Allen Enders

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint How to build a healthy heart from scratch
    KENT L R THORNBURG
    Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA
    Adv Exp Med Biol 814:205-16. 2014
  2. ncbi request reprint Uteroplacental circulation and fetal vascular function and development
    Kent L Thornburg
    Heart Research Center, Oregon Health and Science University, 3303 SW Bond Ave, CH15H, Portland, OR 97239 3098, USA
    Curr Vasc Pharmacol 11:748-57. 2013
  3. doi request reprint The role of growth in heart development
    Kent L Thornburg
    Heart Research Center, Department of Medicine Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Nestle Nutr Workshop Ser Pediatr Program 61:39-51. 2008
  4. doi request reprint Contemporary comparative placenta research--an interview with Allen Enders. Interview by Kent L Thornburg and Joan S Hunt
    Allen Enders
    Heart Research Center, Portland, Oregon, USA
    Int J Dev Biol 54:231-6. 2010
  5. pmc Review: The placenta is a programming agent for cardiovascular disease
    K L Thornburg
    Heart Research Center, Oregon Health and Science University, 3303 SW Bond Avenue, CH15H, Portland, OR 97239, USA
    Placenta 31:S54-9. 2010
  6. pmc Fetal roots of cardiac disease
    K L Thornburg
    Heart Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, Oregon 97239, USA
    Heart 91:867-8. 2005
  7. pmc Regulation of the cardiomyocyte population in the developing heart
    Kent Thornburg
    Heart Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Prog Biophys Mol Biol 106:289-99. 2011
  8. ncbi request reprint Nitric oxide and fetal coronary regulation
    Kent L Thornburg
    Heart Research Center and Department of Medicine Cardiology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Card Surg 17:307-16. 2002
  9. pmc Thyroid hormone drives fetal cardiomyocyte maturation
    Natasha N Chattergoon
    Oregon Health and Science University, Portland, OR, USA
    FASEB J 26:397-408. 2012
  10. ncbi request reprint Hemodynamic changes in pregnancy
    K L Thornburg
    Department of Physiology and Pharmacology, Informatics and Outcomes Research School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Semin Perinatol 24:11-4. 2000

