Matthew M Ford

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 224:537-48. 2012
  2. ncbi Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Alcohol 41:21-9. 2007
  3. ncbi Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 179:265-72. 2007
  4. ncbi The influence of mecamylamine on ethanol and sucrose self-administration
    Matthew M Ford
    Department of Behavioral Neuroscience L 470, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Neuropharmacology 57:250-8. 2009
  5. ncbi Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids?
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Alcohol 37:23-33. 2005
  6. ncbi Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, the Portland Alcohol Research Center, and Veterans Affairs Medical Center Research, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 29:1630-40. 2005
  7. ncbi Determination of an estradiol dose-response relationship in the modulation of ethanol intake
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 28:20-8. 2004
  8. ncbi The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239 3098, USA
    Alcohol Clin Exp Res 35:326-37. 2011
  9. ncbi Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Alcohol Clin Exp Res 32:1408-16. 2008
  10. ncbi Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression
    Michelle A Tanchuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol Clin Exp Res 33:2077-87. 2009

Research Grants

  1. Neurosteroid Modulation of Ethanol Intake and Reward
    Matthew Ford; Fiscal Year: 2004
  2. Nicotine Modulation of Ethanol Consumption and Discrimination
    Matthew Ford; Fiscal Year: 2007

Detail Information

Publications24

  1. ncbi Discrimination of ethanol-nicotine drug mixtures in mice: dual interactive mechanisms of overshadowing and potentiation
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Psychopharmacology (Berl) 224:537-48. 2012
    ..One possible basis for the proclivity of ethanol and nicotine co-abuse is an interaction between the discriminative stimulus (S(D)) effects of each drug...
  2. ncbi Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Alcohol 41:21-9. 2007
    ..These results suggest that the separation of appetitive and consummatory phases of ethanol self-administration may prove useful in future evaluations of the pharmacological and genetic bases of ethanol reinforcement in mice...
  3. ncbi Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Behav Brain Res 179:265-72. 2007
    ..These findings support the premise that manipulations in brain ALLO levels may influence the regulatory processes governing ethanol consumption...
  4. ncbi The influence of mecamylamine on ethanol and sucrose self-administration
    Matthew M Ford
    Department of Behavioral Neuroscience L 470, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Neuropharmacology 57:250-8. 2009
    ..Assessment of drinking topography within an operant self-administration procedure may provide useful insights regarding the role of nAChR function in the regulation of ethanol consumption...
  5. ncbi Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids?
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Alcohol 37:23-33. 2005
    ....
  6. ncbi Neurosteroid modulators of GABA(A) receptors differentially modulate Ethanol intake patterns in male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, the Portland Alcohol Research Center, and Veterans Affairs Medical Center Research, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 29:1630-40. 2005
    ..The purpose of this study was to evaluate the impact of exogenous neurosteroid challenges with the agonist ALLO and the partial agonist/antagonist epipregnanolone (EPI) on the microarchitecture of ethanol drinking patterns...
  7. ncbi Determination of an estradiol dose-response relationship in the modulation of ethanol intake
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 28:20-8. 2004
    ..The purpose of this study was to delineate a dose-response relationship for E2 on ethanol intake with an extended range and number of E2 doses...
  8. ncbi The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, 97239 3098, USA
    Alcohol Clin Exp Res 35:326-37. 2011
    ....
  9. ncbi Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Alcohol Clin Exp Res 32:1408-16. 2008
    ..The primary aim of the current work was to determine whether FIN would reduce the acquisition of drinking in ethanol-naïve mice...
  10. ncbi Selected line difference in the effects of ethanol dependence and withdrawal on allopregnanolone levels and 5alpha-reductase enzyme activity and expression
    Michelle A Tanchuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol Clin Exp Res 33:2077-87. 2009
    ....
  11. ncbi Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice
    Deborah A Finn
    VAMC Research R and D 49, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Psychopharmacology (Berl) 201:423-33. 2008
