Roderick Dashwood

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mutat Res 601:11-8. 2006
  2. pmc A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Clin Epigenetics 4:16. 2012
  3. pmc Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
    Praveen Rajendran
    Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
    Clin Epigenetics 3:4. 2011
  4. pmc Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Cancer 10:68. 2011
  5. pmc Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Carcinog 5:6. 2006
  6. pmc Dietary histone deacetylase inhibitors: from cells to mice to man
    Roderick H Dashwood
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Semin Cancer Biol 17:363-9. 2007
  7. ncbi request reprint Xenobiotic metabolism relevance to cancer
    Roderick H Dashwood
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Nutr 136:2681S-2S. 2006
  8. ncbi request reprint The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol
    R H Dashwood
    Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Food Chem Toxicol 41:1185-92. 2003
  9. pmc Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Biochem Mol Biol 36:35-42. 2003
  10. pmc Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Carcinogenesis 27:344-9. 2006

Research Grants

  1. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick Dashwood; Fiscal Year: 2009
  2. Comparative Mechanisms of Cancer Chemoprevention
    Roderick Dashwood; Fiscal Year: 2007
  3. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2007
  4. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2010

Collaborators

Detail Information

Publications56

  1. pmc Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Mutat Res 601:11-8. 2006
    ..Thus, further studies are warranted on the mechanisms that upregulate beta-catenin at the transcriptional level in human and rodent colon cancers...
  2. pmc A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis
    Mansi A Parasramka
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA
    Clin Epigenetics 4:16. 2012
    ..abstract:..
  3. pmc Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
    Praveen Rajendran
    Cancer Chemoprotection Program, Linus Pauling Institute, 307 Linus Pauling Science Center, Oregon State University, Corvallis OR 97331, USA
    Clin Epigenetics 3:4. 2011
    ....
  4. pmc Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Cancer 10:68. 2011
    ..Here, we examined the time-course and reversibility of SFN-induced HDAC changes in human colon cancer cells...
  5. pmc Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    J Carcinog 5:6. 2006
    ..The single concentration of CHL tested in this study (0.1% in the drinking water) had no significant effects on AFB1-induced foci of the liver and colons of rats...
  6. pmc Dietary histone deacetylase inhibitors: from cells to mice to man
    Roderick H Dashwood
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Semin Cancer Biol 17:363-9. 2007
    ..In a broader context, there is growing interest in dietary HDAC inhibitors and their impact on epigenetic mechanisms affecting other chronic conditions, such as cardiovascular disease, neurodegeneration and aging...
  7. ncbi request reprint Xenobiotic metabolism relevance to cancer
    Roderick H Dashwood
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Nutr 136:2681S-2S. 2006
  8. ncbi request reprint The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol
    R H Dashwood
    Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Food Chem Toxicol 41:1185-92. 2003
    ..The possible significance of the low versus high dose effects are discussed in the context of ongoing clinical trials with I3C and the reported chemopreventive mechanisms in vivo...
  9. pmc Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, and Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    J Biochem Mol Biol 36:35-42. 2003
    ....
  10. pmc Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Carcinogenesis 27:344-9. 2006
    ....
  11. ncbi request reprint A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 64:5767-74. 2004
    ..Collectively, these findings suggest that SFN may be effective as a tumor-suppressing agent and as a chemotherapeutic agent, alone or in combination with other HDAC inhibitors currently undergoing clinical trials...
  12. pmc Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    FASEB J 20:506-8. 2006
    ....
  13. ncbi request reprint Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane
    Melinda C Myzak
    Linus Pauling Institute, Weniger 503, Oregon State University, Corvallis, 97331 6512, USA
    Curr Drug Targets 7:443-52. 2006
    ..This review discusses the role of aberrant histone acetylation in tumorigenesis and describes the potential for cancer chemoprevention and therapy with a particular emphasis on dietary HDAC inhibitors...
  14. pmc Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter
    Hui Nian
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Carcinogenesis 29:1816-24. 2008
    ..The results are discussed in the context of other anticarcinogenic mechanisms ascribed to garlic organosulfur compounds and the metabolic conversion of such compounds to potential HDAC inhibitors in situ...
  15. pmc Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac
    Gayle A Orner
    Linus Pauling Institute and Environmental and Molecular Toxicology Department, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 24:263-7. 2003
    ....
  16. ncbi request reprint Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    Gayle A Orner
    Department of Environmental and Molecular Toxicology, 571 Weniger Hall, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Mutat Res 506:121-7. 2002
    ..Collectively, the data support a chemopreventive role for tea and sulindac against intermediate and late stages of colon cancer, via effects on the beta-catenin/Tcf signaling pathway...