Research Grants

  1. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint How to build a healthy heart from scratch
    KENT L R THORNBURG
    Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR, USA
    Adv Exp Med Biol 814:205-16. 2014
    ..Scientists in this field now have a responsibility to educate the public on the topic of nutrition and health. This chapter honors Lawrence Longo for decades of work in bringing health to pregnant women and their babies. ..
  2. ncbi request reprint Uteroplacental circulation and fetal vascular function and development
    Kent L Thornburg
    Heart Research Center, Oregon Health and Science University, 3303 SW Bond Ave, CH15H, Portland, OR 97239 3098, USA
    Curr Vasc Pharmacol 11:748-57. 2013
    ..Likewise, practical and effective therapeutic strategies to reverse detrimental placental perfusion patterns have yet to be investigated. ..
  3. doi request reprint The role of growth in heart development
    Kent L Thornburg
    Heart Research Center, Department of Medicine Cardiovascular Medicine, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Nestle Nutr Workshop Ser Pediatr Program 61:39-51. 2008
    ..Insults that modify the maturational timeline, final myocyte number, vascularity and endothelial responsiveness in the heart can have effects that persist long after the insult has been ameliorated...
  4. doi request reprint Contemporary comparative placenta research--an interview with Allen Enders. Interview by Kent L Thornburg and Joan S Hunt
    Allen Enders
    Heart Research Center, Portland, Oregon, USA
    Int J Dev Biol 54:231-6. 2010
    ..The story of Allen Enders success will be an inspiration to all up and coming placentologists who are destined to discover the exciting ..
  5. pmc Review: The placenta is a programming agent for cardiovascular disease
    K L Thornburg
    Heart Research Center, Oregon Health and Science University, 3303 SW Bond Avenue, CH15H, Portland, OR 97239, USA
    Placenta 31:S54-9. 2010
    ..Together these models suggest that the ultimate fitness of the heart is determined by hemodynamic, growth factor, and oxygen/nutrient cues before birth, all of which are influenced, if not regulated by the placenta...
  6. pmc Fetal roots of cardiac disease
    K L Thornburg
    Heart Research Center, Oregon Health and Science University, 3181 Sam Jackson Park Road, Portland, Oregon 97239, USA
    Heart 91:867-8. 2005
  7. pmc Regulation of the cardiomyocyte population in the developing heart
    Kent Thornburg
    Heart Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Prog Biophys Mol Biol 106:289-99. 2011
    ..T₃ also suppresses increased mitotic activity of stimulated cardiomyocytes but does so by increasing the cell cycle suppressant, p21, and decreasing the cell cycle activator, cyclin D1...
  8. ncbi request reprint Nitric oxide and fetal coronary regulation
    Kent L Thornburg
    Heart Research Center and Department of Medicine Cardiology, School of Medicine, Oregon Health and Science University, Portland, Oregon 97201, USA
    J Card Surg 17:307-16. 2002
    ..However, in the presence of L-NNA and severe hypoxemia, coronary flow does not exceed flows found during adenosine administration...
  9. pmc Thyroid hormone drives fetal cardiomyocyte maturation
    Natasha N Chattergoon
    Oregon Health and Science University, Portland, OR, USA
    FASEB J 26:397-408. 2012
    ..Thyroidectomized fetuses had reduced cell cycle activity and binucleation. These findings support the hypothesis that T(3) is a prime driver of prenatal cardiomyocyte maturation...
  10. ncbi request reprint Hemodynamic changes in pregnancy
    K L Thornburg
    Department of Physiology and Pharmacology, Informatics and Outcomes Research School of Medicine, Oregon Health Sciences University, Portland 97201, USA
    Semin Perinatol 24:11-4. 2000
    ..The complex hormonal environment is changing throughout pregnancy. In summary, under the influence of circulating chemical mediators blood flow is redistributed to the uterus, breast, and kidney...
  11. ncbi request reprint Coronary flow regulation in the fetal sheep
    K L Thornburg
    Department of Physiology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Am J Physiol 277:R1249-60. 1999
    ....
  12. ncbi request reprint Thyroid hormone inhibits proliferation of fetal cardiac myocytes in vitro
    N N Chattergoon
    Heart Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Endocrinol 192:R1-8. 2007
    ..1) T3 inhibits fetal cardiomyocyte proliferation, while (2) p21 protein levels increase, and (3) cyclin D1 levels decrease. Thus, T3 may be a potent regulator of cardiomyocyte proliferation and maturation in the late gestation fetus...
  13. ncbi request reprint 3D computer modeling of human cardiogenesis
    J O Pentecost
    Congenital Heart Research Center, Oregon Health Sciences University, Portland 97202, USA
    Comput Med Imaging Graph 23:45-9. 1999
    ..These innovations in embryo reconstruction not only facilitate medical education, they also serve as new tools for scientific investigation of cardiogenesis and congenital heart disease...
  14. pmc Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart
    P F O'Tierney
    Heart Research Center, Oregon Health and Sciences Univ, Portland, OR 97239, USA
    Am J Physiol Regul Integr Comp Physiol 299:R573-8. 2010
    ..005) and the left ventricle (P < 0.002) of the enalaprilat-infused fetuses. Thus, we conclude a sustained reduction in systolic pressure load decreases hyperplastic growth in the fetal heart...
  15. pmc The effects of anaemia as a programming agent in the fetal heart
    L Davis
    Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    J Physiol 565:35-41. 2005
    ..New information on these mechanisms is likely to lead to better prevention of and therapies for adult-onset coronary disease...
  16. ncbi request reprint Graphical and stereolithographic models of the developing human heart lumen
    J O Pentecost
    Oregon Health Sciences University, Congenital Heart Research Center, 3181 SW Sam Jackson Park Road, L464, Portland, OR 97201, USA
    Comput Med Imaging Graph 25:459-63. 2001
