Research Topics
| Roderick DashwoodSummaryAffiliation: Oregon State University Country: USA Publications
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Publications
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation statusRong Wang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Mutat Res 601:11-8. 2006..Thus, further studies are warranted on the mechanisms that upregulate beta-catenin at the transcriptional level in human and rodent colon cancers...- A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axisMansi A Parasramka
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
Clin Epigenetics 4:16. 2012..abstract:.. - Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsPraveen Rajendran
Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
Clin Epigenetics 3:4. 2011.... - Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassemblyPraveen Rajendran
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Mol Cancer 10:68. 2011..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells... 
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of ratsGayle A Orner
Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
J Carcinog 5:6. 2006..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats...- Dietary histone deacetylase inhibitors: from cells to mice to manRoderick H Dashwood
Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Semin Cancer Biol 17:363-9. 2007..In a broader context, there is growing interest in dietary HDAC inhibitors and their impact on epigenetic mechanisms affecting other chronic conditions, such as cardiovascular disease, neurodegeneration and aging... 
Xenobiotic metabolism relevance to cancerRoderick H Dashwood
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
J Nutr 136:2681S-2S. 2006- The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinolR H Dashwood
Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
Food Chem Toxicol 41:1185-92. 2003..The possible significance of the low versus high dose effects are discussed in the context of ongoing clinical trials with I3C and the reported chemopreventive mechanisms in vivo... - Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesisRoderick H Dashwood
Department of Environmental and Molecular Toxicology, and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
J Biochem Mol Biol 36:35-42. 2003.... - Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?Roderick H Dashwood
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
Carcinogenesis 27:344-9. 2006.... - A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylaseMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Cancer Res 64:5767-74. 2004..Collectively, these findings suggest that SFN may be effective as a tumor-suppressing agent and as a chemotherapeutic agent, alone or in combination with other HDAC inhibitors currently undergoing clinical trials... - Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus miceMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
FASEB J 20:506-8. 2006.... - Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphaneMelinda C Myzak
Linus Pauling Institute, Weniger 503, Oregon State University, Corvallis, 97331-6512, USA
Curr Drug Targets 7:443-52. 2006..This review discusses the role of aberrant histone acetylation in tumorigenesis and describes the potential for cancer chemoprevention and therapy with a particular emphasis on dietary HDAC inhibitors... - Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoterHui Nian
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
Carcinogenesis 29:1816-24. 2008..The results are discussed in the context of other anticarcinogenic mechanisms ascribed to garlic organosulfur compounds and the metabolic conversion of such compounds to potential HDAC inhibitors in situ... - Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindacGayle A Orner
Linus Pauling Institute and Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 24:263-7. 2003.... - Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)Gayle A Orner
Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
Mutat Res 506:121-7. 2002..Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway... - Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cellsHui Nian
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 30:1416-23. 2009.... - Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cellsMelinda C Myzak
Linus Pauling Institute, Molecular and Cellular Biology Program, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 27:811-9. 2006.... - Frontiers in polyphenols and cancer preventionRoderick H Dashwood
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 137:267S-269S. 2007 - Multi-targeted prevention of cancer by sulforaphaneJohn D Clarke
Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
Cancer Lett 269:291-304. 2008..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability... - Tumor-suppressing effects of antioxidants from teaGayle A Orner
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 134:3177S-3178S. 2004 - Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cellsQingjie Li
Linus Pauling Institute and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331 6512, USA
J Biol Chem 279:45669-75. 2004.... - Endurance exercise results in DNA damage as detected by the comet assayAngela Mastaloudis
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Free Radic Biol Med 36:966-75. 2004..Thus, endurance exercise resulted in DNA damage as shown by the comet assay and AO seemed to enhance recovery in women but not in men... - Dietary sulforaphane, a histone deacetylase inhibitor for cancer preventionEmily Ho
Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA
J Nutr 139:2393-6. 2009..These studies also will provide a strong scientific foundation for future large-scale human clinical intervention studies... - Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrationsWan-Mohaiza Dashwood
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331-6512, USA
Biochem Biophys Res Commun 296:584-8. 2002..These data are consistent with the findings from in vivo studies, showing the suppression of intestinal polyps by tea, via an apparent down-regulation of beta-catenin and Wnt target genes... - Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic modelsRoderick H Dashwood
Department of Environmental and Molecular Toxicology, Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331 6512, USA
Mutat Res 511:89-112. 2002.... - Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studiesChristine A Larsen
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
J Med Chem 52:6543-5. 2009..Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein... - Chemoprotection by sulforaphane: keep one eye beyond Keap1Melinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Cancer Lett 233:208-18. 2006..The present review discusses the more widely established chemoprotective mechanisms of SFN, but makes the case for additional work on mechanisms that might be of importance during later stages of carcinogenesis, beyond Keap1... - Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signalingCarmen A Blum
Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331-6512, USA
Mutat Res 523:217-23. 2003.... - Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeineDavid J Castro
