- Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii InfectionJ Stone Doggett
VA Medical Center, Portland, Oregon, USA Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, USA
Antimicrob Agents Chemother 58:3547-9. 2014..gondii, cryptosporidia, and plasmodia. A lead anti-Toxoplasma BKI, 1294, has been developed to be metabolically stable and orally bioavailable. Herein, we demonstrate the oral efficacy of 1294 against toxoplasmosis in vivo. ..
- Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosisJ Stone Doggett
Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 109:15936-41. 2012..We conclude that ELQ-271 and ELQ-316 are orally bioavailable drugs that are effective against acute and latent toxoplasmosis, likely acting as inhibitors of the Q(i) site of the T. gondii cytochrome bc(1) complex...
- Disseminated Mycobacterium genavense with pulmonary nodules in a kidney transplant recipient: case report and review of the literatureJ S Doggett
Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Transpl Infect Dis 13:38-43. 2011..This case report and literature review illustrates a successful approach to the diagnosis and treatment of disseminated M. genavense and summarizes the reports of M. genavense infection in HIV-negative patients...