    ..This novel use of Carnegie collection images and graphical modeling software provides tools for broadening our understanding of normal and aberrant heart formation...
  17. pmc Augmentation of coronary conductance in adult sheep made anaemic during fetal life
    L Davis
    Department of Obstetrics and the Heart Research Center, Oregon Health Sciences University, Portland, OR 97239 3098, USA
    J Physiol 547:53-9. 2003
    ..Vascular reactivity of the mesenteric arteries was not different. These data suggest that coronary conductance can be modified in utero by anaemia (high flow and hypoxaemia) and that the remodelled coronary tree persists to adulthood...
  18. pmc Angiotensin II stimulates hyperplasia but not hypertrophy in immature ovine cardiomyocytes
    N C Sundgren
    Department of Physiology, Oregon Health and Science University, Portland, USA
    J Physiol 548:881-91. 2003
    ....
  19. ncbi request reprint Cortisol stimulates cell cycle activity in the cardiomyocyte of the sheep fetus
    G D Giraud
    Heart Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Endocrinology 147:3643-9. 2006
    ..Thus, increases in fetal heart mass associated with subpressor doses of cortisol are due to cardiomyocyte proliferation and not hypertrophic growth...
  20. ncbi request reprint Anaemia stimulates aquaporin 1 expression in the fetal sheep heart
    S Jonker
    Departments of Physiology and Pharmacology, Obstetrics, Medicine Cardiology, and Heart Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Exp Physiol 88:691-8. 2003
    ..05). Expression of AQP1 in all groups was greatest in the microvascular endothelium. These data suggest that AQP1 plays an important role in the physiological accommodation to fetal anaemia...
  21. pmc Placental insufficiency decreases cell cycle activity and terminal maturation in fetal sheep cardiomyocytes
    Samantha Louey
    Heart Research Center, Oregon Health and Science University, Portland, OR 97239 3098, USA
    J Physiol 580:639-48. 2007
    ..05). It is concluded that in the absence of fetal arterial hypertension, placental insufficiency is associated with substantially depressed growth of the heart through suppressed proliferation and maturation of cardiomyocytes...
  22. ncbi request reprint Sequential growth of fetal sheep cardiac myocytes in response to simultaneous arterial and venous hypertension
    Sonnet S Jonker
    Heart Research Center, Oregon Health and Science University, Portland, Oregon, USA
    Am J Physiol Regul Integr Comp Physiol 292:R913-9. 2007
    ..This study highlights unique fetal adaptations of the myocardium and the importance of experimental duration when interpreting fetal cardiac growth data...
  23. ncbi request reprint Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes
    Nathan C Sundgren
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1481-9. 2003
    ....
  24. ncbi request reprint Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart
    Sonnet S Jonker
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, USA
    J Appl Physiol (1985) 102:1130-42. 2007
    ..These data on normal cardiac growth may enable a more detailed understanding of the consequences of experimental and pathological interventions in prenatal life...
  25. ncbi request reprint Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmias
    Min Fu
    School of Medicine and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
    Biochem Pharmacol 75:2147-56. 2008
    ..The present study demonstrates a potential method for preventing aconitine-induced arrhythmias by inhibiting Ca(2+) leakage through the sarcoplasmic reticulum RyR(2) channel...
  26. pmc Effect of in utero and early-life conditions on adult health and disease
    Peter D Gluckman
    Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand
    N Engl J Med 359:61-73. 2008
  27. ncbi request reprint A possible link between the pubertal growth of girls and breast cancer in their daughters
    David J P Barker
    Heart Research Center, Oregon Health and Science University, Portland, OR, USA
    Am J Hum Biol 20:127-31. 2008
    ....
  28. ncbi request reprint Fetal anemia leads to augmented contractile response to hypoxic stress in adulthood
    Craig S Broberg
    Division of Maternal Fetal Medicine, Medical Research Bldg, L 458, 3181 SW Sam Jackson Park Rd, Portland, OR 97201 3098, USA
    Am J Physiol Regul Integr Comp Physiol 285:R649-55. 2003
    ..03). We conclude that in sheep, perinatal anemia can alter cardiac responses to hypoxic stress in the adult long after restoration of normocythemia...
  29. ncbi request reprint Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pediatr Res 61:625-9. 2007
    ..Improving the environment to which an individual is exposed during development may be as important as any other public health effort to enhance population health world wide...
  30. ncbi request reprint Modeling cardiogenesis: the challenges and promises of 3D reconstruction
    Jeffrey O Pentecost
    Department of Medical Informatics and Outcomes Research, Oregon Health and Science University, Portland, Oregon 97201, USA
    Curr Top Dev Biol 56:115-43. 2003
  31. ncbi request reprint Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins
    Paul A Rupp
    Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97201, USA
    Gene 293:47-57. 2002
    ..The CRELD1 gene is deleted in the human cytogenetic disorder 3p- syndrome and is in the region of loss of heterozygosity for several types of cancer. A potential role for this protein in these disorders is discussed...
  32. ncbi request reprint The prenatal environment and later cardiovascular disease
    Samantha Louey
    Heart Research Center, Oregon Health and Science University, Portland, Oregon, 97239 3098, USA
    Early Hum Dev 81:745-51. 2005
    ..Thus, adults most vulnerable for coronary artery disease may have experienced rapid weight gain in childhood and now have dyslipidemias and depressed endothelial function...
  33. ncbi request reprint Hypoxia and cardiac programming
    Kent L Thornburg
    J Soc Gynecol Investig 10:251. 2003

Research Grants3

  1. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2010
    ..Low cardiomyocyte numbers could lead to a myocardium that is disadvantaged for the work it will perform in extrauterine life. ..