  17. pmc Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells
    Hui Nian
    Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 30:1416-23. 2009
    ....
  18. pmc Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
    Melinda C Myzak
    Linus Pauling Institute, Molecular and Cellular Biology Program, Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 27:811-9. 2006
    ....
  19. ncbi request reprint Frontiers in polyphenols and cancer prevention
    Roderick H Dashwood
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 137:267S-269S. 2007
  20. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    ..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability...
  21. ncbi request reprint Tumor-suppressing effects of antioxidants from tea
    Gayle A Orner
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 134:3177S-3178S. 2004
  22. pmc Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells
    Qingjie Li
    Linus Pauling Institute and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331 6512, USA
    J Biol Chem 279:45669-75. 2004
    ....
  23. ncbi request reprint Endurance exercise results in DNA damage as detected by the comet assay
    Angela Mastaloudis
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Free Radic Biol Med 36:966-75. 2004
    ..Thus, endurance exercise resulted in DNA damage as shown by the comet assay and AO seemed to enhance recovery in women but not in men...
  24. pmc Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention
    Emily Ho
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis OR 97331, USA
    J Nutr 139:2393-6. 2009
    ..These studies also will provide a strong scientific foundation for future large-scale human clinical intervention studies...
  25. ncbi request reprint Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations
    Wan Mohaiza Dashwood
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochem Biophys Res Commun 296:584-8. 2002
    ..These data are consistent with the findings from in vivo studies, showing the suppression of intestinal polyps by tea, via an apparent down-regulation of beta-catenin and Wnt target genes...
  26. ncbi request reprint Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models
    Roderick H Dashwood
    Department of Environmental and Molecular Toxicology, Linus Pauling Institute, and Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331 6512, USA
    Mutat Res 511:89-112. 2002
    ....
  27. pmc Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies
    Christine A Larsen
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    J Med Chem 52:6543-5. 2009
    ..Here we report on the ability of tea catechins to suppress MET activation in human colon cancer cells and propose a mechanism by which they might compete for the kinase domain of the MET protein...
  28. pmc Chemoprotection by sulforaphane: keep one eye beyond Keap1
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 233:208-18. 2006
    ..The present review discusses the more widely established chemoprotective mechanisms of SFN, but makes the case for additional work on mechanisms that might be of importance during later stages of carcinogenesis, beyond Keap1...
  29. ncbi request reprint Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling
    Carmen A Blum
    Department of Environmental and Molecular Toxicology, Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Mutat Res 523:217-23. 2003
    ....
  30. pmc Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:1581-6. 2008
    ..This is the first demonstration that maternal ingestion of green tea, during pregnancy and nursing, provides protection against transplacental carcinogenesis...
  31. pmc Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun
    Carmen A Blum
    Linus Pauling Institute, Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 6512, USA
    Mol Carcinog 36:195-203. 2003
    ....
  32. pmc Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds
    Hui Nian
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Environ Mol Mutagen 50:213-21. 2009
    ..Collectively, the results from these studies, and others reviewed herein, provide new insights into the relationships between reversible histone modifications, diet, and cancer chemoprevention...
  33. pmc Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse
    Qingjie Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Cancer Lett 283:36-42. 2009
    ....
  34. pmc Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide
    Christine A Larsen
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Biochem Biophys Res Commun 389:527-30. 2009
    ..We conclude that EGCG might be a beneficial therapeutic agent in the colon, inhibiting Met signaling and helping to attenuate tumor spread/metastasis, independent of H(2)O(2)-related mechanisms...
  35. pmc Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat
    Rong Wang
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 29:834-9. 2008
    ..These findings are discussed in the context of epidemiological data which do not support an adverse effect of tea and coffee on colon tumor outcome-indeed, some such studies suggest a protective role for caffeinated beverages...
  36. pmc Dietary manipulation of histone structure and function
    Barbara Delage
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Annu Rev Nutr 28:347-66. 2008
    ....
  37. pmc Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis
    Jane V Higdon
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Pharmacol Res 55:224-36. 2007
    ....
  38. pmc Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32
    Mohamed Al-Fageeh
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Oncogene 23:4839-46. 2004
    ..These results are discussed in the context of previous studies, which indicated that amino-acid residue D32 lies within the ubiquitination recognition motif of beta-catenin...
  39. ncbi request reprint Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters
    Qingjie Li
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Genomics 83:231-42. 2004
    ....
  40. pmc The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells
    Orianna Carter
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    J Nutr 134:3441S-3444S. 2004
    ....
  41. pmc Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate
    Wan Mohaiza Dashwood
    Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331 6512, USA
    Mutat Res 591:161-72. 2005
    ....
  42. pmc Dietary agents as histone deacetylase inhibitors
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 6512, USA
    Mol Carcinog 45:443-6. 2006
    ....
  43. pmc Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects
    Melinda C Myzak
    Linus Pauling Institute, Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Exp Biol Med (Maywood) 232:227-34. 2007
    ..Moreover, the data suggest that HDAC activity in PBMC may be used as a biomarker for assessing exposure to novel dietary HDAC inhibitors in human subjects...
  44. pmc E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin
    Korakod Chimploy
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Int J Cancer 125:2086-94. 2009
    ..We conclude that by inhibiting R1, R2, and p53R2, CHL has the potential to be effective in the clinical setting, when used alone or in combination with currently available cancer therapeutic agents...
  45. pmc Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis
    David J Castro
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Carcinogenesis 30:315-20. 2009
    ..005). This is the first demonstration that CHL can provide potent chemoprotection in a transplacental carcinogenesis model and support a mechanism involving complex-mediated reduction of carcinogen uptake...
  46. ncbi request reprint Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Carcinogenesis 28:1294-302. 2007
    ..0026) and 75% (P = 0.0004), respectively. These results show Chl and CHL provide potent chemoprotection against early biochemical and late pathophysiological biomarkers of AFB(1) carcinogenesis in the rat liver and colon...
  47. pmc (-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells
    Christine A Larsen
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 6512, USA
    Arch Biochem Biophys 501:52-7. 2010
    ..These findings are discussed in the context of the pleiotropic effects of tea catechins, their tissue metabolite levels, and the potential to inhibit colon cancer metastasis and invasion...
  48. ncbi request reprint Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline
    Qingjie Li
    Linus Pauling Institute, Oregon State University, 571 Weniger Hall, Corvallis, OR 97331 6512, USA
    Gene 283:255-62. 2002
    ..Surprisingly, no mutations were found. The results are discussed in the context of the organ-specificity of IQ-induced mutations in beta-catenin, being highly prevalent in colon tumors, but much less common in liver tumors...
  49. ncbi request reprint Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin
    G Dario Díaz
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 63:1254-61. 2003
    ....
  50. ncbi request reprint Antimutagenic activity of selenium-enriched green tea toward the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline
    Adams Amantana
    Department of Envionmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA
    Biol Trace Elem Res 86:177-91. 2002
    ....
  51. pmc Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
    Michael T Simonich
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Food Chem Toxicol 46:1014-24. 2008
    ..001). This is the first demonstration that dietary Chl can reduce tumorigenesis in any whole animal model, and that it may do so by a simple, species-independent mechanism...
  52. ncbi request reprint Antimutagenic activity of spearmint
    Tian Wei Yu
    Cancer Chemoprotection Program, Linus Pauling Institute, Corvallis, Oregon 97331, USA
    Environ Mol Mutagen 44:387-93. 2004
    ..Collectively, these findings suggest that spearmint tea protects against IQ and possibly other heterocyclic amines through inhibition of carcinogen activation and via direct effects on the activated metabolite(s)...
  53. ncbi request reprint Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts
    Orianna Carter
    Ohio University Southern, 1804 Liberty Avenue, Ironton, OH 45638, USA
    Nutr Cancer 58:60-5. 2007
    ..5 +/- 0.4 (P > 0.05, not significant). The data imply that white tea, caffeine, and EGCG may be most effective post-initiation, via the inhibition of cell proliferation in the colon and through the suppression of early lesions...
  54. ncbi request reprint Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin
    Adrian A Franke
    Cancer Research Center of Hawaii, Honolulu 96813, USA
    Adv Exp Med Biol 505:123-33. 2002
  55. pmc Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells
    Daejoong Kwon
    Department of Foods and Nutrition, Yonsei University, Seoul, Korea 120 749
    Biofactors 26:231-44. 2006
    ..keiskei, O. javanica, and B. oleracea, through mechanisms that include inhibition of carcinogen activation and scavenging of reactive oxygen species...
  56. ncbi request reprint In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor
    Zhen Yu
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331 7301, USA
    Cancer Res 66:755-62. 2006
    ....

Research Grants15

  1. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick Dashwood; Fiscal Year: 2009
    ....
  2. Comparative Mechanisms of Cancer Chemoprevention
    Roderick Dashwood; Fiscal Year: 2007
    ..Dashwood, director). Dr. George Bailey will serve as Principal Investigator for the program project. ..
  3. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2007
    ..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
  4. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2010
    ....