    ..However, the neurochemical basis for reinstatement of responding following extinction has not been examined in mice with this model...
  12. ncbi Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis
    Matthew M Ford
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Drug Alcohol Depend 97:73-85. 2008
    ..In conjunction with data in male mice, the present findings indicate that there are sex differences in the physiological regulation of ethanol intake patterns by GABAergic neurosteroids...
  13. ncbi Repeated ethanol administration modifies the temporal structure of sucrose intake patterns in mice: effects associated with behavioral sensitization
    Raul Pastor
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, USA
    Addict Biol 15:324-35. 2010
    ..These data are consistent with current literature suggesting an enhancing effect of drug-induced sensitization on motivational processes involved in reinforcement...
  14. ncbi The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice
    Katherine R Gililland-Kaufman
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Brain Res 1243:113-23. 2008
    ....
  15. ncbi Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration
    Marcia J Ramaker
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Neuropharmacology 63:555-64. 2012
    ....
  16. ncbi Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking
    Michelle A Tanchuck
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol 45:33-44. 2011
    ..MPEP (10 mg/kg) significantly decreased binge alcohol consumption and sucrose self-administration. These results indicate that manipulation of the opioidergic, glutamatergic, and GABAergic systems significantly decreased binge drinking...
  17. ncbi Voluntary ethanol consumption in 22 inbred mouse strains
    Naomi Yoneyama
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA
    Alcohol 42:149-60. 2008
    ..37-0.45). These results add new strains to the strain mean database that will facilitate the identification of genetic relationships between voluntary ethanol consumption, saccharin preference, and other phenotypes...
  18. ncbi Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors
    Deborah A Finn
    Department of Veterans Affairs Medical Research, Portland, OR 97239, USA
    Horm Behav 57:12-22. 2010
    ..Thus, sex differences in the modulation of GABAergic neurosteroids may be an important consideration in understanding and developing therapeutic interventions in alcoholics...
  19. ncbi The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches
    Deborah A Finn
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Pharmacol Ther 101:91-112. 2004
    ....
  20. ncbi Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol
    Marcia J Ramaker
    Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon, USA
    Alcohol Clin Exp Res 35:1994-2007. 2011
    ....
  21. ncbi A genetic animal model of differential sensitivity to methamphetamine reinforcement
    Shkelzen Shabani
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Neuropharmacology 62:2169-77. 2012
    ..Thus, genetic risk factors play a critical role in the reinforcing efficacy of MA and the oral self-administration procedure is suitable for delineating genetic contributions to MA reinforcement...
  22. ncbi A new look at the 5alpha-reductase inhibitor finasteride
    Deborah A Finn
    Department of Veterans Affairs Medical Research, Portland Alcohol Research Center, 97239, USA
    CNS Drug Rev 12:53-76. 2006
    ..The data suggest that endogenous neuroactive steroid levels may be inversely related to symptoms of premenstrual and postpartum dysphoric disorder, catamenial epilepsy, depression, and alcohol withdrawal...
  23. ncbi Microanalysis of ethanol self-administration: estrous cycle phase-related changes in consumption patterns
    Matthew M Ford
    Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 26:635-43. 2002
    ..This study assessed the microstructural components of ethanol intake patterns across the estrus cycle...
  24. ncbi Ethanol consumption in the female Long-Evans rat: a modulatory role of estradiol
    Matthew M Ford
    Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Alcohol 26:103-13. 2002
    ..Together, these findings provide evidence that ovarian hormones, particularly estradiol, exert activational effects on estrogen-responsive substrates to modulate ethanol consumption in the adult female rat...

Research Grants3

  1. Neurosteroid Modulation of Ethanol Intake and Reward
    Matthew Ford; Fiscal Year: 2004
    ..Results from these experiments will provide valuable insights into the mechanisms underlying neurosteroid modulation of ethanol intake and reward. ..
  2. Nicotine Modulation of Ethanol Consumption and Discrimination
    Matthew Ford; Fiscal Year: 2007
    ..This investigational approach will provide valuable insights into the prevalence of their co-abuse liability, with the added potential to identify treatment strategies for ethanol and nicotine co-dependence. ..