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 29:1581-6. 2008..This is the first demonstration that maternal ingestion of green tea, during pregnancy and nursing, provides protection against transplacental carcinogenesis... - Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-junCarmen A Blum
Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
Mol Carcinog 36:195-203. 2003.... - Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compoundsHui Nian
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
Environ Mol Mutagen 50:213-21. 2009..Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention... - Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouseQingjie Li
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Cancer Lett 283:36-42. 2009.... - Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxideChristine A Larsen
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Biochem Biophys Res Commun 389:527-30. 2009..We conclude that EGCG might be a beneficial therapeutic agent in the colon, inhibiting Met signaling and helping to attenuate tumor spread/metastasis, independent of H(2)O(2)-related mechanisms... - Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the ratRong Wang
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 29:834-9. 2008..These findings are discussed in the context of epidemiological data which do not support an adverse effect of tea and coffee on colon tumor outcome-indeed, some such studies suggest a protective role for caffeinated beverages... - Dietary manipulation of histone structure and functionBarbara Delage
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
Annu Rev Nutr 28:347-66. 2008.... - Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basisJane V Higdon
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Pharmacol Res 55:224-36. 2007.... - Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32Mohamed Al-Fageeh
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
Oncogene 23:4839-46. 2004..These results are discussed in the context of previous studies, which indicated that amino-acid residue D32 lies within the ubiquitination recognition motif of beta-catenin... - Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promotersQingjie Li
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Genomics 83:231-42. 2004.... - The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cellsOrianna Carter
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
J Nutr 134:3441S-3444S. 2004.... - Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallateWan-Mohaiza Dashwood
Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331-6512, USA
Mutat Res 591:161-72. 2005.... - Dietary agents as histone deacetylase inhibitorsMelinda C Myzak
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331-6512, USA
Mol Carcinog 45:443-6. 2006.... - Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjectsMelinda C Myzak
Linus Pauling Institute, Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
Exp Biol Med (Maywood) 232:227-34. 2007..Moreover, the data suggest that HDAC activity in PBMC may be used as a biomarker for assessing exposure to novel dietary HDAC inhibitors in human subjects... - E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllinKorakod Chimploy
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Int J Cancer 125:2086-94. 2009..We conclude that by inhibiting R1, R2, and p53R2, CHL has the potential to be effective in the clinical setting, when used alone or in combination with currently available cancer therapeutic agents... - Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesisDavid J Castro
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Carcinogenesis 30:315-20. 2009..005). This is the first demonstration that CHL can provide potent chemoprotection in a transplacental carcinogenesis model and support a mechanism involving complex-mediated reduction of carcinogen uptake... - Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the ratMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Carcinogenesis 28:1294-302. 2007..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon... - (-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cellsChristine A Larsen
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
Arch Biochem Biophys 501:52-7. 2010..These findings are discussed in the context of the pleiotropic effects of tea catechins, their tissue metabolite levels, and the potential to inhibit colon cancer metastasis and invasion... - Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinolineQingjie Li
Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
Gene 283:255-62. 2002..Surprisingly, no mutations were found. The results are discussed in the context of the organ-specificity of IQ-induced mutations in beta-catenin, being highly prevalent in colon tumors, but much less common in liver tumors... - Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllinG Dario Díaz
Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
Cancer Res 63:1254-61. 2003.... - Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinolineAdams Amantana
Department of Envionmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
Biol Trace Elem Res 86:177-91. 2002.... - Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow troutMichael T Simonich
Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Food Chem Toxicol 46:1014-24. 2008..001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism... - Antimutagenic activity of spearmintTian Wei Yu
Cancer Chemoprotection Program, Linus Pauling Institute, Corvallis, Oregon 97331, USA
Environ Mol Mutagen 44:387-93. 2004..Collectively, these findings suggest that spearmint tea protects against IQ and possibly other heterocyclic amines through inhibition of carcinogen activation and via direct effects on the activated metabolite(s)... - Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant cryptsOrianna Carter
Ohio University Southern, 1804 Liberty Avenue, Ironton, OH 45638, USA
Nutr Cancer 58:60-5. 2007..5 +/- 0.4 (P > 0.05, not significant). The data imply that white tea, caffeine, and EGCG may be most effective post-initiation, via the inhibition of cell proliferation in the colon and through the suppression of early lesions... - Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidinAdrian A Franke
Cancer Research Center of Hawaii, Honolulu 96813, USA
Adv Exp Med Biol 505:123-33. 2002 - Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cellsDaejoong Kwon
Department of Foods and Nutrition, Yonsei University, Seoul, Korea 120 749
Biofactors 26:231-44. 2006..keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species... - In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptorZhen Yu
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
Cancer Res 66:755-62. 2006....
Research Grants
- Dietary HDAC Inhibitors in Colon Cancer PreventionRoderick Dashwood; Fiscal Year: 2009....
- Comparative Mechanisms of Cancer ChemopreventionRoderick Dashwood; Fiscal Year: 2007..Dashwood, director). Dr. George Bailey will serve as Principal Investigator for the program project. ..
- MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLINRoderick Dashwood; Fiscal Year: 2007..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
- Dietary HDAC Inhibitors in Colon Cancer PreventionRoderick H Dashwood; Fiscal Year: 2010....