Andrew W Duncan

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Ploidy reductions in murine fusion-derived hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 5:e1000385. 2009
  2. pmc The ploidy conveyor of mature hepatocytes as a source of genetic variation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 467:707-10. 2010
  3. pmc Aneuploidy as a mechanism for stress-induced liver adaptation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Portland, OR, USA
    J Clin Invest 122:3307-15. 2012
  4. pmc Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    Craig Dorrell
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, USA
    Genes Dev 25:1193-203. 2011
  5. pmc Frequent aneuploidy among normal human hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 142:25-8. 2012
  6. pmc Stem cells and liver regeneration
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Gastroenterology 137:466-81. 2009
  7. pmc Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol
    Qing Shuo Zhang
    Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Blood 116:5140-8. 2010

Research Grants

  1. Mechanisms of In Vivo Cell Fusion
    Andrew Duncan; Fiscal Year: 2007

Detail Information

Publications7

  1. pmc Ploidy reductions in murine fusion-derived hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 5:e1000385. 2009
    ..The generation of such daughter cells increases liver diversity, which may increase the likelihood of oncogenesis...
  2. pmc The ploidy conveyor of mature hepatocytes as a source of genetic variation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Nature 467:707-10. 2010
    ..We propose that this mechanism evolved to generate genetic diversity and permits adaptation of hepatocytes to xenobiotic or nutritional injury...
  3. pmc Aneuploidy as a mechanism for stress-induced liver adaptation
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Portland, OR, USA
    J Clin Invest 122:3307-15. 2012
    ..This result indicates that selection of a specific aneuploid karyotype can result in the adaptation of hepatocytes to chronic liver injury. The extent to which aneuploidy promotes hepatic adaptation in humans remains under investigation...
  4. pmc Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
    Craig Dorrell
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, USA
    Genes Dev 25:1193-203. 2011
    ....
  5. pmc Frequent aneuploidy among normal human hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA
    Gastroenterology 142:25-8. 2012
    ..Aneuploidy therefore does not necessarily predispose liver cells to transformation but might promote genetic diversity among hepatocytes...
  6. pmc Stem cells and liver regeneration
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Gastroenterology 137:466-81. 2009
    ..This review will consider liver stem cells in the context of each definition...
  7. pmc Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol
    Qing Shuo Zhang
    Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
    Blood 116:5140-8. 2010
    ..We conclude that Fancd2(-/-) mice have readily quantifiable hematopoietic defects, and that this model is well suited for pharmacologic screening studies...

Research Grants2

  1. Mechanisms of In Vivo Cell Fusion
    Andrew Duncan; Fiscal Year: 2007
    ..Aim 1: To elucidate details of the intrahepatic fusion process. Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. ..