
    Michel Michaelides
    Oregon Retinal Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, OR 97239 4197, USA
    Arch Ophthalmol 129:30-9. 2011
    ..To report the detailed clinical findings of patients with retinal toxicity that developed secondary to the use of hydroxychloroquine sulfate (n = 13), chloroquine phosphate (n = 2), or a combination of the agents (n = 1)...
  14. ncbi Stop mutations in exon 6 of the choroideremia gene, CHM, associated with preservation of the electroretinogram
    Peter J Francis
    Casey Eye Institute, Oregon Health and Science University, 3375 SW Terwilliger Boulevard, Portland, OR 97239 4197, USA
    Arch Ophthalmol 123:1146-9. 2005
  15. doi Prospective randomized controlled trial of combination ranibizumab (Lucentis) and bromfenac (Xibrom) for neovascular age-related macular degeneration: a pilot study
    Christina Flaxel
    Macular Degeneration Center, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239 4197, USA
    Retina 32:417-23. 2012
    ..To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over ranibizumab alone...
  16. ncbi Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family
    Dennis W Schultz
    Macular Degeneration Center, Casey Eye Institute, Portland, OR 97239 4197, USA
    Hum Mol Genet 12:3315-23. 2003
    ....
  17. ncbi Genetics of age-related macular degeneration
    Michael L Klein
    Macular Degeneration Center, Casey Eye Institute, Department of Ophthalmology, Oregon Health and Sciences University, 3375 Southwest Terwilliger Boulevard, Portland, OR 97201, USA
    Ophthalmol Clin North Am 16:567-74. 2003
    ..In the future, as the genetics of this complex disease are unraveled, more effective treatments and preventative measures that target specific molecular defects underlying the development of AMD can be expected...
  18. ncbi Gene therapy and control of angiogenesis
    Peter J Francis
    Casey Eye Institute, Oregon Health Sciences University, 3375 Terwilliger Boulevard, Portland, OR 97201, USA
    Ophthalmol Clin North Am 16:575-82. 2003
    ..It must be hoped that the lessons learned will be beneficial to others attempting to modulate angiogenesis in systemic disorders such as cancer and rheumatoid arthritis...
  19. ncbi Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts New England Medical Center, Boston, MA 02111, USA
    JAMA 297:1793-800. 2007
    ..Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD)...
  20. ncbi Expanded genome scan in extended families with age-related macular degeneration
    Sandra Barral
    Laboratory of Statistical Genetics, Rockefeller University, New York, New York, USA
    Invest Ophthalmol Vis Sci 47:5453-9. 2006
    ..To investigate further the genetic contribution to age-related macular degeneration (AMD), increasing the power of a previous analysis and reproducing the original findings...
  21. pmc Choroideremia: analysis of the retina from a female symptomatic carrier
    Vera L Bonilha
    The Cleveland Clinic Foundation, The Cole Eye Institute, Cleveland, Ohio 44195, USA
    Ophthalmic Genet 29:99-110. 2008
    ..To define the retinal pathology in a 91 year-old affected matriarch of a three-generation choroideremia family with multiple manifesting carriers...
  22. pmc Toll-like receptor 3 and geographic atrophy in age-related macular degeneration
    Zhenglin Yang
    Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, China
    N Engl J Med 359:1456-63. 2008
    ..Advanced age-related macular degeneration consists of geographic atrophy and choroidal neovascularization. The specific genetic variants that predispose patients to geographic atrophy are largely unknown...
  23. ncbi Molecular genetic basis of inherited cataract and associated phenotypes
    M Ashwin Reddy
    Institute of Ophthalmology, and Moorfields Eye Hospital, London, United Kingdom
    Surv Ophthalmol 49:300-15. 2004
    ..Furthermore, it is possible that some of these genes will be implicated in the more common age related cataract, which also has a genetic component to its etiology...
  24. ncbi A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene
    Tin Aung
    Singapore National Eye Centre, Singapore
    Hum Genet 110:52-6. 2002
    ..04, P=0.00001 after correcting for testing four genotypes). These results indicate that polymorphisms in the OPA1 gene are associated with NTG and may be a marker for the disease...